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Related Research Units

Neurology Research
F.M. Kirby Neurobiology Center

Publications

  1. High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia. Nat Commun. 2024 Jan 17; 15(1):584. View Abstract
  2. ALDH5A1-deficient iPSC-derived excitatory and inhibitory neurons display cell type specific alterations. Neurobiol Dis. 2024 Jan; 190:106386. View Abstract
  3. High-Content Small Molecule Screen Identifies a Novel Compound That Restores AP-4-Dependent Protein Trafficking in Neuronal Models of AP-4-Associated Hereditary Spastic Paraplegia. Res Sq. 2023 Jun 12. View Abstract
  4. Itch suppression in mice and dogs by modulation of spinal a2 and a3GABAA receptors. Nat Commun. 2018 08 13; 9(1):3230. View Abstract
  5. Minimization of drug-drug interaction risk and candidate selection in a natural product-based class of gamma-secretase modulators. Bioorg Med Chem Lett. 2015 Apr 01; 25(7):1621-6. View Abstract
  6. Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor. ACS Med Chem Lett. 2014 Apr 10; 5(4):340-5. View Abstract
  7. Efficacy of SPI-1865, a novel gamma-secretase modulator, in multiple rodent models. Alzheimers Res Ther. 2013; 5(2):19. View Abstract
  8. Modulation of gamma-secretase for the treatment of Alzheimer's disease. Int J Alzheimers Dis. 2012; 2012:210756. View Abstract
  9. Optimization of a natural product-based class of ?-secretase modulators. J Med Chem. 2012 Nov 08; 55(21):9270-82. View Abstract
  10. Initial Optimization of a New Series of ?-Secretase Modulators Derived from a Triterpene Glycoside. ACS Med Chem Lett. 2012 Nov 08; 3(11):908-13. View Abstract
  11. Purine derivatives as potent gamma-secretase modulators. Bioorg Med Chem Lett. 2010 Apr 01; 20(7):2279-82. View Abstract
  12. Fluorinated piperidine acetic acids as gamma-secretase modulators. Bioorg Med Chem Lett. 2010 Jan 15; 20(2):755-8. View Abstract
  13. Amino acid derivatives as histone deacetylase inhibitors. Bioorg Med Chem Lett. 2008 Jan 01; 18(1):34-8. View Abstract
  14. A second-generation synthesis of the C1-C28 portion of the altohyrtins (spongistatins). J Am Chem Soc. 2003 Oct 22; 125(42):12836-43. View Abstract
  15. Multigram synthesis of the C29-C51 subunit and completion of the total synthesis of altohyrtin C (spongistatin 2). J Am Chem Soc. 2003 Oct 22; 125(42):12844-9. View Abstract
  16. Ni(II) bis(oxazoline)-catalyzed enantioselective syn aldol reactions of N-propionylthiazolidinethiones in the presence of silyl triflates. J Am Chem Soc. 2003 Jul 23; 125(29):8706-7. View Abstract
  17. Total synthesis of (+/-)-isoschizogamine. Org Lett. 1999 Oct 21; 1(8):1315-7. View Abstract

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