Research Overview

Eva Guinan's research focuses on overcoming problems related to allogenicity in transplantation, decreasing treatment related toxicity, and managing bone marrow failure syndromes. She also works with Harvard University collaborators on ways to spur more innovative translational research. Allogeneic transplantation is limited, in large part, by the ability to find donors of suitable histocompatibility. Global immunosuppression has been an incomplete and highly toxic approach to this problem. Current understanding of T cell activation suggests that blocking B7-CD28 interactions of the costimulatory pathway for human T helper cells may provide an innovative and effective way of producing antigen-specific T cell hyporesponsiveness. Guinan and colleagues are applying these various strategies to the transplant setting. Another area of active investigation is the development of novel agents for prevention or treatment of treatment-related toxicity.

 

Research Background

Eva Guinan received her MD from Harvard Medical School. She completed an internship and residency at Children's Hospital Boston and a fellowship at Children's Hospital/Dana Farber Cancer Institute. Dr. Guinan received the Clare and Richard Morse Research Award, 2000 the Clinical Translational Scientist Award, Burroughs Wellcome, 1999 and the Distinguished Service Award of the Fanconi Anemia Research Foundation in 2009.

 

Education

Medical School

Harvard Medical School
1980 Boston MA

Internship

Boston Children's Hospital
1981 Boston MA

Residency

Pediatrics Boston Children's Hospital
1982 Boston MA

Fellowship

Pediatric Hematology-Oncology Boston Children's Hospital/Dana-Farber Cancer Institute
1984 Boston MA

Publications

  1. Allostimulation leads to emergence of a human B cell population with increased expression of HLA class I antigen presentation-associated molecules and the immunoglobulin receptor FcRL5. Am J Transplant. 2024 Nov; 24(11):1968-1978. View Abstract
  2. Health professionals' perceptions of prehabilitation before haematopoietic cell transplantation to optimise candidacy in older adults. Support Care Cancer. 2024 Jun 26; 32(7):465. View Abstract
  3. Retention rates and reasons for non-retention in exercise oncology trials in the post-treatment phase-a systematic review. J Cancer Surviv. 2024 Apr 03. View Abstract
  4. Donor antigen-specific regulatory T cell administration to recipients of live donor kidneys: A ONE Study consortium pilot trial. Am J Transplant. 2023 12; 23(12):1872-1881. View Abstract
  5. Expanded HCT-CI Definitions Capture Comorbidity Better for Younger Patients of Allogeneic HCT for Nonmalignant Diseases. Transplant Cell Ther. 2023 02; 29(2):125.e1-125.e9. View Abstract
  6. Physical Therapists in Oncology Settings: Experiences in Delivering Cancer Rehabilitation Services, Barriers to Care, and Service Development Needs. Phys Ther. 2022 03 01; 102(3). View Abstract
  7. Conservatism Gets Funded? A Field Experiment on the Role of Negative Information in Novel Project Evaluation. Manage Sci. 2022 Jun; 68(6):4478-4495. View Abstract
  8. Ex vivo generation of regulatory T cells from liver transplant recipients using costimulation blockade. Am J Transplant. 2022 02; 22(2):504-518. View Abstract
  9. Engineering serendipity: When does knowledge sharing lead to knowledge production? Strateg Manag J. 2021 Jun; 42(6):1215-1244. View Abstract
  10. Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials. Lancet. 2020 05 23; 395(10237):1627-1639. View Abstract
  11. Comprehensive Prognostication in Critically Ill Pediatric Hematopoietic Cell Transplant Patients: Results from Merging the Center for International Blood and Marrow Transplant Research (CIBMTR) and Virtual Pediatric Systems (VPS) Registries. Biol Blood Marrow Transplant. 2020 02; 26(2):333-342. View Abstract
  12. Comparison of High Doses of Total Body Irradiation in Myeloablative Conditioning before Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2019 12; 25(12):2398-2407. View Abstract
  13. Use of Crowd Innovation to Develop an Artificial Intelligence-Based Solution for Radiation Therapy Targeting. JAMA Oncol. 2019 May 01; 5(5):654-661. View Abstract
  14. Alloanergization Method for Inducing Allospecific Hyporesponsiveness in PBMC Exposed to Allostimulation In Vitro in the Context of Costimulatory Molecule Blockade. Methods Mol Biol. 2019; 1899:103-118. View Abstract
  15. Combination therapy with atorvastatin and celecoxib delays tumor formation in a Fanconi anemia mouse model. Pediatr Blood Cancer. 2019 01; 66(1):e27460. View Abstract
  16. Toward a more scientific science. Science. 2018 09 21; 361(6408):1194-1197. View Abstract
  17. The Open Translational Science in Schizophrenia (OPTICS) project: an open-science project bringing together Janssen clinical trial and NIMH data. NPJ Schizophr. 2018 Jun 27; 4(1):14. View Abstract
  18. Infusion of Alloanergized Donor Lymphocytes after CD34-selected Haploidentical Myeloablative Hematopoietic Stem Cell Transplantation. Clin Cancer Res. 2018 09 01; 24(17):4098-4109. View Abstract
  19. rBPI21 (Opebacan) Promotes Rapid Trilineage Hematopoietic Recovery in a Murine Model of High-Dose Total Body Irradiation. Am J Hematol. 2018 May 11. View Abstract
  20. Amelioration of Head and Neck Radiation-Induced Mucositis and Distant Marrow Suppression in Fanca-/- and Fancg-/- Mice by Intraoral Administration of GS-Nitroxide (JP4-039). Radiat Res. 2018 06; 189(6):560-578. View Abstract
  21. The views of patients with metastatic prostate cancer towards physical activity: a qualitative exploration. Support Care Cancer. 2018 Jun; 26(6):1747-1754. View Abstract
  22. A Field Experiment on Search Costs and the Formation of Scientific Collaborations. Rev Econ Stat. 2017 10; 99(4):565-576. View Abstract
  23. Physical activity and advanced cancer: the views of oncology and palliative care physicians in Ireland. Ir J Med Sci. 2018 May; 187(2):337-342. View Abstract
  24. Stepwise Distributed Open Innovation Contests for Software Development: Acceleration of Genome-Wide Association Analysis. Gigascience. 2017 05 01; 6(5):1-10. View Abstract
  25. Three sides to a story: Child, parent, and nurse perspectives on the child's experience during hematopoietic stem cell transplantation. Cancer. 2017 Aug 15; 123(16):3159-3166. View Abstract
  26. Radiation-free, alternative-donor HCT for Fanconi anemia patients: results from a prospective multi-institutional study. Blood. 2017 04 20; 129(16):2308-2315. View Abstract
  27. Pre-existing invasive fungal infection is not a contraindication for allogeneic HSCT for patients with hematologic malignancies: a CIBMTR study. Bone Marrow Transplant. 2017 Feb; 52(2):270-278. View Abstract
  28. Ex Vivo Costimulatory Blockade to Generate Regulatory T Cells From Patients Awaiting Kidney Transplantation. Am J Transplant. 2016 07; 16(7):2187-95. View Abstract
  29. Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure. Blood. 2016 Mar 31; 127(13):1656-65. View Abstract
  30. Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2(-/-) (C57BL/6) Mice. Radiat Res. 2016 Feb; 185(2):134-50. View Abstract
  31. Looking Across and Looking Beyond the Knowledge Frontier: Intellectual Distance, Novelty, and Resource Allocation in Science. Manage Sci. 2016 Oct; 62(10):2765-2783. View Abstract
  32. Pilot experience with opebacan/rBPI 21 in myeloablative hematopoietic cell transplantation. F1000Res. 2015; 4:1480. View Abstract
  33. Poly(A)-specific ribonuclease (PARN) mediates 3'-end maturation of the telomerase RNA component. Nat Genet. 2015 Dec; 47(12):1482-8. View Abstract
  34. Parent Outlook: How Parents View the Road Ahead as They Embark on Hematopoietic Stem Cell Transplantation for Their Child. Biol Blood Marrow Transplant. 2016 Jan; 22(1):104-11. View Abstract
  35. The impact of pediatric blood and marrow transplant on parents: introduction of the parent impact scale. Health Qual Life Outcomes. 2015 Apr 09; 13:46. View Abstract
  36. Bone loss and vitamin D deficiency in children undergoing hematopoietic cell transplantation. Pediatr Blood Cancer. 2015 Apr; 62(4):687-92. View Abstract
  37. Changing factors associated with parent activation after pediatric hematopoietic stem cell transplant. Support Care Cancer. 2015 Jul; 23(7):1997-2006. View Abstract
  38. Aplastic anemia in adolescents and young adults. Acta Haematol. 2014; 132(3-4):331-9. View Abstract
  39. Serum citrulline as a biomarker of gastrointestinal function during hematopoietic cell transplantation in children. J Pediatr Gastroenterol Nutr. 2014 Jun; 58(6):709-14. View Abstract
  40. Incidence of malignancy in patients with moderate-to-severe asthma treated with or without omalizumab. J Allergy Clin Immunol. 2014 Sep; 134(3):560-567.e4. View Abstract
  41. Calculating the costs of an 8-week, physiotherapy-led exercise intervention in deconditioned cancer survivors in the early survivorship period (the PEACH trial). Physiotherapy. 2014 Jun; 100(2):182-4. View Abstract
  42. Alloanergization of human T cells results in expansion of alloantigen-specific CD8(+) CD28(-) suppressor cells. Am J Transplant. 2014 Feb; 14(2):305-18. View Abstract
  43. Identification of single nucleotide polymorphisms in hematopoietic cell transplant patients affecting early recognition of, and response to, endotoxin. Innate Immun. 2014 Oct; 20(7):697-711. View Abstract
  44. Feasibility and efficacy of a supervised exercise intervention in de-conditioned cancer survivors during the early survivorship phase: the PEACH trial. J Cancer Surviv. 2013 Dec; 7(4):551-62. View Abstract
  45. Allogeneic hematopoietic cell transplantation for fanconi anemia in patients with pretransplantation cytogenetic abnormalities, myelodysplastic syndrome, or acute leukemia. J Clin Oncol. 2013 May 01; 31(13):1669-76. View Abstract
  46. Experiments in Open Innovation at Harvard Medical School: What happens when an elite academic institution starts to rethink how research gets done? MIT Sloan Manag Rev. 2013; 54(3):45-52. View Abstract
  47. The effect of aerobic exercise on metabolic and inflammatory markers in breast cancer survivors--a pilot study. Support Care Cancer. 2013 Jul; 21(7):1983-92. View Abstract
  48. Prize-based contests can provide solutions to computational biology problems. Nat Biotechnol. 2013 Feb; 31(2):108-11. View Abstract
  49. A young adult with aplastic anemia and gray hair. Clin Chem. 2013 Jan; 59(1):47-50. View Abstract
  50. Effect of weight on outcomes of children undergoing hematopoietic cell transplantation. Pediatr Hematol Oncol. 2013 Mar; 30(2):116-30. View Abstract
  51. Galactomannan Antigen Testing for Diagnosis of Invasive Aspergillosis in Pediatric Hematology Patients. J Pediatric Infect Dis Soc. 2012 Jun; 1(2):103-11. View Abstract
  52. Ex vivo alloanergization with belatacept: a strategy to selectively modulate alloresponses after transplantation. Cell Transplant. 2012; 21(9):2047-61. View Abstract
  53. Attenuation of resting energy expenditure following hematopoietic SCT in children. Bone Marrow Transplant. 2012 Oct; 47(10):1301-6. View Abstract
  54. Effect of titrated parenteral nutrition on body composition after allogeneic hematopoietic stem cell transplantation in children: a double-blind, randomized, multicenter trial. Am J Clin Nutr. 2012 Feb; 95(2):342-51. View Abstract
  55. Factors associated with parental activation in pediatric hematopoietic stem cell transplant. Med Care Res Rev. 2012 Apr; 69(2):194-214. View Abstract
  56. Bactericidal/permeability-increasing protein (rBPI21) and fluoroquinolone mitigate radiation-induced bone marrow aplasia and death. Sci Transl Med. 2011 Nov 23; 3(110):110ra118. View Abstract
  57. Deficient expression of bactericidal/permeability-increasing protein in immunocompromised hosts: translational potential of replacement therapy. Biochem Soc Trans. 2011 Aug; 39(4):994-9. View Abstract
  58. 17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli. J Leukoc Biol. 2011 Sep; 90(3):459-70. View Abstract
  59. Sweet syndrome in patients with Fanconi anaemia: association with extracutaneous manifestations and progression of haematological disease. Br J Haematol. 2011 Jul; 154(2):278-81. View Abstract
  60. Induction of alloantigen-specific anergy in human peripheral blood mononuclear cells by alloantigen stimulation with co-stimulatory signal blockade. J Vis Exp. 2011 Mar 14; (49). View Abstract
  61. Outcome of hematopoietic stem cell transplant in children with congenital heart disease. Pediatr Transplant. 2011 Feb; 15(1):75-80. View Abstract
  62. Diagnosis and management of aplastic anemia. Hematology Am Soc Hematol Educ Program. 2011; 2011:76-81. View Abstract
  63. Therapy for aplastic anemia. Hematology Am Soc Hematol Educ Program. 2011; 2011:82-3. View Abstract
  64. Combining CD19 redirection and alloanergization to generate tumor-specific human T cells for allogeneic cell therapy of B-cell malignancies. Cancer Res. 2010 May 15; 70(10):3915-24. View Abstract
  65. Defibrotide for the treatment of severe hepatic veno-occlusive disease and multiorgan failure after stem cell transplantation: a multicenter, randomized, dose-finding trial. Biol Blood Marrow Transplant. 2010 Jul; 16(7):1005-17. View Abstract
  66. A multi-center, randomized, controlled trial of parenteral nutrition titrated to resting energy expenditure in children undergoing hematopoietic stem cell transplantation ("PNTREE"): rationale and design. Contemp Clin Trials. 2010 Mar; 31(2):157-64. View Abstract
  67. Preservation of immune repertoire by selective depletion of haploidentical grafts. Biol Blood Marrow Transplant. 2010 Jan; 16(1 Suppl):S68-74. View Abstract
  68. Expansion of allospecific regulatory T cells after anergized, mismatched bone marrow transplantation. Sci Transl Med. 2009 Oct 07; 1(1):1ra3. View Abstract
  69. Hepatic veno-occlusive disease following stem cell transplantation: incidence, clinical course, and outcome. Biol Blood Marrow Transplant. 2010 Feb; 16(2):157-68. View Abstract
  70. Acquired aplastic anemia in childhood. Hematol Oncol Clin North Am. 2009 Apr; 23(2):171-91. View Abstract
  71. Induction of alloanergy in human donor T cells without loss of pathogen or tumor immunity. Transplantation. 2008 Sep 27; 86(6):854-64. View Abstract
  72. Results of the Cord Blood Transplantation Study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies. Blood. 2008 Nov 15; 112(10):4318-27. View Abstract
  73. Outcome of alloanergized haploidentical bone marrow transplantation after ex vivo costimulatory blockade: results of 2 phase 1 studies. Blood. 2008 Sep 15; 112(6):2232-41. View Abstract
  74. Weekly measurements accurately represent trends in resting energy expenditure in children undergoing hematopoietic stem cell transplantation. JPEN J Parenter Enteral Nutr. 2008 Jul-Aug; 32(4):427-32. View Abstract
  75. Prognostic factors in the resumption of oral dietary intake after allogeneic hematopoietic stem cell transplantation (HSCT) in children. JPEN J Parenter Enteral Nutr. 2007 Jul-Aug; 31(4):295-301. View Abstract
  76. An update on the management of severe idiopathic aplastic anaemia in children. Br J Haematol. 2007 Feb; 136(4):549-64. View Abstract
  77. Antigen-specific T-lymphocyte function after cord blood transplantation. Biol Blood Marrow Transplant. 2006 Dec; 12(12):1335-42. View Abstract
  78. A novel pattern of transaminase elevation associated with autologous transplant for neuroblastoma. Pediatr Transplant. 2006 Sep; 10(6):669-76. View Abstract
  79. Successful immune reconstitution decreases leukemic relapse and improves survival in recipients of unrelated cord blood transplantation. Biol Blood Marrow Transplant. 2006 Sep; 12(9):919-27. View Abstract
  80. Herpes zoster infection in the post-hematopoietic stem cell transplant pediatric population may be preceded by transaminitis: an institutional experience. Bone Marrow Transplant. 2006 Jan; 37(1):73-80. View Abstract
  81. Oral chronic graft-versus-host disease in pediatric patients after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2005 Sep; 11(9):721-31. View Abstract
  82. Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia. Blood. 2005 Sep 01; 106(5):1749-54. View Abstract
  83. Failure to define window of time for autologous tumor vaccination in patients with newly diagnosed or relapsed acute lymphoblastic leukemia. Exp Hematol. 2005 Mar; 33(3):286-94. View Abstract
  84. Protective antibody responses to pneumococcal conjugate vaccine after autologous hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2005 Mar; 11(3):213-22. View Abstract
  85. Contribution of bone marrow-derived endothelial cells to human tumor vasculature. Nat Med. 2005 Mar; 11(3):261-2. View Abstract
  86. Aplastic anemia: management of pediatric patients. Hematology Am Soc Hematol Educ Program. 2005; 104-9. View Abstract
  87. Presence of anti-kinectin and anti-PMS1 antibodies in Japanese aplastic anaemia patients. Br J Haematol. 2005 Jan; 128(2):221-3. View Abstract
  88. Favorable outcome of allogeneic hematopoietic stem cell transplantation for relapsed or refractory acute promyelocytic leukemia in childhood. Bone Marrow Transplant. 2004 Nov; 34(9):795-8. View Abstract
  89. Measuring T cell immunity to influenza vaccination in children after haemopoietic stem cell transplantation. Br J Haematol. 2004 Nov; 127(3):322-5. View Abstract
  90. Dyskeratosis congenita vs. chronic graft versus host disease: report of a case and a review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Nov; 98(5):566-71. View Abstract
  91. A multiagent strategy to decrease regimen-related toxicity in children undergoing allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2004 Sep; 10(9):635-44. View Abstract
  92. Endotoxemia and elevation of lipopolysaccharide-binding protein after hematopoietic stem cell transplantation. Pediatr Infect Dis J. 2003 Nov; 22(11):978-81. View Abstract
  93. Autoantibodies frequently detected in patients with aplastic anemia. Blood. 2003 Dec 15; 102(13):4567-75. View Abstract
  94. Homozygous alpha-thalassemia treated with intrauterine transfusions and postnatal hematopoietic stem cell transplantation. Bone Marrow Transplant. 2003 Aug; 32(3):341-2. View Abstract
  95. Changes in resting energy expenditure among children undergoing allogeneic stem cell transplantation. Am J Clin Nutr. 2003 Jul; 78(1):104-9. View Abstract
  96. Waiting for organ transplantation: results of an analysis by an Institute of Medicine Committee. Biostatistics. 2003 Apr; 4(2):207-22. View Abstract
  97. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation. Transplantation. 2003 Feb 15; 75(3):389-97. View Abstract
  98. Donor immunization with pneumococcal conjugate vaccine and early protective antibody responses following allogeneic hematopoietic cell transplantation. Blood. 2003 Feb 01; 101(3):831-6. View Abstract
  99. Multi-institutional use of defibrotide in 88 patients after stem cell transplantation with severe veno-occlusive disease and multisystem organ failure: response without significant toxicity in a high-risk population and factors predictive of outcome. Blood. 2002 Dec 15; 100(13):4337-43. View Abstract
  100. Neutrophil defense in patients undergoing bone marrow transplantation: bactericidal/permeability-increasing protein (BPI) and defensins in graft-derived neutrophils. Transplantation. 2002 May 15; 73(9):1522-6. View Abstract
  101. Marrow failure. Hematology Am Soc Hematol Educ Program. 2002; 58-72. View Abstract
  102. Impact of pharmacy practices on the cost of colony-stimulating factor use in pediatric stem cell transplantation: an institution-based analysis. J Pediatr Hematol Oncol. 2001 Jan; 23(1):19-24. View Abstract
  103. Hepatic veno-occlusive disease following hematopoietic stem cell transplantation. Acta Haematol. 2001; 106(1-2):57-68. View Abstract
  104. Balancing efficacy with cost: antiemetic control in the pediatric stem cell transplant (SCT) population. Bone Marrow Transplant. 2000 Mar; 25(5):553-7. View Abstract
  105. The pathology, diagnosis, and treatment of hepatic veno-occlusive disease: current status and novel approaches. Br J Haematol. 1999 Dec; 107(3):485-93. View Abstract
  106. Transplantation of anergic histoincompatible bone marrow allografts. N Engl J Med. 1999 Jun 03; 340(22):1704-14. View Abstract
  107. Phase I/II trial of PIXY321 (granulocyte-macrophage colony stimulating factor/interleukin-3 fusion protein) for treatment of inherited and acquired marrow failure syndromes. Br J Haematol. 1998 Nov; 103(2):304-7. View Abstract
  108. Comparison of multiple immunization schedules for Haemophilus influenzae type b-conjugate and tetanus toxoid vaccines following bone marrow transplantation. Bone Marrow Transplant. 1998 Oct; 22(8):735-41. View Abstract
  109. Treatment of severe veno-occlusive disease with defibrotide: compassionate use results in response without significant toxicity in a high-risk population. Blood. 1998 Aug 01; 92(3):737-44. View Abstract
  110. Subtyping analysis of Fanconi anemia by immunoblotting and retroviral gene transfer. Mol Med. 1998 Jul; 4(7):468-79. View Abstract
  111. Clinical aspects of aplastic anemia. Hematol Oncol Clin North Am. 1997 Dec; 11(6):1025-44. View Abstract
  112. Bone marrow transplantation for therapy-related myelodysplasia: comparison with primary myelodysplasia. Bone Marrow Transplant. 1997 Nov; 20(9):737-43. View Abstract
  113. Inducing amenorrhea during bone marrow transplantation. A pilot study of leuprolide acetate. J Reprod Med. 1997 Sep; 42(9):537-41. View Abstract
  114. Tacrolimus (FK506) in allogeneic bone marrow transplantation for severe aplastic anemia following orthotopic liver transplantation. Bone Marrow Transplant. 1997 Aug; 20(3):257-60. View Abstract
  115. Antibody responses to tetanus toxoid and Haemophilus influenzae type b conjugate vaccines following autologous peripheral blood stem cell transplantation (PBSCT). Bone Marrow Transplant. 1997 Jul; 20(1):33-8. View Abstract
  116. High-dose cyclophosphamide, carmustine, and etoposide with autologous transplantation in Hodgkin's disease: a prognostic model for treatment outcomes. Biol Blood Marrow Transplant. 1997 Jun; 3(2):98-106. View Abstract
  117. Measurement of plasma busulfan concentration by high-performance liquid chromatography with ultraviolet detection. Ther Drug Monit. 1997 Apr; 19(2):169-74. View Abstract
  118. Isolated testicular relapse in an adolescent 5 years following allogeneic bone marrow transplantation for acute myelogenous leukemia. Bone Marrow Transplant. 1997 Apr; 19(8):849-51. View Abstract
  119. Bone marrow transplantation in sickle cell anemia--the dilemma of choice. N Engl J Med. 1996 Aug 08; 335(6):426-8. View Abstract
  120. Haemophilus influenzae type b (HIB)-conjugate immunization before bone marrow harvest in autologous bone marrow transplantation. Bone Marrow Transplant. 1996 Jun; 17(6):1149-55. View Abstract
  121. Complete blockade of B7 family-mediated costimulation is necessary to induce human alloantigen-specific anergy: a method to ameliorate graft-versus-host disease and extend the donor pool. Blood. 1996 Jun 01; 87(11):4887-93. View Abstract
  122. Long-term follow-up of 12 pediatric patients with primary myelodysplastic syndrome treated with HLA-identical sibling donor bone marrow transplantation. Blood. 1996 May 01; 87(9):4020-2. View Abstract
  123. Donor immunization with Haemophilus influenzae type b (HIB)-conjugate vaccine in allogeneic bone marrow transplantation. Blood. 1996 Apr 01; 87(7):3012-8. View Abstract
  124. Diamond-Blackfan anemia. Natural history and sequelae of treatment. Medicine (Baltimore). 1996 Mar; 75(2):77-8. View Abstract
  125. GM-CSF clinical trials: pediatric aplastic anemia and Fanconi's anemia. Pediatr Nurs. 1995 Jul-Aug; 21(4):345-9. View Abstract
  126. Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity. Blood. 1994 Nov 15; 84(10):3261-82. View Abstract
  127. Recombinant human interleukin-1 receptor antagonist in the treatment of steroid-resistant graft-versus-host disease. Blood. 1994 Aug 15; 84(4):1342-8. View Abstract
  128. Polysaccharide conjugate vaccine responses in bone marrow transplant patients. Transplantation. 1994 Mar 15; 57(5):677-84. View Abstract
  129. Evaluation of granulocyte-macrophage colony-stimulating factor for treatment of pancytopenia in children with fanconi anemia. J Pediatr. 1994 Jan; 124(1):144-50. View Abstract
  130. In vitro enhancement of erythropoiesis by steel factor in Diamond-Blackfan anemia and treatment of other congenital cytopenias with recombinant interleukin 3/granulocyte-macrophage colony stimulating factor. Stem Cells. 1993 Jul; 11 Suppl 2:113-22. View Abstract
  131. Prognostic factors for treatment outcome in autotransplantation of intermediate-grade and high-grade non-Hodgkin's lymphoma with cyclophosphamide, carmustine, and etoposide. J Clin Oncol. 1993 Jun; 11(6):1085-91. View Abstract
  132. Effects of interleukin-3 and granulocyte-macrophage colony-stimulating factor on thrombopoiesis in congenital amegakaryocytic thrombocytopenia. Blood. 1993 Apr 01; 81(7):1691-8. View Abstract
  133. Selective depletion of bone marrow T lymphocytes with anti-CD5 monoclonal antibodies: effective prophylaxis for graft-versus-host disease in patients with hematologic malignancies. Blood. 1991 Oct 15; 78(8):2139-49. View Abstract
  134. Bone marrow transplantation for myelodysplasia and secondary acute nonlymphoblastic leukemia. J Clin Oncol. 1990 Oct; 8(10):1707-14. View Abstract
  135. A phase I/II trial of recombinant granulocyte-macrophage colony-stimulating factor for children with aplastic anemia. Blood. 1990 Sep 15; 76(6):1077-82. View Abstract
  136. Renal insufficiency after total body irradiation for pediatric bone marrow transplantation. Radiother Oncol. 1990; 18 Suppl 1:139-42. View Abstract
  137. Depletion of bone marrow T-lymphocytes with an anti-CD5 monoclonal immunotoxin (ST-1 immunotoxin): effective prophylaxis for graft-versus-host disease. Prog Clin Biol Res. 1990; 333:207-15. View Abstract
  138. Bone marrow transplantation for children with myelodysplastic syndromes. Blood. 1989 Feb; 73(2):619-22. View Abstract
  139. Vascular endothelial cells enhance T cell responses by markedly augmenting IL-2 concentrations. Cell Immunol. 1989 Jan; 118(1):166-77. View Abstract
  140. Cytoplasmic transfer between endothelium and lymphocytes: quantitation by flow cytometry. Am J Pathol. 1988 Sep; 132(3):406-9. View Abstract
  141. Intravascular hemolysis and renal insufficiency after bone marrow transplantation. Blood. 1988 Aug; 72(2):451-5. View Abstract
  142. Late onset of renal dysfunction in survivors of bone marrow transplantation. Int J Radiat Oncol Biol Phys. 1988 Jul; 15(1):99-104. View Abstract
  143. Bone marrow transplantation for constitutional pure red cell aplasia. Blood. 1988 Jan; 71(1):226-9. View Abstract
  144. Cyclophosphamide cardiotoxicity: an analysis of dosing as a risk factor. Blood. 1986 Nov; 68(5):1114-8. View Abstract
  145. Recombinant tumor necrosis factor and immune interferon act singly and in combination to reorganize human vascular endothelial cell monolayers. Am J Pathol. 1986 Apr; 123(1):16-24. View Abstract
  146. Efficacy of a cyclophosphamide-procarbazine-antithymocyte serum regimen for prevention of graft rejection following bone marrow transplantation for transfused patients with aplastic anemia. Transplantation. 1985 Jun; 39(6):671-3. View Abstract

Contact Eva Guinan