Research Overview

Brian Quinn has maintained a keen focus on improving patient outcomes through the development and implementation of risk assessment and mitigation strategies, both locally and nationally. Through national multicenter collaboration, Dr. Quinn has been part of numerous ongoing projects involving outcomes research, assessment of procedural risk, and implementation of various patient-centered risk mitigation strategies using quality improvement methodology as a member of a large multicenter collaborative, the Congenital Cardiac Catheterization Project on Outcomes (C3PO). Additionally, Dr. Quinn has developed a system to assess risk of radiation exposure in the catheterization laboratory with a focused longitudinal assessment methodology used to reduce radiation exposure across all participating centers in the multicenter collaborative.

Research Background

Brian Quinn received his MD from Eastern Virginia Medical School. He completed an internship, residency, and fellowship at Children's Hospital Boston.

Education

Undergraduate School

University of Maines
2006 Orono ME

Medical School

Eastern Virginia Medical School
2012 Norfolk ME

Internship

Global Pediatrics Boston Combined Residency Program (BCRP)
2013 Boston MA

Residency

Boston Combined Residency Program (BCRP)
2015 Boston MA

Fellowship

Boston Children's Hospital
2019 Boston MA

Publications

  1. Incidence of High Severity Anesthesia Related Adverse Events With Increasing PREDIC3T Risk Category in Congenital Cardiac Catheterization: A Review of the C3PO Database. Paediatr Anaesth. 2026 Apr; 36(4):379-387. View Abstract
  2. Peripheral Nerve Injuries in Patients Undergoing Congenital Cardiac Surgery and Cardiac Catheterization. J Cardiothorac Vasc Anesth. 2025 Dec 20. View Abstract
  3. Percutaneous Pulmonary Valve Perforation in Pulmonary Atresia With Intact Ventricular Septum: Multicenter Comparison of Radiofrequency Versus Chronic Total Occlusion Wires. J Soc Cardiovasc Angiogr Interv. 2025 Dec; 4(12):104045. View Abstract
  4. Outcomes and Risk Factors of Transcatheter Interventions to Create or Enlarge an Atrial Communication. Pediatr Cardiol. 2025 Oct 17. View Abstract
  5. Prolonged Length of Stay After Elective Same-Day Admissions for Pediatric or Congenital Cardiac Catheterizations: A Potential Measure for Procedural Harm. J Soc Cardiovasc Angiogr Interv. 2025 Sep; 4(9):103804. View Abstract
  6. Congenital Cardiac Catheterization Risk Assessment in Infants Under 2.5 kg. Pediatr Cardiol. 2026 Feb; 47(2):684-695. View Abstract
  7. Comparative Congenital Cardiac Catheterization Registry Analysis From the United States and Low- and Middle-Income Countries. JACC Adv. 2025 Apr; 4(4):101649. View Abstract
  8. Formulation of Quality Improvement Methodology for Risk Mitigation in Congenital Cardiac Catheterization. Pediatr Cardiol. 2025 Oct; 46(7):1992-2003. View Abstract
  9. Evaluating Procedural Performance: A Composite Outcome for Atrial Septal Defect and Patent Ductus Arteriosus Closures. J Soc Cardiovasc Angiogr Interv. 2025 Feb; 4(2):102459. View Abstract
  10. Generating Risk Reduction Analytics in Complex Cardiac Care Environments (GR2AC3E): Risk Prediction in Congenital Catheterization. J Soc Cardiovasc Angiogr Interv. 2025 Mar; 4(3Part B):102434. View Abstract
  11. How We Would Treat Our Own Congenital Cardiac Catheterization Laboratory Patient. J Cardiothorac Vasc Anesth. 2024 Dec; 38(12):2891-2899. View Abstract
  12. Safety and efficacy of combined dilation/stenting of venous abnormalities, including complete obstructions, during lead extractions in patients with congenital heart disease. J Cardiovasc Electrophysiol. 2024 Apr; 35(4):694-700. View Abstract
  13. Catheterization for Congenital Heart Disease Adjustment for Risk Method II. Circ Cardiovasc Interv. 2024 03; 17(3):e012834. View Abstract
  14. Evaluating Procedural Performance: A Composite Outcome for Aortic and Pulmonary Valvuloplasty in Congenital Cardiac Catheterization. J Soc Cardiovasc Angiogr Interv. 2023 Nov-Dec; 2(6Part A):101119. View Abstract
  15. Predictors of Serious Adverse Events and High-Level Cardiorespiratory Support in Patients Undergoing Transcatheter Pulmonary Vein Interventions. Pediatr Cardiol. 2023 Apr; 44(4):806-815. View Abstract
  16. The Need for Surgery After Vascular or Cardiac Trauma, or Technical Adverse Events in the Congenital Cardiac Catheterization Laboratory. Pediatr Cardiol. 2023 Apr; 44(4):795-805. View Abstract
  17. 2 Cases of Spontaneous Coronary Artery Dissection in Neonates. JACC Case Rep. 2023 Jan 18; 6:101704. View Abstract
  18. Changes in Practice/Outcomes of Pediatric/Congenital Catheterization in Response to the First Wave of COVID. JACC Adv. 2022 Dec; 1(5):100143. View Abstract
  19. ICU Admission Tool for Congenital Heart Catheterization (iCATCH): A Predictive Model for High Level Post-Catheterization Care and Patient Management. Pediatr Crit Care Med. 2022 10 01; 23(10):822-830. View Abstract
  20. Procedural Risk in Congenital Cardiac Catheterization (PREDIC3T). J Am Heart Assoc. 2022 01 04; 11(1):e022832. View Abstract
  21. Interpreting Quality Improvement When Introducing New Technology: A Collaborative Experience in ASD Device Closures. Pediatr Cardiol. 2022 Mar; 43(3):596-604. View Abstract
  22. A million persons, a million dreams: a vision for a national center of radiation epidemiology and biology. Int J Radiat Biol. 2022; 98(4):795-821. View Abstract
  23. The Burden of Radiation Exposure During Transcatheter Closure of Atrial Septal Defect. Am J Cardiol. 2021 06 15; 149:126-131. View Abstract
  24. Longitudinal Improvements in Radiation Exposure in Cardiac Catheterization for Congenital Heart Disease: A Prospective Multicenter C3PO-QI Study. Circ Cardiovasc Interv. 2020 05; 13(5):e008172. View Abstract
  25. Perceptions of Junior Faculty in General Internal Medicine Regarding Mentoring Medical Students and Residents in Scholarly Projects. J Gen Intern Med. 2019 07; 34(7):1098-1099. View Abstract
  26. Cohort profile - MSK radiation workers: a feasibility study to establish a deceased worker sub-cohort as part of a multicenter medical radiation worker component in the million person study of low-dose radiation health effects. Int J Radiat Biol. 2022; 98(4):593-599. View Abstract
  27. Combination of acid ß-glucosidase mutation and Saposin C deficiency in mice reveals Gba1 mutation dependent and tissue-specific disease phenotype. Sci Rep. 2019 04 03; 9(1):5571. View Abstract
  28. Radiation Risk Categories in Cardiac Catheterization for Congenital Heart Disease: A Tool to Aid in the Evaluation of Radiation Outcomes. Pediatr Cardiol. 2019 Feb; 40(2):445-453. View Abstract
  29. Patient-specific organ and effective dose estimates in pediatric oncology computed tomography. Phys Med. 2018 Jan; 45:146-155. View Abstract
  30. A comparison of pediatric and adult CT organ dose estimation methods. BMC Med Imaging. 2017 04 26; 17(1):28. View Abstract
  31. Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice. Hum Mol Genet. 2016 12 01; 25(23):5126-5141. View Abstract
  32. Reversal of advanced disease in lysosomal acid lipase deficient mice: a model for lysosomal acid lipase deficiency disease. Mol Genet Metab. 2014 Jul; 112(3):229-41. View Abstract
  33. Multiple pathogenic proteins implicated in neuronopathic Gaucher disease mice. Hum Mol Genet. 2014 Aug 01; 23(15):3943-57. View Abstract
  34. Optimising radiographic bitewing examination to adult and juvenile patients through the use of anthropomorphic phantoms. Radiat Prot Dosimetry. 2014 Jan; 158(1):51-8. View Abstract
  35. Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant mice. Hum Mol Genet. 2013 Jun 15; 22(12):2435-50. View Abstract
  36. PET/CT-guided interventions: personnel radiation dose. Cardiovasc Intervent Radiol. 2013 Aug; 36(4):1063-7. View Abstract
  37. Default mode network abnormalities in idiopathic generalized epilepsy. Epilepsy Behav. 2012 Mar; 23(3):353-9. View Abstract
  38. Individualized localization and cortical surface-based registration of intracranial electrodes. Neuroimage. 2012 Feb 15; 59(4):3563-70. View Abstract
  39. Individual differences in verbal abilities associated with regional blurring of the left gray and white matter boundary. J Neurosci. 2011 Oct 26; 31(43):15257-63. View Abstract
  40. Structural evidence for involvement of a left amygdala-orbitofrontal network in subclinical anxiety. Psychiatry Res. 2011 Dec 30; 194(3):296-303. View Abstract
  41. High rates of Staphylococcus aureus USA400 infection, Northern Canada. Emerg Infect Dis. 2011 Apr; 17(4):722-5. View Abstract
  42. Detection of epileptogenic cortical malformations with surface-based MRI morphometry. PLoS One. 2011 Feb 04; 6(2):e16430. View Abstract
  43. Impact of breast milk on intelligence quotient, brain size, and white matter development. Pediatr Res. 2010 Apr; 67(4):357-62. View Abstract
  44. Phonetically irregular word pronunciation and cortical thickness in the adult brain. Neuroimage. 2010 Jul 15; 51(4):1453-8. View Abstract
  45. Prolonged institutional rearing is associated with atypically large amygdala volume and difficulties in emotion regulation. Dev Sci. 2010 Jan 01; 13(1):46-61. View Abstract
  46. MRI-derived measurements of human subcortical, ventricular and intracranial brain volumes: Reliability effects of scan sessions, acquisition sequences, data analyses, scanner upgrade, scanner vendors and field strengths. Neuroimage. 2009 May 15; 46(1):177-92. View Abstract
  47. Regional white matter volume differences in nondemented aging and Alzheimer's disease. Neuroimage. 2009 Feb 15; 44(4):1247-58. View Abstract
  48. Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice. BMC Neurosci. 2008 Aug 01; 9:76. View Abstract
  49. Dependence of reversibility and progression of mouse neuronopathic Gaucher disease on acid beta-glucosidase residual activity levels. Mol Genet Metab. 2008 Jun; 94(2):190-203. View Abstract
  50. The effect of early human diet on caudate volumes and IQ. Pediatr Res. 2008 Mar; 63(3):308-14. View Abstract
  51. Feasibility of multi-site clinical structural neuroimaging studies of aging using legacy data. Neuroinformatics. 2007; 5(4):235-45. View Abstract
  52. A technique for the deidentification of structural brain MR images. Hum Brain Mapp. 2007 Sep; 28(9):892-903. View Abstract
  53. Abnormal cortical folding patterns within Broca's area in schizophrenia: evidence from structural MRI. Schizophr Res. 2007 Aug; 94(1-3):317-27. View Abstract
  54. Conditional expression of human acid beta-glucosidase improves the visceral phenotype in a Gaucher disease mouse model. J Lipid Res. 2006 Oct; 47(10):2161-70. View Abstract
  55. Reliability of MRI-derived measurements of human cerebral cortical thickness: the effects of field strength, scanner upgrade and manufacturer. Neuroimage. 2006 Aug 01; 32(1):180-94. View Abstract
  56. The functional and structural significance of the frontal shift in the old/new ERP effect. Brain Res. 2006 Apr 07; 1081(1):156-70. View Abstract
  57. Regional cortical thickness matters in recall after months more than minutes. Neuroimage. 2006 Jul 01; 31(3):1343-51. View Abstract
  58. An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage. 2006 Jul 01; 31(3):968-80. View Abstract
  59. Meditation experience is associated with increased cortical thickness. Neuroreport. 2005 Nov 28; 16(17):1893-7. View Abstract
  60. Orbitofrontal thickness, retention of fear extinction, and extraversion. Neuroreport. 2005 Nov 28; 16(17):1909-12. View Abstract
  61. Effects of age on volumes of cortex, white matter and subcortical structures. Neurobiol Aging. 2005 Oct; 26(9):1261-70; discussion 1275-8. View Abstract
  62. Selective increase of cortical thickness in high-performing elderly--structural indices of optimal cognitive aging. Neuroimage. 2006 Feb 01; 29(3):984-94. View Abstract
  63. Thickness of ventromedial prefrontal cortex in humans is correlated with extinction memory. Proc Natl Acad Sci U S A. 2005 Jul 26; 102(30):10706-11. View Abstract
  64. Age does not increase rate of forgetting over weeks--neuroanatomical volumes and visual memory across the adult life-span. J Int Neuropsychol Soc. 2005 Jan; 11(1):2-15. View Abstract
  65. Cortical volume and speed-of-processing are complementary in prediction of performance intelligence. Neuropsychologia. 2005; 43(5):704-13. View Abstract
  66. Sequence-independent segmentation of magnetic resonance images. Neuroimage. 2004; 23 Suppl 1:S69-84. View Abstract

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