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Endocrinology Research

Research Overview

The ultimate goals of Ji Miao’s research are to understand the development of human diseases associated with dysregulated lipid, cholesterol, glucose, and bile acid metabolism, thus enabling the discovery of targets and treatments for these diseases, particularly diabetes, non-alcoholic fatty liver disease, and cardiovascular diseases.

Specific aims in Miao’s laboratory studies include understanding how insulin regulates nuclear receptors and how the activity of these nuclear receptors is altered in the insulin resistant state, as well as understanding the molecular mechanisms underlying the beneficial effects of bariatric surgery on metabolic regulation.

Research Background

Ji Miao received her BS and MS at Beijing University in China and her PhD at the University of Illinois, Urbana-Champaign. In 2010, Ji Miao joined the Division of Endocrinology at Boston Children’s Hospital as a postdoctoral research fellow. She was appointed as Instructor and Principal Investigator in 2013 and Assistant Professor in 2016.

 

Publications

  1. Comments on 'Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex'. J Mol Cell Biol. 2023 08 03; 15(4). View Abstract
  2. Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation. Nat Cell Biol. 2023 Jul; 25(7):950-962. View Abstract
  3. Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. Science. 2023 06 30; 380(6652):1372-1380. View Abstract
  4. Fructose aggravates copper-deficiency-induced non-alcoholic fatty liver disease. J Nutr Biochem. 2023 09; 119:109402. View Abstract
  5. Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex. Cell Rep. 2022 10 18; 41(3):111498. View Abstract
  6. Accuracy of Oxygen Saturation Measurements in Patients with Obesity Undergoing Bariatric Surgery. Obes Surg. 2022 11; 32(11):3581-3588. View Abstract
  7. Salt-Sensitive Ileal Microbiota Plays a Role in Atrial Natriuretic Peptide Deficiency-Induced Cardiac Injury. Nutrients. 2022 Jul 29; 14(15). View Abstract
  8. Insulin Prevents Hypercholesterolemia by Suppressing 12a-Hydroxylated Bile Acids. Circulation. 2022 03 29; 145(13):969-982. View Abstract
  9. An Emerging Role of Defective Copper Metabolism in Heart Disease. Nutrients. 2022 Feb 07; 14(3). View Abstract
  10. Chromatin Immunoprecipitation Assay in Primary Mouse Hepatocytes and Mouse Liver. Methods Mol Biol. 2022; 2455:149-161. View Abstract
  11. Generation of Adenovirus for In Vitro and In Vivo Studies of Hepatocytes. Methods Mol Biol. 2022; 2455:343-358. View Abstract
  12. TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states. Elife. 2021 10 08; 10. View Abstract
  13. FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance. Cell Rep. 2021 03 23; 34(12):108893. View Abstract
  14. Donor myeloid derived suppressor cells (MDSCs) prolong allogeneic cardiac graft survival through programming of recipient myeloid cells in vivo. Sci Rep. 2020 08 28; 10(1):14249. View Abstract
  15. Upregulation of METTL14 mediates the elevation of PERP mRNA N6 adenosine methylation promoting the growth and metastasis of pancreatic cancer. Mol Cancer. 2020 08 25; 19(1):130. View Abstract
  16. Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation. Cell Rep. 2020 04 21; 31(3):107524. View Abstract
  17. ß-Catenin and FGFR2 regulate postnatal rosette-based adrenocortical morphogenesis. Nat Commun. 2020 04 03; 11(1):1680. View Abstract
  18. The Human Novel Gene LNC-HC Inhibits Hepatocellular Carcinoma Cell Proliferation by Sequestering hsa-miR-183-5p. Mol Ther Nucleic Acids. 2020 Jun 05; 20:468-479. View Abstract
  19. Inhibition of XBP1s ubiquitination enhances its protein stability and improves glucose homeostasis. Metabolism. 2020 04; 105:154046. View Abstract
  20. Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction. Cell Metab. 2019 12 03; 30(6):1141-1151.e5. View Abstract
  21. Yin Yang 1 protein ameliorates diabetic nephropathy pathology through transcriptional repression of TGFß1. Sci Transl Med. 2019 09 18; 11(510). View Abstract
  22. Acute suppression of insulin resistance-associated hepatic miR-29 in vivo improves glycemic control in adult mice. Physiol Genomics. 2019 08 01; 51(8):379-389. View Abstract
  23. Publisher Correction: Inactivating hepatic follistatin alleviates hyperglycemia. Nat Med. 2018 Oct; 24(10):1628. View Abstract
  24. Disruption of the Igf2 gene alters hepatic lipid homeostasis and gene expression in the newborn mouse. Am J Physiol Endocrinol Metab. 2018 11 01; 315(5):E735-E744. View Abstract
  25. Inactivating hepatic follistatin alleviates hyperglycemia. Nat Med. 2018 07; 24(7):1058-1069. View Abstract
  26. Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways. J Biol Chem. 2018 02 09; 293(6):2006-2014. View Abstract
  27. YAP suppresses gluconeogenic gene expression through PGC1a. Hepatology. 2017 12; 66(6):2029-2041. View Abstract
  28. Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature. 2016 Oct 20; 538(7625):350-355. View Abstract
  29. Effect of Leptin Replacement on PCSK9 in ob/ob Mice and Female Lipodystrophic Patients. Endocrinology. 2016 Apr; 157(4):1421-9. View Abstract
  30. Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation. J Biol Chem. 2016 Jan 15; 291(3):1115-22. View Abstract
  31. Role of Insulin in the Regulation of Proprotein Convertase Subtilisin/Kexin Type 9. Arterioscler Thromb Vasc Biol. 2015 Jul; 35(7):1589-96. View Abstract
  32. Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis. Nat Commun. 2015 Apr 07; 6:6498. View Abstract
  33. MicroRNA-29 fine-tunes the expression of key FOXA2-activated lipid metabolism genes and is dysregulated in animal models of insulin resistance and diabetes. Diabetes. 2014 Sep; 63(9):3141-8. View Abstract
  34. Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins. J Lipid Res. 2014 Apr; 55(4):659-67. View Abstract
  35. Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. Cell Metab. 2012 Jun 06; 15(6):873-84. View Abstract
  36. Ligand-dependent regulation of the activity of the orphan nuclear receptor, small heterodimer partner (SHP), in the repression of bile acid biosynthetic CYP7A1 and CYP8B1 genes. Mol Endocrinol. 2011 Jul; 25(7):1159-69. View Abstract
  37. SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism. J Biol Chem. 2010 Oct 29; 285(44):33959-70. View Abstract
  38. A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition. J Biol Chem. 2010 Apr 23; 285(17):12604-11. View Abstract
  39. FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states. Cell Metab. 2009 Nov; 10(5):392-404. View Abstract
  40. Functional specificities of Brm and Brg-1 Swi/Snf ATPases in the feedback regulation of hepatic bile acid biosynthesis. Mol Cell Biol. 2009 Dec; 29(23):6170-81. View Abstract
  41. Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation. Genes Dev. 2009 Apr 15; 23(8):986-96. View Abstract
  42. Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism. Mol Cell Biol. 2007 Feb; 27(4):1407-24. View Abstract
  43. Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha. J Biol Chem. 2006 May 26; 281(21):14537-46. View Abstract
  44. Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP. Mol Cell Biol. 2004 Sep; 24(17):7707-19. View Abstract
  45. Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha. Mol Endocrinol. 2003 Mar; 17(3):386-94. View Abstract

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