Education

Undergraduate School

Trinity College
1990 Hartford CT

Graduate School

University of Connecticut School of Medicine
1997 Farmington CT

Medical School

University of Connecticut School of Medicine
1997 Farmington CT

Internship

Pediatrics Yale-New Haven Hospital
New Haven CT

Residency

Pediatrics Yale-New Haven Hospital
2000 New Haven CT

Fellowship

Pediatric Endocrinology Boston Children's Hospital
2003 Boston MA

Publications

  1. RELMß sets the threshold for microbiome-dependent oral tolerance. Nature. 2025 Jan 22. View Abstract
  2. Cataloguing the postnatal small intestinal transcriptome during the first postnatal month. bioRxiv. 2024 Dec 27. View Abstract
  3. Human Mesofluidic Intestinal Model for Studying Transport of Drug Carriers and Bacteria Through a Live Mucosal Barrier. bioRxiv. 2024 Sep 22. View Abstract
  4. Response to Letter to the Editor From Hoekstra: "Adrenal Abcg1 Controls Cholesterol Flux and Steroidogenesis". Endocrinology. 2024 Aug 27; 165(10). View Abstract
  5. Non-canonical Wnt signaling triggered by WNT2B drives adrenal aldosterone production. bioRxiv. 2024 Aug 24. View Abstract
  6. Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma. bioRxiv. 2024 Aug 22. View Abstract
  7. Gut tumors in flies alter the taste valence of an anti-tumorigenic bitter compound. Curr Biol. 2024 Aug 05; 34(15):3591. View Abstract
  8. Pathogenic variants in KMT2C result in a neurodevelopmental disorder distinct from Kleefstra and Kabuki syndromes. Am J Hum Genet. 2024 Aug 08; 111(8):1626-1642. View Abstract
  9. Gut tumors in flies alter the taste valence of an anti-tumorigenic bitter compound. Curr Biol. 2024 Jun 17; 34(12):2623-2632.e5. View Abstract
  10. Faecalibacterium prausnitzii A2-165 metabolizes host- and media-derived chemicals and induces transcriptional changes in colonic epithelium in GuMI human gut microphysiological system. Microbiome Res Rep. 2024; 3(3):30. View Abstract
  11. WNT2B Deficiency Causes Enhanced Susceptibility to Colitis Due to Increased Inflammatory Cytokine Production. Cell Mol Gastroenterol Hepatol. 2024; 18(2):101349. View Abstract
  12. An immune-competent human gut microphysiological system enables inflammation-modulation by Faecalibacterium prausnitzii. NPJ Biofilms Microbiomes. 2024 Mar 29; 10(1):31. View Abstract
  13. Zona Glomerulosa-Derived Klotho Modulates Aldosterone Synthase Expression in Young Female Mice. Endocrinology. 2024 Mar 29; 165(5). View Abstract
  14. Adrenal Abcg1 Controls Cholesterol Flux and Steroidogenesis. Endocrinology. 2024 Jan 16; 165(3). View Abstract
  15. Extracellular carriers control lipid-dependent secretion, delivery, and activity of WNT morphogens. Dev Cell. 2024 Jan 22; 59(2):244-261.e6. View Abstract
  16. Direct therapeutic effect of sulfadoxine-pyrimethamine on nutritional deficiency-induced enteric dysfunction in a human Intestine Chip. EBioMedicine. 2024 Jan; 99:104921. View Abstract
  17. RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release From Enteroendocrine Cells. Gastroenterology. 2024 03; 166(3):437-449. View Abstract
  18. Generation of glucocorticoid-producing cells derived from human pluripotent stem cells. Cell Rep Methods. 2023 11 20; 3(11):100627. View Abstract
  19. Inflammation-induced adrenal dysfunction. Nat Rev Endocrinol. 2023 11; 19(11):622-623. View Abstract
  20. An immune-competent human gut microphysiological system enables inflammation-modulation of Faecalibacterium prausnitzii. Res Sq. 2023 Oct 12. View Abstract
  21. Calcineurin regulates aldosterone production via dephosphorylation of NFATC4. JCI Insight. 2023 07 24; 8(14). View Abstract
  22. ß-Catenin-Driven Differentiation Is a Tissue-Specific Epigenetic Vulnerability in Adrenal Cancer. Cancer Res. 2023 07 05; 83(13):2123-2141. View Abstract
  23. Stomach-derived human insulin-secreting organoids restore glucose homeostasis. Nat Cell Biol. 2023 05; 25(5):778-786. View Abstract
  24. WNT2B Deficiency Causes Increased Susceptibility to Colitis in Mice and Impairs Intestinal Epithelial Development in Humans. bioRxiv. 2023 Apr 22. View Abstract
  25. Stiffness Restricts the Stemness of the Intestinal Stem Cells and Skews Their Differentiation Toward Goblet Cells. Gastroenterology. 2023 06; 164(7):1137-1151.e15. View Abstract
  26. Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice. Nat Commun. 2022 12 21; 13(1):7858. View Abstract
  27. Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants. Nat Commun. 2022 11 09; 13(1):6786. View Abstract
  28. Intrinsic Adrenal TWIK-Related Acid-Sensitive TASK Channel Dysfunction Produces Spontaneous Calcium Oscillations Sufficient to Drive AngII (Angiotensin II)-Unresponsive Hyperaldosteronism. Hypertension. 2022 11; 79(11):2552-2564. View Abstract
  29. Mislocalization of protein kinase A drives pathology in Cushing's syndrome. Cell Rep. 2022 07 12; 40(2):111073. View Abstract
  30. Nutritional deficiency in an intestine-on-a-chip recapitulates injury hallmarks associated with environmental enteric dysfunction. Nat Biomed Eng. 2022 11; 6(11):1236-1247. View Abstract
  31. Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain. J Vis Exp. 2022 05 20; (183). View Abstract
  32. Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn's disease. Gut. 2023 05; 72(5):870-881. View Abstract
  33. Establishment of physiologically relevant oxygen gradients in microfluidic organ chips. Lab Chip. 2022 04 12; 22(8):1584-1593. View Abstract
  34. A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine. Nat Commun. 2022 03 21; 13(1):1503. View Abstract
  35. Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors. Cell. 2022 03 31; 185(7):1157-1171.e22. View Abstract
  36. Telomerase Reverse Transcriptase Expression Marks a Population of Rare Adipose Tissue Stem Cells. Stem Cells. 2022 03 03; 40(1):102-111. View Abstract
  37. Robust differentiation of human enteroendocrine cells from intestinal stem cells. Nat Commun. 2022 01 11; 13(1):261. View Abstract
  38. Triple-Decker Sandwich Cultures of Intestinal Organoids for Long-Term Live Imaging, Uniform Perturbation, and Statistical Sampling. Curr Protoc. 2022 Jan; 2(1):e330. View Abstract
  39. Innervated adrenomedullary microphysiological system to model nicotine and opioid exposure. Organs Chip. 2021 Nov; 3. View Abstract
  40. Coculture of primary human colon monolayer with human gut bacteria. Nat Protoc. 2021 08; 16(8):3874-3900. View Abstract
  41. Rosette morphology in zona glomerulosa formation and function. Mol Cell Endocrinol. 2021 06 15; 530:111287. View Abstract
  42. Telomerase expression marks transitional growth-associated skeletal progenitor/stem cells. Stem Cells. 2021 03; 39(3):296-305. View Abstract
  43. Yersinia pseudotuberculosis YopE prevents uptake by M cells and instigates M cell extrusion in human ileal enteroid-derived monolayers. Gut Microbes. 2021 Jan-Dec; 13(1):1988390. View Abstract
  44. False-positive very long-chain fatty acids in a case of autoimmune adrenal insufficiency. J Pediatr Endocrinol Metab. 2021 Apr 27; 34(4):517-520. View Abstract
  45. Organoid culture system for patient-derived lung metastatic osteosarcoma. Med Oncol. 2020 Oct 20; 37(11):105. View Abstract
  46. Primary human colonic mucosal barrier crosstalk with super oxygen-sensitive Faecalibacterium prausnitzii in continuous culture. Med. 2021 01 15; 2(1):74-98.e9. View Abstract
  47. Cholinergic Activation of Primary Human Derived Intestinal Epithelium Does Not Ameliorate TNF-a Induced Injury. Cell Mol Bioeng. 2020 Oct; 13(5):487-505. View Abstract
  48. Wnt/ß-catenin activation cooperates with loss of p53 to cause adrenocortical carcinoma in mice. Oncogene. 2020 07; 39(30):5282-5291. View Abstract
  49. Rapid Prototyping of Multilayer Microphysiological Systems. ACS Biomater Sci Eng. 2021 07 12; 7(7):2949-2963. View Abstract
  50. Fully synthetic matrices for in vitro culture of primary human intestinal enteroids and endometrial organoids. Biomaterials. 2020 09; 254:120125. View Abstract
  51. Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation. Cell Rep. 2020 04 21; 31(3):107524. View Abstract
  52. Angiotensin II induces coordinated calcium bursts in aldosterone-producing adrenal rosettes. Nat Commun. 2020 04 03; 11(1):1679. View Abstract
  53. ß-Catenin and FGFR2 regulate postnatal rosette-based adrenocortical morphogenesis. Nat Commun. 2020 04 03; 11(1):1680. View Abstract
  54. Intestinal enteroids recapitulate the effects of short-chain fatty acids on the intestinal epithelium. PLoS One. 2020; 15(4):e0230231. View Abstract
  55. Chemogenetic activation of adrenocortical Gq signaling causes hyperaldosteronism and disrupts functional zonation. J Clin Invest. 2020 01 02; 130(1):83-93. View Abstract
  56. Human Colon-on-a-Chip Enables Continuous In Vitro Analysis of Colon Mucus Layer Accumulation and Physiology. Cell Mol Gastroenterol Hepatol. 2020; 9(3):507-526. View Abstract
  57. Sex Differences in Adrenal Bmal1 Deletion-Induced Augmentation of Glucocorticoid Responses to Stress and ACTH in Mice. Endocrinology. 2019 10 01; 160(10):2215-2229. View Abstract
  58. Author Correction: A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip. Nat Biomed Eng. 2019 Jul; 3(7):583. View Abstract
  59. Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells. Nat Microbiol. 2019 10; 4(10):1760-1769. View Abstract
  60. A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip. Nat Biomed Eng. 2019 07; 3(7):520-531. View Abstract
  61. Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites. Microbiome. 2019 03 20; 7(1):43. View Abstract
  62. Adrenal Tissue-Specific Deletion of TASK Channels Causes Aldosterone-Driven Angiotensin II-Independent Hypertension. Hypertension. 2019 02; 73(2):407-414. View Abstract
  63. A ZNRF3-dependent Wnt/ß-catenin signaling gradient is required for adrenal homeostasis. Genes Dev. 2019 02 01; 33(3-4):209-220. View Abstract
  64. The Adrenal Clock Prevents Aberrant Light-Induced Alterations in Circadian Glucocorticoid Rhythms. Endocrinology. 2018 12 01; 159(12):3950-3964. View Abstract
  65. Telomerase Reverse Transcriptase Expression in Mouse Endometrium During Reepithelialization and Regeneration in a Menses-Like Model. Stem Cells Dev. 2019 01 01; 28(1):1-12. View Abstract
  66. Early Identification of Primary Hypothyroidism in Neonates Exposed to Intralymphatic Iodinated Contrast: A Case Series. J Clin Endocrinol Metab. 2018 10 01; 103(10):3585-3588. View Abstract
  67. High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissue. Mucosal Immunol. 2018 11; 11(6):1684-1693. View Abstract
  68. Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations. Am J Hum Genet. 2018 07 05; 103(1):131-137. View Abstract
  69. Adrenocortical development: Lessons from mouse models. Ann Endocrinol (Paris). 2018 Jun; 79(3):95-97. View Abstract
  70. The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile. PLoS Biol. 2018 03; 16(3):e2002417. View Abstract
  71. Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells. Arterioscler Thromb Vasc Biol. 2018 06; 38(6):1283-1296. View Abstract
  72. Move Over Caco-2 Cells: Human-Induced Organoids Meet Gut-on-a-Chip. Cell Mol Gastroenterol Hepatol. 2018; 5(4):634-635. View Abstract
  73. Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids. Sci Rep. 2018 02 13; 8(1):2871. View Abstract
  74. PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal. JCI Insight. 2018 01 25; 3(2). View Abstract
  75. JAK/STAT-1 Signaling Is Required for Reserve Intestinal Stem Cell Activation during Intestinal Regeneration Following Acute Inflammation. Stem Cell Reports. 2018 01 09; 10(1):17-26. View Abstract
  76. Bone Marrow Stem Cells Do Not Contribute to Endometrial Cell Lineages in Chimeric Mouse Models. Stem Cells. 2018 01; 36(1):91-102. View Abstract
  77. Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity. Cell Stem Cell. 2017 07 06; 21(1):78-90.e6. View Abstract
  78. A case report of methadone-associated hypoglycemia in an 11-month-old male. Clin Toxicol (Phila). 2018 01; 56(1):74-76. View Abstract
  79. The Circadian Clock Gene BMAL1 Coordinates Intestinal Regeneration. Cell Mol Gastroenterol Hepatol. 2017 Jul; 4(1):95-114. View Abstract
  80. CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types. Genome Biol. 2016 09 29; 17(1):201. View Abstract
  81. Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature. 2016 Oct 20; 538(7625):350-355. View Abstract
  82. Regulation of zonation and homeostasis in the adrenal cortex. Mol Cell Endocrinol. 2017 02 05; 441:146-155. View Abstract
  83. An enduring role for quiescent stem cells. Dev Dyn. 2016 07; 245(7):718-26. View Abstract
  84. Role of voltage-gated calcium channels in the regulation of aldosterone production from zona glomerulosa cells of the adrenal cortex. J Physiol. 2016 10 15; 594(20):5851-5860. View Abstract
  85. Reprogrammed Stomach Tissue as a Renewable Source of Functional ß Cells for Blood Glucose Regulation. Cell Stem Cell. 2016 Mar 03; 18(3):410-21. View Abstract
  86. Factors regulating quiescent stem cells: insights from the intestine and other self-renewing tissues. J Physiol. 2016 09 01; 594(17):4805-13. View Abstract
  87. The mouse endometrium contains epithelial, endothelial and leucocyte populations expressing the stem cell marker telomerase reverse transcriptase. Mol Hum Reprod. 2016 Apr; 22(4):272-84. View Abstract
  88. Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status. Cell Rep. 2015 Dec 22; 13(11):2403-2411. View Abstract
  89. Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells. Stem Cell Reports. 2015 Nov 10; 5(5):673-681. View Abstract
  90. Circulating IGF-I and IGFBP3 Levels Control Human Colonic Stem Cell Function and Are Disrupted in Diabetic Enteropathy. Cell Stem Cell. 2015 10 01; 17(4):486-498. View Abstract
  91. Oncogenic K-Ras promotes proliferation in quiescent intestinal stem cells. Stem Cell Res. 2015 Jul; 15(1):165-71. View Abstract
  92. Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism. Atherosclerosis. 2014 Oct; 236(2):312-20. View Abstract
  93. Optimised protocols for the identification of the murine cardiac side population. Stem Cell Rev Rep. 2013 Oct; 9(5):731-9. View Abstract
  94. Adrenocortical zonation results from lineage conversion of differentiated zona glomerulosa cells. Dev Cell. 2013 Sep 30; 26(6):666-673. View Abstract
  95. Telomerase expression in the mammalian heart. FASEB J. 2012 Dec; 26(12):4832-40. View Abstract
  96. International workshop: radiation effects on mutation in somatic and germline stem cells. Int J Radiat Biol. 2012 Jun; 88(6):501-6. View Abstract
  97. Tales from the crypt: the expanding role of slow cycling intestinal stem cells. Cell Stem Cell. 2012 Jan 06; 10(1):2-4. View Abstract
  98. Characterization and fate of telomerase-expressing epithelia during kidney repair. J Am Soc Nephrol. 2011 Dec; 22(12):2256-65. View Abstract
  99. Slowly cycling versus rapidly cycling intestinal stem cells: distinct roles or redundancy. Cell Cycle. 2011 Mar 01; 10(5):723-4. View Abstract
  100. Guidelines for the Development of Comprehensive Care Centers for Congenital Adrenal Hyperplasia: Guidance from the CARES Foundation Initiative. Int J Pediatr Endocrinol. 2010; 2010:275213. View Abstract
  101. Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):179-84. View Abstract
  102. Regulation of gene expression in the intestinal epithelium. Prog Mol Biol Transl Sci. 2010; 96:207-29. View Abstract
  103. Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells. Proc Natl Acad Sci U S A. 2008 Jul 29; 105(30):10420-5. View Abstract
  104. Small intestinal stem cell markers. J Anat. 2008 Jul; 213(1):52-8. View Abstract
  105. Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell. 2008 Mar 06; 2(3):230-40. View Abstract
  106. Corticotropin-releasing hormone deficiency increases allergen-induced airway inflammation in a mouse model of asthma. J Allergy Clin Immunol. 2004 Oct; 114(4):747-54. View Abstract
  107. COL1A1 transgene expression in stably transfected osteoblastic cells. Relative contributions of first intron, 3'-flanking sequences, and sequences derived from the body of the human COL1A1 minigene. J Biol Chem. 1997 Dec 12; 272(50):31241-50. View Abstract
  108. Role of the first intron in the regulation of the COL 1A1 gene. Matrix Biol. 1996 Jul; 15(2):62-3; author reply 70. View Abstract
  109. Novel use for BAL 31 nuclease-generated nested deletions: sequencing from the inside out. Biotechniques. 1995 Apr; 18(4):614-7. View Abstract
  110. Inhibition of collagen synthesis by prostaglandins in the immortalized rat osteoblastic cell line Py1a: structure-activity relations and signal transduction mechanisms. J Bone Miner Res. 1994 Dec; 9(12):1935-43. View Abstract
  111. Regulation of the alpha 1(I) collagen promoter in vascular smooth muscle cells. Comparison with other alpha 1(I) collagen-producing cells in transgenic animals and cultured cells. J Biol Chem. 1994 Feb 18; 269(7):4903-9. View Abstract

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