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Related Research Units

Molecular Medicine Research

Publications

  1. Exploration of BMI and circulating metabolic factors as predictors of metformin benefit in CCTG MA.32. JNCI Cancer Spectr. 2026 Apr 30. View Abstract
  2. Recurrent SARS-CoV-2 Omicron broadly neutralizing humanized antibodies in different single human VH1-2-rearranging mouse models. Proc Natl Acad Sci U S A. 2026 Mar 31; 123(13):e2537053123. View Abstract
  3. Effect of the S2' site cleavage on SARS-CoV-2 spike. Nat Commun. 2025 Nov 27; 16(1):11675. View Abstract
  4. Specific Interactions between HIV-1 Env Cytoplasmic Tail and Gag Matrix Domain Probed by NMR. J Am Chem Soc. 2025 May 28; 147(21):17561-17565. View Abstract
  5. SARS-CoV-2 spike protein: structure, viral entry and variants. Nat Rev Microbiol. 2025 Jul; 23(7):455-468. View Abstract
  6. Lessons learned from a candidate gene study investigating aromatase inhibitor treatment outcome in breast cancer. NPJ Breast Cancer. 2025 Feb 19; 11(1):18. View Abstract
  7. Antibody-mediated SARS-CoV-2 entry in cultured cells. EMBO Rep. 2023 12 06; 24(12):e57724. View Abstract
  8. Structural and functional characteristics of the SARS-CoV-2 Omicron subvariant BA.2 spike protein. Nat Struct Mol Biol. 2023 07; 30(7):980-990. View Abstract
  9. Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane. Nature. 2023 07; 619(7969):403-409. View Abstract
  10. Distinct in vitro and in vivo neutralization profiles of monoclonal antibodies elicited by the receptor binding domain of the ancestral SARS-CoV-2. J Med Virol. 2023 03; 95(3):e28673. View Abstract
  11. An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion. Sci Immunol. 2022 10 28; 7(76):eadd5446. View Abstract
  12. Structural and functional impact by SARS-CoV-2 Omicron spike mutations. Cell Rep. 2022 04 26; 39(4):110729. View Abstract
  13. Fighting SARS-CoV-2 with structural biology methods. Nat Methods. 2022 04; 19(4):381-383. View Abstract
  14. Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant. Science. 2021 Dec 10; 374(6573):1353-1360. View Abstract
  15. Mechanisms of SARS-CoV-2 entry into cells. Nat Rev Mol Cell Biol. 2022 01; 23(1):3-20. View Abstract
  16. Structure of SARS-CoV-2 spike protein. Curr Opin Virol. 2021 10; 50:173-182. View Abstract
  17. Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants. Science. 2021 08 06; 373(6555):642-648. View Abstract
  18. Structural impact on SARS-CoV-2 spike protein by D614G substitution. Science. 2021 04 30; 372(6541):525-530. View Abstract
  19. A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent. Nat Struct Mol Biol. 2021 02; 28(2):202-209. View Abstract
  20. Distinct conformational states of SARS-CoV-2 spike protein. Science. 2020 09 25; 369(6511):1586-1592. View Abstract
  21. Structural basis of transmembrane coupling of the HIV-1 envelope glycoprotein. Nat Commun. 2020 05 08; 11(1):2317. View Abstract
  22. HIV-1 fusion inhibitors targeting the membrane-proximal external region of Env spikes. Nat Chem Biol. 2020 05; 16(5):529-537. View Abstract
  23. A hierarchical testing approach for detecting safety signals in clinical trials. Stat Med. 2020 05 15; 39(10):1541-1557. View Abstract
  24. Molecular Mechanism of HIV-1 Entry. Trends Microbiol. 2019 10; 27(10):878-891. View Abstract
  25. Structural basis of coreceptor recognition by HIV-1 envelope spike. Nature. 2019 01; 565(7739):318-323. View Abstract
  26. Structure of the membrane proximal external region of HIV-1 envelope glycoprotein. Proc Natl Acad Sci U S A. 2018 09 18; 115(38):E8892-E8899. View Abstract
  27. Conformational States of a Soluble, Uncleaved HIV-1 Envelope Trimer. J Virol. 2017 05 15; 91(10). View Abstract
  28. Antigenicity-defined conformations of an extremely neutralization-resistant HIV-1 envelope spike. Proc Natl Acad Sci U S A. 2017 04 25; 114(17):4477-4482. View Abstract
  29. Structural basis for membrane anchoring of HIV-1 envelope spike. Science. 2016 Jul 08; 353(6295):172-175. View Abstract
  30. HIV-1 ENVELOPE. Effect of the cytoplasmic domain on antigenic characteristics of HIV-1 envelope glycoprotein. Science. 2015 Jul 10; 349(6244):191-5. View Abstract
  31. Stable, uncleaved HIV-1 envelope glycoprotein gp140 forms a tightly folded trimer with a native-like structure. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):18542-7. View Abstract
  32. Mechanism of HIV-1 neutralization by antibodies targeting a membrane-proximal region of gp41. J Virol. 2014 Jan; 88(2):1249-58. View Abstract
  33. HIV-1 envelope trimer elicits more potent neutralizing antibody responses than monomeric gp120. Proc Natl Acad Sci U S A. 2012 Jul 24; 109(30):12111-6. View Abstract
  34. Crystal structure of HIV-1 primary receptor CD4 in complex with a potent antiviral antibody. Structure. 2010 Dec 08; 18(12):1632-41. View Abstract
  35. Distinct conformational states of HIV-1 gp41 are recognized by neutralizing and non-neutralizing antibodies. Nat Struct Mol Biol. 2010 Dec; 17(12):1486-91. View Abstract
  36. Role of HIV membrane in neutralization by two broadly neutralizing antibodies. Proc Natl Acad Sci U S A. 2009 Dec 01; 106(48):20234-9. View Abstract
  37. A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3739-44. View Abstract
  38. Restraining the conformation of HIV-1 gp120 by removing a flexible loop. EMBO J. 2006 Oct 18; 25(20):5026-35. View Abstract
  39. Structure of an unliganded simian immunodeficiency virus gp120 core. Nature. 2005 Feb 24; 433(7028):834-41. View Abstract
  40. Determining the structure of an unliganded and fully glycosylated SIV gp120 envelope glycoprotein. Structure. 2005 Feb; 13(2):197-211. View Abstract
  41. A chimeric protein of simian immunodeficiency virus envelope glycoprotein gp140 and Escherichia coli aspartate transcarbamoylase. J Virol. 2004 May; 78(9):4508-16. View Abstract
  42. Expression, purification, and characterization of gp160e, the soluble, trimeric ectodomain of the simian immunodeficiency virus envelope glycoprotein, gp160. J Biol Chem. 2000 Nov 10; 275(45):34946-53. View Abstract
  43. De novo and DNA primer-mediated initiation of cDNA synthesis by the mauriceville retroplasmid reverse transcriptase involve recognition of a 3' CCA sequence. J Mol Biol. 1997 Aug 22; 271(3):311-32. View Abstract
  44. Cloning and characterization of the Neurospora crassa cyt-5 gene. A nuclear-coded mitochondrial RNA polymerase with a polyglutamine repeat. J Biol Chem. 1996 Mar 15; 271(11):6537-44. View Abstract

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