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Emergency Medicine Research

Research Overview

Dr. Qiu's research focuses on traumatic brain injury and stroke. Dr. Qiu and his colleagues are investigating the mechanisms of injury-related cognitive dysfunction and neurodegeneration and developing biomarkers to diagnose severity of injury and predict prognosis. His lab is also interested in exploring approaches to treating traumatic brain injury and stroke.

 

Publications

  1. Tumor necrosis factor alpha and Fas receptor contribute to cognitive deficits independent of cell death after concussive traumatic brain injury in mice. J Cereb Blood Flow Metab. 2011 Feb; 31(2):778-89. View Abstract
  2. Biphasic actions of HMGB1 signaling in inflammation and recovery after stroke. Ann N Y Acad Sci. 2010 Oct; 1207:50-7. View Abstract
  3. High-mobility group box 1 promotes metalloproteinase-9 upregulation through Toll-like receptor 4 after cerebral ischemia. Stroke. 2010 Sep; 41(9):2077-82. View Abstract
  4. [Summary of the eleventh national conference on otorhinolaryngology head and neck surgery]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010 Jan; 45(1):75-8. View Abstract
  5. Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation. Stroke. 2009 Nov; 40(11):3618-26. View Abstract
  6. p27Kip1 constrains proliferation of neural progenitor cells in adult brain under homeostatic and ischemic conditions. Stem Cells. 2009 Apr; 27(4):920-7. View Abstract
  7. A critical assessment of Mus musculus gene function prediction using integrated genomic evidence. Genome Biol. 2008; 9 Suppl 1:S2. View Abstract
  8. Early release of HMGB-1 from neurons after the onset of brain ischemia. J Cereb Blood Flow Metab. 2008 May; 28(5):927-38. View Abstract
  9. Acute plasmalemma permeability and protracted clearance of injured cells after controlled cortical impact in mice. J Cereb Blood Flow Metab. 2008 Mar; 28(3):490-505. View Abstract
  10. Expression of cellular FLICE inhibitory proteins (cFLIP) in normal and traumatic murine and human cerebral cortex. J Cereb Blood Flow Metab. 2005 Aug; 25(8):1030-40. View Abstract
  11. Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia. J Cereb Blood Flow Metab. 2005 Jun; 25(6):722-9. View Abstract
  12. [Experimental study of apoptosis and Fas antigen expression in craniocerebral trauma]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2005 May; 17(5):286-8. View Abstract
  13. Direct vascular delivery of primitive hematopoietic cells to bone marrow improves localization but not engraftment. Blood. 2004 Jun 15; 103(12):4685-6. View Abstract
  14. Dose and time-dependent protection of the antioxidant N-L-acetylcysteine against impulse noise trauma. Hear Res. 2004 Jun; 192(1-2):1-9. View Abstract
  15. Cortical spreading depression activates and upregulates MMP-9. J Clin Invest. 2004 May; 113(10):1447-55. View Abstract
  16. Regenerative response in ischemic brain restricted by p21cip1/waf1. J Exp Med. 2004 Apr 05; 199(7):937-45. View Abstract
  17. FGF-2 regulates neurogenesis and degeneration in the dentate gyrus after traumatic brain injury in mice. J Clin Invest. 2003 Oct; 112(8):1202-10. View Abstract
  18. EGF amplifies the replacement of parvalbumin-expressing striatal interneurons after ischemia. J Clin Invest. 2003 Apr; 111(8):1125-32. View Abstract
  19. Upregulation of the Fas receptor death-inducing signaling complex after traumatic brain injury in mice and humans. J Neurosci. 2002 May 01; 22(9):3504-11. View Abstract
  20. Function of BID -- a molecule of the bcl-2 family -- in ischemic cell death in the brain. Eur Surg Res. 2002 Jan-Apr; 34(1-2):37-41. View Abstract

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