The overarching goal of Dr. David Glahn’s research is to discover genes and environmental mechanisms that predispose affective and psychotic disorders in children and adults. To achieve this goal, he develops and applies neuroanatomic, functional neuroimaging, and neurocognitive endophenotypes in large-scale family-based studies. Dr. Glahn’s research program involves four broad scientific aims: 1) To identify and characterize genes and environmental factors influencing risk for psychotic and affective disorders and their endophenotypes; 2) To specify genetic and environmental influences on normal variation of brain structure/function and cognitive ability; 3) To isolate genetic and environmental factors involved in human cognitive and brain development, particularly during adolescence; and 4) To develop novel endophenotypes for psychotic and affective disorders and markers of cognitive and brain development.
Given that psychiatric and cognitive/imaging antecedents of psychosis or affective dysregulation appear in childhood and adolescence, typically years before the formal onset of the illness, a major component of his research focuses on genetic and environmental aspects of individual differences across development. Dr. Glahn believes that recognizing antecedents of psychosis in young children could open a window of opportunity for targeted interventions to forestall disturbing symptoms and mitigate the risk of full-blown disease.
Research Background
Dr. David Glahn is the Associate Chief for Research in the Department of Psychiatry at Boston Children’s Hospital and the Director of the Tommy Fuss Center for Neuropsychiatric Disease Research. In addition, he directs the Early Psychosis Investigation Center (EPICenter) and the Neuropsychiatric Genetics Program (NPG). Dr. Glahn received his PhD in Clinical Psychology from the University of Pennsylvania and a post-doctoral fellowship the University of California at Los Angeles. Glahn has served as Co-Director for the Division of Neurocognition, Neurocomputation, and Neurogenetics at the Yale University School of Medicine, prior to joining Boston Children’s Hospital and Harvard Medical School.
Publications
Genetic Associations Among Inflammation, White Matter Architecture, and Extracellular Free Water. Hum Brain Mapp. 2025 Jan; 46(1):e70101. View Abstract
Effects of gene dosage on cognitive ability: A function-based association study across brain and non-brain processes. Cell Genom. 2024 Dec 11; 4(12):100721. View Abstract
Virtual stressors with real impact: what virtual reality-based biobehavioral research can teach us about typical and atypical stress responsivity. Transl Psychiatry. 2024 Oct 17; 14(1):441. View Abstract
Comparative Analysis of Fecal Microbiota Between Adolescents with Early-Onset Psychosis and Adults with Schizophrenia. Microorganisms. 2024 Oct 16; 12(10). View Abstract
Characterization of pain and somatization and its relationship with psychopathology in early onset psychosis. J Psychiatr Res. 2024 Nov; 179:77-82. View Abstract
Copy-number variants differ in frequency across genetic ancestry groups. HGG Adv. 2024 Oct 10; 5(4):100340. View Abstract
Large-scale analysis of structural brain asymmetries during neurodevelopment: Associations with age and sex in 4265 children and adolescents. Hum Brain Mapp. 2024 Aug 01; 45(11):e26754. View Abstract
Multimodal Neuroimaging Summary Scores as Neurobiological Markers of Psychosis. Schizophr Bull. 2024 07 27; 50(4):792-803. View Abstract
Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm. Nat Commun. 2024 Jul 17; 15(1):5996. View Abstract
Brain-age prediction: Systematic evaluation of site effects, and sample age range and size. Hum Brain Mapp. 2024 Jul 15; 45(10):e26768. View Abstract
Admixture mapping of cognitive function in diverse Hispanic and Latino adults: Results from the Hispanic Community Health Study/Study of Latinos. Alzheimers Dement. 2024 Sep; 20(9):6070-6081. View Abstract
Role of Neurocellular Endoplasmic Reticulum Stress Response in Alzheimer's Disease and Related Dementias Risk. Genes (Basel). 2024 04 28; 15(5). View Abstract
Using rare genetic mutations to revisit structural brain asymmetry. Nat Commun. 2024 Mar 26; 15(1):2639. View Abstract
Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI. bioRxiv. 2024 Mar 01. View Abstract
Normative modelling of brain morphometry across the lifespan with CentileBrain: algorithm benchmarking and model optimisation. Lancet Digit Health. 2024 Mar; 6(3):e211-e221. View Abstract
Bridging the gap: improving correspondence between low-field and high-field magnetic resonance images in young people. Front Neurol. 2024; 15:1339223. View Abstract
Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study. Mol Psychiatry. 2024 Jun; 29(6):1869-1881. View Abstract
Structural brain abnormalities and aggressive behaviour in schizophrenia: Mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium. medRxiv. 2024 Feb 05. View Abstract
Correction: Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals. Mol Psychiatry. 2024 Jan; 29(1):56. View Abstract
Normative Modeling of Brain Morphometry Across the Lifespan Using CentileBrain: Algorithm Benchmarking and Model Optimization. bioRxiv. 2023 Dec 02. View Abstract
Riemannian frameworks for the harmonization of resting-state functional MRI scans. Med Image Anal. 2024 Jan; 91:103043. View Abstract
Estimating multimodal brain variability in schizophrenia spectrum disorders: A worldwide ENIGMA study. bioRxiv. 2023 Nov 02. View Abstract
Two neurostructural subtypes: results of machine learning on brain images from 4,291 individuals with schizophrenia. medRxiv. 2023 Oct 12. View Abstract
Beyond the Global Brain Differences: Intraindividual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers. Biol Psychiatry. 2024 Jan 15; 95(2):147-160. View Abstract
Subcortical Brain Alterations in Carriers of Genomic Copy Number Variants. Am J Psychiatry. 2023 09 01; 180(9):685-698. View Abstract
Returning Individual Research Results from Digital Phenotyping in Psychiatry. Am J Bioeth. 2024 Feb; 24(2):69-90. View Abstract
Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium. Proc Natl Acad Sci U S A. 2023 04 04; 120(14):e2213880120. View Abstract
Children with Early-Onset Psychosis Have Increased Burden of Rare GRIN2A Variants. Genes (Basel). 2023 03 23; 14(4). View Abstract
Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive Function: A Meta-analysis of Community-Based Cohorts. Neurology. 2023 05 02; 100(18):e1930-e1943. View Abstract
Cocktail-party listening and cognitive abilities show strong pleiotropy. Front Neurol. 2023; 14:1071766. View Abstract
Genome-wide significant risk loci for mood disorders in the Old Order Amish founder population. Mol Psychiatry. 2023 Dec; 28(12):5262-5271. View Abstract
Rare CNVs and phenome-wide profiling highlight brain structural divergence and phenotypical convergence. Nat Hum Behav. 2023 Jun; 7(6):1001-1017. View Abstract
Subcortical brain alterations in carriers of genomic copy number variants. medRxiv. 2023 Feb 22. View Abstract
Impact of Copy Number Variants and Polygenic Risk Scores on Psychopathology in the UK Biobank. Biol Psychiatry. 2023 10 01; 94(7):591-600. View Abstract
The contribution of copy number variants to psychiatric symptoms and cognitive ability. Mol Psychiatry. 2023 04; 28(4):1480-1493. View Abstract
Social isolation is linked to classical risk factors of Alzheimer's disease-related dementias. PLoS One. 2023; 18(2):e0280471. View Abstract
Genetic diversity fuels gene discovery for tobacco and alcohol use. Nature. 2022 12; 612(7941):720-724. View Abstract
Co-alteration Network Architecture of Major Depressive Disorder: A Multi-modal Neuroimaging Assessment of Large-scale Disease Effects. Neuroinformatics. 2023 04; 21(2):443-455. View Abstract
Editorial: Irritable Imaging: Interpreting Null Results in Psychiatric Neuroimaging. J Am Acad Child Adolesc Psychiatry. 2023 02; 62(2):130-132. View Abstract
Clinical and cortical similarities identified between bipolar disorder I and schizophrenia: A multivariate approach. Front Hum Neurosci. 2022; 16:1001692. View Abstract
Widening Racial Disparities During COVID-19 Telemedicine Transition: A Study of Child Mental Health Services at Two Large Children's Hospitals. J Am Acad Child Adolesc Psychiatry. 2023 04; 62(4):447-456. View Abstract
Publisher Correction: Brain charts for the human lifespan. Nature. 2022 Oct; 610(7931):E6. View Abstract
Metabolic syndrome predictors of brain gray matter volume in an age-stratified community sample of 776 Mexican- American adults: Results from the genetics of brain structure image archive. Front Aging Neurosci. 2022; 14:999288. View Abstract
Correction: Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals. Mol Psychiatry. 2022 Sep; 27(9):3738. View Abstract
The Genetic contribution to solving the cocktail-party problem. iScience. 2022 Sep 16; 25(9):104997. View Abstract
Similar Rates of Deleterious Copy Number Variants in Early-Onset Psychosis and Autism Spectrum Disorder. Am J Psychiatry. 2022 11 01; 179(11):853-861. View Abstract
Convergence and Divergence of Rare Genetic Disorders on Brain Phenotypes: A Review. JAMA Psychiatry. 2022 08 01; 79(8):818-828. View Abstract
Systematic evaluation of machine learning algorithms for neuroanatomically-based age prediction in youth. Hum Brain Mapp. 2022 12 01; 43(17):5126-5140. View Abstract
Copy Number Variant Risk Scores Associated With Cognition, Psychopathology, and Brain Structure in Youths in the Philadelphia Neurodevelopmental Cohort. JAMA Psychiatry. 2022 07 01; 79(7):699-709. View Abstract
Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals. Mol Psychiatry. 2022 09; 27(9):3731-3737. View Abstract
Specificity of Psychiatric Polygenic Risk Scores and Their Effects on Associated Risk Phenotypes. Biol Psychiatry Glob Open Sci. 2023 Jul; 3(3):519-529. View Abstract
Rare variants implicate NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder. Mol Psychiatry. 2022 09; 27(9):3842-3856. View Abstract
Rare coding variants in ten genes confer substantial risk for schizophrenia. Nature. 2022 04; 604(7906):509-516. View Abstract
Brain charts for the human lifespan. Nature. 2022 04; 604(7906):525-533. View Abstract
Genes To Mental Health (G2MH): A Framework to Map the Combined Effects of Rare and Common Variants on Dimensions of Cognition and Psychopathology. Am J Psychiatry. 2022 03; 179(3):189-203. View Abstract
Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium. Mol Psychiatry. 2022 04; 27(4):2114-2125. View Abstract
Whole genome sequence analysis of platelet traits in the NHLBI Trans-Omics for Precision Medicine (TOPMed) initiative. Hum Mol Genet. 2022 02 03; 31(3):347-361. View Abstract
Stability of polygenic scores across discovery genome-wide association studies. HGG Adv. 2022 Apr 14; 3(2):100091. View Abstract
Author Correction: Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets. Nat Commun. 2021 Dec 08; 12(1):7260. View Abstract
Shared sets of correlated polygenic risk scores and voxel-wise grey matter across multiple traits identified via bi-clustering. Annu Int Conf IEEE Eng Med Biol Soc. 2021 11; 2021:2201-2206. View Abstract
Multivariate alterations in insula - Medial prefrontal cortex linked to genetics in 12q24 in schizophrenia. Psychiatry Res. 2021 12; 306:114237. View Abstract
Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program. Am J Hum Genet. 2021 10 07; 108(10):1836-1851. View Abstract
A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium. Hum Brain Mapp. 2022 01; 43(1):352-372. View Abstract
An opportunity for primary prevention research in psychotic disorders. Schizophr Res. 2022 05; 243:433-439. View Abstract
Regional White Matter Scaling in the Human Brain. J Neurosci. 2021 08 18; 41(33):7015-7028. View Abstract
Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics. Neuropsychopharmacology. 2021 09; 46(10):1788-1801. View Abstract
Identifying the Lipidomic Effects of a Rare Loss-of-Function Deletion in ANGPTL3. Circ Genom Precis Med. 2021 06; 14(3):e003232. View Abstract
Genetic influences on externalizing psychopathology overlap with cognitive functioning and show developmental variation. Eur Psychiatry. 2021 03 31; 64(1):e29. View Abstract
Effects of weather and season on human brain volume. PLoS One. 2021; 16(3):e0236303. View Abstract
1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans. Transl Psychiatry. 2021 03 22; 11(1):182. View Abstract
Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets. J Child Psychol Psychiatry. 2021 10; 62(10):1202-1219. View Abstract
Genetic Overlap Profiles of Cognitive Ability in Psychotic and Affective Illnesses: A Multisite Study of Multiplex Pedigrees. Biol Psychiatry. 2021 09 15; 90(6):373-384. View Abstract
Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs. Hum Brain Mapp. 2022 01; 43(1):300-328. View Abstract
RCL1 copy number variants are associated with a range of neuropsychiatric phenotypes. Mol Psychiatry. 2021 05; 26(5):1706-1718. View Abstract
Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90?years. Hum Brain Mapp. 2022 01; 43(1):431-451. View Abstract
Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90?years. Hum Brain Mapp. 2022 01; 43(1):452-469. View Abstract
A White Matter Connection of Schizophrenia and Alzheimer's Disease. Schizophr Bull. 2021 01 23; 47(1):197-206. View Abstract
Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings. Mol Psychiatry. 2021 08; 26(8):4529-4543. View Abstract
Genome-wide analysis of gene dosage in 24,092 individuals estimates that 10,000 genes modulate cognitive ability. Mol Psychiatry. 2021 06; 26(6):2663-2676. View Abstract
Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders. JAMA Psychiatry. 2021 Jan 01; 78(1):47-63. View Abstract
Associations of cannabis use disorder with cognition, brain structure, and brain function in African Americans. Hum Brain Mapp. 2021 04 15; 42(6):1727-1741. View Abstract
Searching for Imaging Biomarkers of Psychotic Dysconnectivity. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 12; 6(12):1135-1144. View Abstract
Personalized estimates of morphometric similarity in bipolar disorder and schizophrenia. NPJ Schizophr. 2020 Dec 04; 6(1):39. View Abstract
Using the Schmahmann Syndrome Scale to Assess Cognitive Impairment in Young Adults with Metabolic Syndrome: a Hypothesis-Generating Report. Cerebellum. 2021 Apr; 20(2):295-299. View Abstract
Structural and Functional Connectivity of Visual Cortex in Schizophrenia and Bipolar Disorder: A Graph-Theoretic Analysis. Schizophr Bull Open. 2020 Jan; 1(1):sgaa056. View Abstract
Greater male than female variability in regional brain structure across the lifespan. Hum Brain Mapp. 2022 01; 43(1):470-499. View Abstract
Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder. Hum Brain Mapp. 2022 01; 43(1):414-430. View Abstract
Role of miRNA-mRNA Interaction in Neural Stem Cell Differentiation of Induced Pluripotent Stem Cells. Int J Mol Sci. 2020 Sep 23; 21(19). View Abstract
The reliability and heritability of cortical folds and their genetic correlations across hemispheres. Commun Biol. 2020 09 15; 3(1):510. View Abstract
Effect Sizes of Deletions and Duplications on Autism Risk Across the Genome. Am J Psychiatry. 2021 01 01; 178(1):87-98. View Abstract
Structural Brain Architectures Match Intrinsic Functional Networks and Vary across Domains: A Study from 15?000+ Individuals. Cereb Cortex. 2020 09 03; 30(10):5460-5470. View Abstract
Genetic Contributions to Multivariate Data-Driven Brain Networks Constructed via Source-Based Morphometry. Cereb Cortex. 2020 07 30; 30(9):4899-4913. View Abstract
Influence of Processing Pipeline on Cortical Thickness Measurement. Cereb Cortex. 2020 07 30; 30(9):5014-5027. View Abstract
What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group. Hum Brain Mapp. 2022 01; 43(1):56-82. View Abstract
Person-based similarity in brain structure and functional connectivity in bipolar disorder. J Affect Disord. 2020 11 01; 276:38-44. View Abstract
How do substance use disorders compare to other psychiatric conditions on structural brain abnormalities? A cross-disorder meta-analytic comparison using the ENIGMA consortium findings. Hum Brain Mapp. 2022 01; 43(1):399-413. View Abstract
The architecture of co-morbidity networks of physical and mental health conditions in military veterans. Proc Math Phys Eng Sci. 2020 Jul; 476(2239):20190790. View Abstract
Mapping brain asymmetry in health and disease through the ENIGMA consortium. Hum Brain Mapp. 2022 01; 43(1):167-181. View Abstract
Minimal Relationship between Local Gyrification and General Cognitive Ability in Humans. Cereb Cortex. 2020 05 18; 30(6):3439-3450. View Abstract
Heritability and Cognitive Relevance of Structural Brain Controllability. Cereb Cortex. 2020 05 14; 30(5):3044-3054. View Abstract
ENIGMA-DTI: Translating reproducible white matter deficits into personalized vulnerability metrics in cross-diagnostic psychiatric research. Hum Brain Mapp. 2022 01; 43(1):194-206. View Abstract
Association of Copy Number Variation of the 15q11.2 BP1-BP2 Region With Cortical and Subcortical Morphology and Cognition. JAMA Psychiatry. 2020 04 01; 77(4):420-430. View Abstract
The Relationship Between White Matter Microstructure and General Cognitive Ability in Patients With Schizophrenia and Healthy Participants in the ENIGMA Consortium. Am J Psychiatry. 2020 06 01; 177(6):537-547. View Abstract
The genetic architecture of the human cerebral cortex. Science. 2020 03 20; 367(6484). View Abstract
ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries. Transl Psychiatry. 2020 03 20; 10(1):100. View Abstract
Imaging local genetic influences on cortical folding. Proc Natl Acad Sci U S A. 2020 03 31; 117(13):7430-7436. View Abstract
Correction: Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia. Mol Psychiatry. 2020 Mar; 25(3):692-695. View Abstract
Extensions of Multiple-Group Item Response Theory Alignment: Application to Psychiatric Phenotypes in an International Genomics Consortium. Educ Psychol Meas. 2020 Oct; 80(5):870-909. View Abstract
Neurocognitive impairment in type 2 diabetes: evidence for shared genetic aetiology. Diabetologia. 2020 05; 63(5):977-986. View Abstract
Sex differences in brain gene expression among suicide completers. J Affect Disord. 2020 04 15; 267:67-77. View Abstract
Brain Gene Expression Profiling of Individuals With Dual Diagnosis Who Died by Suicide. J Dual Diagn. 2020 Apr-Jun; 16(2):177-190. View Abstract
Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets. Nat Commun. 2019 10 31; 10(1):4958. View Abstract
A resting state fMRI analysis pipeline for pooling inference across diverse cohorts: an ENIGMA rs-fMRI protocol. Brain Imaging Behav. 2019 Oct; 13(5):1453-1467. View Abstract
A framework for the investigation of rare genetic disorders in neuropsychiatry. Nat Med. 2019 10; 25(10):1477-1487. View Abstract
NRXN1 is associated with enlargement of the temporal horns of the lateral ventricles in psychosis. Transl Psychiatry. 2019 09 17; 9(1):230. View Abstract
Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways. Am J Hum Genet. 2019 08 01; 105(2):334-350. View Abstract
No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis. Am J Psychiatry. 2019 12 01; 176(12):1039-1049. View Abstract
Rare DEGS1 variant significantly alters de novo ceramide synthesis pathway. J Lipid Res. 2019 09; 60(9):1630-1639. View Abstract
The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder. Biol Psychiatry. 2019 10 01; 86(7):545-556. View Abstract
Evidence for genetic correlation between human cerebral white matter microstructure and inflammation. Hum Brain Mapp. 2019 10 01; 40(14):4180-4191. View Abstract
A neural signature of metabolic syndrome. Hum Brain Mapp. 2019 08 15; 40(12):3575-3588. View Abstract
Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nat Commun. 2019 May 01; 10(1):2068. View Abstract
Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium. Biol Psychiatry. 2020 06 15; 87(12):1022-1034. View Abstract
Family-based analyses reveal novel genetic overlap between cytokine interleukin-8 and risk for suicide attempt. Brain Behav Immun. 2019 08; 80:292-299. View Abstract
Distinct resting state functional connectivity abnormalities in hoarding disorder and major depressive disorder. J Psychiatr Res. 2019 06; 113:108-116. View Abstract
Person-Based Brain Morphometric Similarity is Heritable and Correlates With Biological Features. Cereb Cortex. 2019 02 01; 29(2):852-862. View Abstract
Efficient Variant Set Mixed Model Association Tests for Continuous and Binary Traits in Large-Scale Whole-Genome Sequencing Studies. Am J Hum Genet. 2019 02 07; 104(2):260-274. View Abstract
Cognitive impairment from early to middle adulthood in patients with affective and nonaffective psychotic disorders. Psychol Med. 2020 01; 50(1):48-57. View Abstract
Human Cortical Thickness Organized into Genetically-determined Communities across Spatial Resolutions. Cereb Cortex. 2019 01 01; 29(1):106-118. View Abstract
fMRI evidence of aberrant neural adaptation for objects in schizophrenia and bipolar disorder. Hum Brain Mapp. 2019 04 01; 40(5):1608-1617. View Abstract
Genomic kinship construction to enhance genetic analyses in the human connectome project data. Hum Brain Mapp. 2019 04 01; 40(5):1677-1688. View Abstract
Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process? Biol Psychiatry. 2019 04 01; 85(7):e35-e39. View Abstract
A QTL on chromosome 3q23 influences processing speed in humans. Genes Brain Behav. 2019 04; 18(4):e12530. View Abstract
Brain Gene Expression Pattern of Subjects with Completed Suicide and Comorbid Substance Use Disorder. Mol Neuropsychiatry. 2019 Mar; 5(1):60-73. View Abstract
Altered amygdala circuits underlying valence processing among manic and depressed phases in bipolar adults. J Affect Disord. 2019 02 15; 245:394-402. View Abstract
Clinical correlates of subsyndromal depression in African American individuals with psychosis: The relationship with positive symptoms and comorbid substance dependence. Schizophr Res. 2019 04; 206:333-346. View Abstract
Genetic influence on cognitive development between childhood and adulthood. Mol Psychiatry. 2021 02; 26(2):656-665. View Abstract
Mega-Analysis of Gray Matter Volume in Substance Dependence: General and Substance-Specific Regional Effects. Am J Psychiatry. 2019 02 01; 176(2):119-128. View Abstract
Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia. Mol Psychiatry. 2020 03; 25(3):584-602. View Abstract
Using structural MRI to identify bipolar disorders - 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group. Mol Psychiatry. 2020 09; 25(9):2130-2143. View Abstract
Fast and powerful genome wide association of dense genetic data with high dimensional imaging phenotypes. Nat Commun. 2018 08 14; 9(1):3254. View Abstract
Comparison of heritability estimates on resting state fMRI connectivity phenotypes using the ENIGMA analysis pipeline. Hum Brain Mapp. 2018 12; 39(12):4893-4902. View Abstract
Disentangling the genetic overlap between cholesterol and suicide risk. Neuropsychopharmacology. 2018 12; 43(13):2556-2563. View Abstract
Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018). Twin Res Hum Genet. 2018 10; 21(5):394-397. View Abstract
Publisher Correction: Whole genome sequencing in psychiatric disorders: the WGSPD consortium. Nat Neurosci. 2018 Jul; 21(7):1017. View Abstract
Rediscovering the value of families for psychiatric genetics research. Mol Psychiatry. 2019 04; 24(4):523-535. View Abstract
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence. Nat Genet. 2018 07; 50(7):912-919. View Abstract
Assessment of Cognition and Personality as Potential Endophenotypes in the Western Australian Family Study of Schizophrenia. Schizophr Bull. 2018 06 06; 44(4):908-921. View Abstract
On testing for spatial correspondence between maps of human brain structure and function. Neuroimage. 2018 09; 178:540-551. View Abstract
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nat Commun. 2018 05 29; 9(1):2098. View Abstract
Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium. Proc Natl Acad Sci U S A. 2018 05 29; 115(22):E5154-E5163. View Abstract
Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium. Biol Psychiatry. 2018 11 01; 84(9):644-654. View Abstract
Reproducibility of myelin content-based human habenula segmentation at 3 Tesla. Hum Brain Mapp. 2018 07; 39(7):3058-3071. View Abstract
Heritability estimates on resting state fMRI data using ENIGMA analysis pipeline. Pac Symp Biocomput. 2018; 23:307-318. View Abstract
Neural mechanism and heritability of complex motor sequence and audiovisual integration: A healthy twin study. Hum Brain Mapp. 2018 03; 39(3):1438-1448. View Abstract
Shared Genetic Factors Influence Head Motion During MRI and Body Mass Index. Cereb Cortex. 2017 12 01; 27(12):5539-5546. View Abstract
Whole genome sequencing in psychiatric disorders: the WGSPD consortium. Nat Neurosci. 2017 12; 20(12):1661-1668. View Abstract
Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets. Cell Rep. 2017 Nov 28; 21(9):2597-2613. View Abstract
Cognitive genomics: Searching for the genetic roots of neuropsychological functioning. Neuropsychology. 2017 11; 31(8):1003-1019. View Abstract
Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group. Mol Psychiatry. 2018 05; 23(5):1261-1269. View Abstract
Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex. Brain Imaging Behav. 2017 Oct; 11(5):1497-1514. View Abstract
GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium. Mol Psychiatry. 2017 11; 22(11):1651-1652. View Abstract
Machine Learning for Large-Scale Quality Control of 3D Shape Models in Neuroimaging. Mach Learn Med Imaging. 2017 Sep; 10541:371-378. View Abstract
Assessing neural tuning for object perception in schizophrenia and bipolar disorder with multivariate pattern analysis of fMRI data. Neuroimage Clin. 2017; 16:491-497. View Abstract
Neural correlates of affective and non-affective cognition in obsessive compulsive disorder: A meta-analysis of functional imaging studies. Eur Psychiatry. 2017 10; 46:25-32. View Abstract
Deficits in visual working-memory capacity and general cognition in African Americans with psychosis. Schizophr Res. 2018 03; 193:100-106. View Abstract
The Role of Intrinsic Brain Functional Connectivity in Vulnerability and Resilience to Bipolar Disorder. Am J Psychiatry. 2017 12 01; 174(12):1214-1222. View Abstract
The Processing-Speed Impairment in Psychosis Is More Than Just Accelerated Aging. Schizophr Bull. 2017 07 01; 43(4):814-823. View Abstract
Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group. Hum Brain Mapp. 2017 09; 38(9):4444-4458. View Abstract
Inferring pathobiology from structural MRI in schizophrenia and bipolar disorder: Modeling head motion and neuroanatomical specificity. Hum Brain Mapp. 2017 08; 38(8):3757-3770. View Abstract
Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group. Mol Psychiatry. 2018 04; 23(4):932-942. View Abstract
Epigenetic Age Acceleration Assessed with Human White-Matter Images. J Neurosci. 2017 05 03; 37(18):4735-4743. View Abstract
Using Polygenic Risk Scores to Establish Endophenotypes: Considerations and Current Constraints. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 03; 2(2):113-114. View Abstract
Serum phosphatidylinositol as a biomarker for bipolar disorder liability. Bipolar Disord. 2017 03; 19(2):107-115. View Abstract
The lipidome in major depressive disorder: Shared genetic influence for ether-phosphatidylcholines, a plasma-based phenotype related to inflammation, and disease risk. Eur Psychiatry. 2017 06; 43:44-50. View Abstract
Novel genetic loci associated with hippocampal volume. Nat Commun. 2017 01 18; 8:13624. View Abstract
GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium. Mol Psychiatry. 2017 03; 22(3):336-345. View Abstract
Deconstructing Bipolar Disorder and Schizophrenia: A cross-diagnostic cluster analysis of cognitive phenotypes. J Affect Disord. 2017 Feb; 209:71-79. View Abstract
Omics-squared: human genomic, transcriptomic and phenotypic data for genetic analysis workshop 19. BMC Proc. 2016; 10(Suppl 7):71-77. View Abstract
Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nat Neurosci. 2016 12; 19(12):1569-1582. View Abstract
The genetic basis of the comorbidity between cannabis use and major depression. Addiction. 2017 01; 112(1):113-123. View Abstract
Enhancing the Informativeness and Replicability of Imaging Genomics Studies. Biol Psychiatry. 2017 08 01; 82(3):157-164. View Abstract
Effect of alcohol and illicit substance use on verbal memory among individuals with bipolar disorder. Psychiatry Res. 2016 Sep 30; 243:225-231. View Abstract
Genome-wide significant loci for addiction and anxiety. Eur Psychiatry. 2016 08; 36:47-54. View Abstract
Progressive Bidirectional Age-Related Changes in Default Mode Network Effective Connectivity across Six Decades. Front Aging Neurosci. 2016; 8:137. View Abstract
Utility of Lymphoblastoid Cell Lines for Induced Pluripotent Stem Cell Generation. Stem Cells Int. 2016; 2016:2349261. View Abstract
A comprehensive tractography study of patients with bipolar disorder and their unaffected siblings. Hum Brain Mapp. 2016 10; 37(10):3474-85. View Abstract
Lipidomic risk score independently and cost-effectively predicts risk of future type 2 diabetes: results from diverse cohorts. Lipids Health Dis. 2016 Apr 04; 15:67. View Abstract
Soluble Forms of Intercellular and Vascular Cell Adhesion Molecules Independently Predict Progression to Type 2 Diabetes in Mexican American Families. PLoS One. 2016; 11(3):e0151177. View Abstract
Reduced hippocampus volume and memory performance in bipolar disorder patients carrying the BDNF val66met met allele. J Affect Disord. 2016 Jul 01; 198:198-205. View Abstract
Abnormal Ventral and Dorsal Attention Network Activity during Single and Dual Target Detection in Schizophrenia. Front Psychol. 2016; 7:323. View Abstract
Psychotic Experiences and Neuropsychological Functioning in a Population-based Sample. JAMA Psychiatry. 2016 Feb; 73(2):129-38. View Abstract
Genome- and epigenome-wide association study of hypertriglyceridemic waist in Mexican American families. Clin Epigenetics. 2016; 8:6. View Abstract
Functional hierarchy underlies preferential connectivity disturbances in schizophrenia. Proc Natl Acad Sci U S A. 2016 Jan 12; 113(2):E219-28. View Abstract
Long-term neural and physiological phenotyping of a single human. Nat Commun. 2015 Dec 09; 6:8885. View Abstract
ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide. Neuroimage. 2017 01 15; 145(Pt B):389-408. View Abstract
Genome-wide linkage on chromosome 10q26 for a dimensional scale of major depression. J Affect Disord. 2016 Feb; 191:123-31. View Abstract
Genetic imaging consortium for addiction medicine: From neuroimaging to genes. Prog Brain Res. 2016; 224:203-23. View Abstract
Recurrent major depression and right hippocampal volume: A bivariate linkage and association study. Hum Brain Mapp. 2016 Jan; 37(1):191-202. View Abstract
Genome-wide significant linkage of schizophrenia-related neuroanatomical trait to 12q24. Am J Med Genet B Neuropsychiatr Genet. 2015 Dec; 168(8):678-86. View Abstract
Exome Sequence Data From Multigenerational Families Implicate AMPA Receptor Trafficking in Neurocognitive Impairment and Schizophrenia Risk. Schizophr Bull. 2016 Mar; 42(2):288-300. View Abstract
Genome-wide autozygosity is associated with lower general cognitive ability. Mol Psychiatry. 2016 06; 21(6):837-43. View Abstract
Genetics of cognitive control: Implications for Nimh's research domain criteria initiative. Am J Med Genet B Neuropsychiatr Genet. 2016 Jan; 171B(1):111-20. View Abstract
Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium. Mol Psychiatry. 2016 04; 21(4):585. View Abstract
Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium. Mol Psychiatry. 2016 Apr; 21(4):547-53. View Abstract
Independent evidence for an association between general cognitive ability and a genetic locus for educational attainment. Am J Med Genet B Neuropsychiatr Genet. 2015 Jul; 168B(5):363-73. View Abstract
Brain structure-function associations in multi-generational families genetically enriched for bipolar disorder. Brain. 2015 Jul; 138(Pt 7):2087-102. View Abstract
Neuroimaging data sharing on the neuroinformatics database platform. Neuroimage. 2016 Jan 01; 124(Pt B):1089-1092. View Abstract
Cortisol Stress Response in Men and Women Modulated Differentially by the Mu-Opioid Receptor Gene Polymorphism OPRM1 A118G. Neuropsychopharmacology. 2015 Oct; 40(11):2546-54. View Abstract
Fast and powerful heritability inference for family-based neuroimaging studies. Neuroimage. 2015 Jul 15; 115:256-68. View Abstract
Heritability of fractional anisotropy in human white matter: a comparison of Human Connectome Project and ENIGMA-DTI data. Neuroimage. 2015 May 01; 111:300-11. View Abstract
The puzzle of processing speed, memory, and executive function impairments in schizophrenia: fitting the pieces together. Biol Psychiatry. 2015 Dec 01; 78(11):786-93. View Abstract
Shared genetic variance between obesity and white matter integrity in Mexican Americans. Front Genet. 2015; 6:26. View Abstract
Common genetic variants influence human subcortical brain structures. Nature. 2015 Apr 09; 520(7546):224-9. View Abstract
Patterns of Gray Matter Abnormalities in Schizophrenia Based on an International Mega-analysis. Schizophr Bull. 2015 Sep; 41(5):1133-42. View Abstract
Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):18031-6. View Abstract
Genome-Wide Analyses of Working-Memory Ability: A Review. Curr Behav Neurosci Rep. 2014 Dec; 1(4):224-233. View Abstract
Pleiotropic locus for emotion recognition and amygdala volume identified using univariate and bivariate linkage. Am J Psychiatry. 2015 Feb 01; 172(2):190-9. View Abstract
Shared genetic factors influence amygdala volumes and risk for alcoholism. Neuropsychopharmacology. 2015 Jan; 40(2):412-20. View Abstract
Discovering schizophrenia endophenotypes in randomly ascertained pedigrees. Biol Psychiatry. 2015 Jan 01; 77(1):75-83. View Abstract
Mediodorsal and visual thalamic connectivity differ in schizophrenia and bipolar disorder with and without psychosis history. Schizophr Bull. 2014 Nov; 40(6):1227-43. View Abstract
Impact of family structure and common environment on heritability estimation for neuroimaging genetics studies using Sequential Oligogenic Linkage Analysis Routines. J Med Imaging (Bellingham). 2014 Jun 27; 1(1):014005. View Abstract
Influence of age, sex and genetic factors on the human brain. Brain Imaging Behav. 2014 Jun; 8(2):143-52. View Abstract
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging Behav. 2014 Jun; 8(2):153-82. View Abstract
Anomalous temporoparietal activity in individuals with a family history of alcoholism: studies from the Oklahoma Family Health Patterns Project. Alcohol Clin Exp Res. 2014 Jun; 38(6):1639-45. View Abstract
Altered global brain signal in schizophrenia. Proc Natl Acad Sci U S A. 2014 May 20; 111(20):7438-43. View Abstract
Differential impact of serotonin transporter activity on temperament and behavior in persons with a family history of alcoholism in the Oklahoma Family Health Patterns Project. Alcohol Clin Exp Res. 2014 Jun; 38(6):1575-81. View Abstract
KIBRA, aging, and gene by environmental interaction: an effect to remember? Biol Psychiatry. 2014 May 01; 75(9):674-5. View Abstract
Heritable changes in regional cortical thickness with age. Brain Imaging Behav. 2014 Jun; 8(2):208-16. View Abstract
Cortical Volume Alterations in Conduct Disordered Adolescents with and without Bipolar Disorder. J Clin Med. 2014 Apr 16; 3(2):416-31. View Abstract
Common genetic variants and gene expression associated with white matter microstructure in the human brain. Neuroimage. 2014 Aug 15; 97:252-61. View Abstract
Novel QTL at chromosome 6p22 for alcohol consumption: Implications for the genetic liability of alcohol use disorders. Am J Med Genet B Neuropsychiatr Genet. 2014 Jun; 165B(4):294-302. View Abstract
Multisystem component phenotypes of bipolar disorder for genetic investigations of extended pedigrees. JAMA Psychiatry. 2014 Apr; 71(4):375-87. View Abstract
Neural substrates of visual masking by object substitution in schizophrenia. Hum Brain Mapp. 2014 Sep; 35(9):4654-62. View Abstract
Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling. Neuroimage. 2014 Jul 15; 95:136-50. View Abstract
Changes in GABA and glutamate concentrations during memory tasks in patients with Parkinson's disease undergoing DBS surgery. Front Hum Neurosci. 2014; 8:81. View Abstract
Arguments for the sake of endophenotypes: examining common misconceptions about the use of endophenotypes in psychiatric genetics. Am J Med Genet B Neuropsychiatr Genet. 2014 Mar; 165B(2):122-30. View Abstract
Cross-diagnostic comparison of visual processing in bipolar disorder and schizophrenia. J Psychiatr Res. 2014 Apr; 51:42-8. View Abstract
Connectivity, pharmacology, and computation: toward a mechanistic understanding of neural system dysfunction in schizophrenia. Front Psychiatry. 2013 Dec 24; 4:169. View Abstract
Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT). Mol Psychiatry. 2014 Feb; 19(2):168-74. View Abstract
Shared genetic factors influence risk for bipolar disorder and alcohol use disorders. Eur Psychiatry. 2014 Jun; 29(5):282-7. View Abstract
Genome-wide significant localization for working and spatial memory: Identifying genes for psychosis using models of cognition. Am J Med Genet B Neuropsychiatr Genet. 2014 Jan; 165B(1):84-95. View Abstract
Genetic basis of neurocognitive decline and reduced white-matter integrity in normal human brain aging. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19006-11. View Abstract
Reduced white matter integrity in sibling pairs discordant for bipolar disorder. Am J Psychiatry. 2013 Nov; 170(11):1317-25. View Abstract
Neuroinformatics Database (NiDB)--a modular, portable database for the storage, analysis, and sharing of neuroimaging data. Neuroinformatics. 2013 Oct; 11(4):495-505. View Abstract
Identification of pleiotropic genetic effects on obesity and brain anatomy. Hum Hered. 2013; 75(2-4):136-43. View Abstract
Sulcal depth-position profile is a genetically mediated neuroscientific trait: description and characterization in the central sulcus. J Neurosci. 2013 Sep 25; 33(39):15618-25. View Abstract
Impulsivity and risk taking in bipolar disorder and schizophrenia. Neuropsychopharmacology. 2014 Jan; 39(2):456-63. View Abstract
Multi-region hemispheric specialization differentiates human from nonhuman primate brain function. Brain Struct Funct. 2014 Nov; 219(6):2187-94. View Abstract
Characterizing thalamo-cortical disturbances in schizophrenia and bipolar illness. Cereb Cortex. 2014 Dec; 24(12):3116-30. View Abstract
Is aberrant functional connectivity a psychosis endophenotype? A resting state functional magnetic resonance imaging study. Biol Psychiatry. 2013 Sep 15; 74(6):458-66. View Abstract
Transcriptomics of cortical gray matter thickness decline during normal aging. Neuroimage. 2013 Nov 15; 82:273-83. View Abstract
Genetics of the connectome. Neuroimage. 2013 Oct 15; 80:475-88. View Abstract
Multi-site genetic analysis of diffusion images and voxelwise heritability analysis: a pilot project of the ENIGMA-DTI working group. Neuroimage. 2013 Nov 01; 81:455-469. View Abstract
Social and nonsocial cognition in bipolar disorder and schizophrenia: relative levels of impairment. Am J Psychiatry. 2013 Mar; 170(3):334-41. View Abstract
Polygenic risk and white matter integrity in individuals at high risk of mood disorder. Biol Psychiatry. 2013 Aug 15; 74(4):280-6. View Abstract
Can risk-taking be an endophenotype for bipolar disorder? A study on patients with bipolar disorder type I and their first-degree relatives. J Int Neuropsychol Soc. 2013 Apr; 19(4):474-82. View Abstract
Neurocognitive phenomics: examining the genetic basis of cognitive abilities. Psychol Med. 2013 Oct; 43(10):2027-36. View Abstract
Testing the hypothesis of accelerated cerebral white matter aging in schizophrenia and major depression. Biol Psychiatry. 2013 Mar 01; 73(5):482-91. View Abstract
Dedifferentiation and substitute strategy: deconstructing the processing-speed impairment in schizophrenia. Schizophr Res. 2012 Dec; 142(1-3):129-36. View Abstract
Relationship between fractional anisotropy of cerebral white matter and metabolite concentrations measured using (1)H magnetic resonance spectroscopy in healthy adults. Neuroimage. 2013 Feb 01; 66:161-8. View Abstract
Meta-analytic connectivity modeling reveals differential functional connectivity of the medial and lateral orbitofrontal cortex. Cereb Cortex. 2014 Jan; 24(1):232-48. View Abstract
Global prefrontal and fronto-amygdala dysconnectivity in bipolar I disorder with psychosis history. Biol Psychiatry. 2013 Mar 15; 73(6):565-73. View Abstract
Cross-cultural standardization of the South Texas Assessment of Neurocognition in India. Indian J Med Res. 2012 Aug; 136(2):280-8. View Abstract
Trait impulsivity as an endophenotype for bipolar I disorder. Bipolar Disord. 2012 Aug; 14(5):565-70. View Abstract
The influence of polygenic risk for bipolar disorder on neural activation assessed using fMRI. Transl Psychiatry. 2012 Jul 03; 2:e130. View Abstract
Meta-analytic evidence for a superordinate cognitive control network subserving diverse executive functions. Cogn Affect Behav Neurosci. 2012 Jun; 12(2):241-68. View Abstract
Genetic contributions to the midsagittal area of the corpus callosum. Twin Res Hum Genet. 2012 Jun; 15(3):315-23. View Abstract
Event-related potential examination of facial affect processing in bipolar disorder and schizophrenia. Psychol Med. 2013 Jan; 43(1):109-17. View Abstract
Cross-diagnostic comparison of duration mismatch negativity and P3a in bipolar disorder and schizophrenia. Bipolar Disord. 2012 May; 14(3):239-48. View Abstract
P-selectin Expression Tracks Cerebral Atrophy in Mexican-Americans. Front Genet. 2012; 3:65. View Abstract
Identification of common variants associated with human hippocampal and intracranial volumes. Nat Genet. 2012 Apr 15; 44(5):552-61. View Abstract
Measuring and comparing brain cortical surface area and other areal quantities. Neuroimage. 2012 Jul 16; 61(4):1428-43. View Abstract
Differences in resting-state functional magnetic resonance imaging functional network connectivity between schizophrenia and psychotic bipolar probands and their unaffected first-degree relatives. Biol Psychiatry. 2012 May 15; 71(10):881-9. View Abstract
A large scale multivariate parallel ICA method reveals novel imaging-genetic relationships for Alzheimer's disease in the ADNI cohort. Neuroimage. 2012 Apr 15; 60(3):1608-21. View Abstract
The functional connectivity of the human caudate: an application of meta-analytic connectivity modeling with behavioral filtering. Neuroimage. 2012 Mar; 60(1):117-29. View Abstract
Genetic analysis of cortical thickness and fractional anisotropy of water diffusion in the brain. Front Neurosci. 2011; 5:120. View Abstract
High dimensional endophenotype ranking in the search for major depression risk genes. Biol Psychiatry. 2012 Jan 01; 71(1):6-14. View Abstract
Genetic influence on the working memory circuitry: behavior, structure, function and extensions to illness. Behav Brain Res. 2011 Dec 01; 225(2):610-22. View Abstract
Genetic architecture of declarative memory: implications for complex illnesses. Neuroscientist. 2012 Oct; 18(5):516-32. View Abstract
Fractional anisotropy of cerebral white matter and thickness of cortical gray matter across the lifespan. Neuroimage. 2011 Sep 01; 58(1):41-9. View Abstract
Common genetic influences on depression, alcohol, and substance use disorders in Mexican-American families. Am J Med Genet B Neuropsychiatr Genet. 2011 Jul; 156B(5):561-8. View Abstract
Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes. Mol Psychiatry. 2011 Nov; 16(11):1096-104, 1063. View Abstract
Association of clinical symptoms and neurocognitive performance in bipolar disorder: a longitudinal study. Bipolar Disord. 2011 Feb; 13(1):118-23. View Abstract
Clinical endophenotypes for bipolar disorder. Curr Top Behav Neurosci. 2011; 5:51-67. View Abstract
Altered dynamic coupling of lateral occipital complex during visual perception in schizophrenia. Neuroimage. 2011 Apr 01; 55(3):1219-26. View Abstract
Blood pressure and cerebral white matter share common genetic factors in Mexican Americans. Hypertension. 2011 Feb; 57(2):330-5. View Abstract
Neurocognitive and neuroimaging predictors of clinical outcome in bipolar disorder. Curr Psychiatry Rep. 2010 Dec; 12(6):499-504. View Abstract
Whole brain and regional hyperintense white matter volume and blood pressure: overlap of genetic loci produced by bivariate, whole-genome linkage analyses. Stroke. 2010 Oct; 41(10):2137-42. View Abstract
Fronto-temporal dysregulation in asymptomatic bipolar I patients: a paired associate functional MRI study. Hum Brain Mapp. 2010 Jul; 31(7):1041-51. View Abstract
A multimodal assessment of the genetic control over working memory. J Neurosci. 2010 Jun 16; 30(24):8197-202. View Abstract
The International Society for Bipolar Disorders-Battery for Assessment of Neurocognition (ISBD-BANC). Bipolar Disord. 2010 Jun; 12(4):351-63. View Abstract
Regional brain activity during early visual perception in unaffected siblings of schizophrenia patients. Biol Psychiatry. 2010 Jul 01; 68(1):78-85. View Abstract
Deconstructing processing speed deficits in schizophrenia: application of a parametric digit symbol coding test. Schizophr Res. 2010 May; 118(1-3):6-11. View Abstract
Comparison of the disparity between Talairach and MNI coordinates in functional neuroimaging data: validation of the Lancaster transform. Neuroimage. 2010 Jun; 51(2):677-83. View Abstract
On the genetic architecture of cortical folding and brain volume in primates. Neuroimage. 2010 Nov 15; 53(3):1103-8. View Abstract
Fractional anisotropy of water diffusion in cerebral white matter across the lifespan. Neurobiol Aging. 2012 Jan; 33(1):9-20. View Abstract
Neurocognitive endophenotypes for bipolar disorder identified in multiplex multigenerational families. Arch Gen Psychiatry. 2010 Feb; 67(2):168-77. View Abstract
Metaanalytic connectivity modeling: delineating the functional connectivity of the human amygdala. Hum Brain Mapp. 2010 Feb; 31(2):173-84. View Abstract
Genetics of microstructure of cerebral white matter using diffusion tensor imaging. Neuroimage. 2010 Nov 15; 53(3):1109-16. View Abstract
Genetic control over the resting brain. Proc Natl Acad Sci U S A. 2010 Jan 19; 107(3):1223-8. View Abstract
Heritability of age of onset of psychosis in schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 05; 153B(1):298-302. View Abstract
Acute effects of hydrocortisone on the human brain: an fMRI study. Psychoneuroendocrinology. 2010 Jan; 35(1):15-20. View Abstract
Genetics of primary cerebral gyrification: Heritability of length, depth and area of primary sulci in an extended pedigree of Papio baboons. Neuroimage. 2010 Nov 15; 53(3):1126-34. View Abstract
Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies. Neuroimage. 2010 Nov 15; 53(3):1135-46. View Abstract
Functional neuroanatomy of visual masking deficits in schizophrenia. Arch Gen Psychiatry. 2009 Dec; 66(12):1295-303. View Abstract
Investigating the functional heterogeneity of the default mode network using coordinate-based meta-analytic modeling. J Neurosci. 2009 Nov 18; 29(46):14496-505. View Abstract
Analysis of genetic variability and whole genome linkage of whole-brain, subcortical, and ependymal hyperintense white matter volume. Stroke. 2009 Dec; 40(12):3685-90. View Abstract
Acute citalopram administration may disrupt contextual information processing in healthy males. Eur Psychiatry. 2010 Mar; 25(2):87-91. View Abstract
Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia. Arch Gen Psychiatry. 2009 Aug; 66(8):811-22. View Abstract
Correspondence of the brain's functional architecture during activation and rest. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):13040-5. View Abstract
Amygdala hyperactivation in untreated depressed individuals. Psychiatry Res. 2009 Aug 30; 173(2):158-61. View Abstract
Fronto-temporal dysregulation in remitted bipolar patients: an fMRI delayed-non-match-to-sample (DNMS) study. Bipolar Disord. 2009 Jun; 11(4):351-60. View Abstract
Prefrontal activation deficits during episodic memory in schizophrenia. Am J Psychiatry. 2009 Aug; 166(8):863-74. View Abstract
Conceptualizing impulsivity and risk taking in bipolar disorder: importance of history of alcohol abuse. Bipolar Disord. 2009 Feb; 11(1):33-40. View Abstract
Differential activation of the anterior cingulate cortex and caudate nucleus during a gambling simulation in persons with a family history of alcoholism: studies from the Oklahoma Family Health Patterns Project. Drug Alcohol Depend. 2009 Feb 01; 100(1-2):17-23. View Abstract
The serotonin transporter 5-HTTPR polymorphism is associated with current and lifetime depression in persons with chronic psychotic disorders. Acta Psychiatr Scand. 2009 Feb; 119(2):117-27. View Abstract
Fronto-limbic circuitry in euthymic bipolar disorder: evidence for prefrontal hyperactivation. Psychiatry Res. 2008 Nov 30; 164(2):106-13. View Abstract
Increased extent of object-selective cortex in schizophrenia. Psychiatry Res. 2008 Nov 30; 164(2):97-105. View Abstract
Cognitive impairment in bipolar disorder: neurodevelopment or neurodegeneration? An ECNP expert meeting report. Eur Neuropsychopharmacol. 2008 Nov; 18(11):787-93. View Abstract
Meta-analysis of gray matter anomalies in schizophrenia: application of anatomic likelihood estimation and network analysis. Biol Psychiatry. 2008 Nov 01; 64(9):774-81. View Abstract
Verbal recall and recognition in twins discordant for schizophrenia. Psychiatry Res. 2008 Jun 30; 159(3):271-80. View Abstract
Comparing the efficacy of interventions that use environmental supports to improve outcomes in patients with schizophrenia. Schizophr Res. 2008 Jul; 102(1-3):312-9. View Abstract
The anatomy of first-episode and chronic schizophrenia: an anatomical likelihood estimation meta-analysis. Am J Psychiatry. 2008 Aug; 165(8):1015-23. View Abstract
Neural phenotypes of common and rare genetic variants. Biol Psychol. 2008 Sep; 79(1):43-57. View Abstract
A collaborative knowledge base for cognitive phenomics. Mol Psychiatry. 2008 Apr; 13(4):350-60. View Abstract
The central sulcus: an observer-independent characterization of sulcal landmarks and depth asymmetry. Cereb Cortex. 2008 Sep; 18(9):1999-2009. View Abstract
Subtle cognitive dysfunction in nonaffected siblings of individuals affected by nonpsychotic disorders. Biol Psychiatry. 2008 Mar 15; 63(6):602-8. View Abstract
Relationships among subjective and objective measures of adherence to oral antipsychotic medications. Psychiatr Serv. 2007 Sep; 58(9):1187-92. View Abstract
Three-dimensional mapping of hippocampal anatomy in unmedicated and lithium-treated patients with bipolar disorder. Neuropsychopharmacology. 2008 May; 33(6):1229-38. View Abstract
Temperament and character traits in patients with bipolar disorder and associations with comorbid alcoholism or anxiety disorders. J Psychiatr Res. 2008 Jun; 42(7):569-77. View Abstract
Electrophysiological correlates of response inhibition in children and adolescents with ADHD: influence of gender, age, and previous treatment history. Psychophysiology. 2007 Nov; 44(6):936-48. View Abstract
A social cognitive approach to emotional intensity judgment deficits in schizophrenia. Schizophr Res. 2007 Aug; 94(1-3):245-52. View Abstract
Heritability of brain volume, surface area and shape: an MRI study in an extended pedigree of baboons. Hum Brain Mapp. 2007 Jun; 28(6):576-83. View Abstract
Electrophysiological effects of stimulant treatment on inhibitory control in children with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2007 Jun; 17(3):356-66. View Abstract
Neuroimaging endophenotypes: strategies for finding genes influencing brain structure and function. Hum Brain Mapp. 2007 Jun; 28(6):488-501. View Abstract
Imaging genomics: mapping the influence of genetics on brain structure and function. Hum Brain Mapp. 2007 Jun; 28(6):461-3. View Abstract
Evidence for disruption in prefrontal cortical functions in juvenile bipolar disorder. Bipolar Disord. 2007 Jun; 9 Suppl 1:145-59. View Abstract
The neurocognitive signature of psychotic bipolar disorder. Biol Psychiatry. 2007 Oct 15; 62(8):910-6. View Abstract
The reliability and validity of the Test of Adaptive Behavior in Schizophrenia (TABS). Psychiatry Res. 2007 May 30; 151(1-2):55-66. View Abstract
Adjudicating neurocognitive endophenotypes for schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2007 Mar 05; 144B(2):242-9. View Abstract
Reduced amygdala activation in young adults at high risk of alcoholism: studies from the Oklahoma family health patterns project. Biol Psychiatry. 2007 Jun 01; 61(11):1306-9. View Abstract
Greater cortical gray matter density in lithium-treated patients with bipolar disorder. Biol Psychiatry. 2007 Jul 01; 62(1):7-16. View Abstract
Trait impulsivity in patients with mood disorders. J Affect Disord. 2007 Jun; 100(1-3):227-31. View Abstract
Mapping cortical thickness in children with 22q11.2 deletions. Cereb Cortex. 2007 Aug; 17(8):1889-98. View Abstract
The relationship between performance and fMRI signal during working memory in patients with schizophrenia, unaffected co-twins, and control subjects. Schizophr Res. 2007 Jan; 89(1-3):191-7. View Abstract
Prefrontal hyperactivation during working memory task in untreated individuals with major depressive disorder. Mol Psychiatry. 2007 Feb; 12(2):158-66. View Abstract
Neuroimaging of inhibitory control areas in children with attention deficit hyperactivity disorder who were treatment naive or in long-term treatment. Am J Psychiatry. 2006 Jun; 163(6):1052-60. View Abstract
Dissociable mechanisms for memory impairment in bipolar disorder and schizophrenia. Psychol Med. 2006 Aug; 36(8):1085-95. View Abstract
Defining and assessing adherence to oral antipsychotics: a review of the literature. Schizophr Bull. 2006 Oct; 32(4):724-42. View Abstract
Patterns of memory impairment in bipolar disorder and unipolar major depression. Psychiatry Res. 2006 Jun 15; 142(2-3):139-50. View Abstract
Differential working memory impairment in bipolar disorder and schizophrenia: effects of lifetime history of psychosis. Bipolar Disord. 2006 Apr; 8(2):117-23. View Abstract
Infant motor development is associated with adult cognitive categorisation in a longitudinal birth cohort study. J Child Psychol Psychiatry. 2006 Jan; 47(1):25-9. View Abstract
Dorsolateral prefrontal cortex activity during maintenance and manipulation of information in working memory in patients with schizophrenia. Arch Gen Psychiatry. 2005 Oct; 62(10):1071-80. View Abstract
Sources of declarative memory impairment in bipolar disorder: mnemonic processes and clinical features. J Psychiatr Res. 2006 Feb; 40(1):47-58. View Abstract
Spatial working memory function in twins with schizophrenia and bipolar disorder. Biol Psychiatry. 2005 Dec 15; 58(12):930-6. View Abstract
Fronto-limbic brain abnormalities in juvenile onset bipolar disorder. Biol Psychiatry. 2005 Oct 01; 58(7):525-31. View Abstract
Magnetic resonance findings in bipolar disorder. Psychiatr Clin North Am. 2005 Jun; 28(2):443-67. View Abstract
Development and Validation of the Design Organization Test (DOT): a rapid screening instrument for assessing visuospatial ability. J Clin Exp Neuropsychol. 2005 May; 27(4):449-59. View Abstract
ALE meta-analysis: controlling the false discovery rate and performing statistical contrasts. Hum Brain Mapp. 2005 May; 25(1):155-64. View Abstract
Beyond hypofrontality: a quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia. Hum Brain Mapp. 2005 May; 25(1):60-9. View Abstract
Memory and verbal learning functions in twins with bipolar-I disorder, and the role of information-processing speed. Psychol Med. 2005 Feb; 35(2):205-15. View Abstract
Disparity of activation onset in sensory cortex from simultaneous auditory and visual stimulation: Differences between perfusion and blood oxygenation level-dependent functional magnetic resonance imaging. J Magn Reson Imaging. 2005 Feb; 21(2):111-7. View Abstract
Attention deficits in bipolar disorder: a comparison based on the Continuous Performance Test. Neurosci Lett. 2005 May 06; 379(2):122-6. View Abstract
A brief cognitive assessment for use with schizophrenia patients in community clinics. Schizophr Res. 2004 Dec 01; 71(2-3):273-83. View Abstract
Regional brain abnormalities in 22q11.2 deletion syndrome: association with cognitive abilities and behavioral symptoms. Neurocase. 2004 Jun; 10(3):198-206. View Abstract
The feasibility of neuropsychological endophenotypes in the search for genes associated with bipolar affective disorder. Bipolar Disord. 2004 Jun; 6(3):171-82. View Abstract
Maintenance and manipulation of information in schizophrenia: further evidence for impairment in the central executive component of working memory. Schizophr Res. 2004 Jun 01; 68(2-3):173-87. View Abstract
Comparison of TCA and ICA techniques in fMRI data processing. J Magn Reson Imaging. 2004 Apr; 19(4):397-402. View Abstract
Neuroimaging studies in bipolar children and adolescents. Int Rev Neurobiol. 2004; 62:121-46. View Abstract
Spatial working memory as an endophenotype for schizophrenia. Biol Psychiatry. 2003 Apr 01; 53(7):624-6. View Abstract
Voltage-clamp study of the activation currents and fast block to polyspermy in the egg of Xenopus laevis. Dev Growth Differ. 2003 Apr; 45(2):187-97. View Abstract
Maintenance and manipulation in spatial working memory: dissociations in the prefrontal cortex. Neuroimage. 2002 Sep; 17(1):201-13. View Abstract
Elucidating continuities and discontinuities between schizotypy and schizophrenia in the nervous system. Schizophr Res. 2002 Mar 01; 54(1-2):151-6. View Abstract
An fMRI study of sex differences in regional activation to a verbal and a spatial task. Brain Lang. 2000 Sep; 74(2):157-70. View Abstract
The inheritance of neuropsychological dysfunction in twins discordant for schizophrenia. Am J Hum Genet. 2000 Aug; 67(2):369-82. View Abstract
Working memory constrains abstraction in schizophrenia. Biol Psychiatry. 2000 Jan 01; 47(1):34-42. View Abstract
Sex differences in brain-behavior relationships between verbal episodic memory and resting regional cerebral blood flow. Neuropsychologia. 2000; 38(4):451-61. View Abstract
Tyrosine kinase inhibitors block sperm-induced egg activation in Xenopus laevis. Dev Biol. 1999 Jan 01; 205(1):171-80. View Abstract
Frontotemporal cerebral blood flow change during executive and declarative memory tasks in schizophrenia: a positron emission tomography study. Neuropsychology. 1998 Jul; 12(3):399-413. View Abstract
Reliability, performance characteristics, construct validity, and an initial clinical application of a visual object learning test (VOLT). Neuropsychology. 1997 Oct; 11(4):602-612. View Abstract
PET regional cerebral blood flow change during working and declarative memory: relationship with task performance. Neuropsychology. 1997 Apr; 11(2):222-31. View Abstract
Assessing declarative memory in schizophrenia using Wisconsin Card Sorting Test stimuli: the Paired Associate Recognition Test. Psychiatry Res. 1996 Mar 29; 60(2-3):135-45. View Abstract