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Related Research Units

Emergency Medicine Research

Research Overview

Dr. Alexandra Geanacopoulos is a clinician investigator and Instructor of Pediatrics in the Division of Emergency Medicine at Boston Children’s Hospital. In 2025, she completed a combined fellowship in pediatric emergency medicine and health services research, along with an MPH in Clinical Effectiveness at the Harvard T.H. Chan School of Public Health. Her research focuses on improving diagnostic decision-making through risk modeling, patient-centered care, and implementation science, with a particular emphasis on acute respiratory illness.

Research Background

Dr. Geanacopoulos has led and contributed to studies on the diagnostic accuracy of chest radiography for pneumonia, clinician thresholds for pneumonia testing and treatment, missed opportunities for improved pneumonia diagnosis, and the impact of diagnostic uncertainty on clinician management and caregiver communication for children with acute respiratory illness. She has also developed and assisted in the development of novel risk prediction tools for pediatric musculoskeletal infections and serious bacterial infection in hypothermic infants. Her long-term goal is to advance data-driven, patient-centered approaches to guide diagnosis for children seeking emergency care.

Education

Undergraduate School

Dartmouth College
2013 Hanover NH

Medical School

Perelman School of Medicine, University of Pennsylvania
2018 Philadelphia PA

Internship

Pediatric Boston Combined Residency Program (BCRP)
2019 Boston MA

Residency

Pediatrics Boston Combined Residency Program (BCRP)
2021 Boston MA

Fellowship

Pediatric Emergency Medicine Boston Children's Hospital
2025 Boston MA

Graduate School

Harvard T. H. Chan School of Public Health
2025 Boston MA

Publications

  1. Clinician Suspicion for Lyme Disease and Clinical Decision-Making in Children with Monoarthritis. medRxiv. 2026 May 08. View Abstract
  2. Managing and Communicating Diagnostic Uncertainty in Pediatric Emergency Care: National Insights and Opportunities for Intervention. Pediatr Emerg Care. 2026 Apr 23. View Abstract
  3. Tranexamic Acid Use for Posttonsillectomy Hemorrhage Across US Children's Hospitals. Pediatr Emerg Care. 2026 Apr 17. View Abstract
  4. Characteristics of Children With Clinically Suspected Pneumonia and Viral Infection. Clin Pediatr (Phila). 2026 Jun; 65(5):653-659. View Abstract
  5. A Pilot Study to Evaluate Artificial Intelligence-Driven Early Retrieval of Medical Histories in the Emergency Department. Ann Emerg Med. 2026 Mar 18. View Abstract
  6. Physician-Reported Diagnostic Uncertainty Among Children Discharged From the Pediatric Emergency Department With Acute Respiratory Illness. Pediatr Emerg Care. 2026 Mar 02. View Abstract
  7. Pediatric Emergency Department Provider Experience Using the Revised Safer Dx for Self-Directed Feedback on Diagnostic Performance. J Contin Educ Health Prof. 2026 Winter 01; 46(1):23-28. View Abstract
  8. Radiographic Uncertainty and Antibiotic Prescribing in Pediatric Pneumonia. Pediatrics. 2025 Nov 01; 156(5). View Abstract
  9. Interrater Reliability of Pediatric Respiratory Auscultation Findings. Hosp Pediatr. 2025 Aug 25. View Abstract
  10. Pneumonia Among Children Presenting to the Emergency Department With Chest Pain. Pediatr Emerg Care. 2026 Jan 01; 42(1):8-12. View Abstract
  11. Pediatric Intravenous Fluid Use in the Emergency Department During Hurricane Helene. JAMA Pediatr. 2025 Aug 01; 179(8):919-922. View Abstract
  12. Concordance Between Emergency Department Triage Score and Resource Utilization for Children From Different Racial and Ethnic Groups. Acad Emerg Med. 2025 Dec; 32(12):1356-1359. View Abstract
  13. State-Level Policies and Antibiotic Use for Pediatric Conjunctivitis. JAMA Pediatr. 2025 Jun 01; 179(6):679-681. View Abstract
  14. Utility of Cytokine Biomarkers for the Diagnosis of Pediatric Pyogenic Musculoskeletal Infections. Open Forum Infect Dis. 2025 Apr; 12(4):ofaf139. View Abstract
  15. Missed Opportunities to Address SNAP for Nonenrolled Children. Pediatrics. 2025 Feb 13. View Abstract
  16. Pediatric Triage Accuracy in Pediatric and General Emergency Departments. Hosp Pediatr. 2025 Jan 01; 15(1):37-45. View Abstract
  17. Testing and Treatment Thresholds for Pediatric Pneumonia in the Emergency Department. Hosp Pediatr. 2024 Dec 01; 14(12):992-1000. View Abstract
  18. Association between Unmet Social Need and Ambulatory Quality of Care for US Children. Acad Pediatr. 2025 03; 25(2):102589. View Abstract
  19. Antibiotic Treatment and Health Care Use in Children and Adolescents With Conjunctivitis. JAMA Ophthalmol. 2024 Aug 01; 142(8):779-780. View Abstract
  20. Enrollment of underserved racial and ethnic populations in pediatric asthma clinical trials. J Allergy Clin Immunol Glob. 2024 Nov; 3(4):100315. View Abstract
  21. Community-Acquired Pneumonia Diagnosis Following Emergency Department Visits for Respiratory Illness. Clin Pediatr (Phila). 2025 Jan; 64(1):83-90. View Abstract
  22. Pediatric antiarrhythmics and toxicity: A clinical review. J Am Coll Emerg Physicians Open. 2024 Feb; 5(1):e13090. View Abstract
  23. Cost of Pediatric Pneumonia Episodes With or Without Chest Radiography. Hosp Pediatr. 2024 02 01; 14(2):146-152. View Abstract
  24. Association of Chest Radiography With Outcomes in Pediatric Pneumonia: A Population-Based Study. Hosp Pediatr. 2023 07 01; 13(7):614-623. View Abstract
  25. Impact of Viral Radiographic Features on Antibiotic Treatment for Pediatric Pneumonia. J Pediatric Infect Dis Soc. 2022 May 30; 11(5):207-213. View Abstract
  26. Pediatric Intern Clinical Exposure During the COVID-19 Pandemic. Hosp Pediatr. 2021 07; 11(7):e106-e110. View Abstract
  27. Declines in the Number of Lumbar Punctures Performed at United States Children's Hospitals, 2009-2019. J Pediatr. 2021 04; 231:87-93.e1. View Abstract
  28. Trends in Chest Radiographs for Pneumonia in Emergency Departments. Pediatrics. 2020 03; 145(3). View Abstract
  29. Bronchoscopic and histologic findings during lymphatic intervention for plastic bronchitis. Pediatr Pulmonol. 2018 11; 53(11):1574-1581. View Abstract
  30. Pediatric Readmissions After Hospitalizations for Lower Respiratory Infections. Pediatrics. 2017 Aug; 140(2). View Abstract
  31. Measuring pediatric hospital readmission rates to drive quality improvement. Acad Pediatr. 2014 Sep-Oct; 14(5 Suppl):S39-46. View Abstract

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