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Emergency Medicine Research

Research Overview

During my doctoral training, I have become fascinated by the heterogeneity within a brain injury. The overarching questions that now drive my research interests in the traumatic brain injury (TBI) field are: How do the mechanics of TBI influence the different outcomes of a brain injury? What are the mechanisms of glial response post-TBI? Significantly, how are these mechanisms disrupted or turned into pathological in neurodegeneration?

My thesis work involved a combination of biological and engineering solutions to the complex brain injury problem, allowing me to identify strategies and technologies to address and improve TBI outcomes. Therefore, for my postdoctoral work, I plan to develop a more holistic skillset as a scientist to answer the question of translational approaches for TBI.

Research Background

Undergraduate Research: Worked at Dr. James P. Herman's laboratory on creating a novel animal model of stress by studying the physiological impact of loss. Furthermore, conducted a Scientific initiation trainee at Dr. Fernando Morgan's laboratory, involved in learning techniques for rodent handling and anesthesia, and sterile surgical procedures for stereotaxic implantation of intracerebral guide cannulas for injecting chemicals into Central Nervous System structures.

Research Assistant: Worked for Children’s Hospital affiliated with the University of Cincinnati at Dr. Nathan Evansons laboratory. Designed and conducted primary source research for a closed-head pediatric murine model of traumatic brain injury.

Graduate Research: Conducted doctoral degree at Dr. Pamela VandeVord's laboratory under the Translational Biology, Medicine, and Health (TBMH) graduate program at Virginia Tech. Characterized and provided a comprehensive view of phenotypical and functional changes of astrocyte mitochondrial dynamics (fission and fusion) to understand its role in astrocyte reactivity post bTBI using in vitro and in vivo models. Furthermore, collaborated on a project to understand astrocytes’ response post-bTBI and unilateral controlled cortical impact (CCI) and its connection to post-traumatic epilepsy outcomes.

Publications

  1. Hormone resistance and short stature: A journey through the pathways of hormone signaling. Mol Cell Endocrinol. 2021 10 01; 536:111416. View Abstract
  2. Is There a Difference Between Minimal and Gross Extension into the Strap Muscles for the Risk of Recurrence in Papillary Thyroid Carcinomas? Thyroid. 2020 07; 30(7):1008-1016. View Abstract
  3. Update on new GH-IGF axis genetic defects. Arch Endocrinol Metab. 2019 Nov-Dec; 63(6):608-617. View Abstract
  4. Combined pituitary hormone deficiency caused by PROP1 mutations: update 20 years post-discovery. Arch Endocrinol Metab. 2019 May 13; 63(2):167-174. View Abstract
  5. Genetic diagnosis of congenital hypopituitarism by a target gene panel: novel pathogenic variants in GLI2, OTX2 and GHRHR. Endocr Connect. 2019 May 01; 8(5):590-595. View Abstract
  6. Quality of Life and Coping in Multiple Endocrine Neoplasia Type 2. J Endocr Soc. 2019 Jun 01; 3(6):1167-1174. View Abstract
  7. Pathogenic copy number variants in patients with congenital hypopituitarism associated with complex phenotypes. Clin Endocrinol (Oxf). 2018 03; 88(3):425-431. View Abstract
  8. Growth hormone deficiency with advanced bone age: phenotypic interaction between GHRH receptor and CYP21A2 mutations diagnosed by sanger and whole exome sequencing. Arch Endocrinol Metab. 2017 Dec; 61(6):633-636. View Abstract
  9. Successful Pregnancies After Adequate Hormonal Replacement in Patients With Combined Pituitary Hormone Deficiencies. J Endocr Soc. 2017 Oct 01; 1(10):1322-1330. View Abstract
  10. Molecular analysis of brazilian patients with combined pituitary hormone deficiency and orthotopic posterior pituitary lobe reveals eight different PROP1 alterations with three novel mutations. Clin Endocrinol (Oxf). 2017 Dec; 87(6):725-732. View Abstract
  11. A homozygous point mutation in the GH1 promoter (c.-223C>T) leads to reduced GH1 expression in siblings with isolated GH deficiency (IGHD). Eur J Endocrinol. 2016 Aug; 175(2):K7-K15. View Abstract
  12. Frequent development of combined pituitary hormone deficiency in patients initially diagnosed as isolated growth hormone deficiency: a long term follow-up of patients from a single center. Pituitary. 2015 Aug; 18(4):561-7. View Abstract
  13. FGFR1 and PROKR2 rare variants found in patients with combined pituitary hormone deficiencies. Endocr Connect. 2015 Jun; 4(2):100-7. View Abstract
  14. Genome-wide screening of copy number variants in children born small for gestational age reveals several candidate genes involved in growth pathways. Eur J Endocrinol. 2014 Aug; 171(2):253-62. View Abstract
  15. Microbiological changes after periodontal therapy in diabetic patients with inadequate metabolic control. Braz Oral Res. 2014; 28. View Abstract

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