Our lab has three main broad areas of research: drug delivery, biomaterials, and nanomedicine, with considerable overlap between these. Some of our projects are driven by developing new technologies, others by trying to find cures for specific diseases. Pain, otitis media and other otic diseases, ophthalmic diseases, peritoneal adhesions, sepsis, and cancer are among the medical conditions that receive the most attention in our group.
Research Background
Dr. Daniel S. Kohane obtained his MD and a PhD in Physiology from Boston University. He subsequently completed residencies in Pediatrics (Boston Children's Hospital) and Anesthesiology (Massachusetts general Hospital), followed by a fellowship in Pediatric Critical Care (Boston Children's Hospital). He is currently a Senior Associate in Pediatric Critical Care at Boston Children's Hospital at Harvard Medical School, where he directs the Laboratory for Biomaterials and Drug Delivery.
Education
Graduate School
PhD, Physiology
Boston University School of Medicine
1990
Boston
MA
Medical School
Boston University School of Medicine
1990
Boston
MA
Internship
Pediatrics
Boston Children's Hospital
1991
Boston
MA
Residency
Pediatrics/Anesthesia
Boston Combined Residency Program (BCRP)
1995
Boston
MA
Fellowship
Pediatric Critical Care
Boston Children's Hospital
Hybrid Nanoparticle-Hydrogel Systems for Drug Delivery Depots and Other Biomedical Applications. ACS Nano. 2024 Aug 27; 18(34):22780-22792. View Abstract
Reciprocal Interaction with Neutrophils Facilitates Cutaneous Accumulation of Liposomes. ACS Nano. 2024 Jul 16; 18(28):18769-18784. View Abstract
Polymeric Prodrugs using Dynamic Covalent Chemistry for Prolonged Local Anesthesia. Angew Chem Int Ed Engl. 2024 07 29; 63(31):e202406158. View Abstract
Injectable hydrogel based on liposome self-assembly for controlled release of small hydrophilic molecules. Acta Biomater. 2024 Jul 15; 183:101-110. View Abstract
Correction to "A Simple, Yet Multifunctional, Nanoformulation for Eradicating Tumors and Preventing Recurrence with Safely Low Administration Dose". Nano Lett. 2024 May 08; 24(18):5670-5671. View Abstract
Miniaturized therapeutic systems for ultrasound-modulated drug delivery to the central and peripheral nervous system. Adv Drug Deliv Rev. 2024 05; 208:115275. View Abstract
Corrigendum to "Selective binding of C-6OH sulfated hyaluronic acid to the angiogenic isoform of VEGF165" [Biomaterials 77(2016) 130-138]. Biomaterials. 2024 Jun; 307:122501. View Abstract
A hybrid nanoparticle-protein hydrogel system for prolonged local anesthesia. Biomaterials. 2024 Apr; 306:122494. View Abstract
Correction to "Enhanced Photothermal Effect of Plasmonic Nanoparticles Coated with Reduced Graphene Oxide". Nano Lett. 2024 Jan 31; 24(4):1464-1465. View Abstract
On-Demand Opioid Effect Reversal with an Injectable Light-Triggered Polymer-Naloxone Conjugate. Nano Lett. 2023 Nov 22; 23(22):10545-10553. View Abstract
Aromatized liposomes for sustained drug delivery. Nat Commun. 2023 10 20; 14(1):6659. View Abstract
Methyl-Branched Liposomes as a Depot for Sustained Drug Delivery. Nano Lett. 2023 10 25; 23(20):9250-9256. View Abstract
Ablation of Venous Malformations by Photothermal Therapy with Intravenous Gold Nanoshells. Nano Lett. 2023 08 09; 23(15):7092-7099. View Abstract
Enhancement of polymer thermoresponsiveness and drug delivery across biological barriers by addition of small molecules. Heliyon. 2023 Jun; 9(6):e16923. View Abstract
Squaraine Dye-Sensitized Upconversion with Enhanced Stability and Minimized Aggregation-Caused Quenching. Nano Lett. 2023 Jun 14; 23(11):5209-5216. View Abstract
An aptamer-based depot system for sustained release of small molecule therapeutics. Nat Commun. 2023 04 28; 14(1):2444. View Abstract
Materials for Controlled Release of Local Anesthetics. ChemMedChem. 2023 06 01; 18(11):e202300009. View Abstract
Benzonatate as a local anesthetic. PLoS One. 2023; 18(4):e0284401. View Abstract
Terbinafine Nanohybrid: Proposing a Hydrogel Carrying Nanoparticles for Topical Release. Pharmaceutics. 2023 Mar 04; 15(3). View Abstract
Enhancement of Trans-Tympanic Drug Delivery by Pharmacological Induction of Inflammation. Mol Pharm. 2023 02 06; 20(2):1375-1381. View Abstract
Topical Sustained Delivery of Miltefosine Via Drug-Eluting Contact Lenses to Treat Acanthamoeba Keratitis. Pharmaceutics. 2022 Dec 08; 14(12). View Abstract
Enhancement of single upconversion nanoparticle imaging by topologically segregated core-shell structure with inward energy migration. Nat Commun. 2022 10 07; 13(1):5927. View Abstract
Prolonged Retrobulbar Local Anesthesia of the Cornea Does Not Cause Keratopathy in Mice. Transl Vis Sci Technol. 2022 01 03; 11(1):33. View Abstract
A novel, sensitive, and widely accessible besifloxacin quantification method by HPLC-fluorescence: Application to an ocular pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Nov 15; 1185:123010. View Abstract
Modular ketal-linked prodrugs and biomaterials enabled by organocatalytic transisopropenylation of alcohols. Nat Commun. 2021 09 20; 12(1):5532. View Abstract
Delivery of local anaesthetics by a self-assembled supramolecular system mimicking their interactions with a sodium channel. Nat Biomed Eng. 2021 09; 5(9):1099-1109. View Abstract
Dexamethasone-Eluting Contact Lens for the Prevention of Postphotorefractive Keratectomy Scar in a New Zealand White Rabbit Model. Cornea. 2021 Sep 01; 40(9):1175-1180. View Abstract
Targeting Nanoparticles to Bioengineered Human Vascular Networks. Nano Lett. 2021 08 11; 21(15):6609-6616. View Abstract
Synergy in Nanomedicine: What It Is Not, and What It Might Be. Nano Lett. 2021 07 14; 21(13):5457-5460. View Abstract
Permeation of polyethylene glycols across the tympanic membrane. Giant (Oxf). 2021 Jun; 6. View Abstract
Enhancement of the Mechanical and Drug-Releasing Properties of Poloxamer 407 Hydrogels with Casein. Pharm Res. 2021 Mar; 38(3):515-522. View Abstract
Initial Method for Characterization of Tympanic Membrane Drug Permeability in Human Temporal Bones In Situ. Front Neurol. 2021; 12:580392. View Abstract
Keeping Nanomedicine on Target. Nano Lett. 2021 01 13; 21(1):3-5. View Abstract
Drug Delivery across Barriers to the Middle and Inner Ear. Adv Funct Mater. 2021 Oct 26; 31(44). View Abstract
Local anesthesia enhanced with increasing high-frequency ultrasound intensity. Drug Deliv Transl Res. 2020 10; 10(5):1507-1516. View Abstract
Steroid-eluting contact lenses for corneal and intraocular inflammation. Acta Biomater. 2020 10 15; 116:149-161. View Abstract
Dually Enzyme- and Acid-Triggered Self-Immolative Ketal Glycoside Nanoparticles for Effective Cancer Prodrug Monotherapy. Nano Lett. 2020 07 08; 20(7):5465-5472. View Abstract
Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia. Nat Commun. 2020 05 08; 11(1):2323. View Abstract
Functionalized Multiarmed Polycaprolactones as Biocompatible Tissue Adhesives. ACS Appl Mater Interfaces. 2020 Apr 15; 12(15):17314-17320. View Abstract
Synthesis of Poly(acyclic orthoester)s: Acid-Sensitive Biomaterials for Enhancing Immune Responses of Protein Vaccine. Angew Chem Int Ed Engl. 2020 04 27; 59(18):7235-7239. View Abstract
The Duration of Nerve Block from Local Anesthetic Formulations in Male and Female Rats. Pharm Res. 2019 Nov 08; 36(12):179. View Abstract
Transcytosis of Nanomedicine for Tumor Penetration. Nano Lett. 2019 11 13; 19(11):8010-8020. View Abstract
Prolonged Duration Topical Corneal Anesthesia With the Cationic Lidocaine Derivative QX-314. Transl Vis Sci Technol. 2019 Sep; 8(5):28. View Abstract
Prolonged Duration Local Anesthesia by Combined Delivery of Capsaicin- and Tetrodotoxin-Loaded Liposomes. Anesth Analg. 2019 09; 129(3):709-717. View Abstract
Nanoscale systems for local drug delivery. Nano Today. 2019 Oct; 28. View Abstract
A Simple, Yet Multifunctional, Nanoformulation for Eradicating Tumors and Preventing Recurrence with Safely Low Administration Dose. Nano Lett. 2019 08 14; 19(8):5515-5523. View Abstract
Topical sustained drug delivery to the retina with a drug-eluting contact lens. Biomaterials. 2019 10; 217:119285. View Abstract
Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity. Nat Commun. 2019 06 12; 10(1):2566. View Abstract
Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy. Proc Natl Acad Sci U S A. 2019 05 28; 116(22):10674-10680. View Abstract
Quantile Regression and Its Applications: A Primer for Anesthesiologists. Anesth Analg. 2019 04; 128(4):820-830. View Abstract
Prolonged Duration Local Anesthesia by Combined Delivery of Capsaicin- and Tetrodotoxin-Loaded Liposomes. Anesth Analg. 2019 Mar 11. View Abstract
Transtympanic Delivery of Local Anesthetics for Pain in Acute Otitis Media. Mol Pharm. 2019 04 01; 16(4):1555-1562. View Abstract
Intravenous treatment of choroidal neovascularization by photo-targeted nanoparticles. Nat Commun. 2019 02 18; 10(1):804. View Abstract
Nanoscale Bupivacaine Formulations To Enhance the Duration and Safety of Intravenous Regional Anesthesia. ACS Nano. 2019 01 22; 13(1):18-25. View Abstract
PLGA-encapsulation of the Pseudomonas aeruginosa PopB vaccine antigen improves Th17 responses and confers protection against experimental acute pneumonia. Vaccine. 2018 11 12; 36(46):6926-6932. View Abstract
Treatment of Streptococcus pneumoniae otitis media in a chinchilla model by transtympanic delivery of antibiotics. JCI Insight. 2018 10 04; 3(19). View Abstract
Predicting the tissue depth for remote triggering of drug delivery systems. J Control Release. 2018 09 28; 286:55-63. View Abstract
Antibody-modified conduits for highly selective cytokine elimination from blood. JCI Insight. 2018 07 12; 3(13). View Abstract
Synergy between chemical permeation enhancers and drug permeation across the tympanic membrane. J Control Release. 2018 11 10; 289:94-101. View Abstract
Prolonged Duration Local Anesthesia Using Liposomal Bupivacaine Combined With Liposomal Dexamethasone and Dexmedetomidine. Anesth Analg. 2018 04; 126(4):1170-1175. View Abstract
BaTiO3-core Au-shell nanoparticles for photothermal therapy and bimodal imaging. Acta Biomater. 2018 05; 72:287-294. View Abstract
High-frequency, low-intensity ultrasound and microbubbles enhance nerve blockade. J Control Release. 2018 04 28; 276:150-156. View Abstract
Ultrasound-triggered liposomes for on-demand local anesthesia. Ther Deliv. 2018 01; 9(1):5-8. View Abstract
Hollow Silica Nanoparticles Penetrate the Peripheral Nerve and Enhance the Nerve Blockade from Tetrodotoxin. Nano Lett. 2018 01 10; 18(1):32-37. View Abstract
Light-Emitting Photon-Upconversion Nanoparticles in the Generation of Transdermal Reactive-Oxygen Species. ACS Appl Mater Interfaces. 2017 Dec 06; 9(48):41737-41747. View Abstract
Enhanced Triggering of Local Anesthetic Particles by Photosensitization and Photothermal Effect Using a Common Wavelength. Nano Lett. 2017 11 08; 17(11):7138-7145. View Abstract
Ultrasound-triggered local anaesthesia. Nat Biomed Eng. 2017; 1:644-653. View Abstract
Multiply repeatable and adjustable on-demand phototriggered local anesthesia. J Control Release. 2017 04 10; 251:68-74. View Abstract
Ultrasensitive Phototriggered Local Anesthesia. Nano Lett. 2017 02 08; 17(2):660-665. View Abstract
Drug delivery systems for prolonged duration local anesthesia. Mater Today (Kidlington). 2017 Jan-Feb; 20(1):22-31. View Abstract
1074: SEVERITY OF HEMODYNAMIC INSTABILITY AROUND HIGH-DOSE VASOACTIVE SYRINGE CHANGES IN THE PICU. Crit Care Med. 2016 Dec; 44(12 Suppl 1):344. View Abstract
Incorporation of heparin-binding proteins into preformed dextran sulfate-chitosan nanoparticles. Int J Nanomedicine. 2016; 11:6149-6159. View Abstract
Phototriggered Drug Delivery Using Inorganic Nanomaterials. Bioconjug Chem. 2017 01 18; 28(1):98-104. View Abstract
Core-Shell Nanostars for Multimodal Therapy and Imaging. Theranostics. 2016; 6(13):2306-2313. View Abstract
Treatment of otitis media by transtympanic delivery of antibiotics. Sci Transl Med. 2016 09 14; 8(356):356ra120. View Abstract
Extended Release of Native Drug Conjugated in Polyketal Microparticles. J Am Chem Soc. 2016 05 18; 138(19):6127-30. View Abstract
Titanium Coating of the Boston Keratoprosthesis. Transl Vis Sci Technol. 2016 Apr; 5(2):17. View Abstract
Self-assembled gemcitabine-gadolinium nanoparticles for magnetic resonance imaging and cancer therapy. Acta Biomater. 2016 Mar; 33:34-9. View Abstract
Phototriggered Local Anesthesia. Nano Lett. 2016 Jan 13; 16(1):177-81. View Abstract
Repeatable and adjustable on-demand sciatic nerve block with phototriggerable liposomes. Proc Natl Acad Sci U S A. 2015 Dec 22; 112(51):15719-24. View Abstract
Selective binding of C-6 OH sulfated hyaluronic acid to the angiogenic isoform of VEGF(165). Biomaterials. 2016 Jan; 77:130-138. View Abstract
New Strategies in Cancer Nanomedicine. Annu Rev Pharmacol Toxicol. 2016; 56:41-57. View Abstract
Ultraviolet light-mediated drug delivery: Principles, applications, and challenges. J Control Release. 2015 Dec 10; 219:31-42. View Abstract
Photoresponsive nanoparticles for drug delivery. Nano Today. 2015 Aug 01; 10(4):451-467. View Abstract
Efficient Triplet-Triplet Annihilation-Based Upconversion for Nanoparticle Phototargeting. Nano Lett. 2015 Oct 14; 15(10):6332-8. View Abstract
Corneal Anesthesia With Site 1 Sodium Channel Blockers and Dexmedetomidine. Invest Ophthalmol Vis Sci. 2015 Jun; 56(6):3820-6. View Abstract
Nonlinear Optics: NIR-Triggered Drug Delivery by Collagen-Mediated Second Harmonic Generation (Adv. Healthcare Mater. 8/2015). Adv Healthc Mater. 2015 Jun; 4(8):1108. View Abstract
NIR-triggered drug delivery by collagen-mediated second harmonic generation. Adv Healthc Mater. 2015 Jun 03; 4(8):1159-63. View Abstract
Preparation and characterization of SDF-1a-chitosan-dextran sulfate nanoparticles. J Vis Exp. 2015 Jan 22; (95):52323. View Abstract
Aptamer photoregulation in vivo. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17099-103. View Abstract
Clinicians' perspectives on the use of drug-eluting contact lenses for the treatment of glaucoma. Ther Deliv. 2014 Oct; 5(10):1077-83. View Abstract
SDF-1a in glycan nanoparticles exhibits full activity and reduces pulmonary hypertension in rats. Biomacromolecules. 2013 Nov 11; 14(11):4009-20. View Abstract
In vivo performance of a drug-eluting contact lens to treat glaucoma for a month. Biomaterials. 2014 Jan; 35(1):432-9. View Abstract
Enhanced photothermal effect of plasmonic nanoparticles coated with reduced graphene oxide. Nano Lett. 2013 Sep 11; 13(9):4075-9. View Abstract
Long-lasting antifouling coating from multi-armed polymer. Langmuir. 2013 Aug 13; 29(32):10087-94. View Abstract
Topical drug formulations for prolonged corneal anesthesia. Cornea. 2013 Jul; 32(7):1040-5. View Abstract
Microdevices for nanomedicine. Mol Pharm. 2013 Jun 03; 10(6):2127-44. View Abstract
A Stiff Injectable Biodegradable Elastomer. Adv Funct Mater. 2013 Mar 25; 23(12):1527-1533. View Abstract
Local toxicity from local anesthetic polymeric microparticles. Anesth Analg. 2013 Apr; 116(4):794-803. View Abstract
Controlled-release systems in neuropathic pain. Pain Manag. 2013 Mar; 3(2):91-3. View Abstract
Synthetic ligand-coated magnetic nanoparticles for microfluidic bacterial separation from blood. Nano Lett. 2014 Jan 08; 14(1):1-5. View Abstract
Synthesis and proton NMR spectroscopy of intra-vesicular gamma-aminobutyric acid (GABA). Annu Int Conf IEEE Eng Med Biol Soc. 2013; 2013:1093-5. View Abstract
Benchtop fabrication of microfluidic systems based on curable polymers with improved solvent compatibility. Lab Chip. 2013 Jan 21; 13(2):252-9. View Abstract
Materials to clinical devices: technologies for remotely triggered drug delivery. Clin Ther. 2012 Nov; 34(11):S25-35. View Abstract
Prolonged nerve blockade delays the onset of neuropathic pain. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17555-60. View Abstract
Nanocomposite gold-silk nanofibers. Nano Lett. 2012 Oct 10; 12(10):5403-6. View Abstract
Duration and local toxicity of sciatic nerve blockade with coinjected site 1 sodium-channel blockers and quaternary lidocaine derivatives. Reg Anesth Pain Med. 2012 Sep-Oct; 37(5):483-9. View Abstract
Remotely triggerable drug delivery systems. Adv Mater. 2010 Nov 24; 22(44):4925-43. View Abstract
Combinatorial extracellular matrices for human embryonic stem cell differentiation in 3D. Biomacromolecules. 2010 Aug 09; 11(8):1909-14. View Abstract
A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery. Biomaterials. 2010 Jul; 31(19):5208-17. View Abstract
Prolonged sensory-selective nerve blockade. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3740-5. View Abstract
Rheological blends for drug delivery. I. Characterization in vitro. J Biomed Mater Res A. 2010 Feb; 92(2):575-85. View Abstract
Rheological blends for drug delivery. II. Prolongation of nerve blockade, biocompatibility, and in vitro-in vivo correlations. J Biomed Mater Res A. 2010 Feb; 92(2):586-95. View Abstract
Photo-targeted nanoparticles. Nano Lett. 2010 Jan; 10(1):250-4. View Abstract
Injectable in situ cross-linking hydrogels for local antifungal therapy. Biomaterials. 2010 Feb; 31(6):1444-52. View Abstract
Three-dimensional conductive constructs for nerve regeneration. J Biomed Mater Res A. 2009 Nov; 91(2):519-27. View Abstract
A magnetically triggered composite membrane for on-demand drug delivery. Nano Lett. 2009 Oct; 9(10):3651-7. View Abstract
Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery. Small. 2009 Jul; 5(13):1575-81. View Abstract
Contact lenses for drug delivery. Semin Ophthalmol. 2009 May-Jun; 24(3):156-60. View Abstract
Prolonged duration local anesthesia with minimal toxicity. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7125-30. View Abstract
A drug-eluting contact lens. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3346-52. View Abstract
Intracellular drug delivery by poly(lactic-co-glycolic acid) nanoparticles, revisited. Mol Pharm. 2009 Jan-Feb; 6(1):190-201. View Abstract
Effect of chemical permeation enhancers on nerve blockade. Mol Pharm. 2009 Jan-Feb; 6(1):265-73. View Abstract
Spray-dried lipid-hyaluronan-polymethacrylate microparticles for drug delivery in the peritoneum. J Biomed Mater Res A. 2008 Dec 01; 87(3):825-31. View Abstract
The biocompatibility of mesoporous silicates. Biomaterials. 2008 Oct; 29(30):4045-55. View Abstract
Microparticles for inhalational delivery of antipseudomonal antibiotics. AAPS J. 2008 Jun; 10(2):254-60. View Abstract
Local myotoxicity from sustained release of bupivacaine from microparticles. Anesthesiology. 2008 May; 108(5):921-8. View Abstract
Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation. Am J Respir Crit Care Med. 2007 Dec 01; 176(11):1138-45. View Abstract
Antifungal hydrogels. Proc Natl Acad Sci U S A. 2007 Aug 07; 104(32):12994-8. View Abstract
Polymers in the prevention of peritoneal adhesions. Eur J Pharm Biopharm. 2008 Jan; 68(1):57-66. View Abstract
Peritoneal adhesion prevention with an in situ cross-linkable hyaluronan gel containing tissue-type plasminogen activator in a rabbit repeated-injury model. Biomaterials. 2007 Sep; 28(25):3704-13. View Abstract
Prevention of peritoneal adhesions with an in situ cross-linkable hyaluronan hydrogel delivering budesonide. J Control Release. 2007 Jul 31; 120(3):178-85. View Abstract
Photocrosslinkable hydrogel for myocyte cell culture and injection. J Biomed Mater Res B Appl Biomater. 2007 May; 81(2):312-22. View Abstract
In situ cross-linkable hyaluronan hydrogels containing polymeric nanoparticles for preventing postsurgical adhesions. Ann Surg. 2007 May; 245(5):819-24. View Abstract
Dextran-based in situ cross-linked injectable hydrogels to prevent peritoneal adhesions. Biomaterials. 2007 Aug; 28(23):3418-26. View Abstract
Microparticles and nanoparticles for drug delivery. Biotechnol Bioeng. 2007 Feb 01; 96(2):203-9. View Abstract
Anti-inflammatory function of an in situ cross-linkable conjugate hydrogel of hyaluronic acid and dexamethasone. Biomaterials. 2007 Apr; 28(10):1778-86. View Abstract
Tetrodotoxin for prolonged local anesthesia with minimal myotoxicity. Muscle Nerve. 2006 Dec; 34(6):747-53. View Abstract
Hyaluronic acid-based microgels and microgel networks for vocal fold regeneration. Biomacromolecules. 2006 Dec; 7(12):3336-44. View Abstract
The prevention of peritoneal adhesions by in situ cross-linking hydrogels of hyaluronic acid and cellulose derivatives. Biomaterials. 2007 Feb; 28(6):975-83. View Abstract
Peritoneal application of chitosan and UV-cross-linkable chitosan. J Biomed Mater Res A. 2006 Sep 15; 78(4):668-75. View Abstract
Micromolding of photocrosslinkable chitosan hydrogel for spheroid microarray and co-cultures. Biomaterials. 2006 Oct; 27(30):5259-67. View Abstract
In situ cross-linkable hyaluronic acid hydrogels prevent post-operative abdominal adhesions in a rabbit model. Biomaterials. 2006 Sep; 27(27):4698-705. View Abstract
A photolithographic method to create cellular micropatterns. Biomaterials. 2006 Sep; 27(27):4755-64. View Abstract
Biodegradable polymeric microspheres and nanospheres for drug delivery in the peritoneum. J Biomed Mater Res A. 2006 May; 77(2):351-61. View Abstract
Tissue injury from tricyclic antidepressants used as local anesthetics. Anesth Analg. 2005 Dec; 101(6):1838-1843. View Abstract
Prolonged duration local anesthesia with lipid-protein-sugar particles containing bupivacaine and dexamethasone. J Biomed Mater Res A. 2005 Nov 01; 75(2):458-64. View Abstract
Complex coacervates for thermally sensitive controlled release of flavor compounds. J Agric Food Chem. 2005 Sep 21; 53(19):7518-25. View Abstract
Case records of the Massachusetts General Hospital. Case 16-2005. A nine-year-old girl with headaches and hypertension. N Engl J Med. 2005 May 26; 352(21):2223-31. View Abstract
In vivo evaluation of tetrahedral amorphous carbon. Biomaterials. 2005 Feb; 26(5):465-73. View Abstract
Injectable microparticle-gel system for prolonged and localized lidocaine release. I. In vitro characterization. J Biomed Mater Res A. 2004 Sep 01; 70(3):412-9. View Abstract
Injectable microparticle-gel system for prolonged and localized lidocaine release. II. In vivo anesthetic effects. J Biomed Mater Res A. 2004 Sep 01; 70(3):459-66. View Abstract
pH-triggered microparticles for peptide vaccination. J Immunol. 2004 Aug 15; 173(4):2578-85. View Abstract
Prolongation of sciatic nerve blockade by in situ cross-linked hyaluronic acid. Biomaterials. 2004 Aug; 25(19):4797-804. View Abstract
Site 1 sodium channel blockers prolong the duration of sciatic nerve blockade from tricyclic antidepressants. Pain. 2004 Jul; 110(1-2):432-8. View Abstract
Microparticulate formulations for the controlled release of interleukin-2. J Pharm Sci. 2004 May; 93(5):1100-9. View Abstract
Effect of excipient composition on the biocompatibility of bupivacaine-containing microparticles at the sciatic nerve. J Biomed Mater Res A. 2004 Mar 15; 68(4):651-9. View Abstract
pH-triggered release of macromolecules from spray-dried polymethacrylate microparticles. Pharm Res. 2003 Oct; 20(10):1533-8. View Abstract
Local anesthetics inhibit uterine activity in vitro. Possible application on preterm labor prevention and treatment. Fetal Diagn Ther. 2003 Sep-Oct; 18(5):292-6. View Abstract
Prolonged duration local anesthesia from tetrodotoxin-enhanced local anesthetic microspheres. Pain. 2003 Jul; 104(1-2):415-21. View Abstract
Effectiveness of muscimol-containing microparticles against pilocarpine-induced focal seizures. Epilepsia. 2002 Dec; 43(12):1462-8. View Abstract
Lipid-sugar particles for intracranial drug delivery: safety and biocompatibility. Brain Res. 2002 Aug 16; 946(2):206-13. View Abstract
Biocompatibility of lipid-protein-sugar particles containing bupivacaine in the epineurium. J Biomed Mater Res. 2002 Mar 05; 59(3):450-9. View Abstract
BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia. Proc Natl Acad Sci U S A. 2001 Dec 18; 98(26):15318-23. View Abstract
High concentrations of adrenergic antagonists prolong sciatic nerve blockade by tetrodotoxin. Acta Anaesthesiol Scand. 2001 Aug; 45(7):899-905. View Abstract
Effects of adrenergic agonists and antagonists on tetrodotoxin-induced nerve block. Reg Anesth Pain Med. 2001 May-Jun; 26(3):239-45. View Abstract
The local anesthetic properties and toxicity of saxitonin homologues for rat sciatic nerve block in vivo. Reg Anesth Pain Med. 2000 Jan-Feb; 25(1):52-9. View Abstract
Vanilloid receptor agonists potentiate the in vivo local anesthetic activity of percutaneously injected site 1 sodium channel blockers. Anesthesiology. 1999 Feb; 90(2):524-34. View Abstract
Sciatic nerve blockade in infant, adolescent, and adult rats: a comparison of ropivacaine with bupivacaine. Anesthesiology. 1998 Nov; 89(5):1199-208; discussion 10A. View Abstract
A re-examination of tetrodotoxin for prolonged duration local anesthesia. Anesthesiology. 1998 Jul; 89(1):119-31. View Abstract
Stress-induced proteins in aortic smooth muscle cells and aorta of hypertensive rats. Am J Physiol. 1990 Jun; 258(6 Pt 2):H1699-705. View Abstract