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Molecular Medicine Research

Publications

  1. Antibody-mediated SARS-CoV-2 entry in cultured cells. EMBO Rep. 2023 Dec 06; 24(12):e57724. View Abstract
  2. Structural and functional characteristics of the SARS-CoV-2 Omicron subvariant BA.2 spike protein. Nat Struct Mol Biol. 2023 07; 30(7):980-990. View Abstract
  3. Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane. Nature. 2023 Jul; 619(7969):403-409. View Abstract
  4. Distinct in vitro and in vivo neutralization profiles of monoclonal antibodies elicited by the receptor binding domain of the ancestral SARS-CoV-2. J Med Virol. 2023 03; 95(3):e28673. View Abstract
  5. An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion. Sci Immunol. 2022 10 28; 7(76):eadd5446. View Abstract
  6. Structural and functional impact by SARS-CoV-2 Omicron spike mutations. Cell Rep. 2022 04 26; 39(4):110729. View Abstract
  7. Fighting SARS-CoV-2 with structural biology methods. Nat Methods. 2022 04; 19(4):381-383. View Abstract
  8. Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant. Science. 2021 Dec 10; 374(6573):1353-1360. View Abstract
  9. Mechanisms of SARS-CoV-2 entry into cells. Nat Rev Mol Cell Biol. 2022 01; 23(1):3-20. View Abstract
  10. Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants. Science. 2021 08 06; 373(6555):642-648. View Abstract
  11. Structural impact on SARS-CoV-2 spike protein by D614G substitution. Science. 2021 04 30; 372(6541):525-530. View Abstract
  12. A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent. Nat Struct Mol Biol. 2021 02; 28(2):202-209. View Abstract
  13. Distinct conformational states of SARS-CoV-2 spike protein. Science. 2020 09 25; 369(6511):1586-1592. View Abstract
  14. Structural basis of transmembrane coupling of the HIV-1 envelope glycoprotein. Nat Commun. 2020 05 08; 11(1):2317. View Abstract
  15. HIV-1 fusion inhibitors targeting the membrane-proximal external region of Env spikes. Nat Chem Biol. 2020 05; 16(5):529-537. View Abstract
  16. Molecular Mechanism of HIV-1 Entry. Trends Microbiol. 2019 10; 27(10):878-891. View Abstract
  17. Structural basis of coreceptor recognition by HIV-1 envelope spike. Nature. 2019 01; 565(7739):318-323. View Abstract
  18. Structure of the membrane proximal external region of HIV-1 envelope glycoprotein. Proc Natl Acad Sci U S A. 2018 09 18; 115(38):E8892-E8899. View Abstract
  19. Conformational States of a Soluble, Uncleaved HIV-1 Envelope Trimer. J Virol. 2017 05 15; 91(10). View Abstract
  20. Antigenicity-defined conformations of an extremely neutralization-resistant HIV-1 envelope spike. Proc Natl Acad Sci U S A. 2017 04 25; 114(17):4477-4482. View Abstract
  21. Structural basis for membrane anchoring of HIV-1 envelope spike. Science. 2016 Jul 08; 353(6295):172-175. View Abstract
  22. HIV-1 ENVELOPE. Effect of the cytoplasmic domain on antigenic characteristics of HIV-1 envelope glycoprotein. Science. 2015 Jul 10; 349(6244):191-5. View Abstract
  23. Stable, uncleaved HIV-1 envelope glycoprotein gp140 forms a tightly folded trimer with a native-like structure. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):18542-7. View Abstract
  24. Mechanism of HIV-1 neutralization by antibodies targeting a membrane-proximal region of gp41. J Virol. 2014 Jan; 88(2):1249-58. View Abstract
  25. HIV-1 envelope trimer elicits more potent neutralizing antibody responses than monomeric gp120. Proc Natl Acad Sci U S A. 2012 Jul 24; 109(30):12111-6. View Abstract
  26. Crystal structure of HIV-1 primary receptor CD4 in complex with a potent antiviral antibody. Structure. 2010 Dec 08; 18(12):1632-41. View Abstract
  27. Distinct conformational states of HIV-1 gp41 are recognized by neutralizing and non-neutralizing antibodies. Nat Struct Mol Biol. 2010 Dec; 17(12):1486-91. View Abstract
  28. Role of HIV membrane in neutralization by two broadly neutralizing antibodies. Proc Natl Acad Sci U S A. 2009 Dec 01; 106(48):20234-9. View Abstract
  29. A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3739-44. View Abstract
  30. Restraining the conformation of HIV-1 gp120 by removing a flexible loop. EMBO J. 2006 Oct 18; 25(20):5026-35. View Abstract
  31. Structure of an unliganded simian immunodeficiency virus gp120 core. Nature. 2005 Feb 24; 433(7028):834-41. View Abstract
  32. Determining the structure of an unliganded and fully glycosylated SIV gp120 envelope glycoprotein. Structure. 2005 Feb; 13(2):197-211. View Abstract
  33. A chimeric protein of simian immunodeficiency virus envelope glycoprotein gp140 and Escherichia coli aspartate transcarbamoylase. J Virol. 2004 May; 78(9):4508-16. View Abstract
  34. Expression, purification, and characterization of gp160e, the soluble, trimeric ectodomain of the simian immunodeficiency virus envelope glycoprotein, gp160. J Biol Chem. 2000 Nov 10; 275(45):34946-53. View Abstract
  35. De novo and DNA primer-mediated initiation of cDNA synthesis by the mauriceville retroplasmid reverse transcriptase involve recognition of a 3' CCA sequence. J Mol Biol. 1997 Aug 22; 271(3):311-32. View Abstract
  36. Cloning and characterization of the Neurospora crassa cyt-5 gene. A nuclear-coded mitochondrial RNA polymerase with a polyglutamine repeat. J Biol Chem. 1996 Mar 15; 271(11):6537-44. View Abstract

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