Dongxian Guan

Publications

1. Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss. Cell Metab. 2024 Apr 02; 36(4):857-876.e10. View Abstract
2. Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin a2ß1. Cell Metab. 2024 03 05; 36(3):598-616.e9. View Abstract
3. Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation. Nat Cell Biol. 2023 Jul; 25(7):950-962. View Abstract
4. Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. Science. 2023 06 30; 380(6652):1372-1380. View Abstract
5. FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity. Cell Metab. 2022 07 05; 34(7):1004-1022.e8. View Abstract
6. Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry. Cell Metab. 2022 03 01; 34(3):424-440.e7. View Abstract
7. The Human Novel Gene LNC-HC Inhibits Hepatocellular Carcinoma Cell Proliferation by Sequestering hsa-miR-183-5p. Mol Ther Nucleic Acids. 2020 Jun 05; 20:468-479. View Abstract
8. Lipocalin 2 Does Not Play A Role in Celastrol-Mediated Reduction in Food Intake and Body Weight. Sci Rep. 2019 09 05; 9(1):12809. View Abstract
9. IL1R1 is required for celastrol's leptin-sensitization and antiobesity effects. Nat Med. 2019 04; 25(4):575-582. View Abstract
10. Recruitment of phosphatase PP2A by RACK1 adaptor protein deactivates transcription factor IRF3 and limits type I interferon signaling. Immunity. 2014 Apr 17; 40(4):515-29. View Abstract
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