Information

Related Research Units

Psychiatry Research
Psychology Research
Als Laboratory Research

Research Overview

As a research neuropsychologist with background in statistical analysis and design methodologies, Dr. McAnulty’s primary research focus has been the development and evaluation of two innovative approaches to clinical diagnosis of neurological diseases and neurobehavioral disorders: quantified EEG (qEEG) and the Assessment of Preterm Infants’ Behavior (APIB). 

Her research interests also include the intersection of neurocognitive function, qEEG and advanced MR imaging technology in disorders including brain tumor, schizophrenia, Alzheimer’s disease, depression, dyslexia and autism as well as healthy aging.

As a licensed neuropsychologist with clinical expertise in infancy, prematurity and high-risk birth, her second focus has been in the development, evaluation and dissemination of a field changing approach to NICU care delivery, Newborn Individualized Care and Assessment Program (NIDCAP). 

She serves as site Principal Investigator of a multi-disciplinary NIH/NIMH research project whose goal is to develop clinically feasible time efficient methods for the fast acquisition of diffusion magnetic resonance imaging of pediatric patients and apply it to study the neuropathology in attention-deficit hyperactivity-disorder.

Research Background

As a research neuropsychologist with background in research design and analysis, I have been involved in the development and evaluation of two innovative approaches to clinical diagnosis of neurological diseases and neurobehavioral disorders: quantified EEG (qEEG) and the Assessment of Preterm Infants' Behavior (APIB). I began my career at Boston Children's Hospital working with qEEG's neurologist originator, Frank Duffy, MD evaluating qEEG's diagnostic sensitivity for disorders including brain tumor, schizophrenia, Alzheimer's disease, depression, dyslexia and autism as well as healthy aging. I worked on its statistical development with quantified mapping, unrestricted principal component and coherence analyses. This area grew to include MR imaging technology to define anatomical relationship to brain function findings.

As a clinical neuropsychologist with expertise in prematurity and high-risk birth, my work involves the development, evaluation and dissemination of a field changing approach to NICU care, Newborn Individualized Care and Assessment Program (NIDCAP). I have had the opportunity to evaluate a preterm infant diagnostic assessment (APIB) and participate in the quality assurance and dissemination of a system changing approach developed from the same theoretical model with the model's originator, Heidelise Als, PhD, serving as collaborator and Associate Director of the research laboratory Neurobehavioral Infant and Child Studies.

Publications

  1. Multi-level hypothalamic neuromodulation of self-regulation and cognition in preterm infants: Towards a control systems model. Compr Psychoneuroendocrinol. 2022 Feb; 9:100109. View Abstract
  2. Detecting microstructural white matter abnormalities of frontal pathways in children with ADHD using advanced diffusion models. Brain Imaging Behav. 2020 Aug; 14(4):981-997. View Abstract
  3. Suprathreshold fiber cluster statistics: Leveraging white matter geometry to enhance tractography statistical analysis. Neuroimage. 2018 05 01; 171:341-354. View Abstract
  4. A unique pattern of cortical connectivity characterizes patients with attention deficit disorders: a large electroencephalographic coherence study. BMC Med. 2017 Mar 09; 15(1):51. View Abstract
  5. Corticosteroid therapy in regressive autism: a retrospective study of effects on the Frequency Modulated Auditory Evoked Response (FMAER), language, and behavior. BMC Neurol. 2014 May 15; 14:70. View Abstract
  6. NIDCAP Federation International response. Pediatrics. 2013 Aug; 132(2):e550-1. View Abstract
  7. The relationship of Asperger's syndrome to autism: a preliminary EEG coherence study. BMC Med. 2013 Jul 31; 11:175. View Abstract
  8. School-age effects of the newborn individualized developmental care and assessment program for preterm infants with intrauterine growth restriction: preliminary findings. BMC Pediatr. 2013 Feb 19; 13:25. View Abstract
  9. NIDCAP improves brain function and structure in preterm infants with severe intrauterine growth restriction. J Perinatol. 2012 Oct; 32(10):797-803. View Abstract
  10. School Age Effects of the Newborn Individualized Developmental Care and Assessment Program for Medically Low-Risk Preterm Infants: Preliminary Findings. J Clin Neonatol. 2012; 1(4):184-194. View Abstract
  11. The Newborn Individualized Developmental Care and Assessment Program (NIDCAP) with Kangaroo Mother Care (KMC): Comprehensive Care for Preterm Infants. Curr Womens Health Rev. 2011 Aug; 7(3):288-301. View Abstract
  12. EEG spectral coherence data distinguish chronic fatigue syndrome patients from healthy controls and depressed patients--a case control study. BMC Neurol. 2011 Jul 01; 11:82. View Abstract
  13. Melatonin and mental capacities in newborn infants. J Pediatr. 2011 Jul; 159(1):99-103.e1. View Abstract
  14. Is the Newborn Individualized Developmental Care and Assessment Program (NIDCAP) effective for preterm infants with intrauterine growth restriction? J Perinatol. 2011 Feb; 31(2):130-6. View Abstract
  15. Individualized developmental care for a large sample of very preterm infants: health, neurobehaviour and neurophysiology. Acta Paediatr. 2009 Dec; 98(12):1920-6. View Abstract
  16. Effects of the Newborn Individualized Developmental Care and Assessment Program (NIDCAP) at age 8 years: preliminary data. Clin Pediatr (Phila). 2010 Mar; 49(3):258-70. View Abstract
  17. Displacement of brain regions in preterm infants with non-synostotic dolichocephaly investigated by MRI. Neuroimage. 2007 Jul 15; 36(4):1074-85. View Abstract
  18. Regional brain development in serial magnetic resonance imaging of low-risk preterm infants. Pediatrics. 2006 Jul; 118(1):23-33. View Abstract
  19. Focus on the Brain, Part 1: The Science of Preterm Infant Development. Part 2: Clinical Care Practices for Special Care Nurseries. Part 3: No Matter How Small. A Parent Guide to Preterm Infant Development. Additional: Focus on the Brain: Professional Resources [DVD 3 part series and CD additional section]. 2006. View Abstract
  20. Regional brain development of low-risk preterm infants differs from fullterm infants. Abstract 2005 Pediatric Academic Societies' Meeting. 2005. View Abstract
  21. The Assessment of Preterm Infants' Behavior (APIB): furthering the understanding and measurement of neurodevelopmental competence in preterm and full-term infants. Ment Retard Dev Disabil Res Rev. 2005; 11(1):94-102. View Abstract
  22. Prolonged T*2 values in newborn versus adult brain: Implications for fMRI studies of newborns. Magn Reson Med. 2004 Jun; 51(6):1287-91. View Abstract
  23. Early experience alters brain function and structure. Pediatrics. 2004 Apr; 113(4):846-57. View Abstract
  24. A three-center, randomized, controlled trial of individualized developmental care for very low birth weight preterm infants: medical, neurodevelopmental, parenting, and caregiving effects. J Dev Behav Pediatr. 2003 Dec; 24(6):399-408. View Abstract
  25. Event-related correlations in learning impaired children during A hybrid go/no-go choice reaction visual-motor task. Clin Electroencephalogr. 2003 Jul; 34(3):99-109. View Abstract
  26. Effectiveness of individualized developmental care for preterm infants: Neurobehavioral and neurostructural evidence. Abstract Proceedings, Biennial Meeting for the Society for Research in Child Development. 2003. View Abstract
  27. Infant EEG spectral coherence data during quiet sleep: unrestricted principal components analysis--relation of factors to gestational age, medical risk, and neurobehavioral status. Clin Electroencephalogr. 2003 Apr; 34(2):54-69. View Abstract
  28. Earliest brain development and experience: Behavior, qEEG, and MRI. Abstract Proceedings, Thirteenth Annual NIDCAP Trainers Meeting, NIDCAP Federation International. 2002. View Abstract
  29. Prolonged T2* Values in Newborns vs Adult brain: Implications for fMRI Studies of Newborns. Proceedings of the International Society for Magnetic Resonance in Medicine 10th Scientific Meeting. 2002. View Abstract
  30. DTI Study of the Premature Infant Brain Shows Change in Diffusion Properties of White Matter May Precede Myelination. Proceedings. ISMRM 10th Scientific Meeting. 2002. View Abstract
  31. Auditory evoked responses to similar words with phonemic difference: comparison between children with good and poor reading scores. Clin Electroencephalogr. 2001 Jul; 32(3):160-7. View Abstract
  32. Auditory evoked response data reduction by PCA: development of variables sensitive to reading disability. Clin Electroencephalogr. 2001 Jul; 32(3):168-78. View Abstract
  33. Auditory evoked responses to single tones and closely spaced tone pairs in children grouped by reading or matrices abilities. Clin Electroencephalogr. 1999 Jul; 30(3):84-93. View Abstract
  34. Effectiveness of individualized neurodevelopmental care in the newborn intensive care unit (NICU). Acta Paediatr Suppl. 1996 Oct; 416:21-30. View Abstract
  35. Effects of age upon interhemispheric EEG coherence in normal adults. Neurobiol Aging. 1996 Jul-Aug; 17(4):587-99. View Abstract
  36. Effectiveness of individualized developmental care for low-risk preterm infants: behavioral and electrophysiologic evidence. Pediatrics. 1995 Nov; 96(5 Pt 1):923-32. View Abstract
  37. Temporoparietal electrophysiological differences characterize patients with Alzheimer's disease: a split-half replication study. Cereb Cortex. 1995 May-Jun; 5(3):215-21. View Abstract
  38. Spectral coherence in normal adults: unrestricted principal components analysis; relation of factors to age, gender, and neuropsychologic data. Clin Electroencephalogr. 1995 Jan; 26(1):30-46. View Abstract
  39. Developmental care for very low-birth-weight infants. Journal of the American Medical Association. 1995; 273:1577-78. View Abstract
  40. Individualized developmental care for the very low-birth-weight preterm infant. Medical and neurofunctional effects. JAMA. 1994 Sep 21; 272(11):853-8. View Abstract
  41. The principal component reduction of extremely large numbers of qEEG variables to meaningful factors. Proceedings of the American Statistical Association. 1994. View Abstract
  42. Brain electrical correlates of psychological measures: strategies and problems. Brain Topogr. 1993; 5(4):399-412. View Abstract
  43. The pattern of age-related differences in electrophysiological activity of healthy males and females. Neurobiol Aging. 1993 Jan-Feb; 14(1):73-84. View Abstract
  44. Abnormal flash visual evoked response in melancholia: a replication study. Biol Psychiatry. 1992 Feb 15; 31(4):325-36. View Abstract
  45. Unrestricted principal components analysis of brain electrical activity: issues of data dimensionality, artifact, and utility. Brain Topogr. 1992; 4(4):291-307. View Abstract
  46. Linguistic profiles of dyslexics and good readers. Ann Dyslex. 1991; 41:221-45. View Abstract
  47. Linguistic profiles of dyslexic and good readers. Ann Dyslexia. 1991 Jan; 41(1):221-45. View Abstract
  48. Linguistic profiles of dyslexics and good readers. Presented at the Orton Dyslexia Society Conference. 1990. View Abstract
  49. Behavioral and electrophysiological evidence for gestational age effects in healthy preterm and fullterm infants studied two weeks after expected due date. Child Dev. 1990 Aug; 61(4):271-86. View Abstract
  50. Electrophysiologic comparisons between two groups of patients with Alzheimer's disease. Arch Neurol. 1990 Aug; 47(8):857-63. View Abstract
  51. Neurophysiological heterogeneity and the definition of dyslexia: preliminary evidence for plasticity. Neuropsychologia. 1990; 28(6):555-71. View Abstract
  52. Quantified neurophysiology with mapping: statistical inference, exploratory and confirmatory data analysis. Brain Topogr. 1990; 3(1):3-12. View Abstract
  53. Neurobehavioral regulation disorder of prematurity. Infant Behavior and Development. 1990; 13:159. View Abstract
  54. Prediction of dyslexia in kindergarten boys. Ann Dyslexia. 1990 Jan; 40(1):152-69. View Abstract
  55. Prediction of dyslexia in kindergarten boys. Ann Dyslex. 1990; 40:152-69. View Abstract
  56. Abnormal visual evoked response in melancholia. Biol Psychiatry. 1989 Mar 15; 25(6):785-8. View Abstract
  57. Continuity of neurobehavioral functioning in preterm and fullterm newborns. Bornstein M, Krasnegor N, editors. Stability and Continuity in Mental Development. 1989; 3-28. View Abstract
  58. The APIB, an assessment of functional competence in preterm and fullterm newborns regardless of gestational age at birth: II. Infant Behav Dev. 1988; 11:319-31. View Abstract
  59. Electrophysiological studies. Albert MS, Moss M, editors. Geriatric Neuropsychology. 1988; 262-89. View Abstract
  60. Individualized behavioral and environmental care for the VLBW preterm infant at high risk for bronchopulmonary dysplasia and intraventricular hemorrhage. Study II: NICU outcome. New England Perinatal Society. 1988. View Abstract
  61. Behavioral differences between preterm and fullterm and newborns as measured with the APIB System Scores: I. Infant Behav Dev. 1988; 11:305-18. View Abstract
  62. Brain mapping in normal aging and dementia. Bulletin of Clinical Neuroscience. 1988; 53:89-93. View Abstract
  63. Neurophysiological studies in dyslexia. Plum F, editor. Language, Communication and the Brain. 1988; 66:149-70. View Abstract
  64. Neurophysiological studies in dyslexia. Res Publ Assoc Res Nerv Ment Dis. 1988; 66:149-70. View Abstract
  65. Lecithin: absence of neurophysiologic effect in Alzheimer's disease by EEG topography. Neurology. 1987 Jun; 37(6):1015-9. View Abstract
  66. Outcome 5-7 years after severe perinatal asphyxia (SPA) in term infants. Pediatric Research 21. 1987; 5. View Abstract
  67. Individualized behavioral and environmental care for the very low birth weight preterm infant at high risk for bronchopulmonary dysplasia: neonatal intensive care unit and developmental outcome. Pediatrics. 1986 Dec; 78(6):1123-32. View Abstract
  68. CT and EEG Validators for Alzheimer's disease. Poon L, editor. Handbook of Clinical Memory Assessment. 1986; 514-30. View Abstract
  69. Individualized behavioral and environmental care for the VLBW preterm infant at high risk for bronchopulmonary dysplasia. Study I: NICU outcome. New England Perinatal Society. 1986. View Abstract
  70. Structure and function: brain electrical activity mapping and computed tomography in schizophrenia. Biol Psychiatry. 1985 Jan; 20(1):3-19. View Abstract
  71. Age-related differences in brain electrical activity of healthy subjects. Ann Neurol. 1984 Oct; 16(4):430-8. View Abstract
  72. Brain electrical activity in patients with presenile and senile dementia of the Alzheimer type. Ann Neurol. 1984 Oct; 16(4):439-48. View Abstract
  73. Pathological left-handedness and familial sinistrality in relation to degree of mental retardation. Brain Cogn. 1984; 3:349-56.. View Abstract
  74. Brain electrical activity mapping (BEAM): search for a physiological signature of dyslexia. Duffy FH, Geschwind N, editors. Dyslexia: A Neuroscientific Approach to Clinical Evaluation. 1984; 105-22. View Abstract
  75. Brain electrical activity mapping. Geschwind N, Galaburda AM, editors. Cerebral Dominance: The Biological Foundations. 1984; 53-74. View Abstract
  76. Brain electrical activity mapping and rhythm perception. Annals of Neurology. 1983; 14:143-144. View Abstract
  77. Left visual field superiority in lexical discriminants. Brain Lang. 1979; 1:10-18.. View Abstract
  78. Neuropathology of Left-Handedness. Dissertations & Theses. 1979; (No. AAT7918777). View Abstract
  79. Neuropathology of Left-Handedness. 1979. View Abstract
  80. Vocal-manual tradeoffs in hemispheric sharing of human performance control. J Mot Behav. 1978; 10:1-6. View Abstract

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Phone: 617-355-8249
Fax: 617-730-0224
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