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Related Research Units

Ophthalmology Research
Chen Laboratory Research

Publications

  1. Assessment of Inner Blood-Retinal Barrier: Animal Models and Methods. Cells. 2023 10 12; 12(20). View Abstract
  2. Oxidative stress in retinal pigment epithelium degeneration: from pathogenesis to therapeutic targets in dry age-related macular degeneration. Neural Regen Res. 2023 Oct; 18(10):2173-2181. View Abstract
  3. Oxidative Stress and Antioxidants in Age-Related Macular Degeneration. Antioxidants (Basel). 2023 Jul 03; 12(7). View Abstract
  4. Ectopic Rod Photoreceptor Development in Mice with Genetic Deficiency of WNT2B. Cells. 2023 03 28; 12(7). View Abstract
  5. Genetic deficiency and pharmacological modulation of RORa regulate laser-induced choroidal neovascularization. Aging (Albany NY). 2023 01 10; 15(1):37-52. View Abstract
  6. Retinoic Acid Receptor-Related Orphan Receptors (RORs) in Eye Development and Disease. Adv Exp Med Biol. 2023; 1415:327-332. View Abstract
  7. Amino acid transporter SLC38A5 regulates developmental and pathological retinal angiogenesis. Elife. 2022 12 01; 11. View Abstract
  8. Endothelial Cell Transcytosis Assay as an In Vitro Model to Evaluate Inner Blood-Retinal Barrier Permeability. J Vis Exp. 2022 06 07; (184). View Abstract
  9. REV-ERBa regulates age-related and oxidative stress-induced degeneration in retinal pigment epithelium via NRF2. Redox Biol. 2022 05; 51:102261. View Abstract
  10. Wnt Signaling in Inner Blood-Retinal Barrier Maintenance. Int J Mol Sci. 2021 Nov 02; 22(21). View Abstract
  11. Stress Signal Regulation by Na/K-ATPase As a New Approach to Promote Physiological Revascularization in a Mouse Model of Ischemic Retinopathy. Invest Ophthalmol Vis Sci. 2020 12 01; 61(14):9. View Abstract
  12. Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier. Sci Adv. 2020 08; 6(35):eaba7457. View Abstract
  13. MicroRNAs in Vascular Eye Diseases. Int J Mol Sci. 2020 Jan 19; 21(2). View Abstract
  14. Loss of RAR-related orphan receptor alpha (RORa) selectively lowers docosahexaenoic acid in developing cerebellum. Prostaglandins Leukot Essent Fatty Acids. 2020 01; 152:102036. View Abstract
  15. Assessment and Characterization of Hyaloid Vessels in Mice. J Vis Exp. 2019 05 15; (147). View Abstract
  16. MicroRNA-145 Regulates Pathological Retinal Angiogenesis by Suppression of TMOD3. Mol Ther Nucleic Acids. 2019 Jun 07; 16:335-347. View Abstract
  17. Intravenous treatment of choroidal neovascularization by photo-targeted nanoparticles. Nat Commun. 2019 02 18; 10(1):804. View Abstract
  18. Wnt Signaling in vascular eye diseases. Prog Retin Eye Res. 2019 05; 70:110-133. View Abstract
  19. Animal models of ocular angiogenesis: from development to pathologies. FASEB J. 2017 11; 31(11):4665-4681. View Abstract
  20. RORa modulates semaphorin 3E transcription and neurovascular interaction in pathological retinal angiogenesis. FASEB J. 2017 10; 31(10):4492-4502. View Abstract
  21. Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail. Sci Rep. 2017 06 13; 7(1):3375. View Abstract
  22. ?-3 and ?-6 long-chain PUFAs and their enzymatic metabolites in neovascular eye diseases. Am J Clin Nutr. 2017 Jul; 106(1):16-26. View Abstract
  23. Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos. J Exp Med. 2017 06 05; 214(6):1753-1767. View Abstract
  24. Retinal expression of small non-coding RNAs in a murine model of proliferative retinopathy. Sci Rep. 2016 Sep 22; 6:33947. View Abstract
  25. Pharmacologic Activation of Wnt Signaling by Lithium Normalizes Retinal Vasculature in a Murine Model of Familial Exudative Vitreoretinopathy. Am J Pathol. 2016 10; 186(10):2588-600. View Abstract
  26. Neurovascular cross talk in diabetic retinopathy: Pathophysiological roles and therapeutic implications. Am J Physiol Heart Circ Physiol. 2016 09 01; 311(3):H738-49. View Abstract
  27. Corrigendum: Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016 06 07; 22(6):692. View Abstract
  28. TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis. Circ Res. 2016 07 22; 119(3):450-62. View Abstract
  29. Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016 Apr; 22(4):439-45. View Abstract
  30. SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth. Sci Signal. 2015 Sep 22; 8(395):ra94. View Abstract
  31. Endothelial microRNA-150 is an intrinsic suppressor of pathologic ocular neovascularization. Proc Natl Acad Sci U S A. 2015 Sep 29; 112(39):12163-8. View Abstract
  32. Nuclear receptor RORa regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10401-6. View Abstract
  33. Optimization of an Image-Guided Laser-Induced Choroidal Neovascularization Model in Mice. PLoS One. 2015; 10(7):e0132643. View Abstract
  34. Netrin-1 - DCC Signaling Systems and Age-Related Macular Degeneration. PLoS One. 2015; 10(5):e0125548. View Abstract
  35. Nanoparticle-mediated expression of a Wnt pathway inhibitor ameliorates ocular neovascularization. Arterioscler Thromb Vasc Biol. 2015 Apr; 35(4):855-64. View Abstract
  36. Dietary ?-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin. Am J Clin Nutr. 2015 Apr; 101(4):879-88. View Abstract
  37. Endothelial TWIST1 promotes pathological ocular angiogenesis. Invest Ophthalmol Vis Sci. 2014 Nov 20; 55(12):8267-77. View Abstract
  38. Enhancing reliability of the laser-induced choroidal neovascularization mouse model: insights from a new study. Invest Ophthalmol Vis Sci. 2014 Oct 16; 55(10):6535. View Abstract
  39. Cytochrome P450 2C8 ?3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):581-6. View Abstract
  40. Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy. PLoS One. 2014; 9(1):e85031. View Abstract
  41. Twist1 controls lung vascular permeability and endotoxin-induced pulmonary edema by altering Tie2 expression. PLoS One. 2013; 8(9):e73407. View Abstract
  42. Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy. Angiogenesis. 2013 Oct; 16(4):985-92. View Abstract
  43. Choroid sprouting assay: an ex vivo model of microvascular angiogenesis. PLoS One. 2013; 8(7):e69552. View Abstract
  44. Altered cholesterol homeostasis in aged macrophages linked to neovascular macular degeneration. Cell Metab. 2013 Apr 02; 17(4):471-2. View Abstract
  45. DNA sequence variants in PPARGC1A, a gene encoding a coactivator of the ?-3 LCPUFA sensing PPAR-RXR transcription complex, are associated with NV AMD and AMD-associated loci in genes of complement and VEGF signaling pathways. PLoS One. 2013; 8(1):e53155. View Abstract
  46. Author response: Different efficacy of propranolol in mice with oxygen-induced retinopathy: could differential effects of propranolol be related to differences in mouse strains? Invest Ophthalmol Vis Sci. 2012 Nov 19; 53(12):7728-9. View Abstract
  47. LRP5 regulates development of lung microvessels and alveoli through the angiopoietin-Tie2 pathway. PLoS One. 2012; 7(7):e41596. View Abstract
  48. Omega-3 polyunsaturated fatty acids preserve retinal function in type 2 diabetic mice. Nutr Diabetes. 2012 Jul 23; 2:e36. View Abstract
  49. SOCS3 is an endogenous inhibitor of pathologic angiogenesis. Blood. 2012 Oct 04; 120(14):2925-9. View Abstract
  50. Propranolol inhibition of ß-adrenergic receptor does not suppress pathologic neovascularization in oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2012 May 17; 53(6):2968-77. View Abstract
  51. Protective inflammasome activation in AMD. Nat Med. 2012 May 04; 18(5):658-60. View Abstract
  52. Retinal expression of Wnt-pathway mediated genes in low-density lipoprotein receptor-related protein 5 (Lrp5) knockout mice. PLoS One. 2012; 7(1):e30203. View Abstract
  53. Wnt signaling mediates pathological vascular growth in proliferative retinopathy. Circulation. 2011 Oct 25; 124(17):1871-81. View Abstract
  54. Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15231-6. View Abstract
  55. Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice. Invest Ophthalmol Vis Sci. 2011 Apr; 52(5):2809-16. View Abstract
  56. Current update on retinopathy of prematurity: screening and treatment. Curr Opin Pediatr. 2011 Apr; 23(2):173-8. View Abstract
  57. Lipid metabolites in the pathogenesis and treatment of neovascular eye disease. Br J Ophthalmol. 2011 Nov; 95(11):1496-501. View Abstract
  58. 5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ?-3 polyunsaturated fatty acids. Sci Transl Med. 2011 Feb 09; 3(69):69ra12. View Abstract
  59. Postnatal weight gain modifies severity and functional outcome of oxygen-induced proliferative retinopathy. Am J Pathol. 2010 Dec; 177(6):2715-23. View Abstract
  60. Vitreal levels of erythropoietin are increased in patients with retinal vein occlusion and correlate with vitreal VEGF and the extent of macular edema. Retina. 2010 Oct; 30(9):1524-9. View Abstract
  61. SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci. 2010 Jul 21; 30(29):9695-707. View Abstract
  62. Short communication: PPAR gamma mediates a direct antiangiogenic effect of omega 3-PUFAs in proliferative retinopathy. Circ Res. 2010 Aug 20; 107(4):495-500. View Abstract
  63. The mouse retina as an angiogenesis model. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):2813-26. View Abstract
  64. Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis. Nat Protoc. 2009; 4(11):1565-73. View Abstract
  65. Computer-aided quantification of retinal neovascularization. Angiogenesis. 2009; 12(3):297-301. View Abstract
  66. Light-induced translocation of cyclic-GMP phosphodiesterase on rod disc membranes in rat retina. Mol Vis. 2008; 14:2509-17. View Abstract
  67. Quantification and localization of the IGF/insulin system expression in retinal blood vessels and neurons during oxygen-induced retinopathy in mice. Invest Ophthalmol Vis Sci. 2009 Apr; 50(4):1831-7. View Abstract
  68. Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy. Invest Ophthalmol Vis Sci. 2009 Mar; 50(3):1329-35. View Abstract
  69. A double-edged sword: erythropoietin eyed in retinopathy of prematurity. J AAPOS. 2008 Jun; 12(3):221-2. View Abstract
  70. Erythropoietin deficiency decreases vascular stability in mice. J Clin Invest. 2008 Feb; 118(2):526-33. View Abstract
  71. Overstaying their welcome: defective CX3CR1 microglia eyed in macular degeneration. J Clin Invest. 2007 Oct; 117(10):2758-62. View Abstract
  72. Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med. 2007 Jul; 13(7):868-873. View Abstract
  73. IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth. Proc Natl Acad Sci U S A. 2007 Jun 19; 104(25):10589-94. View Abstract
  74. Retinopathy of prematurity. Angiogenesis. 2007; 10(2):133-40. View Abstract
  75. Subcellular localization of phosducin in rod photoreceptors. Vis Neurosci. 2005 Jan-Feb; 22(1):19-25. View Abstract
  76. Rethinking the role of phosducin: light-regulated binding of phosducin to 14-3-3 in rod inner segments. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4693-8. View Abstract
  77. Protein-protein recognition: exploring the energy funnels near the binding sites. Proteins. 1999 Feb 01; 34(2):255-67. View Abstract

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