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Research Overview

Dr. Rodrigue's research is aimed at understanding the biological underpinnings of psychiatric disorders, especially those related to psychosis, using structural and functional magnetic resonance imaging (MRI) and genetics. She primarily uses these tools for biomarker discovery, characterization, and validation. To accomplish this goal Dr. Rodrigue uses multiple imaging modalities and large scale datasets from both family-based and population-based cohorts. Current interests include genetic influences underlying brain based psychosis biomarkers and validation of existing neuroimaging biomarkers in psychosis using machine learning.

 

Research Background

Dr. Rodrigue completed her master's degree in Experimental Psychology from the University of Louisiana at Lafayette followed by a PhD in Psychology from the University of Georgia. She is currently a postdoc working under the supervision of Dr. David Glahn.

Publications

  1. Genetic Associations Among Inflammation, White Matter Architecture, and Extracellular Free Water. Hum Brain Mapp. 2025 Jan; 46(1):e70101. View Abstract
  2. Sex differences in deep brain shape and asymmetry persist across schizophrenia and healthy individuals: A meta-analysis from the ENIGMA-Schizophrenia Working Group. bioRxiv. 2024 Oct 26. View Abstract
  3. Multimodal Neuroimaging Summary Scores as Neurobiological Markers of Psychosis. Schizophr Bull. 2024 07 27; 50(4):792-803. View Abstract
  4. Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm. Nat Commun. 2024 Jul 17; 15(1):5996. View Abstract
  5. Admixture mapping of cognitive function in diverse Hispanic and Latino adults: Results from the Hispanic Community Health Study/Study of Latinos. Alzheimers Dement. 2024 Sep; 20(9):6070-6081. View Abstract
  6. Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI. bioRxiv. 2024 Mar 01. View Abstract
  7. Structural brain abnormalities and aggressive behaviour in schizophrenia: Mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium. medRxiv. 2024 Feb 05. View Abstract
  8. Correction: Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals. Mol Psychiatry. 2024 Jan; 29(1):56. View Abstract
  9. Estimating multimodal brain variability in schizophrenia spectrum disorders: A worldwide ENIGMA study. bioRxiv. 2023 Nov 02. View Abstract
  10. Two neurostructural subtypes: results of machine learning on brain images from 4,291 individuals with schizophrenia. medRxiv. 2023 Oct 12. View Abstract
  11. Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive Function: A Meta-analysis of Community-Based Cohorts. Neurology. 2023 05 02; 100(18):e1930-e1943. View Abstract
  12. Cocktail-party listening and cognitive abilities show strong pleiotropy. Front Neurol. 2023; 14:1071766. View Abstract
  13. Impact of Copy Number Variants and Polygenic Risk Scores on Psychopathology in the UK Biobank. Biol Psychiatry. 2023 10 01; 94(7):591-600. View Abstract
  14. Correction: Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals. Mol Psychiatry. 2022 Sep; 27(9):3738. View Abstract
  15. The Genetic contribution to solving the cocktail-party problem. iScience. 2022 Sep 16; 25(9):104997. View Abstract
  16. Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals. Mol Psychiatry. 2022 09; 27(9):3731-3737. View Abstract
  17. Specificity of Psychiatric Polygenic Risk Scores and Their Effects on Associated Risk Phenotypes. Biol Psychiatry Glob Open Sci. 2023 Jul; 3(3):519-529. View Abstract
  18. Brain charts for the human lifespan. Nature. 2022 04; 604(7906):525-533. View Abstract
  19. Shared sets of correlated polygenic risk scores and voxel-wise grey matter across multiple traits identified via bi-clustering. Annu Int Conf IEEE Eng Med Biol Soc. 2021 11; 2021:2201-2206. View Abstract
  20. Regional White Matter Scaling in the Human Brain. J Neurosci. 2021 08 18; 41(33):7015-7028. View Abstract
  21. Genetic influences on externalizing psychopathology overlap with cognitive functioning and show developmental variation. Eur Psychiatry. 2021 03 31; 64(1):e29. View Abstract
  22. Antisaccade error rates and gap effects in psychosis syndromes from bipolar-schizophrenia network for intermediate phenotypes 2 (B-SNIP2). Psychol Med. 2022 10; 52(13):2692-2701. View Abstract
  23. Associations of cannabis use disorder with cognition, brain structure, and brain function in African Americans. Hum Brain Mapp. 2021 04 15; 42(6):1727-1741. View Abstract
  24. Searching for Imaging Biomarkers of Psychotic Dysconnectivity. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 12; 6(12):1135-1144. View Abstract
  25. Structural Brain Architectures Match Intrinsic Functional Networks and Vary across Domains: A Study from 15?000+ Individuals. Cereb Cortex. 2020 09 03; 30(10):5460-5470. View Abstract
  26. Genetic Contributions to Multivariate Data-Driven Brain Networks Constructed via Source-Based Morphometry. Cereb Cortex. 2020 07 30; 30(9):4899-4913. View Abstract
  27. Minimal Relationship between Local Gyrification and General Cognitive Ability in Humans. Cereb Cortex. 2020 05 18; 30(6):3439-3450. View Abstract
  28. Heritability and Cognitive Relevance of Structural Brain Controllability. Cereb Cortex. 2020 05 14; 30(5):3044-3054. View Abstract
  29. Imaging local genetic influences on cortical folding. Proc Natl Acad Sci U S A. 2020 03 31; 117(13):7430-7436. View Abstract
  30. Neurocognitive impairment in type 2 diabetes: evidence for shared genetic aetiology. Diabetologia. 2020 05; 63(5):977-986. View Abstract
  31. Evidence for genetic correlation between human cerebral white matter microstructure and inflammation. Hum Brain Mapp. 2019 10 01; 40(14):4180-4191. View Abstract
  32. Family-based analyses reveal novel genetic overlap between cytokine interleukin-8 and risk for suicide attempt. Brain Behav Immun. 2019 08; 80:292-299. View Abstract
  33. Person-Based Brain Morphometric Similarity is Heritable and Correlates With Biological Features. Cereb Cortex. 2019 02 01; 29(2):852-862. View Abstract
  34. Cognitive impairment from early to middle adulthood in patients with affective and nonaffective psychotic disorders. Psychol Med. 2020 01; 50(1):48-57. View Abstract
  35. Microstructural differences in visual white matter tracts in people with aniridia. Neuroreport. 2018 12 05; 29(17):1473-1478. View Abstract
  36. A QTL on chromosome 3q23 influences processing speed in humans. Genes Brain Behav. 2019 04; 18(4):e12530. View Abstract
  37. Regularized aggregation of statistical parametric maps. Hum Brain Mapp. 2019 01; 40(1):65-79. View Abstract
  38. Evaluating the Specificity of Cognitive Control Deficits in Schizophrenia Using Antisaccades, Functional Magnetic Resonance Imaging, and Healthy Individuals With Poor Cognitive Control. Front Psychiatry. 2018; 9:107. View Abstract
  39. Multivariate Relationships Between Cognition and Brain Anatomy Across the Psychosis Spectrum. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 12; 3(12):992-1002. View Abstract
  40. White matter fiber integrity of the saccadic eye movement network differs between schizophrenia and healthy groups. Psychophysiology. 2017 Dec; 54(12):1967-1977. View Abstract
  41. Plasticity of prefrontal cortex connectivity in schizophrenia in response to antisaccade practice. Psychiatry Res Neuroimaging. 2017 Jul 30; 265:77-86. View Abstract
  42. Brain activation differences in schizophrenia during context-dependent processing of saccade tasks. Behav Brain Funct. 2016 Jun 24; 12(1):19. View Abstract
  43. White matter structural integrity differs between people with schizophrenia and healthy groups as a function of cognitive control. Schizophr Res. 2015 Dec; 169(1-3):62-68. View Abstract
  44. Antisaccade-related brain activation in children with attention-deficit/hyperactivity disorder--A pilot study. Psychiatry Res. 2015 Nov 30; 234(2):272-9. View Abstract
  45. Increased functional connectivity in intrinsic neural networks in individuals with aniridia. Front Hum Neurosci. 2014; 8:1013. View Abstract
  46. The relationship between uncinate fasciculus white matter integrity and verbal memory proficiency in children. Neuroreport. 2014 Aug 20; 25(12):921-5. View Abstract
  47. An 8-month exercise intervention alters frontotemporal white matter integrity in overweight children. Psychophysiology. 2014 Aug; 51(8):728-33. View Abstract
  48. Improved frontoparietal white matter integrity in overweight children is associated with attendance at an after-school exercise program. Dev Neurosci. 2014; 36(1):1-9. View Abstract
  49. An eight month randomized controlled exercise intervention alters resting state synchrony in overweight children. Neuroscience. 2014 Jan 03; 256:445-55. View Abstract
  50. An 8-month randomized controlled exercise trial alters brain activation during cognitive tasks in overweight children. Obesity (Silver Spring). 2014 Jan; 22(1):232-42. View Abstract

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