John Kheir

Publications

1. Biventricular Repair of Univentricular Heart Lowers Risk of Liver Disease Compared With the Fontan Operation. JACC Adv. 2025 Jan; 4(1):101429. View Abstract
2. Systemically injected oxygen within rapidly dissolving microbubbles improves the outcomes of severe hypoxaemia in swine. Nat Biomed Eng. 2024 Nov; 8(11):1396-1411. View Abstract
3. Pediatric Sedation Gets a Wake-Up Call. J Am Coll Cardiol. 2024 Sep 10; 84(11):1022-1024. View Abstract
4. Efficacy and safety of early postoperative ablation in patients with congenital heart disease. Heart Rhythm. 2024 Sep 06. View Abstract
5. Esophageal oxyhemoglobin saturation as a resuscitative metric in hemorrhagic shock. Trauma Surg Acute Care Open. 2024; 9(1):e001480. View Abstract
6. Arch watch: current approaches and opportunities for improvement. J Perinatol. 2024 Mar; 44(3):325-332. View Abstract
7. Social Drivers of Health and Pediatric Extracorporeal Membrane Oxygenation Outcomes. Pediatrics. 2023 Dec 01; 152(6). View Abstract
8. Administration of Milrinone Following Tetralogy of Fallot Repair Increases Postoperative Volume Administration Without Improving Cardiac Output. Anesth Analg. 2023 Nov 01; 137(5):1056-1065. View Abstract
9. Impact of Dexmedetomidine Infusion on Opioid and Benzodiazepine Doses in Ventilated Pediatric Patients in the Cardiac Intensive Care Unit. Paediatr Drugs. 2023 Nov; 25(6):709-718. View Abstract
10. Predicting favorable response to intravenous morphine in pediatric critically ill cardiac patients. Pharmacotherapy. 2023 07; 43(7):579-587. View Abstract
11. Injectable Oxygen Microparticles Boost Radiation-Mediated In Situ Vaccination and Systemic Antitumor Immune Responses. Int J Radiat Oncol Biol Phys. 2023 Jul 15; 116(4):906-915. View Abstract
12. Insight into the Role of the Child Opportunity Index on Surgical Outcomes in Congenital Heart Disease. J Pediatr. 2023 08; 259:113464. View Abstract
13. Clinical risk prediction score for postoperative accelerated junctional rhythm and junctional ectopic tachycardia in children with congenital heart disease. Heart Rhythm. 2023 07; 20(7):1011-1017. View Abstract
14. Low-Fouling Zwitterionic Polymeric Colloids as Resuscitation Fluids for Hemorrhagic Shock. Adv Mater. 2022 Nov; 34(47):e2207376. View Abstract
15. Prediction of impending central-line-associated bloodstream infections in hospitalized cardiac patients: development and testing of a machine-learning model. J Hosp Infect. 2022 Sep; 127:44-50. View Abstract
16. A microfluidic device for real-time on-demand intravenous oxygen delivery. Proc Natl Acad Sci U S A. 2022 03 29; 119(13):e2115276119. View Abstract
17. Safety of Prolonged Inhalation of Hydrogen Gas in Air in Healthy Adults. Crit Care Explor. 2021 Oct; 3(10):e543. View Abstract
18. Modeling severe functional impairment or death following ECPR in pediatric cardiac patients: Planning for an interventional trial. Resuscitation. 2021 10; 167:12-21. View Abstract
19. Development of Care Curves Following the Stage 1 Palliation: A Comparison of Intensive Care Among 5 Centers. J Am Heart Assoc. 2021 06; 10(11):e019396. View Abstract
20. Commentary: Hydrogen: Lightweight molecule takes on a heavyweight problem. J Thorac Cardiovasc Surg. 2022 12; 164(6):e286-e287. View Abstract
21. Avoidable Serum Potassium Testing in the Cardiac ICU: Development and Testing of a Machine-Learning Model. Pediatr Crit Care Med. 2021 04 01; 22(4):392-400. View Abstract
22. Socioeconomic and Racial and/or Ethnic Disparities in Multisystem Inflammatory Syndrome. Pediatrics. 2021 05; 147(5). View Abstract
23. Shock Index, Coronary Perfusion Pressure, and Rate Pressure Product As Predictors of Adverse Outcome After Pediatric Cardiac Surgery. Pediatr Crit Care Med. 2021 01 01; 22(1):e67-e78. View Abstract
24. Vein of Galen Malformation. Neoreviews. 2020 10; 21(10):e678-e686. View Abstract
25. Sensitivity of a Next-Generation NIRS Device to Detect Low Mixed Venous Oxyhemoglobin Saturations in the Single Ventricle Population. Anesth Analg. 2020 09; 131(3):e138-e141. View Abstract
26. Hyperbaric polymer microcapsules for tunable oxygen delivery. J Control Release. 2020 11 10; 327:420-428. View Abstract
27. Value of provocative electrophysiology testing in the management of pediatric patients after congenital heart surgery. Pacing Clin Electrophysiol. 2020 09; 43(9):901-907. View Abstract
28. WITHDRAWN: Complete Heart Block, Severe Ventricular Dysfunction and Myocardial Inflammation in a Child with COVID-19 Infection. JACC Case Rep. 2020 May 27. View Abstract
29. Complete Heart Block, Severe Ventricular Dysfunction, and Myocardial Inflammation in a Child With COVID-19 Infection. JACC Case Rep. 2020 Jul 15; 2(9):1351-1355. View Abstract
30. Red Blood Cell Transfusion After Stage I Palliation Is Associated With Worse Clinical Outcomes. J Am Heart Assoc. 2020 05 18; 9(10):e015304. View Abstract
31. Development of a Respiratory Support Score as a Visualization Tool in Intensive Care. Respir Care. 2020 Sep; 65(9):1268-1275. View Abstract
32. Impact of the superior cavopulmonary anastomosis on cerebral oxygenation. Cardiol Young. 2020 Apr; 30(4):585-587. View Abstract
33. Value of Troponin Testing for Detection of Heart Disease in Previously Healthy Children. J Am Heart Assoc. 2020 02 18; 9(4):e012897. View Abstract
34. Fontan with lateral tunnel is associated with improved survival compared with extracardiac conduit. J Thorac Cardiovasc Surg. 2020 04; 159(4):1480-1491.e2. View Abstract
35. Safety of inhaled hydrogen gas in healthy mice. Med Gas Res. 2019 Jul-Sep; 9(3):133-138. View Abstract
36. Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine. JACC Basic Transl Sci. 2019 Apr; 4(2):176-187. View Abstract
37. Reply to Li, J "The Fick principle remains accurate to calculate cardiac output under hyperoxia". Acta Anaesthesiol Scand. 2019 07; 63(6):828. View Abstract
38. Intravenous Amiodarone and Sotalol Impair Contractility and Cardiac Output, but Procainamide Does Not: A Langendorff Study. J Cardiovasc Pharmacol Ther. 2019 05; 24(3):288-297. View Abstract
39. Tunable Nonlinear Acoustic Reporters Using Micro- and Nanosized Air Bubbles with Porous Polymeric Hard Shells. ACS Appl Mater Interfaces. 2019 Jan 09; 11(1):7-12. View Abstract
40. Injectable Oxygen: Interfacing Materials Chemistry with Resuscitative Science. Chemistry. 2018 Dec 17; 24(71):18820-18829. View Abstract
41. Physiologic effects of delayed sternal closure following stage 1 palliation. Cardiol Young. 2018 Dec; 28(12):1393-1403. View Abstract
42. Changes in tissue oxygen tension, venous saturation, and Fick-based assessments of cardiac output during hyperoxia. Acta Anaesthesiol Scand. 2019 01; 63(1):93-100. View Abstract
43. Tunable Polymer Microcapsules for Controlled Release of Therapeutic Gases. Langmuir. 2018 08 07; 34(31):9175-9183. View Abstract
44. A Device for the Quantification of Oxygen Consumption and Caloric Expenditure in the Neonatal Range. Anesth Analg. 2018 07; 127(1):95-104. View Abstract
45. Impact of a Composite Valved RV-PA Graft After Stage 1 Palliation. Ann Thorac Surg. 2018 11; 106(5):1452-1459. View Abstract
46. An anticoagulation protocol for use after congenital cardiac surgery. J Thorac Cardiovasc Surg. 2018 07; 156(1):343-352.e4. View Abstract
47. Partial thromboplastin time is more predictive of bleeding than anti-Xa levels in heparinized pediatric patients after cardiac surgery. J Thorac Cardiovasc Surg. 2018 07; 156(1):332-340.e1. View Abstract
48. Use of Oxyhemoglobin Saturation or Oxygen Tension-an Unsolved Question-Reply. JAMA Pediatr. 2018 04 01; 172(4):390-391. View Abstract
49. Interfacial Nanoprecipitation toward Stable and Responsive Microbubbles and Their Use as a Resuscitative Fluid. Angew Chem Int Ed Engl. 2018 01 26; 57(5):1271-1276. View Abstract
50. Measurement of Dead Space Fraction Upon ICU Admission Predicts Length of Stay and Clinical Outcomes Following Bidirectional Cavopulmonary Anastomosis. Pediatr Crit Care Med. 2018 01; 19(1):23-31. View Abstract
51. Use of Oxyhemoglobin Saturation, Rather Than Oxygen Tension, as a Marker of Oxygenation in Cyanotic Patients. JAMA Pediatr. 2017 10 01; 171(10):1012-1014. View Abstract
52. Responsive monitoring of mitochondrial redox states in heart muscle predicts impending cardiac arrest. Sci Transl Med. 2017 Sep 20; 9(408). View Abstract
53. Hemodynamic Effects of Lipid-Based Oxygen Microbubbles via Rapid Intravenous Injection in Rodents. Pharm Res. 2017 Oct; 34(10):2156-2162. View Abstract
54. Cerebral near-infrared spectroscopy insensitively detects low cerebral venous oxygen saturations after stage 1 palliation. J Thorac Cardiovasc Surg. 2017 09; 154(3):1056-1062. View Abstract
55. Accuracy of Oxygen Consumption and Carbon Dioxide Elimination Measurements in 2 Breath-by-Breath Devices. Respir Care. 2017 Apr; 62(4):475-480. View Abstract
56. Reply to Span et al.: Rational design of oxygen microparticles for radiation therapy. Proc Natl Acad Sci U S A. 2016 12 13; 113(50):E8010. View Abstract
57. 191: QUANTIFYING ICU SUPPORT IN THE CONTEXT OF DISEASE-MATCHED PATIENTS OVER TIME USING PERCENTILE CURVES. Crit Care Med. 2016 Dec; 44(12 Suppl 1):125. View Abstract
58. 450: SUBOPTIMAL PROTEIN INTAKE MAY PROLONG CICU LENGTH OF STAY AND WORSEN NUTRITIONAL STATUS IN CHILDREN. Crit Care Med. 2016 Dec; 44(12 Suppl 1):189. View Abstract
59. 462: BEDSIDE VCO2 AS A GUIDE TO INDIVIDUALIZED ENERGY PRESCRIPTION IN VENTILATED CHILDREN IN THE CICU. Crit Care Med. 2016 Dec; 44(12 Suppl 1):192. View Abstract
60. Phosphodiesterase Inhibitor-Based Vasodilation Improves Oxygen Delivery and Clinical Outcomes Following Stage 1 Palliation. J Am Heart Assoc. 2016 11 02; 5(11). View Abstract
61. Oxygen delivery using engineered microparticles. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):12380-12385. View Abstract
62. Rodent Working Heart Model for the Study of Myocardial Performance and Oxygen Consumption. J Vis Exp. 2016 08 16; (114). View Abstract
63. Effects of commonly used inotropes on myocardial function and oxygen consumption under constant ventricular loading conditions. J Appl Physiol (1985). 2016 07 01; 121(1):7-14. View Abstract
64. Neosaxitoxin in Rat Sciatic Block: Improved Therapeutic Index Using Combinations with Bupivacaine, with and without Epinephrine. Anesthesiology. 2015 Oct; 123(4):886-98. View Abstract
65. The effects of lung recruitment maneuvers on exhaled breath condensate pH. J Breath Res. 2015 Sep 03; 9(3):036009. View Abstract
66. Manufacture of concentrated, lipid-based oxygen microbubble emulsions by high shear homogenization and serial concentration. J Vis Exp. 2014 May 26; (87). View Abstract
67. Optimization and characterization of stable lipid-based, oxygen-filled microbubbles by mixture design. J Biomed Mater Res B Appl Biomater. 2014 Aug; 102(6):1148-56. View Abstract
68. Bulk manufacture of concentrated oxygen gas-filled microparticles for intravenous oxygen delivery. Adv Healthc Mater. 2013 Aug; 2(8):1131-41. View Abstract
69. Comparison of 2 lung recruitment strategies in children with acute lung injury. Respir Care. 2013 Aug; 58(8):1280-90. View Abstract
70. Reversal of dependent lung collapse predicts response to lung recruitment in children with early acute lung injury. Pediatr Crit Care Med. 2012 Sep; 13(5):509-15. View Abstract
71. Oxygen gas-filled microparticles provide intravenous oxygen delivery. Sci Transl Med. 2012 Jun 27; 4(140):140ra88. View Abstract
72. Respiratory, neuromuscular, and cardiovascular effects of neosaxitoxin in isoflurane-anesthetized sheep. Reg Anesth Pain Med. 2012 Mar-Apr; 37(2):152-8. View Abstract
73. Phospholipid-stabilized microbubble foam for injectable oxygen delivery. Langmuir. 2010 Oct 19; 26(20):15726-9. View Abstract
74. Neuropathology of a fatal case of posterior reversible encephalopathy syndrome. Pediatr Dev Pathol. 2010 Sep-Oct; 13(5):397-403. View Abstract
75. Implementation of a medical emergency team in a large pediatric teaching hospital prevents respiratory and cardiopulmonary arrests outside the intensive care unit. Pediatr Crit Care Med. 2007 May; 8(3):236-46; quiz 247. View Abstract
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