Research Overview

Dr. Wassner’s clinical research focuses on the evaluation and management of thyroid disease in children, particularly pediatric thyroid nodules and cancer, as well as congenital hypothyroidism. His basic research has investigated the role of thyroid hormone metabolism in modulating local and systemic thyroid hormone signaling in disease states including heart failure and liver injury.

Research Background

Ari Wassner earned his MD from Harvard Medical School and completed residency and chief residency in Pediatrics, followed by fellowship in Pediatric Endocrinology, at Boston Children’s Hospital. In addition to his roles as Director of the Thyroid Program and Associate Director of the Endocrinology Fellowship Training Program at Boston Children's Hospital, he is deeply involved in medical education and curriculum development at Harvard Medical School

 

Education

Undergraduate School

Haverford College
2000 Haverford PA

Medical School

Harvard Medical School
2005 Boston MA

Residency

Pediatrics Boston Combined Residency Program (BCRP)
2008 Boston MA

Residency

Chief Resident Boston Combined Residency Program (BCRP)
2009 Boston MA

Fellowship

Pediatric Endocrinology Boston Children's Hospital
2012 Boston MA

Media

Caregiver Profile

Meet Dr. Ari J. Wassner

Thyroid Cancer Q&A

Watch at Drs. Biren Modi and Ari Wassner of the Thyroid Center answer questions about thyroid cancer.

Publications

  1. Congenital Hypothyroidism: Screening and Management. Pediatrics. 2023 01 01; 151(1). View Abstract
  2. Congenital Hypothyroidism: Screening and Management. Pediatrics. 2023 01 01; 151(1). View Abstract
  3. Pediatric thyroid cancer: Recent developments. Best Pract Res Clin Endocrinol Metab. 2023 Jan; 37(1):101715. View Abstract
  4. Autoimmune Thyroiditis and Risk of Malignancy in Children with Thyroid Nodules. Thyroid. 2022 09; 32(9):1109-1117. View Abstract
  5. Investigations Into Obesity and the Risk of Malignant Disease in Pediatric Thyroid Nodules-Reply. JAMA Otolaryngol Head Neck Surg. 2022 08 01; 148(8):793-794. View Abstract
  6. Is Thyroid Monitoring Warranted in Infants and Young Children After Intravascular Administration of Iodine-Based Contrast Media? AJR Am J Roentgenol. 2023 01; 220(1):144-145. View Abstract
  7. Association Between Body Mass Index and Thyroid Cancer in Children With Thyroid Nodules. JAMA Otolaryngol Head Neck Surg. 2022 04 01; 148(4):375-377. View Abstract
  8. Thyroid Nodules in Children With Familial Adenomatous Polyposis. Am J Gastroenterol. 2022 07 01; 117(7):1166-1168. View Abstract
  9. Germline pathogenic variants in cancer risk genes among patients with thyroid cancer and suspected predisposition. Cancer Med. 2022 04; 11(8):1745-1752. View Abstract
  10. Subtype of atypia on cytology and risk of malignancy in pediatric thyroid nodules. Cancer Cytopathol. 2022 05; 130(5):330-335. View Abstract
  11. Belzutifan, a Potent HIF2a Inhibitor, in the Pacak-Zhuang Syndrome. N Engl J Med. 2021 11 25; 385(22):2059-2065. View Abstract
  12. Predictors of Bilateral Disease in Pediatric Differentiated Thyroid Cancer. J Clin Endocrinol Metab. 2021 09 27; 106(10):e4242-e4250. View Abstract
  13. Clinical utility of sonographic features in indeterminate pediatric thyroid nodules. Eur J Endocrinol. 2021 May; 184(5):657-665. View Abstract
  14. Re: "The Use of the Bethesda System for Reporting Thyroid Cytopathology in Pediatric Thyroid Nodules: A Meta-Analysis" by Vuong et al. Thyroid. 2021 09; 31(9):1441. View Abstract
  15. Relationship of Preoperative Thyroid Dysfunction to Clinical Outcomes in Pediatric Cardiac Surgery. J Clin Endocrinol Metab. 2021 04 23; 106(5):e2129-e2136. View Abstract
  16. Natural History of Thyroid Disease in Children with PTEN Hamartoma Tumor Syndrome. J Clin Endocrinol Metab. 2021 03 08; 106(3):e1121-e1130. View Abstract
  17. Risk Stratification in Pediatric Thyroid Cancer: Growing Evidence for Individualized Therapy. J Clin Endocrinol Metab. 2021 03 08; 106(3):e1471-e1472. View Abstract
  18. Severity of Proteinuria Is Directly Associated With Risk of Hypothyroidism in Adults. J Clin Endocrinol Metab. 2021 01 23; 106(2):e757-e762. View Abstract
  19. Severity of Proteinuria Is Directly Associated With Risk of Hypothyroidism in Adults. J Clin Endocrinol Metab. 2021 Jan 23; 106(2):e757-e762. View Abstract
  20. Consensus statement by the American Association of Clinical Endocrinology (AACE) and the American Head and Neck Society Endocrine Surgery Section (AHNS-ES) on Pediatric Benign and Malignant Thyroid Surgery. Head Neck. 2021 04; 43(4):1027-1042. View Abstract
  21. Graves' disease in a five-month-old boy with an unusual treatment course. J Pediatr Endocrinol Metab. 2021 Mar 26; 34(3):401-406. View Abstract
  22. Consensus Statement by the American Association of Clinical Endocrinology (AACE) and the American Head and Neck Society Endocrine Surgery Section (AHNS) on Pediatric Benign and Malignant Thyroid Surgery. Endocr Pract. 2021 Mar; 27(3):174-184. View Abstract
  23. Undernutrition and Pubertal Timing in Female Survivors of Medulloblastoma and Other Embryonal Tumors. J Clin Endocrinol Metab. 2020 10 01; 105(10). View Abstract
  24. Unraveling the Genetics of Congenital Hypothyroidism: Challenges and Opportunities. J Clin Endocrinol Metab. 2020 09 01; 105(9). View Abstract
  25. MCT8 deficiency: collaborative rare disease phenotyping for care and research. Lancet Diabetes Endocrinol. 2020 07; 8(7):555-557. View Abstract
  26. Update on congenital hypothyroidism. Curr Opin Endocrinol Diabetes Obes. 2020 02; 27(1):63-69. View Abstract
  27. Assessment of American College of Radiology Thyroid Imaging Reporting and Data System (TI-RADS) for Pediatric Thyroid Nodules. Radiology. 2020 02; 294(2):415-420. View Abstract
  28. A Novel ALK Fusion in Pediatric Medullary Thyroid Carcinoma. Thyroid. 2019 11; 29(11):1704-1707. View Abstract
  29. COINCIDENT SUPPURATIVE THYROIDITIS AND GRAVES DISEASE IN A PATIENT WITH INFECTED BRANCHIAL CLEFT CYST. AACE Clin Case Rep. 2019 Nov-Dec; 5(6):e365-e368. View Abstract
  30. Differences in Thyroid Nodule Cytology and Malignancy Risk Between Children and Adults. Thyroid. 2019 08; 29(8):1097-1104. View Abstract
  31. Thyroid hormone therapy in congenital hypothyroidism and pediatric hypothyroidism. Endocrine. 2019 10; 66(1):51-62. View Abstract
  32. Natural History and Outcomes of Cytologically Benign Thyroid Nodules in Children. J Clin Endocrinol Metab. 2018 09 01; 103(9):3557-3565. View Abstract
  33. Thyroid Nodules in Pediatric Patients: Sonographic Characteristics and Likelihood of Cancer. Radiology. 2018 08; 288(2):591-599. View Abstract
  34. Congenital Hypothyroidism. Clin Perinatol. 2018 03; 45(1):1-18. View Abstract
  35. Whole exome sequencing frequently detects a monogenic cause in early onset nephrolithiasis and nephrocalcinosis. Kidney Int. 2018 01; 93(1):204-213. View Abstract
  36. Congenital hypothyroidism: insights into pathogenesis and treatment. Int J Pediatr Endocrinol. 2017; 2017:11. View Abstract
  37. Prevalence and Significance of Thyroglobulin Antibodies in Pediatric Thyroid Cancer. J Clin Endocrinol Metab. 2017 09 01; 102(9):3146-3153. View Abstract
  38. Pediatric Hypothyroidism: Diagnosis and Treatment. Paediatr Drugs. 2017 Aug; 19(4):291-301. View Abstract
  39. Myocardial Induction of Type 3 Deiodinase in Dilated Cardiomyopathy. Thyroid. 2017 05; 27(5):732-737. View Abstract
  40. Mutations in SLC26A1 Cause Nephrolithiasis. Am J Hum Genet. 2016 06 02; 98(6):1228-1234. View Abstract
  41. Liothyronine Improves Biochemical Control of Congenital Hypothyroidism in Patients with Central Resistance to Thyroid Hormone. J Pediatr. 2016 08; 175:167-172.e1. View Abstract
  42. Prevalence of Monogenic Causes in Pediatric Patients with Nephrolithiasis or Nephrocalcinosis. Clin J Am Soc Nephrol. 2016 Apr 07; 11(4):664-72. View Abstract
  43. Subclinical Hypothyroidism in Infancy: To Treat or Not to Treat, That Is the Question. J Pediatr. 2016 Mar; 170:17-9. View Abstract
  44. Congenital hypothyroidism: recent advances. Curr Opin Endocrinol Diabetes Obes. 2015 Oct; 22(5):407-12. View Abstract
  45. Fourteen monogenic genes account for 15% of nephrolithiasis/nephrocalcinosis. J Am Soc Nephrol. 2015 Mar; 26(3):543-51. View Abstract
  46. Mice with hepatocyte-specific deficiency of type 3 deiodinase have intact liver regeneration and accelerated recovery from nonthyroidal illness after toxin-induced hepatonecrosis. Endocrinology. 2014 Oct; 155(10):4061-8. View Abstract
  47. Severe hypercalcaemia due to subcutaneous fat necrosis: presentation, management and complications. Arch Dis Child Fetal Neonatal Ed. 2014 Sep; 99(5):F419-21. View Abstract
  48. How are childhood thyroid nodules discovered: opportunities for improving early detection. J Pediatr. 2014 Mar; 164(3):658-60. View Abstract
  49. Rates of medical errors and preventable adverse events among hospitalized children following implementation of a resident handoff bundle. JAMA. 2013 Dec 04; 310(21):2262-70. View Abstract
  50. Endocrine physiology in the newborn. Semin Pediatr Surg. 2013 Nov; 22(4):205-10. View Abstract
  51. Hypothyroidism in the newborn period. Curr Opin Endocrinol Diabetes Obes. 2013 Oct; 20(5):449-54. View Abstract
  52. A standardized assessment of thyroid nodules in children confirms higher cancer prevalence than in adults. J Clin Endocrinol Metab. 2013 Aug; 98(8):3238-45. View Abstract
  53. Isolated central hypothyroidism in young siblings as a manifestation of PROP1 deficiency: clinical impact of whole exome sequencing. Horm Res Paediatr. 2013; 79(6):379-86. View Abstract
  54. Synthesis and ion conductance behavior of a tetrameric alamethicin ion channel. Org Lett. 2002 May 16; 4(10):1647-9. View Abstract

Contact Ari J. Wassner

Print Profile