Research Overview

Dr. Eugene D’Angelo’s professional work is guided by the conviction that evidence-based practice --- that is, assessments and treatments that have been evaluated through research -- is the most effective and efficient way to address the challenges of real world mental health service delivery to children and their families. As such, his work focuses on the enhancement of clinical outcomes through implementation of innovative mental health prevention and treatment efforts in complex clinical settings. The “real world” of clinical practice is an environment of complex co-occurring and severe psychopathology; diverse ethnic, racial, and cultural communities; contextual issues such as a patient’s motivation for change, family resources, and resiliencies/vulnerabilities. Additionally, there are a multiplicity of service system difficulties which adversely impact an individual’s access to care. His research efforts focus on  the “adaptations of evidence-based practices” in the following contexts:  1) adaptation of a family depression intervention for Latino families (D’Angelo, et al., 2009); 2) refinement of relaxation training which relies on use of relationally-based imagery with anxious Latino patients (LaRoche, et al); 3) adaptation of group treatment protocols to enhance clinical outcome (D’Angelo & Botta, 2007); and 4) evaluation of a multi-site NIMH adolescent group preventive intervention (Garber et al., 2009). 
His research in developmental psychopathology focuses on the developmental and behavioral manifestations of early symptoms of psychosis, with a particular focus on identifying these clinically high risk youth who are also evidencing suicidal ideation. He is working on trying to better establish the parameters of risk for psychosis by focusing on refining identification of relevant behavioral symptoms below the age of 10 years and the cognitive correlates between the earliest features of disorganized thinking, social cognition, and interpersonal communication skills.

Research Background

Dr. Eugene D’Angelo is Chief for the Division of Psychology and Director of the Outpatient Psychiatry Services in the Department of Psychiatry. Dr. D’Angelo holds the Linda and Timothy O’Neill Chair in Psychology at Boston Children’s Hospital. He is an Associate Professor of Psychology, Department of Psychiatry, Harvard Medical School. Dr. D’Angelo received his PhD from the University of Michigan, completed his internship training at Boston Children’s Hospital, and a postdoctoral fellowship at the Judge Baker Children’s Center/Boston Children’s Hospital. He is board certified in Clinical Psychology from the American Board of Professional Psychology.

Dr. D’Angelo is a Past President of the American Academy of Clinical Psychology and also of the Massachusetts Psychological Association.

Education

Graduate School

University of Michigan
1980 Ann Arbor MI

Fellowship

Judge Baker Children's Center/Boston Children's Hospital
1981 Roxbury Crossing MA

Publications

  1. Heterogeneity of clinical symptomatology in pediatric patients at clinical high risk for psychosis. BMC Res Notes. 2024 Mar 26; 17(1):88. View Abstract
  2. Burden Experienced by Primary Caregivers of Children With Psychotic Disorders and at Clinical High Risk for Psychosis. J Am Psychiatr Nurses Assoc. 2024 May-Jun; 30(3):518-531. View Abstract
  3. Similar Rates of Deleterious Copy Number Variants in Early-Onset Psychosis and Autism Spectrum Disorder. Am J Psychiatry. 2022 11 01; 179(11):853-861. View Abstract
  4. Establishing psychological safety in clinical supervision: Multi-professional perspectives. Clin Teach. 2022 04; 19(2):71-78. View Abstract
  5. Depressive symptom screening and endorsement of psychosis risk-related experiences in a diverse adolescent and young adult outpatient clinic in the US. Schizophr Res. 2022 10; 248:353-360. View Abstract
  6. Multi-informant reports of depressive symptoms and suicidal ideation among adolescent inpatients. Suicide Life Threat Behav. 2022 02; 52(1):99-109. View Abstract
  7. RCL1 copy number variants are associated with a range of neuropsychiatric phenotypes. Mol Psychiatry. 2021 05; 26(5):1706-1718. View Abstract
  8. Implementing Evidence-Based Treatments for Youth in Acute and Intensive Treatment Settings. J Cogn Psychother. 2020 08 01; 34(3):185-199. View Abstract
  9. Does function predict persistence? Nonsuicidal self-injury among adolescents during and after hospitalization. Psychiatry Res. 2020 Feb 04; 286:112839. View Abstract
  10. P300 amplitude attenuation in high risk and early onset psychosis youth. Schizophr Res. 2019 08; 210:228-238. View Abstract
  11. De novo variant of TRRAP in a patient with very early onset psychosis in the context of non-verbal learning disability and obsessive-compulsive disorder: a case report. BMC Med Genet. 2018 11 13; 19(1):197. View Abstract
  12. Young children with psychotic symptoms and risk for suicidal thoughts and behaviors: a research note. BMC Res Notes. 2018 Aug 10; 11(1):568. View Abstract
  13. Social impairment and social language deficits in children and adolescents with and at risk for psychosis. Schizophr Res. 2019 02; 204:304-310. View Abstract
  14. De novo ATP1A3 and compound heterozygous NLRP3 mutations in a child with autism spectrum disorder, episodic fatigue and somnolence, and muckle-wells syndrome. Mol Genet Metab Rep. 2018 Sep; 16:23-29. View Abstract
  15. Potentially traumatic events in youth with and at clinical high risk for psychosis. Early Interv Psychiatry. 2019 08; 13(4):805-809. View Abstract
  16. Implicit Cognitions as a Behavioral Marker of Suicide Attempts in Adolescents. Arch Suicide Res. 2019 Jan-Mar; 23(1):47-63. View Abstract
  17. Suicidal behaviors and their relationship with psychotic-like symptoms in children and adolescents at clinical high risk for psychosis. Compr Psychiatry. 2017 10; 78:31-37. View Abstract
  18. Social cognitive impairment in 22q11 deletion syndrome: A review. Psychiatry Res. 2017 07; 253:99-106. View Abstract
  19. A Developmental Perspective on Social-Cognition Difficulties in Youth at Clinical High Risk for Psychosis. Harv Rev Psychiatry. 2017 Jan/Feb; 25(1):4-14. View Abstract
  20. Suicidal behaviors in children and adolescents with psychotic disorders. Schizophr Res. 2017 01; 179:13-16. View Abstract
  21. Capturing Psychologists' Work in Academic Health Settings: The Role of the Educational Value Unit (EVU). J Clin Psychol Med Settings. 2016 Mar; 23(1):21-32. View Abstract
  22. Overlapping 16p13.11 deletion and gain of copies variations associated with childhood onset psychosis include genes with mechanistic implications for autism associated pathways: Two case reports. Am J Med Genet A. 2016 May; 170A(5):1165-73. View Abstract
  23. Examining potential iatrogenic effects of viewing suicide and self-injury stimuli. Psychol Assess. 2016 11; 28(11):1510-1515. View Abstract
  24. N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth. Neural Plast. 2016; 2016:4209831. View Abstract
  25. Early auditory processing evoked potentials (N100) show a continuum of blunting from clinical high risk to psychosis in a pediatric sample. Schizophr Res. 2015 Dec; 169(1-3):340-345. View Abstract
  26. Neurophysiological differences between patients clinically at high risk for schizophrenia and neurotypical controls--first steps in development of a biomarker. BMC Med. 2015 Nov 02; 13:276. View Abstract
  27. Using Implicit and Explicit Measures to Predict Nonsuicidal Self-Injury Among Adolescent Inpatients. J Am Acad Child Adolesc Psychiatry. 2016 Jan; 55(1):62-8. View Abstract
  28. Developmentally informed evaluation of depression: evidence-based instruments. Child Adolesc Psychiatr Clin N Am. 2012 Apr; 21(2):279-98, viii. View Abstract
  29. Evidence-based treatment approach to autism spectrum disorders. Pediatr Ann. 2011 Nov; 40(11):569-74. View Abstract
  30. A culturally competent relaxation intervention for Latino/as: assessing a culturally specific match model. Am J Orthopsychiatry. 2011 Oct; 81(4):535-42. View Abstract
  31. A content analyses of guided imagery scripts: a strategy for the development of cultural adaptations. J Clin Psychol. 2011 Jan; 67(1):45-57. View Abstract
  32. Prevention of depression in at-risk adolescents: a randomized controlled trial. JAMA. 2009 Jun 03; 301(21):2215-24. View Abstract
  33. Adaptation of the preventive intervention program for depression for use with predominantly low-income Latino families. Fam Process. 2009 Jun; 48(2):269-91. View Abstract
  34. Linkage analysis of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 05; 147B(8):1387-91. View Abstract
  35. Rapid mental health triage: A practical guide for clinicians. Boston: Blue Cross Blue Shield of Massachusetts. (In Press). 2007. View Abstract
  36. Linkage Analysis of Attention Deficit Hyperactivity Disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2007. View Abstract
  37. Training Manual: Mindfulness-enhanced parent management training for disruptive behaviors. 36 pages. Department of Psychiatry, Children's Hospital Boston. 2007. View Abstract
  38. Training Manual: Evidenced Based Treatment for Children with Anxiety – Cognitive Behavioral Therapy for Anxious Children. 48 pages. Department of Psychiatry, Children's Hospital Boston. 2007. View Abstract
  39. An Act Improving and Expanding Behavioral Health Services for Children in the Commonwealth, HB 1872, SB 1133. 2007. View Abstract
  40. Parenting stress and parental post-traumatic stress disorder in families after pediatric heart transplantation. J Heart Lung Transplant. 2007 Feb; 26(2):120-6. View Abstract
  41. Adapted manual for the Prevention of Depression in Families Program for use with Latino families. 32 pages. Bethesda, MD: Center for Mental Health Services/SAMHSA. 2007. View Abstract
  42. Generalization of social skills among young adolescents with Asperger’s Disorder. AANE News. 2007; 20:8-9. View Abstract
  43. Parenting stress and parental post-traumatic stress disorder in families after pediatric heart transplantation. The Journal of Heart and Lung Transplantation. 2007; 26:120-126. View Abstract
  44. Training Manual: Parent Management Training for Disruptive Behaviors. 49 pages. Department of Psychiatry, Children's Hospital Boston. 2006. View Abstract
  45. Culturally sensitive guided imagery for allocentric Latinos: A pilot study. Psychotherapy (Chic). 2006; 43(4):555-60. View Abstract
  46. Culturally sensitive guided imagery for allocentric Latinos: A pilot study. Psychotherapy: Theory, Research, Practice, Training. 2006; 43:555-560. View Abstract
  47. In honor of our founding members and a focus on our future. Bulletin of the American Academy of Clinical Psychology. 2005; 10(Fall '05 / Winter '06):1-2. View Abstract
  48. Final Report: Governor's Commission on Children's Mental Health. 2005. View Abstract
  49. Problems your child may have. Boston Bar Association, editors. The Parents' How-to-Guide to Children's Mental Health Services in Massachusetts. 2004; 5-24. View Abstract
  50. Training pediatric psychologists for the 21st century. Roberts M, editor. The handbook of pediatric psychology, 3rd edition. 2004. View Abstract
  51. The psychologist's role in advocacy. MSPP Pulse. 2004; 3(1):8-9. View Abstract
  52. Society of pediatric psychology task force report: recommendations for the training of pediatric psychologists. J Pediatr Psychol. 2003 Mar; 28(2):85-98. View Abstract
  53. Depression and anxiety in adults with congenital heart disease: a pilot study. Heart Lung. 2003 Mar-Apr; 32(2):105-10. View Abstract
  54. Hope, meaning, and continuity: Adapting a depression prevention program for Latino families facing depression. 37 pages. Conceptual Review for the Center for Mental Health Services/SAMHSA. 2003. View Abstract
  55. A hope for peace and freedom from fear. Massachusetts Psychological Association Quarterly. 2003; 47(1):3-4. View Abstract
  56. State associations and the belief in the future of psychology. Massachusetts Psychological Association Quarterly. 2002; 46(1):3,13. View Abstract
  57. Advocacy, public policy and the voice of psychology. Massachusetts Psychological Association Quarterly. 2002; 46(3):3. View Abstract
  58. A year of remembrance. Massachusetts Psychological Association Quarterly. 2002; 46(2):3. View Abstract
  59. School Readiness in Massachusetts: A Report of the Governor’s Commission on School Readiness. 2001. View Abstract
  60. An Act Relative to Reimbursement for Collateral Services by Mental Health Providers, HB 3352. 2001. View Abstract
  61. Schizophrenia in children and adolescents, by H. Remschmidt, editor [review]. Readings: A journal of reviews and commentary in mental health. 2001; 16(3):30-1. View Abstract
  62. The evolution of law and the psyche of a nation. Massachusetts Psychological Association Quarterly. 2001; 45(3). View Abstract
  63. Helping children cope with frightening events without frightening them. 2001. View Abstract
  64. Psychological functioning in children and adolescents undergoing radiofrequency catheter ablation. Psychosomatics. 2000 Mar-Apr; 41(2):134-9. View Abstract
  65. Clinical outcome studies and internship training: A conceptual overview. . Massachusetts Psychological Association Quarterly. 2000; 44:9-11. View Abstract
  66. Where are the psychologists in the debate on public policy?. Massachusetts Psychological Association Quarterly. 1997; 41(1):2,7. View Abstract
  67. Treating Schizophrenia, by S. Vinogradov, editor [review]. Readings: A Journal of Reviews and Commentary in Mental Health. 1996; 11:23. View Abstract
  68. Pediatric compliance and the roles of distinct treatment characteristics, treatment attitudes, and family stress: a preliminary report. J Dev Behav Pediatr. 1995 Oct; 16(5):350-8. View Abstract
  69. Psychopathology in the families of children and adolescents with borderline personality disorder. Am J Psychiatry. 1993 Dec; 150(12):1832-5. View Abstract
  70. Conceptual disorganization in children at risk for schizophrenia. Psychopathology. 1993; 26(3-4):195-202. View Abstract
  71. Physical and sexual abuse histories among children with borderline personality disorder. Am J Psychiatry. 1992 Dec; 149(12):1723-6. View Abstract
  72. Correlates of medical compliance among hemophilic boys. J Clin Psychol. 1992 Sep; 48(5):672-80. View Abstract
  73. The evolution of practice in child psychotherapy. Freedheim DK, Freudenberger HJ, editors. The History of Psychotherapy. 1992; 457-92. View Abstract
  74. Convergent and discriminant validity of the Borderline Syndrome Index. . Psychological Reports. 1991; 69:631-5. View Abstract
  75. Culture, madness, and religious belief. Harvard Divinity Bulletin. 1990; 20:21. View Abstract
  76. Significance of Infant Observational Research on Clinical Work with Children, Adolescents, and Adults, by S. Dowling, A. Rothstein, editors [review]. Readings: A Journal of Reviews and Commentary in Mental Health. 1990; 5:23. View Abstract
  77. School functioning and disease severity in boys with hemophilia. J Dev Behav Pediatr. 1989 Apr; 10(2):81-5. View Abstract
  78. A Developmental Approach to Adult Psychopathology, by E. Zigler & M. Glick [review]. Readings: A journal of reviews and commentary in mental health. 1987; 2(2):30. View Abstract
  79. Defenses and recovery from schizophrenic episodes: Dr. D'Angelo replies. Hillside Journal of Clinical Psychiatry. 1987; 9:118-9. View Abstract
  80. Pediatric Psychology, by M. Roberts [review]. Journal of Pediatric Psychology. 1987; 12:651-2. View Abstract
  81. Security of attachment in infants with schizophrenic, depressed, and unaffected mothers. J Genet Psychol. 1986 Sep; 147(3):421-2. View Abstract
  82. Defensive constellation and styles of recovery from schizophrenic episodes. Hillside J Clin Psychiatry. 1986; 8(1):3-14. View Abstract
  83. The surgical decision-making of parents who have infants with a congenital heart defect. Pediatric Cardiology: Proceedings of the Second World Congress. 1985; 767-9. View Abstract
  84. Developmental and temperamental characteristics of infants at risk for serious psychopathology. Call J, Galenson H, Tyson R, editors. Frontiers of Infant Psychiatry, Vol 2. 1984; 190-200. View Abstract
  85. Chronic subdural hematoma: A clinical and statistical review of 43 operative cases. Surgical Forum. 1983; 34:540-2. View Abstract
  86. Understanding the borderline syndromes [review]. Journal of Personality Assessment. 1982; 46:193-5. View Abstract
  87. Reversed cerebral asymmetries as a potential risk factor in autism: a reconsideration. Percept Mot Skills. 1981 Aug; 53(1):101-2. View Abstract
  88. Relation of community mental health ideology and the community adaptation of formerly hospitalized individuals. Psychol Rep. 1980 Aug; 47(1):39-43. View Abstract
  89. Communication deviance, thought disorder, and attention dysfunction in mothers of children at risk for schizophrenia. 1980. View Abstract
  90. Life events and clinical theorists [review]. Journal of Personality Assessment. 1980; 44:101-2. View Abstract

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