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Research Overview

Jurriaan M. Peters MD, PhD, is the principal epileptologist at the Multidisciplinary Tuberous Sclerosis Clinic at Boston Children’s Hospital. His research in the Laboratory of Translational Neuroimaging and in the Computational Radiology Laboratory focuses on novel MRI and EEG modeling techniques in the localization of the seizure onset zone in children with medically refractory epilepsy, on how focal lesions give rise to a generalized epileptic encephalopathy, and on early medical and surgical treatment of epilepsy to mitigate detrimental effects on neurodevelopment.

Research Background

Dr. Peters is an Associate Professor of Neurology at Harvard Medical School, and is a pediatric neurologist with additional expertise in epilepsy, clinical neurophysiology and neuroimaging. He earned his MD at the Catholic University of Leuven, Belgium, and his PhD at the University of Utrecht, the Netherlands. He did his Child Neurology training and Clinical Neurophysiology fellowship training at Boston Children’s Hospital.

Education

Medical School

Faculty of Medicine, Catholic University of Leuven
2002 Leuven Belgium

Residency

Adult Neurology VU University Medical Center Amsterdam
2003 Amsterdam Netherlands

Residency

Adult Neurology Haga Teaching Hospital
2006 Houten Netherlands

Fellowship

Epilepsy & Clinical Neurophysiology Boston Children's Hospital
2007 Boston MA

Residency

Child Neurology Boston Children's Hospital
2010 Boston MA

Internship

Pediatrics Boston Combined Residency Program (BCRP)
2011 Boston MA

Fellowship

Neuroimaging at Neurology (ABPN Neuroscience Track) Boston Children's Hospital
2012 Boston MA

Publications

  1. Accumulated seizure burden predicts neurodevelopmental outcome at 36?months of age in patients with tuberous sclerosis complex. Epilepsia. 2025 Jan; 66(1):117-133. View Abstract
  2. Association of earlier surgery with improved postoperative language development in children with tuberous sclerosis complex. J Neurosurg Pediatr. 2024 Oct 01; 34(4):384-392. View Abstract
  3. Drug-Resistant Epilepsy in Tuberous Sclerosis Complex Is Associated With TSC2 Genotype: More Findings From the Preventing Epilepsy Using Vigatrin (PREVeNT) Trial. Pediatr Neurol. 2024 Oct; 159:62-71. View Abstract
  4. Short-Term Impact of Seizures and Mitigation Opportunities. Curr Neurol Neurosci Rep. 2024 Aug; 24(8):303-314. View Abstract
  5. Publisher Correction to: Morphological Features of Language Regions in Individuals with Tuberous Sclerosis Complex. J Autism Dev Disord. 2024 Mar; 54(3):1232. View Abstract
  6. Taking a Newer, Faster, Intranasal Route: A Narrative Review of Transitioning to a Less-Invasive Rescue Treatment for Seizure Clusters. Patient Prefer Adherence. 2024; 18:383-389. View Abstract
  7. Analyses of patients who self-administered diazepam nasal spray for acute treatment of seizure clusters. Epilepsy Behav Rep. 2024; 25:100644. View Abstract
  8. Comment on: Failure to use new breakthrough treatments for epilepsy. Epilepsia. 2023 11; 64(11):3109-3110. View Abstract
  9. Mapping Lesion-Related Epilepsy to a Human Brain Network. JAMA Neurol. 2023 09 01; 80(9):891-902. View Abstract
  10. Early Treatment with Vigabatrin Does Not Decrease Focal Seizures or Improve Cognition in Tuberous Sclerosis Complex: The PREVeNT Trial. Ann Neurol. 2023 Aug 28. View Abstract
  11. Acute seizure therapies in people with epilepsy: Fact or fiction? A U.S. Perspective. Epilepsy Behav Rep. 2023; 23:100612. View Abstract
  12. Morphological Features of Language Regions in Individuals with Tuberous Sclerosis Complex. J Autism Dev Disord. 2024 Aug; 54(8):3155-3175. View Abstract
  13. Concomitant cannabidiol does not impact safety and effectiveness of diazepam nasal spray for seizure clusters: Post hoc analysis of a phase 3 safety study. Epilepsy Behav. 2023 Jul; 144:109248. View Abstract
  14. Focal epilepsies: Update on diagnosis and classification. Epileptic Disord. 2023 Feb; 25(1):1-17. View Abstract
  15. Treatment-Resistant Epilepsy and Tuberous Sclerosis Complex: Treatment, Maintenance, and Future Directions. Neuropsychiatr Dis Treat. 2023; 19:733-748. View Abstract
  16. Aluminum Thin Film Nanostructure Traces in Pediatric EEG Net for MRI and CT Artifact Reduction. Sensors (Basel). 2023 Mar 31; 23(7). View Abstract
  17. Epilepsy Severity Is Associated With Head Circumference and Growth Rate in Infants With Tuberous Sclerosis Complex. Pediatr Neurol. 2023 07; 144:26-32. View Abstract
  18. The nose has it: Opportunities and challenges for intranasal drug administration for neurologic conditions including seizure clusters. Epilepsy Behav Rep. 2023; 21:100581. View Abstract
  19. Tubers Affecting the Fusiform Face Area Are Associated with Autism Diagnosis. Ann Neurol. 2023 03; 93(3):577-590. View Abstract
  20. Significant improvements in SEIzure interVAL (time between seizure clusters) across time in patients treated with diazepam nasal spray as intermittent rescue therapy for seizure clusters. Epilepsia. 2022 10; 63(10):2684-2693. View Abstract
  21. Limited utility of structural MRI to identify the epileptogenic zone in young children with tuberous sclerosis. J Neuroimaging. 2022 09; 32(5):991-1000. View Abstract
  22. Reply to "Added value of high-resolution electrical source imaging of ictal activity in children with structural focal epilepsy". Clin Neurophysiol. 2022 08; 140:254-255. View Abstract
  23. Virtual implantation using conventional scalp EEG delineates seizure onset and predicts surgical outcome in children with epilepsy. Clin Neurophysiol. 2022 07; 139:49-57. View Abstract
  24. Comment on "Intranasal midazolam versus intravenous/rectal benzodiazepines for acute seizure control in children: A systematic review and meta-analysis". Epilepsy Behav. 2022 03; 128:108550. View Abstract
  25. Infantile Hemiconvulsion-Hemiplegia and Epilepsy (IHHE) in a boy with tuberous sclerosis complex. Epilepsy Behav Rep. 2021; 16:100473. View Abstract
  26. Startle Epilepsy Triggered By Maternal Cough. Neuropediatrics. 2021 08; 52(4):341-342. View Abstract
  27. Convolutional neural networks to identify malformations of cortical development: A feasibility study. Seizure. 2021 Oct; 91:81-90. View Abstract
  28. Source imaging of seizure onset predicts surgical outcome in pediatric epilepsy. Clin Neurophysiol. 2021 07; 132(7):1622-1635. View Abstract
  29. High-Density EEG in Current Clinical Practice and Opportunities for the Future. J Clin Neurophysiol. 2021 Mar 01; 38(2):112-123. View Abstract
  30. Tuber Locations Associated with Infantile Spasms Map to a Common Brain Network. Ann Neurol. 2021 04; 89(4):726-739. View Abstract
  31. Hippocampal Involvement With Vigabatrin-Related MRI Signal Abnormalities in Patients With Infantile Spasms: A Novel Finding. J Child Neurol. 2021 06; 36(7):575-582. View Abstract
  32. Patient-Specific Sensor Registration for Electrical Source Imaging Using a Deformable Head Model. IEEE Trans Biomed Eng. 2021 01; 68(1):267-275. View Abstract
  33. LEARNING TO DETECT BRAIN LESIONS FROM NOISY ANNOTATIONS. Proc IEEE Int Symp Biomed Imaging. 2020 Apr; 2020:1910-1914. View Abstract
  34. A structural brain network of genetic vulnerability to psychiatric illness. Mol Psychiatry. 2021 06; 26(6):2089-2100. View Abstract
  35. Deep learning in rare disease. Detection of tubers in tuberous sclerosis complex. PLoS One. 2020; 15(4):e0232376. View Abstract
  36. The Connectivity Fingerprint of the Fusiform Gyrus Captures the Risk of Developing Autism in Infants with Tuberous Sclerosis Complex. Cereb Cortex. 2020 04 14; 30(4):2199-2214. View Abstract
  37. Pilot Study of Neurodevelopmental Impact of Early Epilepsy Surgery in Tuberous Sclerosis Complex. Pediatr Neurol. 2020 08; 109:39-46. View Abstract
  38. EEG Spectral Features in Sleep of Autism Spectrum Disorders in Children with Tuberous Sclerosis Complex. J Autism Dev Disord. 2020 Mar; 50(3):916-923. View Abstract
  39. Update on Drug Management of Refractory Epilepsy in Tuberous Sclerosis Complex. Paediatr Drugs. 2020 Feb; 22(1):73-84. View Abstract
  40. Clinical Reasoning: A 6-week-old infant with migrating focal seizures. Neurology. 2020 01 28; 94(4):178-183. View Abstract
  41. Lesion-Constrained Electrical Source Imaging: A Novel Approach in Epilepsy Surgery for Tuberous Sclerosis Complex. J Clin Neurophysiol. 2020 Jan; 37(1):79-86. View Abstract
  42. Early white matter development is abnormal in tuberous sclerosis complex patients who develop autism spectrum disorder. J Neurodev Disord. 2019 12 16; 11(1):36. View Abstract
  43. Scalp EEG spikes predict impending epilepsy in TSC infants: A longitudinal observational study. Epilepsia. 2019 12; 60(12):2428-2436. View Abstract
  44. Reproducibility of Structural and Diffusion Tensor Imaging in the TACERN Multi-Center Study. Front Integr Neurosci. 2019; 13:24. View Abstract
  45. Resting-State fMRI Networks in Children with Tuberous Sclerosis Complex. J Neuroimaging. 2019 11; 29(6):750-759. View Abstract
  46. Increased electroencephalography connectivity precedes epileptic spasm onset in infants with tuberous sclerosis complex. Epilepsia. 2019 08; 60(8):1721-1732. View Abstract
  47. The Evolution of Subclinical Seizures in Children With Tuberous Sclerosis Complex. J Child Neurol. 2019 10; 34(12):770-777. View Abstract
  48. White matter mean diffusivity correlates with myelination in tuberous sclerosis complex. Ann Clin Transl Neurol. 2019 07; 6(7):1178-1190. View Abstract
  49. Seizure Prediction Models in the Neonatal Intensive Care Unit. J Clin Neurophysiol. 2019 May; 36(3):186-194. View Abstract
  50. Recurrent SLC1A2 variants cause epilepsy via a dominant negative mechanism. Ann Neurol. 2019 06; 85(6):921-926. View Abstract
  51. Multi-Resolution Graph Based Volumetric Cortical Basis Functions From Local Anatomic Features. IEEE Trans Biomed Eng. 2019 12; 66(12):3381-3392. View Abstract
  52. Assessing the localization accuracy and clinical utility of electric and magnetic source imaging in children with epilepsy. Clin Neurophysiol. 2019 04; 130(4):491-504. View Abstract
  53. Longitudinal Effects of Everolimus on White Matter Diffusion in Tuberous Sclerosis Complex. Pediatr Neurol. 2019 01; 90:24-30. View Abstract
  54. High vigabatrin dosage is associated with lower risk of infantile spasms relapse among children with tuberous sclerosis complex. Epilepsy Res. 2018 12; 148:1-7. View Abstract
  55. Corpus Callosum White Matter Diffusivity Reflects Cumulative Neurological Comorbidity in Tuberous Sclerosis Complex. Cereb Cortex. 2018 10 01; 28(10):3665-3672. View Abstract
  56. Surgical resection of ripple onset predicts outcome in pediatric epilepsy. Ann Neurol. 2018 09; 84(3):331-346. View Abstract
  57. A Comparison of Point and Complete Electrode Models in a Finite Difference Model of Invasive Electrode Measurements. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:4677-4680. View Abstract
  58. Presurgical language fMRI: Technical practices in epilepsy surgical planning. Hum Brain Mapp. 2018 10; 39(10):4032-4042. View Abstract
  59. Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy. Ann Neurol. 2018 06; 83(6):1133-1146. View Abstract
  60. Vigabatrin for Epileptic Spasms and Tonic Seizures in Tuberous Sclerosis Complex. J Child Neurol. 2018 07; 33(8):519-524. View Abstract
  61. Detailed Magnetic Resonance Imaging (MRI) Analysis in Infantile Spasms. J Child Neurol. 2018 05; 33(6):405-412. View Abstract
  62. Presurgical language fMRI: Clinical practices and patient outcomes in epilepsy surgical planning. Hum Brain Mapp. 2018 07; 39(7):2777-2785. View Abstract
  63. Response to clobazam in continuous spike-wave during sleep. Dev Med Child Neurol. 2018 03; 60(3):283-289. View Abstract
  64. Presentation and Diagnosis of Tuberous Sclerosis Complex in Infants. Pediatrics. 2017 Dec; 140(6). View Abstract
  65. Localization of stereo-electroencephalography signals using a finite difference complete electrode model. Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul; 2017:3600-3603. View Abstract
  66. Systemic Manifestations in Pyridox(am)ine 5'-Phosphate Oxidase Deficiency. Pediatr Neurol. 2017 Nov; 76:47-53. View Abstract
  67. Reduced thalamic volume in patients with Electrical Status Epilepticus in Sleep. Epilepsy Res. 2017 02; 130:74-80. View Abstract
  68. Dynamic Electrical Source Imaging (DESI) of Seizures and Interictal Epileptic Discharges Without Ensemble Averaging. IEEE Trans Med Imaging. 2017 01; 36(1):98-110. View Abstract
  69. Extensions to a manifold learning framework for time-series analysis on dynamic manifolds in bioelectric signals. Phys Rev E. 2016 04; 93(4):042218. View Abstract
  70. A pediatric epilepsy diagnostic tool for use in resource-limited settings: A pilot study. Epilepsy Behav. 2016 06; 59:57-61. View Abstract
  71. SCN2A-Related Early-Onset Epileptic Encephalopathy Responsive to Phenobarbital. J Pediatr Epilepsy. 2016 Mar; 5(1):42-46. View Abstract
  72. Improved fidelity of brain microstructure mapping from single-shell diffusion MRI. Med Image Anal. 2015 Dec; 26(1):268-86. View Abstract
  73. Tubers are neither static nor discrete: Evidence from serial diffusion tensor imaging. Neurology. 2015 Nov 03; 85(18):1536-45. View Abstract
  74. Clinical Electroencephalographic Biomarker for Impending Epilepsy in Asymptomatic Tuberous Sclerosis Complex Infants. Pediatr Neurol. 2016 Jan; 54:29-34. View Abstract
  75. Tuberous Sclerosis: A New Frontier in Targeted Treatment of Autism. Neurotherapeutics. 2015 Jul; 12(3):572-83. View Abstract
  76. Teaching video neuroimages: nonepileptic myoclonus in a neonate following severe hypoxic-ischemic injury. Neurology. 2015 Mar 24; 84(12):e90. View Abstract
  77. Altered Structural Brain Networks in Tuberous Sclerosis Complex. Cereb Cortex. 2016 May; 26(5):2046-58. View Abstract
  78. Localization of sleep spindles, k-complexes, and vertex waves with subdural electrodes in children. J Clin Neurophysiol. 2014 Aug; 31(4):367-74. View Abstract
  79. Safety and retention rate of rufinamide in 300 patients: a single pediatric epilepsy center experience. Epilepsia. 2014 Aug; 55(8):1235-44. View Abstract
  80. Treatment for continuous spikes and waves during sleep (CSWS): survey on treatment choices in North America. Epilepsia. 2014 Jul; 55(7):1099-108. View Abstract
  81. Clobazam: effect on frequency of seizures and safety profile in different subgroups of children with epilepsy. Pediatr Neurol. 2014 Jul; 51(1):60-6. View Abstract
  82. A fully Bayesian inference framework for population studies of the brain microstructure. Med Image Comput Comput Assist Interv. 2014; 17(Pt 1):25-32. View Abstract
  83. Insult to injury: transient encephalopathy in a brain-injured adolescent. J Paediatr Child Health. 2014 May; 50(5):411-4. View Abstract
  84. Clinical value of magnetoencephalographic spike propagation represented by spatiotemporal source analysis: correlation with surgical outcome. Epilepsy Res. 2014 Feb; 108(2):280-8. View Abstract
  85. A mathematical framework for the registration and analysis of multi-fascicle models for population studies of the brain microstructure. IEEE Trans Med Imaging. 2014 Feb; 33(2):504-17. View Abstract
  86. Long-term response to high-dose diazepam treatment in continuous spikes and waves during sleep. Pediatr Neurol. 2013 Sep; 49(3):163-170.e4. View Abstract
  87. Diffusion tensor imaging and related techniques in tuberous sclerosis complex: review and future directions. Future Neurol. 2013 Sep; 8(5):583-597. View Abstract
  88. Continuous Spikes and Waves during Sleep: Electroclinical Presentation and Suggestions for Management. Epilepsy Res Treat. 2013; 2013:583531. View Abstract
  89. [The brain functional network of children with autism: redundancy and disconnection]. Med Sci (Paris). 2013 Jun-Jul; 29(6-7):567-9. View Abstract
  90. Electrode localization for planning surgical resection of the epileptogenic zone in pediatric epilepsy. Int J Comput Assist Radiol Surg. 2014 Jan; 9(1):91-105. View Abstract
  91. Brain functional networks in syndromic and non-syndromic autism: a graph theoretical study of EEG connectivity. BMC Med. 2013 Feb 27; 11:54. View Abstract
  92. A magnetic resonance imaging study of cerebellar volume in tuberous sclerosis complex. Pediatr Neurol. 2013 Feb; 48(2):105-10. View Abstract
  93. Automated quantification of spikes. Epilepsy Behav. 2013 Feb; 26(2):143-52. View Abstract
  94. Whole Brain Group Network Analysis Using Network Bias and Variance Parameters. 2012; (in press):Proc IEEE Int Conf Biom Imag. View Abstract
  95. Electrical status epilepticus in sleep: clinical presentation and pathophysiology. Pediatr Neurol. 2012 Dec; 47(6):390-410. View Abstract
  96. The tower of Babel: survey on concepts and terminology in electrical status epilepticus in sleep and continuous spikes and waves during sleep in North America. Epilepsia. 2013 Apr; 54(4):741-50. View Abstract
  97. Impaired language pathways in tuberous sclerosis complex patients with autism spectrum disorders. Cereb Cortex. 2013 Jul; 23(7):1526-32. View Abstract
  98. Clinical staging and electroencephalographic evolution of continuous spikes and waves during sleep. Epilepsia. 2012 Jul; 53(7):1185-95. View Abstract
  99. Short-term response of sleep-potentiated spiking to high-dose diazepam in electric status epilepticus during sleep. Pediatr Neurol. 2012 May; 46(5):312-8. View Abstract
  100. WHOLE BRAIN GROUP NETWORK ANALYSIS USING NETWORK BIAS AND VARIANCE PARAMETERS. Proc IEEE Int Symp Biomed Imaging. 2012 May; 2012:1511-1514. View Abstract
  101. Early thalamic lesions in patients with sleep-potentiated epileptiform activity. Neurology. 2012 May 29; 78(22):1721-7. View Abstract
  102. Patients with electrical status epilepticus in sleep share similar clinical features regardless of their focal or generalized sleep potentiation of epileptiform activity. J Child Neurol. 2013 Jan; 28(1):83-9. View Abstract
  103. Behavioral measures and EEG monitoring using the Brain Symmetry Index during the Wada test in children. Epilepsy Behav. 2012 Mar; 23(3):247-53. View Abstract
  104. Good outcome with early empiric treatment of neural larva migrans due to Baylisascaris procyonis. Pediatrics. 2012 Mar; 129(3):e806-11. View Abstract
  105. Loss of white matter microstructural integrity is associated with adverse neurological outcome in tuberous sclerosis complex. Acad Radiol. 2012 Jan; 19(1):17-25. View Abstract
  106. Registration and analysis of white matter group differences with a multi-fiber model. Med Image Comput Comput Assist Interv. 2012; 15(Pt 3):313-20. View Abstract
  107. Spinal cord involvement in a child with raccoon roundworm (Baylisascaris procyonis) meningoencephalitis. Pediatr Radiol. 2012 Mar; 42(3):369-73. View Abstract
  108. Continuous spike and waves during sleep and electrical status epilepticus in sleep. J Clin Neurophysiol. 2011 Apr; 28(2):154-64. View Abstract
  109. Guillain-Barré syndrome in a child with pain: lessons learned from a late diagnosis. Acta Paediatr. 2010 Oct; 99(10):1589-91. View Abstract
  110. High-dose intravenous levetiracetam for acute seizure exacerbation in children with intractable epilepsy. Epilepsia. 2010 Jul; 51(7):1319-22. View Abstract
  111. Rapid resolution of diffusion weighted MRI abnormality in a patient with a stuttering stroke. BMJ Case Rep. 2010; 2010. View Abstract
  112. Picture of the month--quiz case. Moyamoya disease. Arch Pediatr Adolesc Med. 2009 Feb; 163(2):179-80. View Abstract
  113. Intracranial penetration of a halo pin causing an epileptic seizure. J Bone Joint Surg Br. 2006 Dec; 88(12):1654-5. View Abstract
  114. Tijdschr Neurol Neurochir. Neuromonitoring met on-line qEEG tijdens carotisendarteriectomie: ervaringen met de Brain Symmetry Index. 2005; 106(4):143-150. View Abstract
  115. A brain symmetry index (BSI) for online EEG monitoring in carotid endarterectomy. Clin Neurophysiol. 2004 May; 115(5):1189-94. View Abstract
  116. Event-related correlations in learning impaired children during A hybrid go/no-go choice reaction visual-motor task. Clin Electroencephalogr. 2003 Jul; 34(3):99-109. View Abstract
  117. Tijdschr Neurol Neurochir. Continue EEG-monitoring op de intensive care. 2003; 104(5):276-282. View Abstract
  118. Population study of benign rolandic epilepsy: is treatment needed? Neurology. 2001 Aug 14; 57(3):537-9. View Abstract

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