Education

Medical School

Colombian School of Medicine
1991 Bogota Colombia

Internship

Surgical Boston University
1997 Boston MA

Residency

Anesthesia Brigham and Women's Hospital
2000 Boston MA

Fellowship

Pediatric Anesthesia and Critical Care Boston Children's Hospital
2001 Boston MA

Fellowship

Research Boston Children's Hospital
2002 Boston MA

Publications

  1. Formulation of Quality Improvement Methodology for Risk Mitigation in Congenital Cardiac Catheterization. Pediatr Cardiol. 2025 Jan 14. View Abstract
  2. Neutrophil extracellular traps formation is associated with postoperative complications in congenital cardiac surgery. Pediatr Res. 2024 Nov 11. View Abstract
  3. Thromboelastography-guided Intraoperative Platelet Transfusion in Pediatric Heart Surgery. Ann Thorac Surg. 2024 12; 118(6):1271-1278. View Abstract
  4. Mouse embryo CoCoPUTs: novel murine transcriptomic-weighted usage website featuring multiple strains, tissues, and stages. BMC Bioinformatics. 2024 Sep 06; 25(1):294. View Abstract
  5. Perioperative Hyper-coagulation and Thrombosis: Cost Analysis After Congenital Heart Surgery. Pediatr Cardiol. 2024 Jun 20. View Abstract
  6. Barriers to healthcare access for children with congenital heart disease in eight Latin American countries. Paediatr Anaesth. 2024 09; 34(9):893-905. View Abstract
  7. Neutrophil extracellular traps formation is associated with postoperative complications in neonates and infants undergoing congenital cardiac surgery. bioRxiv. 2023 Dec 23. View Abstract
  8. Synonymous ADAMTS13 variants impact molecular characteristics and contribute to variability in active protein abundance. Blood Adv. 2022 09 27; 6(18):5364-5378. View Abstract
  9. Implications of Transfusion in Adults with Congenital Heart Disease Undergoing Cardiac Surgery. Pediatr Cardiol. 2023 Jan; 44(1):218-227. View Abstract
  10. ICU Admission Tool for Congenital Heart Catheterization (iCATCH): A Predictive Model for High Level Post-Catheterization Care and Patient Management. Pediatr Crit Care Med. 2022 10 01; 23(10):822-830. View Abstract
  11. Contribution of ADAMTS13-independent VWF regulation in sickle cell disease. J Thromb Haemost. 2022 09; 20(9):2098-2108. View Abstract
  12. Clinical implications of acute shunt thrombosis in paediatric patients with systemic-to-pulmonary shunt re-interventions. Cardiol Young. 2023 May; 33(5):726-732. View Abstract
  13. Definitive Closure of the Patent Ductus Arteriosus in Preterm Infants and Subsequent Short-Term Respiratory Outcomes. Respir Care. 2022 05; 67(5):594-606. View Abstract
  14. Comparison of Thromboelastography Devices TEG®6S Point of Care Device vs. TEG®5000 in Pediatric Patients Undergoing Cardiac Surgery. J Extra Corpor Technol. 2022 Mar; 54(1):42-49. View Abstract
  15. Safety and feasibility of the paediatric post-cardiac catheterisation Wrap: a pilot study. Cardiol Young. 2023 Jan; 33(1):11-20. View Abstract
  16. Plasma and Platelet Transfusions Strategies in Neonates and Children Undergoing Cardiac Surgery With Cardiopulmonary Bypass or Neonates and Children Supported by Extracorporeal Membrane Oxygenation: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022 01 01; 23(13 Supple 1 1S):e25-e36. View Abstract
  17. Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding (TAXI-CAB). Pediatr Crit Care Med. 2022 01 01; 23(1):34-51. View Abstract
  18. Phenotyping respiratory decompensation following definitive closure of the patent ductus arteriosus in preterm infants. J Perinatol. 2022 05; 42(5):649-654. View Abstract
  19. Distinct signatures of codon and codon pair usage in 32 primary tumor types in the novel database CancerCoCoPUTs for cancer-specific codon usage. Genome Med. 2021 07 28; 13(1):122. View Abstract
  20. In Silico Evaluation of Cyclophilin Inhibitors as Potential Treatment for SARS-CoV-2. Open Forum Infect Dis. 2021 Jun; 8(6):ofab189. View Abstract
  21. Thromboelastography During Rewarming for Management of Pediatric Cardiac Surgery Patients. Ann Thorac Surg. 2022 04; 113(4):1248-1255. View Abstract
  22. Coagulopathy and Thrombosis as a Result of Severe COVID-19 Infection: A Microvascular Focus. Thromb Haemost. 2020 Dec; 120(12):1668-1679. View Abstract
  23. In silico features of ADAMTS13 contributing to plasmatic ADAMTS13 levels in neonates with congenital heart disease. Thromb Res. 2020 09; 193:66-76. View Abstract
  24. TissueCoCoPUTs: Novel Human Tissue-Specific Codon and Codon-Pair Usage Tables Based on Differential Tissue Gene Expression. J Mol Biol. 2020 05 15; 432(11):3369-3378. View Abstract
  25. Magnetic Resonance-Based Diagnostics for Bleeding Assessment in Neonatal Cardiac Surgery. Ann Thorac Surg. 2020 06; 109(6):1931-1936. View Abstract
  26. Transition from Hemochron Response to Hemochron Signature Elite Activated Clotting Time Devices in a Congenital Cardiac Surgery Practice. J Extra Corpor Technol. 2019 Dec; 51(4):221-226. View Abstract
  27. A Single Synonymous Variant (c.354G>A [p.P118P]) in ADAMTS13 Confers Enhanced Specific Activity. Int J Mol Sci. 2019 Nov 15; 20(22). View Abstract
  28. Results of a phase 1 multicentre investigation of dexmedetomidine bolus and infusion in corrective infant cardiac surgery. Br J Anaesth. 2019 12; 123(6):839-852. View Abstract
  29. Translational and transcriptional responses in human primary hepatocytes under hypoxia. Am J Physiol Gastrointest Liver Physiol. 2019 06 01; 316(6):G720-G734. View Abstract
  30. von Willebrand factor/ADAMTS-13 interactions at birth: implications for thrombosis in the neonatal period. J Thromb Haemost. 2019 Mar; 17(3):429-440. View Abstract
  31. Thromboelastography Is Associated With Surrogates for Bleeding After Pediatric Cardiac Operations. Ann Thorac Surg. 2018 09; 106(3):799-806. View Abstract
  32. A red cell preservation strategy reduces postoperative transfusions in pediatric heart surgery patients. Paediatr Anaesth. 2018 05; 28(5):450-457. View Abstract
  33. Preoperative Thromboelastographic Profile of Patients with Congenital Heart Disease: Association of Hypercoagulability and Decreased Heparin Response. J Cardiothorac Vasc Anesth. 2018 08; 32(4):1657-1663. View Abstract
  34. Elevated preoperative von Willebrand factor is associated with perioperative thrombosis in infants and neonates with congenital heart disease. J Thromb Haemost. 2017 12; 15(12):2306-2316. View Abstract
  35. Compounding variants rescue the effect of a deleterious ADAMTS13 mutation in a child with severe congenital heart disease. Thromb Res. 2017 10; 158:98-101. View Abstract
  36. Relationship Between Transfusion of Blood Products and the Incidence of Thrombotic Complications in Neonates and Infants Undergoing Cardiac Surgery. J Cardiothorac Vasc Anesth. 2017 Dec; 31(6):1943-1948. View Abstract
  37. Hypoxic preconditioning decreases nuclear factor ?B activity via Disrupted in Schizophrenia-1. Int J Biochem Cell Biol. 2016 Jan; 70:140-8. View Abstract
  38. Effects of the fibroblast activation protein on the invasion and migration of gastric cancer. Exp Mol Pathol. 2013 Dec; 95(3):350-56. View Abstract
  39. Effects of the fibroblast activation protein on the invasion and migration of gastric cancer. Exp Mol Pathol. 2013 Oct 25. View Abstract
  40. ß-Ionone arrests cell cycle of gastric carcinoma cancer cells by a MAPK pathway. Arch Toxicol. 2013 Oct; 87(10):1797-808. View Abstract
  41. Methods to assess tissue permeability. Methods Mol Biol. 2013; 1066:81-8. View Abstract
  42. Apoptosis initiation of ß-ionone in SGC-7901 gastric carcinoma cancer cells via a PI3K-AKT pathway. Arch Toxicol. 2013 Mar; 87(3):481-90. View Abstract
  43. Ketamine activates cell cycle signaling and apoptosis in the neonatal rat brain. Anesthesiology. 2010 May; 112(5):1155-63. View Abstract
  44. Disrupted in Schizophrenia-1 (DISC1)Regulates ATM-mediated NFkappaB Activation during Hypoxia and Re-oxygenation. FASEB meeting. 2010. View Abstract
  45. Dexmedetomidine is less pro-apoptotic than ketamine in the neonatal rat brain. ASA. 2009. View Abstract
  46. Adenosine signaling mediates SUMO-1 modification of IkappaBalpha during hypoxia and reoxygenation. J Biol Chem. 2009 May 15; 284(20):13686-13695. View Abstract
  47. Adenosine signaling mediates small ubiquitin-like protein (sumo-1) modification of IKappaBalpha during hypoxia and re-oxygenation. In press, Journal of Biological Chemistry. 2009. View Abstract
  48. Anesthesia for Pediatric Thoracic Surgery. Springer Science and Business Media ( Phillip Hartigan). 2009. View Abstract
  49. Prolonged exposure to ketamine increases brain derived neurotrophic factor levels in developing rat brains. 2009; 4(1):11-16. View Abstract
  50. Prolonged exposure to ketamine increases brain derived neurotrophic factor levels in developing rat brains. Curr Drug Saf. 2009 Jan; 4(1):11-6. View Abstract
  51. Noxious Stimulation Attenuates Ketamine and Isoflurane-Induced Neuroapoptosis in the P7 Rat Brain. ASA, 2008. 2008. View Abstract
  52. Ketamine Activates Cell Cycle Events and Apoptosis in the Neonatal Rat Brain. ASA, 2008. 2008. View Abstract
  53. Pulmonary anti-inflammatory adaptation to hypoxia through adenosine-mediated Cullin-1 Deneddylation. ASA, San Francisco CA. 2007. View Abstract
  54. Central Venous Access in the Neonate. 2007. View Abstract
  55. Identification of ectonucleotidases CD39 and CD73 in innate protection during acute lung injury. J Immunol. 2007 Jun 15; 178(12):8127-37. View Abstract
  56. Antiinflammatory adaptation to hypoxia through adenosine-mediated cullin-1 deneddylation. FASEB meeting, 2007. Washington DC. 2007. View Abstract
  57. Identification of ecto-nucleotidases CD39 and CD73 in innate protection during acute lung injury. J Immunol, In press. 2007. View Abstract
  58. Antiinflammatory adaptation to hypoxia through adenosine-mediated cullin-1 deneddylation. J Clin Invest. 2007 Mar; 117(3):703-11. View Abstract
  59. Mechanical Ventilation of the Neonate. Cambridge Press. 2007. View Abstract
  60. Early tracheal extubation after liver or multivisceral transplantation in infant and toddler recipients: Is it safe?. ASA. 2006. View Abstract
  61. Transcriptional Repression of Na-K-2Cl-cotransporter NKCC1 by Hypoxia Inducible Factor-1. AJP. Cell Physiol. 2006; 291:C282-C289. View Abstract
  62. Identification of Molecular Anti-inflammatory Mechanisms of Adenosine: Cullin-1 Denedddylation during Hypoxic Preconditioning. 8th International Symposium on Adenosine and Adenine Nucleotides. 2006. View Abstract
  63. Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26. Blood. 2006 Sep 01; 108(5):1602-10. View Abstract
  64. Endothelial Catabolism of Extracellular Adenosine during Hypoxia: Role of Surface Adenosine Deaminase and CD26. Blood. Epub ahead of print. 2006. View Abstract
  65. HIF-dependent Repression of Na-K-2Clcotransporter (NKCC1) in Hypoxia. FASEB meeting 2006. San Francisco CA. 2006. View Abstract
  66. Transcriptional repression of Na-K-2Cl cotransporter NKCC1 by hypoxia-inducible factor-1. Am J Physiol Cell Physiol. 2006 Aug; 291(2):C282-9. View Abstract
  67. Anesthetic Management of a Patient with Hepatopulmonary Syndrome, Prolonged QTc Interval and Panhypopituitarism for Liver Transplantation. Society of Pediatric Anesthesia meeting. 2006. View Abstract
  68. Methods to assess tissue permeability. Methods Mol Biol. 2006; 341:111-7. View Abstract
  69. Transcriptional Repression of Na-K-2Cl-cotransporter (NKCC1) by Hypoxia Inducible Factor 1. Keystone Symposia. 2005. View Abstract
  70. Anesthesia for Emergent non-cardiac Surgery in neonates with Unpalliated Hypoplastic Left Heart Syndrome. SPA/AAP. 2005. View Abstract
  71. Methods in Molecular Biology. Methods to Assess Tissue Permeability. Cell-Cell Interactions. 2005; 341:111-117. View Abstract
  72. Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia. J Exp Med. 2004 Dec 06; 200(11):1395-405. View Abstract
  73. Critical Role for ecto-5'nucleotidase in pulmonary vascular permeability during hypoxia. ASA. 2004. View Abstract
  74. Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. Blood. 2004 Dec 15; 104(13):3986-92. View Abstract
  75. The dynamic influences of hypoxia on extracellular nucleotide metabolism and nucleoside signalling. Purines 2004. 2004. View Abstract
  76. Prolonged Ketamine Administration increases brain derived neurotrophic factor in developing rat brains. 2003. View Abstract
  77. Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors. J Exp Med. 2003 Sep 01; 198(5):783-96. View Abstract
  78. Implications of hypoxia on mucosal barrier function. Cell Mol Biol (Noisy-le-grand). 2003 Feb; 49(1):77-87. View Abstract
  79. Lung growth after reduced size transplantation in a sheep model. Transplantation. 1999 Jan 27; 67(2):233-40. View Abstract
  80. The use of expandable metallic stents for acute tracheal stenosis in the growing lamb. J Pediatr Surg. 1998 Jul; 33(7):1038-41; discussion 1041-2. View Abstract
  81. Insulin-like growth factor-I gene expression in three models of accelerated lung growth. J Pediatr Surg. 1998 Jul; 33(7):1057-60; discussion 1061. View Abstract
  82. Lung growth following reduced-size lung transplantation in a sheep model. 1998. View Abstract
  83. Pulmonary blood flow distribution during partial liquid ventilation. J Appl Physiol (1985). 1998 May; 84(5):1540-50. View Abstract
  84. Insulin like growth factor I gene expression in three models of accelerated lung growth. 1997. View Abstract
  85. The use of expandable metallic stents for acute tracheal stenosis in the growing lamb. 1997. View Abstract
  86. Effects of nitric oxide on hyperinflation-induced pulmonary hypertension in the isolated-perfused lung. Crit Care Med. 1996 Aug; 24(8):1388-95. View Abstract
  87. Continuos intrapulmonary distention with perfluorocarbon does not result in postnatal lung growth in adult sheep. 1996. View Abstract
  88. Redistribution of pulmonary blood flow during partial liquid ventilation. 1996. View Abstract
  89. University of Wisconsin cerebroplegia in a piglet survival model of circulatory arrest. Ann Thorac Surg. 1995 Dec; 60(6 Suppl):S494-500. View Abstract
  90. The effect of nitric oxide on overdistention pulmonary hypertension in the isolated sheep lung model. 1995. View Abstract
  91. Limb fractures associated with craneoencephalic trauma. 1991. View Abstract

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