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Related Research Units

Hematology and Oncology Research
Daley Laboratory Research

Research Background

Caroline earned her PhD in Molecular Biomedicine from Bonn University (Germany) in December 2015. During her Ph.D. she analyzed mechanisms governing the lineage barrier between the somatic and extraembryonic lineage. She succeeded in generating fully functional induced trophoblast stem cells from murine fibroblasts. Following her interest in stem cell engineering she joined the Daley lab to work on hematopoietic stem cell differentiation from human induced pluripotent stem cells. Her postdoctoral research is supported by a fellowship from the “Deutsche Forschungsgemeinschaft (DFG)”.

 

Publications

  1. Reassembling embryos in vitro from component stem cells. Cell Res. 2017 Aug; 27(8):961-962. View Abstract
  2. Breaking the first lineage barrier - many roads to trophoblast stem cell fate. Placenta. 2017 12; 60 Suppl 1:S52-S56. View Abstract
  3. Protocol for the Direct Conversion of Murine Embryonic Fibroblasts into Trophoblast Stem Cells. J Vis Exp. 2016 07 25; (113). View Abstract
  4. Tpbpa-Cre-mediated deletion of TFAP2C leads to deregulation of Cdkn1a, Akt1 and the ERK pathway, causing placental growth arrest. Development. 2016 Mar 01; 143(5):787-98. View Abstract
  5. Direct Induction of Trophoblast Stem Cells from Murine Fibroblasts. Cell Stem Cell. 2015 Nov 05; 17(5):557-68. View Abstract
  6. Derivation and maintenance of murine trophoblast stem cells under defined conditions. Stem Cell Reports. 2014 Feb 11; 2(2):232-42. View Abstract
  7. The role of transcription factor Tcfap2c/TFAP2C in trophectoderm development. Reprod Biomed Online. 2012 Jul; 25(1):12-20. View Abstract
  8. Lineage conversion of murine extraembryonic trophoblast stem cells to pluripotent stem cells. Mol Cell Biol. 2011 Apr; 31(8):1748-56. View Abstract

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