Information

Related Research Units

Gastroenterology, Hepatology and Nutrition Research
Developmental Medicine Research

Research Overview

Dr. Liu' research has been focused on nutritional status and its association with health outcomes, with emphasis on child and HIV-infected populations.

  1. Randomized controlled trials of micronutrient supplementation (e.g. multivitamins, zinc) and child nutritional status, morbidity, and mortality.
  2. Practice of exclusive breastfeeding by HIV-infected mothers and its relationships to infant growth, morbidity, and death.
  3. Nutritional status and morbidity and treatment outcomes among HIV-infected patients on anti-retroviral therapy.

Research Background

Dr. Liu has a broad background in medicine, biostatistics and epidemiology with specific training and expertise in nutritional epidemiology. Within extensive experience in study design and statistical methods, she has been involved in several large observational cohorts and randomized controlled trials. She performed tremendous data analysis based these studies, with emphasis on dietary and nutritional factors, and their associations with health outcomes in adults and children. Her efforts in the field have resulted in dozens of publications in peer reviewed scientific journals.

Besides research efforts, Dr. Liu is also responsible for training and mentoring of clinical staff, fellows, and junior faculty on statistical methods and data analysis, both through didactic lectures and individualized instruction. She has travelled multiple times to Tanzania to provide educational courses and on-site guidance on study design and data management and analysis to local researchers.

Publications

  1. Low-Dose Interleukin 2 for the Treatment of Moderate to Severe Ulcerative Colitis. Gastroenterology. 2023 08; 165(2):492-495.e2. View Abstract
  2. Assessing environmental enteric dysfunction via multiplex assay and its relation to growth and development among HIV-exposed uninfected Tanzanian infants. PLoS Negl Trop Dis. 2023 03; 17(3):e0011181. View Abstract
  3. Helicobacter pylori Antimicrobial Resistance in a Pediatric Population From the New England Region of the United States. Clin Gastroenterol Hepatol. 2023 12; 21(13):3458-3460.e2. View Abstract
  4. Oral iron supplementation and anaemia in children according to schedule, duration, dose and cosupplementation: a systematic review and meta-analysis of 129 randomised trials. BMJ Glob Health. 2023 02; 8(2). View Abstract
  5. Neuropsychological and mental health concerns in a multicenter clinical sample of youth with turner syndrome. Am J Med Genet A. 2023 04; 191(4):962-976. View Abstract
  6. Efficacy and Safety of Sulfasalazine Suspension in Children With Ulcerative Colitis. J Pediatr Gastroenterol Nutr. 2023 04 01; 76(4):460-467. View Abstract
  7. Gastrointestinal factors associated with risk of bronchiectasis in children. Pediatr Pulmonol. 2023 03; 58(3):899-907. View Abstract
  8. Effects of prenatal nutritional supplements on gestational weight gain in low- and middle-income countries: a meta-analysis of individual participant data. Am J Clin Nutr. 2022 12 19; 116(6):1864-1876. View Abstract
  9. A Prospective Study of Brief Resolved Unexplained Events: Risk Factors for Persistent Symptoms. Hosp Pediatr. 2022 12 01; 12(12):1030-1043. View Abstract
  10. Biomarkers of environmental enteric dysfunction and adverse birth outcomes: An observational study among pregnant women living with HIV in Tanzania. EBioMedicine. 2022 Oct; 84:104257. View Abstract
  11. Clinical Phenotypes and Outcomes in Monogenic Versus Non-monogenic Very Early Onset Inflammatory Bowel Disease. J Crohns Colitis. 2022 Sep 08; 16(9):1380-1396. View Abstract
  12. Approaches to Identify Factors Associated with Pubertal Timing in Self-Limited Delayed Puberty. Horm Res Paediatr. 2023; 96(3):267-277. View Abstract
  13. Enteral Multiple Micronutrient Supplementation in Preterm and Low Birth Weight Infants: A Systematic Review and Meta-analysis. Pediatrics. 2022 08 01; 150(Suppl 1). View Abstract
  14. A prospective study of intrapyloric botulinum toxin and EndoFLIP in children with nausea and vomiting. Neurogastroenterol Motil. 2022 Nov; 34(11):e14428. View Abstract
  15. Health Disparities Likely Emerge Early in the Course of Type-1 Diabetes in Youth. J Diabetes Sci Technol. 2022 07; 16(4):929-933. View Abstract
  16. Antibiotic Therapy for Culture-Proven Bacterial Overgrowth in Children With Intestinal Failure Results in Improved Symptoms and Growth. J Pediatr Gastroenterol Nutr. 2022 09 01; 75(3):345-350. View Abstract
  17. Multivitamin Supplementation Is Associated with Greater Adequacy of Gestational Weight Gain among Pregnant Women in Tanzania. J Nutr. 2022 04 01; 152(4):1091-1098. View Abstract
  18. Cost-effectiveness of zinc supplementation for prevention of childhood diarrhoea in Tanzania. Public Health Nutr. 2022 Jul; 25(7):1979-1988. View Abstract
  19. Associations between Gestational Weight Gain Adequacy and Neonatal Outcomes in Tanzania. Ann Nutr Metab. 2022; 78(3):156-165. View Abstract
  20. Risk Factors for Bile Aspiration and its Impact on Clinical Outcomes. Clin Transl Gastroenterol. 2021 12 07; 12(12):e00434. View Abstract
  21. Plasma concentrations of leptin at mid-pregnancy are associated with gestational weight gain among pregnant women in Tanzania: a prospective cohort study. BMC Pregnancy Childbirth. 2021 Oct 06; 21(1):675. View Abstract
  22. Predictors of Bilateral Disease in Pediatric Differentiated Thyroid Cancer. J Clin Endocrinol Metab. 2021 09 27; 106(10):e4242-e4250. View Abstract
  23. The interferon landscape along the respiratory tract impacts the severity of COVID-19. Cell. 2021 09 16; 184(19):4953-4968.e16. View Abstract
  24. A Comparison of Demographic and Psychosocial Characteristics Between Transgender Youth Enrolling Versus Not Enrolling in a Multisite Study. Transgend Health. 2021 Aug; 6(4):229-234. View Abstract
  25. Acid Suppression Does Not Improve Laryngomalacia Outcomes but Treatment for Oropharyngeal Dysphagia Might Be Protective. J Pediatr. 2021 Nov; 238:42-49.e2. View Abstract
  26. Severity of SARS-CoV-2 infection as a function of the interferon landscape across the respiratory tract of COVID-19 patients. bioRxiv. 2021 Mar 30. View Abstract
  27. Natural History of Thyroid Disease in Children with PTEN Hamartoma Tumor Syndrome. J Clin Endocrinol Metab. 2021 03 08; 106(3):e1121-e1130. View Abstract
  28. Methodological approaches to imputing early-pregnancy weight based on weight measures collected during pregnancy. BMC Med Res Methodol. 2021 02 05; 21(1):24. View Abstract
  29. Identifying Infants and Young Children at Risk of Unplanned Hospital Admissions and Clinic Visits in Dar es Salaam, Tanzania. Pediatr Infect Dis J. 2020 12; 39(12):e428-e434. View Abstract
  30. Gestational weight gain in low-income and middle-income countries: a modelling analysis using nationally representative data. BMJ Glob Health. 2020 11; 5(11). View Abstract
  31. Lower-Dose Zinc for Childhood Diarrhea - A Randomized, Multicenter Trial. N Engl J Med. 2020 09 24; 383(13):1231-1241. View Abstract
  32. Risk factors for mortality among Tanzanian infants and children. Trop Med Health. 2020; 48:43. View Abstract
  33. Portal Venous Metabolite Profiling After RYGB in Male Rats Highlights Changes in Gut-Liver Axis. J Endocr Soc. 2020 Feb 01; 4(2):bvaa003. View Abstract
  34. Continuous Feedings Are Not Associated With Lower Rates of Gastroesophageal Reflux When Compared With Bolus Feedings. J Pediatr Gastroenterol Nutr. 2019 12; 69(6):678-681. View Abstract
  35. Natural history of children with mild Crohn's disease. World J Gastroenterol. 2019 08 14; 25(30):4235-4245. View Abstract
  36. Effects of animal protein supplementation of mothers, preterm infants, and term infants on growth outcomes in childhood: a systematic review and meta-analysis of randomized trials. Am J Clin Nutr. 2019 08 01; 110(2):410-429. View Abstract
  37. The Impact of the American Academy of Pediatrics Brief Resolved Unexplained Event Guidelines on Gastrointestinal Testing and Prescribing Practices. J Pediatr. 2019 08; 211:112-119.e4. View Abstract
  38. Effect of dose reduction of supplemental zinc for childhood diarrhoea: study protocol for a double-masked, randomised controlled trial in India and Tanzania. BMJ Paediatr Open. 2019; 3(1):e000460. View Abstract
  39. The Utility of Potassium Monitoring in Gender-Diverse Adolescents Taking Spironolactone. J Endocr Soc. 2019 May 01; 3(5):1031-1038. View Abstract
  40. Markers of Systemic Inflammation and Environmental Enteric Dysfunction Are Not Reduced by Zinc or Multivitamins in Tanzanian Infants: A Randomized, Placebo-Controlled Trial. J Pediatr. 2019 07; 210:34-40.e1. View Abstract
  41. Biomarkers of Systemic Inflammation and Growth in Early Infancy are Associated with Stunting in Young Tanzanian Children. Nutrients. 2018 Aug 24; 10(9). View Abstract
  42. Creation of Experience-based Celiac Benchmarks: The First Step in Pretransition Self-management Assessment. J Pediatr Gastroenterol Nutr. 2018 07; 67(1):e6-e10. View Abstract
  43. Markers of Environmental Enteric Dysfunction Are Associated With Neurodevelopmental Outcomes in Tanzanian Children. J Pediatr Gastroenterol Nutr. 2018 Jun; 66(6):953-959. View Abstract
  44. The Impact of Combination Therapy on Infliximab Levels and Antibodies in Children and Young Adults With Inflammatory Bowel Disease. Inflamm Bowel Dis. 2018 05 18; 24(6):1344-1351. View Abstract
  45. Validity of an FFQ to measure nutrient and food intakes in Tanzania. Public Health Nutr. 2018 08; 21(12):2211-2220. View Abstract
  46. Effect of Zinc Supplementation on Growth Outcomes in Children under 5 Years of Age. Nutrients. 2018 Mar 20; 10(3). View Abstract
  47. Serum anti-flagellin and anti-lipopolysaccharide immunoglobulins as predictors of linear growth faltering in Pakistani infants at risk for environmental enteric dysfunction. PLoS One. 2018; 13(3):e0193768. View Abstract
  48. Incidence and Risk Factors for Overweight and Obesity after Initiation of Antiretroviral Therapy in Dar es Salaam, Tanzania. J Int Assoc Provid AIDS Care. 2018 Jan-Dec; 17:2325958218759759. View Abstract
  49. Dietary determinants of serum total cholesterol among middle-aged and older adults: a population-based cross-sectional study in Dar es Salaam, Tanzania. BMJ Open. 2017 06 06; 7(5):e015028. View Abstract
  50. Infant Nutritional Status and Markers of Environmental Enteric Dysfunction are Associated with Midchildhood Anthropometry and Blood Pressure in Tanzania. J Pediatr. 2017 08; 187:225-233.e1. View Abstract
  51. Complementary Feeding and Diarrhea and Respiratory Infection Among HIV-Exposed Tanzanian Infants. J Acquir Immune Defic Syndr. 2017 Mar 01; 74(3):265-272. View Abstract
  52. Impact of gastroesophageal reflux and delayed gastric emptying on pediatric lung transplant outcomes. J Heart Lung Transplant. 2017 Aug; 36(8):854-861. View Abstract
  53. Angiogenic proteins, placental weight and perinatal outcomes among pregnant women in Tanzania. PLoS One. 2016; 11(12):e0167716. View Abstract
  54. Determinants of high blood pressure and barriers to diagnosis and treatment in Dar es Salaam, Tanzania. J Hypertens. 2016 12; 34(12):2353-2364. View Abstract
  55. Dietary iron and calcium intakes during pregnancy are associated with lower risk of prematurity, stillbirth and neonatal mortality among women in Tanzania. Public Health Nutr. 2017 03; 20(4):678-686. View Abstract
  56. High Burden of Morbidity and Mortality but Not Growth Failure in Infants Exposed to but Uninfected with Human Immunodeficiency Virus in Tanzania. J Pediatr. 2017 01; 180:191-199.e2. View Abstract
  57. Prevalence of Hypertension and Its Associated Risk Factors among 34,111 HAART Naïve HIV-Infected Adults in Dar es Salaam, Tanzania. Int J Hypertens. 2016; 2016:5958382. View Abstract
  58. Nutritional status and complementary feeding among HIV-exposed infants: a prospective cohort study. Matern Child Nutr. 2017 07; 13(3). View Abstract
  59. Intra-Cluster Correlation Estimates for HIV-related Outcomes from Care and Treatment Clinics in Dar es Salaam, Tanzania. Contemp Clin Trials Commun. 2016 Dec 15; 4:161-169. View Abstract
  60. Maternal Antiretroviral Therapy Is Associated with Lower Risk of Diarrhea in Early Childhood. J Pediatr. 2016 08; 175:54-60. View Abstract
  61. Elevations in serum anti-flagellin and anti-LPS Igs are related to growth faltering in young Tanzanian children. Am J Clin Nutr. 2016 06; 103(6):1548-54. View Abstract
  62. HIV virological failure and drug resistance in a cohort of Tanzanian HIV-infected adults. J Antimicrob Chemother. 2016 07; 71(7):1966-74. View Abstract
  63. Exclusive Breast-feeding Protects against Mother-to-Child Transmission of HIV-1 through 12 Months of Age in Tanzania. J Trop Pediatr. 2016 08; 62(4):301-7. View Abstract
  64. Active Tuberculosis in HIV-Exposed Tanzanian Children up to 2 years of Age: Early-Life Nutrition, Multivitamin Supplementation and Other Potential Risk Factors. J Trop Pediatr. 2016 Feb; 62(1):29-37. View Abstract
  65. Antiretroviral Therapy in Relation to Birth Outcomes among HIV-infected Women: A Cohort Study. J Infect Dis. 2016 Apr 01; 213(7):1057-64. View Abstract
  66. Tuberculosis incidence rate and risk factors among HIV-infected adults with access to antiretroviral therapy. AIDS. 2015 Jul 17; 29(11):1391-9. View Abstract
  67. Prevalence and risk factors of cervical squamous intraepithelial lesions among HIV-infected women in Dar es Salaam, Tanzania. Int J STD AIDS. 2016 Mar; 27(3):219-25. View Abstract
  68. Gender differences in diet and nutrition among adults initiating antiretroviral therapy in Dar es Salaam, Tanzania. AIDS Care. 2015; 27(6):706-15. View Abstract
  69. Prevalence and Risk Factors for Overweight and Obesity among HIV-Infected Adults in Dar es Salaam, Tanzania. J Int Assoc Provid AIDS Care. 2016 11; 15(6):512-521. View Abstract
  70. Maternal mortality among HIV-infected pregnant women in Tanzania. Acta Obstet Gynecol Scand. 2014 May; 93(5):463-8. View Abstract
  71. Maternal hyperglycemia and adverse pregnancy outcomes in Dar es Salaam, Tanzania. Int J Gynaecol Obstet. 2014 Apr; 125(1):22-7. View Abstract
  72. Multivitamin supplementation improves haematologic status in children born to HIV-positive women in Tanzania. J Int AIDS Soc. 2013 Aug 13; 16:18022. View Abstract
  73. Incident tuberculosis and risk factors among HIV-infected children in Tanzania. AIDS. 2013 May 15; 27(8):1273-81. View Abstract
  74. First-line antiretroviral therapy and changes in lipid levels over 3 years among HIV-infected adults in Tanzania. Clin Infect Dis. 2013 Jun; 56(12):1820-8. View Abstract
  75. Exclusive breastfeeding reduces risk of mortality in infants up to 6 mo of age born to HIV-positive Tanzanian women. Am J Clin Nutr. 2012 Nov; 96(5):1071-8. View Abstract
  76. Predicted 25-hydroxyvitamin D score and change in fasting plasma glucose in the Framingham offspring study. Eur J Clin Nutr. 2012 Jan; 66(1):139-41. View Abstract
  77. Nutritional status and mortality among HIV-infected patients receiving antiretroviral therapy in Tanzania. J Infect Dis. 2011 Jul 15; 204(2):282-90. View Abstract
  78. Medical history and the risk of biliary tract cancers in Shanghai, China: implications for a role of inflammation. Cancer Causes Control. 2011 Sep; 22(9):1289-96. View Abstract
  79. Dyslipidemia in an HIV-positive antiretroviral treatment-naive population in Dar es Salaam, Tanzania. J Acquir Immune Defic Syndr. 2011 Jun 01; 57(2):141-5. View Abstract
  80. Relationship of exclusive breast-feeding to infections and growth of Tanzanian children born to HIV-infected women. Public Health Nutr. 2011 Jul; 14(7):1251-8. View Abstract
  81. Predicted 25-hydroxyvitamin D score and incident type 2 diabetes in the Framingham Offspring Study. Am J Clin Nutr. 2010 Jun; 91(6):1627-33. View Abstract
  82. Gender-related differences in the prevalence of cardiovascular disease risk factors and their correlates in urban Tanzania. BMC Cardiovasc Disord. 2009 Jul 17; 9:30. View Abstract
  83. Cross-sectional association of dietary patterns with insulin-resistant phenotypes among adults without diabetes in the Framingham Offspring Study. Br J Nutr. 2009 Aug; 102(4):576-83. View Abstract
  84. Plasma 25-hydroxyvitamin d is associated with markers of the insulin resistant phenotype in nondiabetic adults. J Nutr. 2009 Feb; 139(2):329-34. View Abstract
  85. Tea drinking and the risk of biliary tract cancers and biliary stones: a population-based case-control study in Shanghai, China. Int J Cancer. 2006 Jun 15; 118(12):3089-94. View Abstract
  86. [Tea consumption and risk of biliary tract cancers and gallstone disease: a population-based case-control study in Shanghai, China]. Zhonghua Zhong Liu Za Zhi. 2005 Nov; 27(11):667-71. View Abstract
  87. [A prospective cohort study on body mass index and mortality among middle-aged and elderly men in urban Shanghai]. Zhonghua Liu Xing Bing Xue Za Zhi. 2005 Jun; 26(6):394-9. View Abstract
  88. Aspirin use and risk of biliary tract cancer: a population-based study in Shanghai, China. Cancer Epidemiol Biomarkers Prev. 2005 May; 14(5):1315-8. View Abstract
  89. [Cigarette smoking and cancer mortality: a prospective cohort study in urban males in Shanghai]. Zhonghua Liu Xing Bing Xue Za Zhi. 2004 Oct; 25(10):837-40. View Abstract
  90. [Methods for time trend analysis of cancer incidence rates]. Zhonghua Liu Xing Bing Xue Za Zhi. 2004 Feb; 25(2):173-7. View Abstract

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Phone: 857-218-3822
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