Research Overview

Neuroimaging of networks related to migraine in the developing brain; Clinical evaluation of autonomic nervous system changes in patients with headache.

 

Education

Medical School

Tufts University School of Medicine
1983 Boston MA

Internship

Boston Floating Hospital for Infants and Children, New England Medical Center
1985 Boston MA

Residency

Boston Floating Hospital for Infants and Children, New England Medical Center
1985 Boston MA

Residency

Child Neurology Massachusetts General Hospital
1989 Boston MA

Fellowship

Pain Management Massachusetts General Hospital
1991 Boston MA

Media

Caregiver Profile

Meet Dr. Alyssa Lebel

Publications

  1. The Photo- and Phonosensitivity Avoidance Behavior Scales: Evaluating Clinical Utility in Pediatric Primary Chronic Headache. Children (Basel). 2024 Oct 31; 11(11). View Abstract
  2. Pediatric Pain. Continuum (Minneap Minn). 2024 Oct 01; 30(5):1517-1535. View Abstract
  3. Hippocampal volume changes across developmental periods in female migraineurs. Neurobiol Pain. 2023 Aug-Dec; 14:100137. View Abstract
  4. Placebos in pediatrics: A cross-sectional survey investigating physicians' perspectives. J Psychosom Res. 2023 09; 172:111421. View Abstract
  5. OnabotulinumtoxinA for Pediatric Migraine. Pain Manag Nurs. 2023 Dec; 24(6):610-616. View Abstract
  6. Evidence of Chronic Complement Activation in Asymptomatic Pediatric Brain Injury Patients: A Pilot Study. Children (Basel). 2022 Dec 26; 10(1). View Abstract
  7. Alterations in the structure and function of the brain in adolescents with new daily persistent headache: A pilot MRI study. Headache. 2022 07; 62(7):858-869. View Abstract
  8. Integrated Features for Optimizing Machine Learning Classifiers of Pediatric and Young Adults With a Post-Traumatic Headache From Healthy Controls. Front Pain Res (Lausanne). 2022; 3:859881. View Abstract
  9. Health Mindsets in Pediatric Chronic Headache. J Pediatr Psychol. 2022 04 08; 47(4):391-402. View Abstract
  10. Biological laterality and peripheral nerve DTI metrics. PLoS One. 2021; 16(12):e0260256. View Abstract
  11. DTI and MTR Measures of Nerve Fiber Integrity in Pediatric Patients With Ankle Injury. Front Pediatr. 2021; 9:656843. View Abstract
  12. From One Pain to Many: The Emergence of Overlapping Pains in Children and Adolescents. Clin J Pain. 2021 06 01; 37(6):404-412. View Abstract
  13. Left to themselves: Time to target chronic pain in childhood rare diseases. Neurosci Biobehav Rev. 2021 07; 126:276-288. View Abstract
  14. Pediatric Episodic Migraine with Aura: A Unique Entity? Children (Basel). 2021 Mar 17; 8(3). View Abstract
  15. Pain stickiness in pediatric complex regional pain syndrome: A role for the nucleus accumbens. Neurobiol Pain. 2021 Jan-Jul; 9:100062. View Abstract
  16. Altered Brain Network Connectivity Underlies Persistent Post-Traumatic Headache following Mild Traumatic Brain Injury in Youth. J Neurotrauma. 2021 06 15; 38(12):1632-1641. View Abstract
  17. Biological and behavioral markers of pain following nerve injury in humans. Neurobiol Pain. 2020 Jan-Jul; 7:100038. View Abstract
  18. The Impact of Sleep on Disability and School Functioning: Results From a Tertiary Pediatric Headache Center. J Child Neurol. 2020 03; 35(3):221-227. View Abstract
  19. Parenting, self-regulation, and treatment adherence in pediatric chronic headache: A self-determination theory perspective. J Health Psychol. 2021 09; 26(10):1637-1650. View Abstract
  20. Pediatric Headache and Sleep Disturbance: A Comparison of Diagnostic Groups - A Response. Headache. 2019 09; 59(8):1387-1388. View Abstract
  21. Shifting brain circuits in pain chronicity. Hum Brain Mapp. 2019 10 15; 40(15):4381-4396. View Abstract
  22. Migraine in the Young Brain: Adolescents vs. Young Adults. Front Hum Neurosci. 2019; 13:87. View Abstract
  23. Predictors of Primary Intracranial Hypertension in Children Using a Newly Suggested Opening Pressure Cutoff of 280 mm H2O. Pediatr Neurol. 2019 02; 91:27-33. View Abstract
  24. Design and Reporting Characteristics of Clinical Trials of Select Chronic and Recurrent Pediatric Pain Conditions: An Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks Systematic Review. J Pain. 2019 04; 20(4):394-404. View Abstract
  25. Differences in Pediatric Headache Prescription Patterns by Diagnosis. Paediatr Drugs. 2018 Jun; 20(3):273-284. View Abstract
  26. Rapid Screening of Risk in Pediatric Headache: Application of the Pediatric Pain Screening Tool. J Pediatr Psychol. 2018 04 01; 43(3):243-251. View Abstract
  27. Pediatric Headache and Sleep Disturbance: A Comparison of Diagnostic Groups. Headache. 2018 Feb; 58(2):217-228. View Abstract
  28. The Sleep Hygiene Inventory for Pediatrics: Development and Validation of a New Measure of Sleep in a Sample of Children and Adolescents With Chronic Headache. J Child Neurol. 2017 Nov; 32(13):1040-1046. View Abstract
  29. Age- and sex-related differences in the presentation of paediatric migraine: A retrospective cohort study. Cephalalgia. 2018 05; 38(6):1107-1118. View Abstract
  30. In child and adult migraineurs the somatosensory cortex stands out … again: An arterial spin labeling investigation. Hum Brain Mapp. 2017 08; 38(8):4078-4087. View Abstract
  31. Parental Attitudes About Placebo Use in Children. J Pediatr. 2017 02; 181:272-278.e10. View Abstract
  32. Autonomic dysfunction in pediatric patients with headache: migraine versus tension-type headache. Clin Auton Res. 2016 12; 26(6):455-459. View Abstract
  33. Cerebral Proliferative Angiopathy. Pediatr Neurol. 2017 Jan; 66:115-116. View Abstract
  34. "Headache Tools to Stay in School": Assessment, Development, and Implementation of an Educational Guide for School Nurses. J Sch Health. 2016 09; 86(9):645-52. View Abstract
  35. Psychosis following traumatic brain injury and cannabis use in late adolescence. Am J Addict. 2016 Mar; 25(2):91-3. View Abstract
  36. Fear and Reward Circuit Alterations in Pediatric CRPS. Front Hum Neurosci. 2015; 9:703. View Abstract
  37. The migraine brain in transition: girls vs boys. Pain. 2015 Nov; 156(11):2212-2221. View Abstract
  38. Depression as a mediator of the relation between family functioning and functional disability in youth with chronic headaches. Headache. 2016 Mar; 56(3):491-500. View Abstract
  39. Butalbital and pediatric headache: stay off the downward path. Headache. 2015 Feb; 55(2):327-30. View Abstract
  40. Rapid treatment-induced brain changes in pediatric CRPS. Brain Struct Funct. 2016 Mar; 221(2):1095-111. View Abstract
  41. "Pain Can't Stop Me": Examining Pain Self-Efficacy and Acceptance as Resilience Processes Among Youth With Chronic Headache. J Pediatr Psychol. 2015 Oct; 40(9):926-33. View Abstract
  42. Intrinsic brain networks normalize with treatment in pediatric complex regional pain syndrome. Neuroimage Clin. 2014; 6:347-69. View Abstract
  43. Harnessing the placebo effect in pediatric migraine clinic. J Pediatr. 2014 Oct; 165(4):659-65. View Abstract
  44. Pediatric migraine prescription patterns at a large academic hospital. Pediatr Neurol. 2014 Nov; 51(5):706-12. View Abstract
  45. The responsive amygdala: treatment-induced alterations in functional connectivity in pediatric complex regional pain syndrome. Pain. 2014 Sep; 155(9):1727-1742. View Abstract
  46. Fear of pain in pediatric headache. Cephalalgia. 2015 Jan; 35(1):36-44. View Abstract
  47. Sex and the migraine brain. Neurobiol Dis. 2014 Aug; 68:200-14. View Abstract
  48. The interplay of pain-related self-efficacy and fear on functional outcomes among youth with headache. J Pain. 2014 May; 15(5):527-34. View Abstract
  49. Habenula functional resting-state connectivity in pediatric CRPS. J Neurophysiol. 2014 Jan; 111(2):239-47. View Abstract
  50. Transient and persistent pain induced connectivity alterations in pediatric complex regional pain syndrome. PLoS One. 2013; 8(3):e57205. View Abstract
  51. Relations between pain characteristics, child and parent variables, and school functioning in adolescents with chronic headache: a comparison of tension-type headache and migraine. J Pediatr Psychol. 2013 May; 38(4):351-64. View Abstract
  52. School functioning and chronic tension headaches in adolescents: improvement only after multidisciplinary evaluation. J Child Neurol. 2013 Jun; 28(6):719-24. View Abstract
  53. The young brain and concussion: imaging as a biomarker for diagnosis and prognosis. Neurosci Biobehav Rev. 2012 Jul; 36(6):1510-31. View Abstract
  54. Mapping pain activation and connectivity of the human habenula. J Neurophysiol. 2012 May; 107(10):2633-48. View Abstract
  55. Pediatric analgesic clinical trial designs, measures, and extrapolation: report of an FDA scientific workshop. Pediatrics. 2012 Feb; 129(2):354-64. View Abstract
  56. Commentary: health and behavior codes in a pediatric headache program: reimbursement data and recommendations for practice. J Pediatr Psychol. 2012 Jun; 37(5):509-13. View Abstract
  57. The pediatrician's guide to managing the difficult pediatric headache patient. Clin Pediatr (Phila). 2012 Feb; 51(2):175-80. View Abstract
  58. Recommendations for the pharmacological management of neuropathic pain: an overview and literature update. Mayo Clin Proc. 2010 Mar; 85(3 Suppl):S3-14. View Abstract
  59. Neuropathic pain in children: Special considerations. Mayo Clin Proc. 2010 Mar; 85(3 Suppl):S33-41. View Abstract
  60. Challenges of functional imaging research of pain in children. Mol Pain. 2009 Jun 16; 5:30. View Abstract
  61. Pharmacology. J Pediatr Gastroenterol Nutr. 2008 Nov; 47(5):703-5. View Abstract
  62. fMRI reveals distinct CNS processing during symptomatic and recovered complex regional pain syndrome in children. Brain. 2008 Jul; 131(Pt 7):1854-79. View Abstract
  63. Complex regional pain syndromes in children and adolescents. Anesthesiology. 2005 Feb; 102(2):252-5. View Abstract
  64. Patterns of spread in complex regional pain syndrome, type I (reflex sympathetic dystrophy). Pain. 2000 Dec 01; 88(3):259-266. View Abstract
  65. Functional G-CSF pathways in t(8;21) leukemic cells allow for differentiation induction and degradation of AML1-ETO. Hematol J. 2000; 1(5):316-28. View Abstract

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