Frederick Alt

Publications

1. Editorial Expression of Concern: Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature. 2025 Jan 23. View Abstract
2. An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations. Sci Transl Med. 2025 Jan 08; 17(780):eadr2218. View Abstract
3. Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies. Nat Commun. 2024 Nov 03; 15(1):9503. View Abstract
4. Orientation Regulation of Class-switch Recombination in Human B Cells. J Immunol. 2024 Oct 15; 213(8):1093-1104. View Abstract
5. Corrigendum: Abnormalities of thymic stroma may contribute to immune dysregulation in murine models of leaky severe combined immunodeficiency. Front Immunol. 2024; 15:1467807. View Abstract
6. Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site. Sci Immunol. 2024 Aug 30; 9(98):eadk9550. View Abstract
7. Comparison of the immunogenicity of mRNA-encoded and protein HIV-1 Env-ferritin nanoparticle designs. J Virol. 2024 Sep 17; 98(9):e0013724. View Abstract
8. Author Correction: Vaccination induces broadly neutralizing antibody precursors to HIV gp41. Nat Immunol. 2024 Jul; 25(7):1307. View Abstract
9. Vaccination induces broadly neutralizing antibody precursors to HIV gp41. Nat Immunol. 2024 Jun; 25(6):1073-1082. View Abstract
10. Molecular basis for differential Igk versus Igh V(D)J joining mechanisms. Nature. 2024 Jun; 630(8015):189-197. View Abstract
11. Heterologous prime-boost vaccination drives early maturation of HIV broadly neutralizing antibody precursors in humanized mice. Sci Transl Med. 2024 May 22; 16(748):eadn0223. View Abstract
12. Mutation-guided vaccine design: A process for developing boosting immunogens for HIV broadly neutralizing antibody induction. Cell Host Microbe. 2024 May 08; 32(5):693-709.e7. View Abstract
13. The lipid globotriaosylceramide promotes germinal center B cell responses and antiviral immunity. Science. 2024 Feb 16; 383(6684):eadg0564. View Abstract
14. Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies. bioRxiv. 2023 Dec 30. View Abstract
15. The lipid Gb3 promotes germinal center B cell responses and anti-viral immunity. bioRxiv. 2023 Sep 24. View Abstract
16. Contribution of the IGCR1 regulatory element and the 3'Igh CTCF-binding elements to regulation of Igh V(D)J recombination. Proc Natl Acad Sci U S A. 2023 06 27; 120(26):e2306564120. View Abstract
17. Contribution of the IGCR1 regulatory element and the 3 'Igh CBEs to Regulation of Igh V(D)J Recombination. bioRxiv. 2023 Apr 25. View Abstract
18. Mesoscale DNA feature in antibody-coding sequence facilitates somatic hypermutation. Cell. 2023 05 11; 186(10):2193-2207.e19. View Abstract
19. Author Correction: Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies. Nat Rev Immunol. 2023 Apr; 23(4):265. View Abstract
20. Humanized V(D)J-rearranging and TdT-expressing mouse vaccine models with physiological HIV-1 broadly neutralizing antibody precursors. Proc Natl Acad Sci U S A. 2023 01 03; 120(1):e2217883120. View Abstract
21. Structural principles of B cell antigen receptor assembly. Nature. 2022 12; 612(7938):156-161. View Abstract
22. Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies. Nat Rev Immunol. 2023 03; 23(3):142-158. View Abstract
23. An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion. Sci Immunol. 2022 10 28; 7(76):eadd5446. View Abstract
24. SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination. Nat Commun. 2022 06 28; 13(1):3707. View Abstract
25. Switch Tandem Repeats Influence the Choice of the Alternative End-Joining Pathway in Immunoglobulin Class Switch Recombination. Front Immunol. 2022; 13:870933. View Abstract
26. C-terminal deletion-induced condensation sequesters AID from IgH targets in immunodeficiency. EMBO J. 2022 06 01; 41(11):e109324. View Abstract
27. mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice. Cell Rep. 2022 03 15; 38(11):110514. View Abstract
28. The role of chromatin loop extrusion in antibody diversification. Nat Rev Immunol. 2022 09; 22(9):550-566. View Abstract
29. Ig Enhancers Increase RNA Polymerase II Stalling at Somatic Hypermutation Target Sequences. J Immunol. 2022 01 01; 208(1):143-154. View Abstract
30. eccDNAs are apoptotic products with high innate immunostimulatory activity. Nature. 2021 11; 599(7884):308-314. View Abstract
31. Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons. Cell Rep. 2021 09 07; 36(10):109666. View Abstract
32. Ku70 suppresses alternative end joining in G1-arrested progenitor B cells. Proc Natl Acad Sci U S A. 2021 05 25; 118(21). View Abstract
33. An in vivo method for diversifying the functions of therapeutic antibodies. Proc Natl Acad Sci U S A. 2021 03 09; 118(10). View Abstract
34. Physiological role of the 3'IgH CBEs super-anchor in antibody class switching. Proc Natl Acad Sci U S A. 2021 01 19; 118(3). View Abstract
35. Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth. Immunity. 2021 02 09; 54(2):324-339.e8. View Abstract
36. Loop extrusion mediates physiological Igh locus contraction for RAG scanning. Nature. 2021 02; 590(7845):338-343. View Abstract
37. Direct analysis of brain phenotypes via neural blastocyst complementation. Nat Protoc. 2020 10; 15(10):3154-3181. View Abstract
38. CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning. Nature. 2020 10; 586(7828):305-310. View Abstract
39. BCR selection and affinity maturation in Peyer's patch germinal centres. Nature. 2020 06; 582(7812):421-425. View Abstract
40. Induction of recurrent break cluster genes in neural progenitor cells differentiated from embryonic stem cells in culture. Proc Natl Acad Sci U S A. 2020 05 12; 117(19):10541-10546. View Abstract
41. Conditional antibody expression to avoid central B cell deletion in humanized HIV-1 vaccine mouse models. Proc Natl Acad Sci U S A. 2020 04 07; 117(14):7929-7940. View Abstract
42. Immune checkpoint modulation enhances HIV-1 antibody induction. Nat Commun. 2020 02 19; 11(1):948. View Abstract
43. Increased Neural Progenitor Proliferation in a hiPSC Model of Autism Induces Replication Stress-Associated Genome Instability. Cell Stem Cell. 2020 02 06; 26(2):221-233.e6. View Abstract
44. Targeted selection of HIV-specific antibody mutations by engineering B cell maturation. Science. 2019 12 06; 366(6470). View Abstract
45. Fundamental roles of chromatin loop extrusion in antibody class switching. Nature. 2019 11; 575(7782):385-389. View Abstract
46. The fundamental role of chromatin loop extrusion in physiological V(D)J recombination. Nature. 2019 09; 573(7775):600-604. View Abstract
47. Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. Science. 1993. 259: 822-825. J Immunol. 2019 03 01; 202(5):1317-1320. View Abstract
48. Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors. Nat Commun. 2018 11 12; 9(1):4760. View Abstract
49. Neural blastocyst complementation enables mouse forebrain organogenesis. Nature. 2018 11; 563(7729):126-130. View Abstract
50. Guiding a mutator in antibody diversification. Cell Res. 2018 10; 28(10):963-964. View Abstract
51. Parp3 promotes long-range end joining in murine cells. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):10076-10081. View Abstract
52. RAG Chromatin Scanning During V(D)J Recombination and Chromatin Loop Extrusion are Related Processes. Adv Immunol. 2018; 139:93-135. View Abstract
53. DNA double-strand breaks as drivers of neural genomic change, function, and disease. DNA Repair (Amst). 2018 11; 71:158-163. View Abstract
54. Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination. Proc Natl Acad Sci U S A. 2018 08 21; 115(34):8615-8620. View Abstract
55. Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies. Immunity. 2018 08 21; 49(2):301-311.e5. View Abstract
56. DNA melting initiates the RAG catalytic pathway. Nat Struct Mol Biol. 2018 08; 25(8):732-742. View Abstract
57. CTCF-Binding Elements Mediate Accessibility of RAG Substrates During Chromatin Scanning. Cell. 2018 06 28; 174(1):102-116.e14. View Abstract
58. Three classes of recurrent DNA break clusters in brain progenitors identified by 3D proximity-based break joining assay. Proc Natl Acad Sci U S A. 2018 02 20; 115(8):1919-1924. View Abstract
59. DNA double-strand break response factors influence end-joining features of IgH class switch and general translocation junctions. Proc Natl Acad Sci U S A. 2018 01 23; 115(4):762-767. View Abstract
60. Mechanism of tandem duplication formation in BRCA1-mutant cells. Nature. 2017 11 30; 551(7682):590-595. View Abstract
61. Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination. Proc Natl Acad Sci U S A. 2017 12 05; 114(49):E10560-E10567. View Abstract
62. Ectopic expression of RAD52 and dn53BP1 improves homology-directed repair during CRISPR-Cas9 genome editing. Nat Biomed Eng. 2017 11; 1(11):878-888. View Abstract
63. AID Recognizes Structured DNA for Class Switch Recombination. Mol Cell. 2017 Aug 03; 67(3):361-373.e4. View Abstract
64. Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70. DNA Repair (Amst). 2017 09; 57:133-138. View Abstract
65. Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies. Proc Natl Acad Sci U S A. 2017 08 08; 114(32):8614-8619. View Abstract
66. Phosphatidylinositol 3-kinase d blockade increases genomic instability in B cells. Nature. 2017 02 23; 542(7642):489-493. View Abstract
67. Human Ig knockin mice to study the development and regulation of HIV-1 broadly neutralizing antibodies. Immunol Rev. 2017 01; 275(1):89-107. View Abstract
68. An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between Vd and Dd Gene Segments. J Immunol. 2016 10 15; 197(8):3188-3197. View Abstract
69. Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires. Cell. 2016 Sep 08; 166(6):1471-1484.e18. View Abstract
70. PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):10619-24. View Abstract
71. Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development. J Exp Med. 2016 08 22; 213(9):1921-36. View Abstract
72. Highly sensitive and unbiased approach for elucidating antibody repertoires. Proc Natl Acad Sci U S A. 2016 07 12; 113(28):7846-51. View Abstract
73. Pillars Article: A Functional T3 Molecule Associated with a Novel Heterodimer on the Surface of Immature Human Thymocytes. Nature. 1986. 322: 179-181. J Immunol. 2016 05 01; 196(9):3514-6. View Abstract
74. Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing. Nat Protoc. 2016 May; 11(5):853-71. View Abstract
75. Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):2258-63. View Abstract
76. Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells. Cell. 2016 Feb 11; 164(4):644-55. View Abstract
77. Sequential activation and distinct functions for distal and proximal modules within the IgH 3' regulatory region. Proc Natl Acad Sci U S A. 2016 Feb 09; 113(6):1618-23. View Abstract
78. Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes. Cell. 2015 Nov 19; 163(5):1124-1137. View Abstract
79. Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes. Cell. 2015 Nov 05; 163(4):947-59. View Abstract
80. Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching. Nature. 2015 Sep 03; 525(7567):134-139. View Abstract
81. A Rapid Embryonic Stem Cell-Based Mouse Model for B-cell Lymphomas Driven by Epstein-Barr Virus Protein LMP1. Cancer Immunol Res. 2015 Jun; 3(6):641-9. View Abstract
82. An oncogenic role for alternative NF-?B signaling in DLBCL revealed upon deregulated BCL6 expression. Cell Rep. 2015 May 05; 11(5):715-26. View Abstract
83. Aberrant TCRd rearrangement underlies the T-cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency. Blood. 2015 Apr 23; 125(17):2665-8. View Abstract
84. Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination. Microbiol Spectr. 2015 Feb; 3(1):MDNA3-0037-2014. View Abstract
85. CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination. Proc Natl Acad Sci U S A. 2015 Feb 10; 112(6):1815-20. View Abstract
86. Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases. Nat Biotechnol. 2015 Feb; 33(2):179-86. View Abstract
87. Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability. Cell. 2014 Dec 18; 159(7):1538-48. View Abstract
88. Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10269-74. View Abstract
89. Mechanisms that can promote peripheral B-cell lymphoma in ATM-deficient mice. Cancer Immunol Res. 2014 Sep; 2(9):857-66. View Abstract
90. Reprint of "Functional overlaps between XLF and the ATM-dependent DNA double strand break response". DNA Repair (Amst). 2014 May; 17:52-63. View Abstract
91. Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes. Proc Natl Acad Sci U S A. 2014 Apr 08; 111(14):5147-52. View Abstract
92. Functional overlaps between XLF and the ATM-dependent DNA double strand break response. DNA Repair (Amst). 2014 Apr; 16:11-22. View Abstract
93. IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2644-9. View Abstract
94. Michael Neuberger (1953-2013). Immunity. 2013 Dec 12; 39(6):987-8. View Abstract
95. A systematic analysis of recombination activity and genotype-phenotype correlation in human recombination-activating gene 1 deficiency. J Allergy Clin Immunol. 2014 Apr; 133(4):1099-108. View Abstract
96. SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. Cell Rep. 2013 Nov 14; 5(3):654-665. View Abstract
97. Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus. Nature. 2013 Nov 21; 503(7476):406-9. View Abstract
98. Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire. Immunity. 2013 Aug 22; 39(2):229-44. View Abstract
99. Microbial colonization influences early B-lineage development in the gut lamina propria. Nature. 2013 Sep 05; 501(7465):112-5. View Abstract
100. 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell. 2013 Jun 06; 153(6):1266-80. View Abstract
101. Genome architecture and expression. Curr Opin Genet Dev. 2013 Apr; 23(2):79-80. View Abstract
102. Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2. PLoS Genet. 2013; 9(2):e1003298. View Abstract
103. Conditional inactivation of p53 in mature B cells promotes generation of nongerminal center-derived B-cell lymphomas. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):2934-9. View Abstract
104. Mechanisms of programmed DNA lesions and genomic instability in the immune system. Cell. 2013 Jan 31; 152(3):417-29. View Abstract
105. Localized DNA demethylation at recombination intermediates during immunoglobulin heavy chain gene assembly. PLoS Biol. 2013; 11(1):e1001475. View Abstract
106. Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells. J Biol Chem. 2013 Mar 08; 288(10):7086-95. View Abstract
107. Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2234-9. View Abstract
108. Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions. Nat Immunol. 2012 Dec; 13(12):1205-12. View Abstract
109. Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly. Infect Immun. 2012 Dec; 80(12):4071-7. View Abstract
110. Reprogramming IgH isotype-switched B cells to functional-grade induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13745-50. View Abstract
111. Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function. Blood. 2012 Apr 26; 119(17):3966-74. View Abstract
112. Spatial organization of the mouse genome and its role in recurrent chromosomal translocations. Cell. 2012 Mar 02; 148(5):908-21. View Abstract
113. Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2455-60. View Abstract
114. Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1). Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2473-8. View Abstract
115. Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell. 1985. 40: 271-281. J Immunol. 2012 Jan 01; 188(1):10-20. View Abstract
116. Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks. Adv Immunol. 2012; 116:1-49. View Abstract
117. Immature B cells preferentially switch to IgE with increased direct Sµ to Se recombination. J Exp Med. 2011 Dec 19; 208(13):2733-46. View Abstract
118. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell. 2011 Oct 21; 44(2):177-90. View Abstract
119. Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell. 2011 Sep 30; 147(1):107-19. View Abstract
120. CTCF-binding elements mediate control of V(D)J recombination. Nature. 2011 Sep 11; 477(7365):424-30. View Abstract
121. The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia. Blood. 2011 Oct 13; 118(15):4169-73. View Abstract
122. Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination. J Exp Med. 2011 Aug 01; 208(8):1649-60. View Abstract
123. The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat Immunol. 2011 Jun; 12(6):536-43. View Abstract
124. Abnormalities of thymic stroma may contribute to immune dysregulation in murine models of leaky severe combined immunodeficiency. Front Immunol. 2011 May 10; 2(15). View Abstract
125. PAIRing for distal Igh locus V(D)J recombination. Immunity. 2011 Feb 25; 34(2):139-41. View Abstract
126. Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2873-8. View Abstract
127. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell. 2011 Feb 04; 144(3):353-63. View Abstract
128. Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):2028-33. View Abstract
129. Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining. J Immunol. 2011 Feb 15; 186(4):2336-43. View Abstract
130. Mechanisms that promote and suppress chromosomal translocations in lymphocytes. Annu Rev Immunol. 2011; 29:319-50. View Abstract
131. ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks. Nature. 2011 Jan 13; 469(7329):250-4. View Abstract
132. SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab. 2010 Dec 01; 12(6):654-61. View Abstract
133. Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22207-12. View Abstract
134. Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21790-4. View Abstract
135. Analysis of mice lacking DNaseI hypersensitive sites at the 5' end of the IgH locus. PLoS One. 2010 Nov 15; 5(11):e13992. View Abstract
136. ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification. J Exp Med. 2010 Jul 05; 207(7):1369-80. View Abstract
137. Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency. J Exp Med. 2010 Jul 05; 207(7):1541-54. View Abstract
138. Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes. J Exp Med. 2010 Jun 07; 207(6):1145-52. View Abstract
139. Hypomorphic Rag mutations can cause destructive midline granulomatous disease. Blood. 2010 Aug 26; 116(8):1263-71. View Abstract
140. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 2010 Mar 04; 464(7285):121-5. View Abstract
141. Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. J Exp Med. 2010 Feb 15; 207(2):417-27. View Abstract
142. Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3024-9. View Abstract
143. Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3040-5. View Abstract
144. Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3034-9. View Abstract
145. Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single excisable vector. Stem Cells. 2010 Jan; 28(1):64-74. View Abstract
146. The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers. Adv Immunol. 2010; 106:93-133. View Abstract
147. Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region. Nature. 2009 Dec 10; 462(7274):803-7. View Abstract
148. Differential utilization of T cell receptor TCR alpha/TCR delta locus variable region gene segments is mediated by accessibility. Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41):17487-92. View Abstract
149. Mre11: roles in DNA repair beyond homologous recombination. Nat Struct Mol Biol. 2009 Aug; 16(8):798-800. View Abstract
150. Mechanisms promoting translocations in editing and switching peripheral B cells. Nature. 2009 Jul 09; 460(7252):231-6. View Abstract
151. Calorie restriction alters mitochondrial protein acetylation. Aging Cell. 2009 Sep; 8(5):604-6. View Abstract
152. Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation. Biochem Soc Trans. 2009 Jun; 37(Pt 3):561-8. View Abstract
153. Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Mol Cell. 2009 May 15; 34(3):285-97. View Abstract
154. A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation. J Exp Med. 2009 May 11; 206(5):1019-27. View Abstract
155. Assembled DJ beta complexes influence TCR beta chain selection and peripheral V beta repertoire. J Immunol. 2009 May 01; 182(9):5586-95. View Abstract
156. Post-translational regulation of activation-induced cytidine deaminase. Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12; 364(1517):667-73. View Abstract
157. Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability. J Exp Med. 2009 Feb 16; 206(2):477-90. View Abstract
158. Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2717-22. View Abstract
159. Chromosomal location targets different MYC family gene members for oncogenic translocations. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2265-70. View Abstract
160. Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner. Nat Med. 2009 Feb; 15(2):206-10. View Abstract
161. Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation. Blood. 2009 Mar 26; 113(13):2965-75. View Abstract
162. Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching. J Exp Med. 2008 Dec 22; 205(13):3079-90. View Abstract
163. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell. 2008 Nov 28; 135(5):907-18. View Abstract
164. Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase. Mol Cell. 2008 Oct 24; 32(2):285-91. View Abstract
165. Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Mol Cell. 2008 Sep 05; 31(5):631-40. View Abstract
166. Vbeta cluster sequences reduce the frequency of primary Vbeta2 and Vbeta14 rearrangements. Eur J Immunol. 2008 Sep; 38(9):2564-72. View Abstract
167. AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development. J Exp Med. 2008 Sep 01; 205(9):1949-57. View Abstract
168. SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell. 2008 Jul 25; 134(2):317-28. View Abstract
169. Complementary functions of ATM and H2AX in development and suppression of genomic instability. Proc Natl Acad Sci U S A. 2008 Jul 08; 105(27):9302-6. View Abstract
170. Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev. 2008 Jun 15; 22(12):1662-76. View Abstract
171. Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev. 2008 Jul 01; 22(13):1753-7. View Abstract
172. Sgamma3 switch sequences function in place of endogenous Sgamma1 to mediate antibody class switching. J Exp Med. 2008 Jul 07; 205(7):1567-72. View Abstract
173. DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination. J Exp Med. 2008 Mar 17; 205(3):557-64. View Abstract
174. A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A. 2008 Mar 04; 105(9):3374-9. View Abstract
175. Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3843-8. View Abstract
176. Productive coupling of accessible Vbeta14 segments and DJbeta complexes determines the frequency of Vbeta14 rearrangement. J Immunol. 2008 Feb 15; 180(4):2339-46. View Abstract
177. SIRT6 in DNA repair, metabolism and ageing. J Intern Med. 2008 Feb; 263(2):128-41. View Abstract
178. Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Mol Cell Biol. 2008 Mar; 28(5):1688-701. View Abstract
179. Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus. Adv Immunol. 2008; 99:1-32. View Abstract
180. Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol Cell. 2007 Dec 28; 28(6):1045-57. View Abstract
181. From gene amplification to V(D)J recombination and back: a personal account of my early years in B cell biology. Eur J Immunol. 2007 Nov; 37 Suppl 1:S138-47. View Abstract
182. S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase. Immunity. 2007 Nov; 27(5):711-22. View Abstract
183. SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev. 2007 Oct 15; 21(20):2644-58. View Abstract
184. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007 Dec; 27(24):8807-14. View Abstract
185. Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15424-9. View Abstract
186. Aberrant V(D)J recombination is not required for rapid development of H2ax/p53-deficient thymic lymphomas with clonal translocations. Blood. 2008 Feb 15; 111(4):2163-9. View Abstract
187. IgH class switching and translocations use a robust non-classical end-joining pathway. Nature. 2007 Sep 27; 449(7161):478-82. View Abstract
188. Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas. Oncogene. 2008 Jan 10; 27(3):318-22. View Abstract
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