Near Infrared Spectroscopy in pediatric cardiac surgery with respect to cerebral oxygenation and the relationship to neurologic outcome.
Assessment of the cortical response to external stimuli in anesthetized subjects using near infrared spectroscopy.
Pediatric validation of a commercial NIRS monitor.
Education
Medical School
MBBCh
University of Witwatersrand Medical School
1984
Johannesburg
South Africa
Internship
General Surgery/Internal Medicine
Johannesburg Hospital (now The Charlotte Maxeke Johannesburg Academic Hospital)
1985
Johannesburg
South Africa
Residency
Anesthesiology
Johannesburg Hospital (now The Charlotte Maxeke Johannesburg Academic Hospital)
1989
Johannesburg
South Africa
Residency
Anesthesiology
Groote Schuur Hospital
1993
Cape Town
South Africa
Fellowship
Pediatric Anesthesia
Boston Children's Hospital
1995
Boston
MA
Fellowship
Cardiac Anesthesia
Boston Children’s Hospital/Beth Israel Deaconess Medical Center
1996
Boston
MA
Publications
Can pain under anesthesia be measured? Pain-related brain function using functional near-infrared spectroscopy during knee surgery. Neurophotonics. 2023 Apr; 10(2):025014. View Abstract
A Survey of the Congenital Cardiac Anesthesia Society on the Use and Clinical Application of Near- Infrared Tissue Oximetry in Pediatric Cardiac Surgery. J Cardiothorac Vasc Anesth. 2022 09; 36(9):3617-3625. View Abstract
Measuring "pain load" during general anesthesia. Cereb Cortex Commun. 2022; 3(2):tgac019. View Abstract
Preventing pediatric chronic postsurgical pain: Time for increased rigor. Can J Pain. 2022; 6(2):73-84. View Abstract
Brain-based measures of nociception during general anesthesia with remifentanil: A randomized controlled trial. PLoS Med. 2022 04; 19(4):e1003965. View Abstract
fNIRS brain measures of ongoing nociception during surgical incisions under anesthesia. Neurophotonics. 2022 Jan; 9(1):015002. View Abstract
Rhythmic Change of Cortical Hemodynamic Signals Associated with Ongoing Nociception in Awake and Anesthetized Individuals: An Exploratory Functional Near Infrared Spectroscopy Study. Anesthesiology. 2021 11 01; 135(5):877-892. View Abstract
Commentary: Thoracic epidural anesthesia for pediatric cardiac surgery and enhanced recovery: Still lessons yet to be learned. JTCVS Tech. 2022 Feb; 11:69-70. View Abstract
Cerebral Emboli Monitoring Using Transcranial Doppler Ultrasonography in Adults and Children: A Review of the Current Technology and Clinical Applications in the Perioperative and Intensive Care Setting. Anesth Analg. 2021 08 01; 133(2):379-392. View Abstract
NIRS measures in pain and analgesia: Fundamentals, features, and function. Neurosci Biobehav Rev. 2021 01; 120:335-353. View Abstract
Sensitivity of a Next-Generation NIRS Device to Detect Low Mixed Venous Oxyhemoglobin Saturations in the Single Ventricle Population. Anesth Analg. 2020 09; 131(3):e138-e141. View Abstract
A Time-Frequency Approach for Cerebral Embolic Load Monitoring. IEEE Trans Biomed Eng. 2020 04; 67(4):1007-1018. View Abstract
Validation of a Second-Generation Near-Infrared Spectroscopy Monitor in Children With Congenital Heart Disease. Anesth Analg. 2019 04; 128(4):661-668. View Abstract
Non-invasive Assessment of Cerebral Blood Flow and Oxygen Metabolism in Neonates during Hypothermic Cardiopulmonary Bypass: Feasibility and Clinical Implications. Sci Rep. 2017 03 09; 7:44117. View Abstract
Anesthesia, brain changes, and behavior: Insights from neural systems biology. Prog Neurobiol. 2017 06; 153:121-160. View Abstract
Cerebral High-Intensity Transient Signals during Pediatric Cardiac Catheterization: A Pilot Study Using Transcranial Doppler Ultrasonography. J Neuroimaging. 2017 07; 27(4):381-387. View Abstract
White Matter Volume Predicts Language Development in Congenital Heart Disease. J Pediatr. 2017 02; 181:42-48.e2. View Abstract
Noninvasive Cardiac Output Estimation by Inert Gas Rebreathing in Mechanically Ventilated Pediatric Patients. J Pediatr. 2016 10; 177:184-190.e3. View Abstract
Capturing Pain in the Cortex during General Anesthesia: Near Infrared Spectroscopy Measures in Patients Undergoing Catheter Ablation of Arrhythmias. PLoS One. 2016; 11(7):e0158975. View Abstract
Brain measures of nociception using near-infrared spectroscopy in patients undergoing routine screening colonoscopy. Pain. 2016 Apr; 157(4):840-848. View Abstract
Reply to Letter: "Surgically Induced Neuropathic Pain: Understanding the Perioperative Process". Ann Surg. 2015 Jun; 261(6):e162-3. View Abstract
Evaluation of cerebral oxygenation and perfusion with conversion from an arterial-to-systemic shunt circulation to the bidirectional Glenn circulation in patients with univentricular cardiac abnormalities. J Cardiothorac Vasc Anesth. 2015 Feb; 29(1):95-100. View Abstract
Advances in the Care of Adults With Congenital Heart Disease. Semin Cardiothorac Vasc Anesth. 2015 Sep; 19(3):175-86. View Abstract
Cerebral blood flow velocity and neurodevelopmental outcome in infants undergoing surgery for congenital heart disease. Ann Thorac Surg. 2014 Jul; 98(1):125-32. View Abstract
Case 6-2013: Perioperative management of an adult patient with tetralogy of fallot and pheochromocytoma. J Cardiothorac Vasc Anesth. 2013 Dec; 27(6):1399-406. View Abstract
Surgically induced neuropathic pain: understanding the perioperative process. Ann Surg. 2013 Mar; 257(3):403-12. View Abstract
Massive air embolism in a Fontan patient. J Extra Corpor Technol. 2011 Jun; 43(2):79-83. View Abstract
2010 meeting of the Congenital Cardiac Anesthesia Society (CCAS) and the Society for Pediatric Anesthesia (SPA). Anesth Analg. 2010 Nov; 111(5):1331-3. View Abstract
Anesthesia and perioperative stress: consequences on neural networks and postoperative behaviors. Prog Neurobiol. 2010 Dec; 92(4):601-12. View Abstract
Relationship of intraoperative cerebral oxygen saturation to neurodevelopmental outcome and brain magnetic resonance imaging at 1 year of age in infants undergoing biventricular repair. Circulation. 2010 Jul 20; 122(3):245-54. View Abstract
Subtle hemorrhagic brain injury is associated with neurodevelopmental impairment in infants with repaired congenital heart disease. J Thorac Cardiovasc Surg. 2009 Aug; 138(2):374-81. View Abstract
Cerebral oximetry during infant cardiac surgery: evaluation and relationship to early postoperative outcome. Anesth Analg. 2009 Apr; 108(4):1122-31. View Abstract
Congenital supravalvular aortic stenosis and sudden death associated with anesthesia: what's the mystery? Anesth Analg. 2008 Dec; 107(6):1848-54. View Abstract
Matrix-array 3-dimensional echocardiographic assessment of volumes, mass, and ejection fraction in young pediatric patients with a functional single ventricle: a comparison study with cardiac magnetic resonance. Circulation. 2008 Apr 08; 117(14):1842-8. View Abstract
Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery. J Thorac Cardiovasc Surg. 2008 Feb; 135(2):347-54, 354.e1-4. View Abstract
The frequency of anesthesia-related cardiac arrests in patients with congenital heart disease undergoing cardiac surgery. Anesth Analg. 2007 Aug; 105(2):335-43. View Abstract
Cerebral perfusion and oxygenation after the Norwood procedure: comparison of right ventricle-pulmonary artery conduit with modified Blalock-Taussig shunt. J Thorac Cardiovasc Surg. 2007 Mar; 133(3):648-55. View Abstract
Anesthetic management of pial synangiosis and intracranial hemorrhage with a Fontan circulation. Paediatr Anaesth. 2006 Jan; 16(1):72-6. View Abstract
Anesthetic management of the neonate with congenital complete heart block: a 16-year review. Paediatr Anaesth. 2005 Dec; 15(12):1059-66. View Abstract
An evaluation of bilateral monitoring of cerebral oxygen saturation during pediatric cardiac surgery. Anesth Analg. 2005 Nov; 101(5):1294-1300. View Abstract
Hemodynamic responses to etomidate on induction of anesthesia in pediatric patients. Anesth Analg. 2005 Sep; 101(3):645-650. View Abstract
Evaluation of plasma fentanyl concentrations in infants during cardiopulmonary bypass with low-volume circuits. J Cardiothorac Vasc Anesth. 2005 Jun; 19(3):316-21. View Abstract
Iatrogenic hyperthermia during cardiac magnetic resonance imaging. Anesth Analg. 2004 Oct; 99(4):1055. View Abstract
Anesthetic implications of primary cardiac tumors in infants and children. J Cardiothorac Vasc Anesth. 2002 Oct; 16(5):582-6. View Abstract
Bispectral index monitoring during infant cardiac surgery: relationship of BIS to the stress response and plasma fentanyl levels. Paediatr Anaesth. 2001 Nov; 11(6):663-9. View Abstract
Severe hypercarbia during cardiopulmonary bypass: a complication of CO2 flooding of the surgical field. Anesth Analg. 1998 Feb; 86(2):264-6. View Abstract
Pethidine-associated seizure in a healthy adolescent receiving pethidine for postoperative pain control. Paediatr Anaesth. 1998; 8(4):349-52. View Abstract
Administration of magnesium sulphate before rocuronium: effects on speed of onset and duration of neuromuscular block. Br J Anaesth. 1997 Jul; 79(1):122-4. View Abstract
Chylous ascites following abdominal aortic surgery. S Afr J Surg. 1995 Mar; 33(1):26-8. View Abstract
Acetazolamide in the treatment of metabolic alkalosis in critically ill patients. Heart Lung. 1991 Sep; 20(5 Pt 1):455-9. View Abstract