Research Overview

Dr. Dedeoglu’s research focuses on autoinflammatory diseases, specifically, periodic fever syndromes and juvenile localized scleroderma.

Education

Medical School

Istanbul School of Medicine
1986 Istanbul Turkey

Residency

Monmouth Medical Center
1999 Long Branch NJ

Fellowship

Boston Children's Hospital
2003 Boston MA

Publications

  1. Clinical Features and Outcome Measures Across Still Disease (Systemic Juvenile Idiopathic Arthritis and Adult-Onset Still Disease) Cohorts Worldwide: A Systematic Literature Review. J Rheumatol. 2026 Feb 01; 53(2):134-143. View Abstract
  2. Congruence Between Child Self-Reported and Caregiver-Proxy-Reported Health-Related Quality of Life in Children With Juvenile Idiopathic Arthritis and Systemic Lupus Erythematosus. J Rheumatol. 2026 Jan 15. View Abstract
  3. Diagnostic Implications and Correlates of Plasma Adenosine Deaminase 2 Activity and ADA2 Variants. Arthritis Rheumatol. 2026 Mar; 78(3):734-742. View Abstract
  4. Identifying domains for CNO and SAPHO: A scoping review to create domains from existing outcomes by the OMERACT CNO and SAPHO working group. Semin Arthritis Rheum. 2025 Dec; 75:152862. View Abstract
  5. Barriers to Surgical Care in Craniofacial Scleroderma (Parry-Romberg Syndrome). Cleft Palate Craniofac J. 2025 Oct 31; 10556656251375135. View Abstract
  6. Juvenile localized scleroderma: a large retrospective cohort study from a tertiary care center. Pediatr Rheumatol Online J. 2025 Jun 06; 23(1):63. View Abstract
  7. Sex Differences in B Cells From the Joints of Children With Oligoarticular Juvenile Idiopathic Arthritis. Arthritis Rheumatol. 2025 Aug; 77(8):1092-1105. View Abstract
  8. Improvement in dermatomyositis-associated muscle disease with anifrolumab. Br J Dermatol. 2025 May 19; 192(6):1126-1128. View Abstract
  9. EULAR/American College of Rheumatology Classification Criteria for Pediatric Chronic Nonbacterial Osteomyelitis. Arthritis Rheumatol. 2026 Mar; 78(3):537-547. View Abstract
  10. Three-dimensional stereophotogrammetry: an effective tool for detecting disease progression in lupus erythematosus panniculitis. Clin Exp Dermatol. 2025 Mar 26; 50(4):901-903. View Abstract
  11. EULAR/ACR classification criteria for paediatric chronic nonbacterial osteomyelitis (CNO). Ann Rheum Dis. 2025 Sep; 84(9):1458-1468. View Abstract
  12. Features of hyperinflammation link the biology of Epstein-Barr virus infection and cytokine storm syndromes. J Allergy Clin Immunol. 2025 Apr; 155(4):1346-1356.e9. View Abstract
  13. Comparison of 3D facial photographs and clinical documentation in patients with craniofacial morphea. Skin Health Dis. 2024 Dec; 4(6):e438. View Abstract
  14. Severe Features of Systemic Juvenile Idiopathic Arthritis in Patients With Congenital Heart Disease. J Rheumatol. 2024 Aug 01; 51(8):811-817. View Abstract
  15. Disease-Tailored Brief Intervention for Alcohol Use Among Youths With Chronic Medical Conditions: A Secondary Analysis of a Randomized Clinical Trial. JAMA Netw Open. 2024 07 01; 7(7):e2419858. View Abstract
  16. Capturing the Range of Disease Involvement in Localized Scleroderma: The Localized Scleroderma Total Severity Scale. Arthritis Care Res (Hoboken). 2024 05; 76(5):616-626. View Abstract
  17. Rapid Improvement in Recalcitrant Cutaneous Juvenile Dermatomyositis With Anifrolumab Treatment. JAMA Dermatol. 2024 02 01; 160(2):237-238. View Abstract
  18. Elevation of IL-17 Cytokines Distinguishes Kawasaki Disease From Other Pediatric Inflammatory Disorders. Arthritis Rheumatol. 2024 02; 76(2):285-292. View Abstract
  19. Type I interferon signature and cycling lymphocytes in macrophage activation syndrome. J Clin Invest. 2023 11 15; 133(22). View Abstract
  20. Corrigendum: Increase in pediatric recurrent fever evaluations during the first year of the COVID-19 pandemic in North America. Front Pediatr. 2023; 11:1323946. View Abstract
  21. Use of 3-Dimensional Stereophotogrammetry to Detect Disease Progression in Craniofacial Morphea. JAMA Dermatol. 2023 11 01; 159(11):1232-1239. View Abstract
  22. Development of a Screening Algorithm for Lung Disease in Systemic Juvenile Idiopathic Arthritis. ACR Open Rheumatol. 2023 Oct; 5(10):556-562. View Abstract
  23. Increase in pediatric recurrent fever evaluations during the first year of the COVID-19 pandemic in North America. Front Pediatr. 2023; 11:1240242. View Abstract
  24. Update on autoinflammatory diseases. Curr Opin Rheumatol. 2023 09 01; 35(5):285-292. View Abstract
  25. Feasibility of Conducting Comparative Effectiveness Research and Validation of a Clinical Disease Activity Score for Chronic Nonbacterial Osteomyelitis. J Rheumatol. 2023 10; 50(10):1333-1340. View Abstract
  26. Incidence and Risk Factors for Eosinophilia and Lung Disease in Biologic-Exposed Children With Systemic Juvenile Idiopathic Arthritis. Arthritis Care Res (Hoboken). 2023 10; 75(10):2063-2072. View Abstract
  27. Gathering expert consensus to inform a proposed trial in chronic nonbacterial osteomyelitis (CNO). Clin Immunol. 2023 06; 251:109344. View Abstract
  28. Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis Syndrome and Syndrome of Unexplained Recurrent Fevers in Children and Adults. J Allergy Clin Immunol Pract. 2023 06; 11(6):1676-1687. View Abstract
  29. Case report: Novel variants in RELA associated with familial Behcet's-like disease. Front Immunol. 2023; 14:1127085. View Abstract
  30. Botulinum toxin for refractory Raynaud's phenomenon: A "how to" guide for pediatric patients. Pediatr Dermatol. 2023 May-Jun; 40(3):587-589. View Abstract
  31. Construct validity of Patient-Reported Outcomes Measurement Information System Paediatric measures in juvenile idiopathic arthritis and systemic lupus erythematosus: cross-sectional evaluation. BMJ Open. 2023 01 27; 13(1):e063675. View Abstract
  32. Biologics and JAK inhibitors for the treatment of monogenic systemic autoinflammatory diseases in children. J Allergy Clin Immunol. 2023 03; 151(3):607-618. View Abstract
  33. Disordered T cell-B cell interactions in autoantibody-positive inflammatory arthritis. Front Immunol. 2022; 13:1068399. View Abstract
  34. How Have the Diagnosis and Treatment of Chronic Recurrent Multifocal Osteomyelitis Changed Over Time? J Oral Maxillofac Surg. 2023 02; 81(2):238-247. View Abstract
  35. An Evidence-Based Guideline Improves Outcomes for Patients With Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome. J Rheumatol. 2022 Sep; 49(9):1042-1051. View Abstract
  36. Features predicting colchicine efficacy in treatment of children with undefined systemic autoinflammatory disease: A retrospective cohort study. Eur J Rheumatol. 2022 07; 9(3):116-121. View Abstract
  37. Pilot use of 3-dimensional photography to aid clinical decision-making in craniofacial morphea. JAAD Case Rep. 2022 Jul; 25:100-103. View Abstract
  38. The 2021 EULAR/American College of Rheumatology points to consider for diagnosis, management and monitoring of the interleukin-1 mediated autoinflammatory diseases: cryopyrin-associated periodic syndromes, tumour necrosis factor receptor-associated periodic syndrome, mevalonate kinase deficiency, and deficiency of the interleukin-1 receptor antagonist. Ann Rheum Dis. 2022 07; 81(7):907-921. View Abstract
  39. Dysregulation of the cGAS-STING Pathway in Monogenic Autoinflammation and Lupus. Front Immunol. 2022; 13:905109. View Abstract
  40. The 2021 EULAR/American College of Rheumatology Points to Consider for Diagnosis, Management and Monitoring of the Interleukin-1 Mediated Autoinflammatory Diseases: Cryopyrin-Associated Periodic Syndromes, Tumour Necrosis Factor Receptor-Associated Periodic Syndrome, Mevalonate Kinase Deficiency, and Deficiency of the Interleukin-1 Receptor Antagonist. Arthritis Rheumatol. 2022 07; 74(7):1102-1121. View Abstract
  41. Genetic diagnosis of immune dysregulation can lead to targeted therapy for interstitial lung disease: A case series and single center approach. Pediatr Pulmonol. 2022 07; 57(7):1577-1587. View Abstract
  42. Dental Anomalies in Parry-Romberg Syndrome: A 40-Year Retrospective Review. Cleft Palate Craniofac J. 2023 08; 60(8):956-961. View Abstract
  43. Th1 polarization defines the synovial fluid T cell compartment in oligoarticular juvenile idiopathic arthritis. JCI Insight. 2021 09 22; 6(18). View Abstract
  44. Microbiome is not linked to clinical disease severity of familial Mediterranean fever in an international cohort of children. Clin Exp Rheumatol. 2021 Sep-Oct; 39 Suppl 132(5):102-108. View Abstract
  45. Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: A review. World J Otorhinolaryngol Head Neck Surg. 2021 Jul; 7(3):166-173. View Abstract
  46. Establishing core domain sets for Chronic Nonbacterial Osteomyelitis (CNO) and Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis (SAPHO): A report from the OMERACT 2020 special interest group. Semin Arthritis Rheum. 2021 08; 51(4):957-961. View Abstract
  47. Comprehensive analysis of ADA2 genetic variants and estimation of carrier frequency driven by a function-based approach. J Allergy Clin Immunol. 2022 01; 149(1):379-387. View Abstract
  48. Multiple Emergency Department Visits for a Diagnosis of Kawasaki Disease: An Examination of Risk Factors and Outcomes. J Pediatr. 2021 05; 232:127-132.e3. View Abstract
  49. Distinct clinical and immunological features of SARS-CoV-2-induced multisystem inflammatory syndrome in children. J Clin Invest. 2020 11 02; 130(11):5942-5950. View Abstract
  50. Burden of illness in hereditary periodic fevers: a multinational observational patient diary study. Clin Exp Rheumatol. 2020 Sep-Oct; 38 Suppl 127(5):26-34. View Abstract
  51. Safety Protocols for Adolescent Substance Use Research in Clinical Settings. J Adolesc Health. 2021 05; 68(5):999-1005. View Abstract
  52. Common genetic susceptibility loci link PFAPA syndrome, Behçet's disease, and recurrent aphthous stomatitis. Proc Natl Acad Sci U S A. 2020 06 23; 117(25):14405-14411. View Abstract
  53. Consensus treatment plans for periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA): a framework to evaluate treatment responses from the childhood arthritis and rheumatology research alliance (CARRA) PFAPA work group. Pediatr Rheumatol Online J. 2020 Apr 15; 18(1):31. View Abstract
  54. Inflammatory manifestations in patients with Shwachman-Diamond syndrome: A novel phenotype. Am J Med Genet A. 2020 07; 182(7):1754-1760. View Abstract
  55. Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis. JCI Insight. 2020 03 26; 5(6). View Abstract
  56. Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic juvenile idiopathic arthritis. Ann Rheum Dis. 2020 02; 79(2):225-231. View Abstract
  57. Initial Results from a Pilot Comparative Effectiveness Study of 3 Methotrexate-based Consensus Treatment Plans for Juvenile Localized Scleroderma. J Rheumatol. 2020 08 01; 47(8):1242-1252. View Abstract
  58. Developing comparative effectiveness studies for a rare, understudied pediatric disease: lessons learned from the CARRA juvenile localized scleroderma consensus treatment plan pilot study. Pediatr Rheumatol Online J. 2019 Jul 15; 17(1):43. View Abstract
  59. Risk Model Development and Validation for Prediction of Coronary Artery Aneurysms in Kawasaki Disease in a North American Population. J Am Heart Assoc. 2019 06 04; 8(11):e011319. View Abstract
  60. Screening and Counseling for Alcohol Use in Adolescents With Chronic Medical Conditions in the Ambulatory Setting. J Adolesc Health. 2019 06; 64(6):804-806. View Abstract
  61. Classification criteria for autoinflammatory recurrent fevers. Ann Rheum Dis. 2019 08; 78(8):1025-1032. View Abstract
  62. Calm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome. Pediatr Rheumatol Online J. 2019 Feb 14; 17(1):7. View Abstract
  63. Vasculitis in Systemic Autoinflammatory Diseases. Front Pediatr. 2018; 6:377. View Abstract
  64. Using Smartphone Crowdsourcing to Redefine Normal and Febrile Temperatures in Adults: Results from the Feverprints Study. J Gen Intern Med. 2018 12; 33(12):2046-2047. View Abstract
  65. Impact of biologics on disease course in systemic onset juvenile idiopathic arthritis. Clin Rheumatol. 2018 Dec; 37(12):3263-3273. View Abstract
  66. In silico validation of the Autoinflammatory Disease Damage Index. Ann Rheum Dis. 2018 11; 77(11):1599-1605. View Abstract
  67. Consensus Treatment Plans for Chronic Nonbacterial Osteomyelitis Refractory to Nonsteroidal Antiinflammatory Drugs and/or With Active Spinal Lesions. Arthritis Care Res (Hoboken). 2018 08; 70(8):1228-1237. View Abstract
  68. De novo ATP1A3 and compound heterozygous NLRP3 mutations in a child with autism spectrum disorder, episodic fatigue and somnolence, and muckle-wells syndrome. Mol Genet Metab Rep. 2018 Sep; 16:23-29. View Abstract
  69. An international delphi survey for the definition of the variables for the development of new classification criteria for periodic fever aphtous stomatitis pharingitis cervical adenitis (PFAPA). Pediatr Rheumatol Online J. 2018 Apr 18; 16(1):27. View Abstract
  70. The safety of live-attenuated vaccines in patients using IL-1 or IL-6 blockade: an international survey. Pediatr Rheumatol Online J. 2018 Mar 21; 16(1):19. View Abstract
  71. Adding patient-reported outcomes to a multisite registry to quantify quality of life and experiences of disease and treatment for youth with juvenile idiopathic arthritis. J Patient Rep Outcomes. 2018; 2. View Abstract
  72. Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration. J Exp Med. 2017 Jul 03; 214(7):1937-1947. View Abstract
  73. Predicting Coronary Artery Aneurysms in Kawasaki Disease at a North American Center: An Assessment of Baseline z Scores. J Am Heart Assoc. 2017 May 31; 6(6). View Abstract
  74. Physicians' perspectives on the diagnosis and management of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. Rheumatol Int. 2017 Jun; 37(6):883-889. View Abstract
  75. Physicians' Perspectives on the Diagnosis and Treatment of Chronic Nonbacterial Osteomyelitis. Int J Rheumatol. 2017; 2017:7694942. View Abstract
  76. Periodic Fever, Aphthosis, Pharyngitis, and Adenitis Syndrome: Analysis of Patients From Two Geographic Areas. Arthritis Care Res (Hoboken). 2016 12; 68(12):1859-1865. View Abstract
  77. Development of the autoinflammatory disease damage index (ADDI). Ann Rheum Dis. 2017 May; 76(5):821-830. View Abstract
  78. Diagnostic criteria for cryopyrin-associated periodic syndrome (CAPS). Ann Rheum Dis. 2017 Jun; 76(6):942-947. View Abstract
  79. Systemic onset juvenile idiopathic arthritis and exposure to fine particulate air pollution. Clin Exp Rheumatol. 2016 Sep-Oct; 34(5):946-952. View Abstract
  80. Next-Generation Sequencing Reveals Restriction and Clonotypic Expansion of Treg Cells in Juvenile Idiopathic Arthritis. Arthritis Rheumatol. 2016 07; 68(7):1758-68. View Abstract
  81. A Screening Tool for Assessing Alcohol Use Risk among Medically Vulnerable Youth. PLoS One. 2016; 11(5):e0156240. View Abstract
  82. A81: spectrum of mevalonate kinase deficiency: is colitis more common than we think? Arthritis Rheumatol. 2014 Mar; 66 Suppl 11:S114. View Abstract
  83. A119: deep sequencing analysis of the T regulatory and T effector repertoire in juvenile idiopathic arthritis. Arthritis Rheumatol. 2014 Mar; 66 Suppl 11:S156. View Abstract
  84. A121: in search of infectious triggers of periodic Fever, aphthous stomatitis, pharyngitis and adenitis syndrome. Arthritis Rheumatol. 2014 Mar; 66 Suppl 11:S158. View Abstract
  85. Autoinflammatory diseases in pediatrics. Dermatol Clin. 2013 Jul; 31(3):481-94. View Abstract
  86. Urine proteomics for discovery of improved diagnostic markers of Kawasaki disease. EMBO Mol Med. 2013 Feb; 5(2):210-20. View Abstract
  87. Pediatric chronic nonbacterial osteomyelitis. Pediatrics. 2012 Nov; 130(5):e1190-7. View Abstract
  88. Long-term surgical outcomes of adenotonsillectomy for PFAPA syndrome. Arch Otolaryngol Head Neck Surg. 2012 Oct; 138(10):902-6. View Abstract
  89. Multiple juvenile idiopathic arthritis subtypes demonstrate proinflammatory IgG glycosylation. Arthritis Rheum. 2012 Sep; 64(9):3025-33. View Abstract
  90. Development of consensus treatment plans for juvenile localized scleroderma: a roadmap toward comparative effectiveness studies in juvenile localized scleroderma. Arthritis Care Res (Hoboken). 2012 Aug; 64(8):1175-85. View Abstract
  91. A novel missense mutation in MVK associated with MK deficiency and dyserythropoietic anemia. Pediatrics. 2010 Apr; 125(4):e964-8. View Abstract
  92. Drug-induced autoimmunity. Curr Opin Rheumatol. 2009 Sep; 21(5):547-51. View Abstract
  93. Complete and sustained remission of juvenile dermatomyositis resulting from aggressive treatment. Arthritis Rheum. 2009 Jun; 60(6):1825-1830. View Abstract
  94. NOD2-associated diseases: Bridging innate immunity and autoinflammation. Clin Immunol. 2010 Mar; 134(3):251-61. View Abstract
  95. Chronic minocycline-induced autoimmunity in children. J Pediatr. 2008 Sep; 153(3):314-9. View Abstract
  96. B-cell receptor cross-linking delays activation-induced cytidine deaminase induction and inhibits class-switch recombination to IgE. J Allergy Clin Immunol. 2008 Jan; 121(1):191-196.e2. View Abstract
  97. Vasculitis in children. Rheum Dis Clin North Am. 2007 Aug; 33(3):555-83. View Abstract
  98. Update on pediatric vasculitis. Curr Opin Pediatr. 2005 Dec; 17(6):695-702. View Abstract
  99. Coronary artery dilation among patients presenting with systemic-onset juvenile idiopathic arthritis. Pediatrics. 2005 Jul; 116(1):e89-93. View Abstract
  100. Vasculitis in children. Pediatr Clin North Am. 2005 Apr; 52(2):547-75, vii. View Abstract
  101. TACI and BAFF-R mediate isotype switching in B cells. J Exp Med. 2005 Jan 03; 201(1):35-9. View Abstract
  102. Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB. Int Immunol. 2004 Mar; 16(3):395-404. View Abstract
  103. Impaired IgA class switching in APRIL-deficient mice. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3903-8. View Abstract
  104. Emergency Department management of Lyme disease. Clinical Pediatric Emergency Medicine. 2004; 5(1):54-62. View Abstract
  105. Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation. J Exp Med. 2003 Oct 20; 198(8):1189-200. View Abstract
  106. The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching. Immunity. 2002 Sep; 17(3):265-76. View Abstract
  107. Successful treatment of retroperitoneal fibrosis with tamoxifen in a child. J Rheumatol. 2001 Jul; 28(7):1693-5. View Abstract
  108. “ Periodic Fever Disorders.”. International Seminars in Pediatric Gastroenterology and Nutrition. 2000; 9(3):9-15. View Abstract
  109. Cross-reactions of anti-immunoglobulin sera with synthetic T-cell receptor beta peptides: mapping on a 3-dimension model. Adv Exp Med Biol. 1994; 347:93-8. View Abstract
  110. Light and heavy chains specifying a human IgM kappa autoantibody to a T-cell receptor V beta-antigen. Immunol Lett. 1993 Nov; 38(3):223-7. View Abstract
  111. Reactions of anti-immunoglobulin sera with synthetic T cell receptor peptides: implications for the three-dimensional structure and function of the TCR beta chain. Int Immunol. 1993 May; 5(5):491-502. View Abstract
  112. Lack of preferential V beta usage in synovial T cells of rheumatoid arthritis patients. Immunol Res. 1993; 12(1):12-20. View Abstract
  113. Human autoantibodies reactive with synthetic autoantigens from T-cell receptor beta chain. Proc Natl Acad Sci U S A. 1992 Apr 15; 89(8):3325-9. View Abstract
  114. Antigenic mapping of a human lambda light chain: correlation with three dimensional structure. J Protein Chem. 1992 Apr; 11(2):129-37. View Abstract
  115. T-cell receptors of man and mouse studied with antibodies against synthetic peptides. Exp Clin Immunogenet. 1992; 9(2):95-108. View Abstract
  116. Antigenic mapping of light chains and T cell receptor beta chains. Adv Exp Med Biol. 1991; 303:235-42. View Abstract
  117. "Cross-reactions of anti immunoglobulin sera with T cell receptor-beta peptides: mapping on a 3- dimensional model. Proceedings of the Seventh International Symposium on Immunobiology of Proteins and Peptides. 1991. View Abstract
  118. "Antigenic mapping of light chains and Tcell receptor b chain". Proceedings of the Sixth International Symposium on Immunobiology of Proteins and Peptides. 1991; 235-242. View Abstract
  119. "Urinary tract infection caused by Corynebacterium jeikeium ( Corynebacterium Group JK) " . Turkish J. of Infection. 1989; 3(4):465-472. View Abstract
  120. "Cases of urinary tract infections caused by Salmonella thyphymurium". Turkish J. of Infection. 1989; 3(2):201-208. View Abstract
  121. Leptospirosis: A case report". Turkish J. of Infection. 1989; 3(3):373-380. View Abstract
  122. "Corynebacterium Group D2 infection: A case report". Turkish J. of Infection. 1989; 3(4):450-463. View Abstract

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