Alan Cantor's laboratory is focused on further elucidating the transcriptional mechanisms that regulate normal hematopoiesis and understanding how they are perturbed in certain inherited blood disorders and hematologic malignancies. They are also interested in understanding the mechanisms that regulate human developmental globin gene switching and applying this knowledge to the treatment of beta-hemoglobinopathies such as sickle cell anemia and beta-thalassemia. Cantor and colleagues are specifically interested in the role of GATA, FOG, RUNX and ETS family transcription factors and their association with epigenetic regulators and cell-signaling molecules. The Cantor laboratory is currently taking a number of approaches to these studies. These include: (1) proteomic techniques to isolate and characterize multiprotein complexes involving these factors; (2) chromatin immunoprecipitation coupled to high throughput DNA sequencing (ChIP-seq) to identify sites occupied by these transcription factors across the genome; (3) gene targeting in mice; (4) shRNA-mediated gene knock down in primary human CD34+-derived cells; (5) analysis of patient derived induced pluripotent (iPS) stem cells; and (6) whole exome sequencing and genetic linkage studies of families with inherited thrombocytopenia and predisposition to leukemia.
Research Background
Alan Cantor is a graduate of Washington University Medical School. He completed an internship and residency at St. Louis Children's Hospital and a postgraduate fellowship at Boston Children's Hospital and Dana-Farber Cancer Institute.
Education
Undergraduate School
Cornell University
Ithaca
NY
Graduate School
PhD
Washington University School of Medicine
St. Louis
MO
Medical School
Washington University School of Medicine
St. Louis
MO
Internship
St. Louis Children's Hospital
St. Louis
MO
Residency
St. Louis Children's Hospital
St. Louis
MO
Fellowship
Pediatric Hematology-Oncology
Boston Children's Hospital/Dana-Farber Cancer Institute
Boston
MA
Publications
Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in RUNX1, GATA2, and DDX41. Blood Adv. 2023 10 24; 7(20):6092-6107. View Abstract
Transient neonatal hemolytic anemia due to the novel gamma globin gene mutation HBG2:C.290T>C, p.Leu97Pro (hemoglobin Wareham). Pediatr Blood Cancer. 2023 01; 70(1):e30067. View Abstract
Germline GATA1s-generating mutations predispose to leukemia with acquired trisomy 21 and Down syndrome-like phenotype. Blood. 2022 05 26; 139(21):3159-3165. View Abstract
Opening the window for endothelial-to-hematopoietic transition. Genes Dev. 2021 11 01; 35(21-22):1398-1400. View Abstract
The RUNX1 database (RUNX1db): establishment of an expert curated RUNX1 registry and genomics database as a public resource for familial platelet disorder with myeloid malignancy. Haematologica. 2021 11 01; 106(11):3004-3007. View Abstract
B-cell acute lymphoblastic leukemia in patients with germline RUNX1 mutations. Blood Adv. 2021 08 24; 5(16):3199-3202. View Abstract
Familial thrombocytopenia due to a complex structural variant resulting in a WAC-ANKRD26 fusion transcript. J Exp Med. 2021 06 07; 218(6). View Abstract
Profound intravascular hemolysis due to clostridial sepsis in an infant with necrotizing enterocolitis. Blood. 2021 04 22; 137(16):2273. View Abstract
Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits. Nat Genet. 2020 12; 52(12):1333-1345. View Abstract
A phase II study of continuous oral mTOR inhibitor everolimus for recurrent, radiographic-progressive neurofibromatosis type 1-associated pediatric low-grade glioma: a Neurofibromatosis Clinical Trials Consortium study. Neuro Oncol. 2020 10 14; 22(10):1527-1535. View Abstract
CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23626-23635. View Abstract
Infantile Myelofibrosis and Myeloproliferation with CDC42 Dysfunction. J Clin Immunol. 2020 05; 40(4):554-566. View Abstract
Role of RUNX Family Transcription Factors in DNA Damage Response. Mol Cells. 2020 Feb 29; 43(2):99-106. View Abstract
Reproducibility of cognitive endpoints in clinical trials: lessons from neurofibromatosis type 1. Ann Clin Transl Neurol. 2019 12; 6(12):2555-2565. View Abstract
Zfp281 (ZBP-99) plays a functionally redundant role with Zfp148 (ZBP-89) during erythroid development. Blood Adv. 2019 08 27; 3(16):2499-2511. View Abstract
Bone Marrow Morphology Associated With Germline RUNX1 Mutations in Patients With Familial Platelet Disorder With Associated Myeloid Malignancy. Pediatr Dev Pathol. 2019 Jul-Aug; 22(4):315-328. View Abstract
A home-based mentored vegetable gardening intervention demonstrates feasibility and improvements in physical activity and performance among breast cancer survivors. Cancer. 2018 08; 124(16):3427-3435. View Abstract
Pilot Randomized Controlled Trial of a Home Vegetable Gardening Intervention among Older Cancer Survivors Shows Feasibility, Satisfaction, and Promise in Improving Vegetable and Fruit Consumption, Reassurance of Worth, and the Trajectory of Central Adiposity. J Acad Nutr Diet. 2018 04; 118(4):689-704. View Abstract
Contextual factors influencing the implementation of the obstetrics hemorrhage initiative in Florida. J Perinatol. 2017 02; 37(2):150-156. View Abstract
Randomized placebo-controlled study of lovastatin in children with neurofibromatosis type 1. Neurology. 2016 Dec 13; 87(24):2575-2584. View Abstract
RhoH participates in a multi-protein complex with the zinc finger protein kaiso that regulates both cytoskeletal structures and chemokine-induced T cells. Small GTPases. 2018 05 04; 9(3):260-273. View Abstract
Detailed methods of two home-based vegetable gardening intervention trials to improve diet, physical activity, and quality of life in two different populations of cancer survivors. Contemp Clin Trials. 2016 09; 50:201-12. View Abstract
Pregnancy and Birth Outcomes among Women with Idiopathic Thrombocytopenic Purpura. J Pregnancy. 2016; 2016:8297407. View Abstract
Runx1 Phosphorylation by Src Increases Trans-activation via Augmented Stability, Reduced Histone Deacetylase (HDAC) Binding, and Increased DNA Affinity, and Activated Runx1 Favors Granulopoiesis. J Biol Chem. 2016 Jan 08; 291(2):826-36. View Abstract
Utility of Wood's light in margin determination of melanoma in situ after excisional biopsy. Dermatol Surg. 2015 May; 41(5):572-8. View Abstract
The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. Sci Signal. 2015 Apr 14; 8(372):ra34. View Abstract
Bmi1 promotes erythroid development through regulating ribosome biogenesis. Stem Cells. 2015 Mar; 33(3):925-38. View Abstract
Myeloid Proliferations Associated with Down Syndrome. J Hematop. 2015 Sep; 8(3):169-176. View Abstract
Tanning accelerators: prevalence, predictors of use, and adverse effects. J Am Acad Dermatol. 2015 Jan; 72(1):99-104. View Abstract
Sirolimus for progressive neurofibromatosis type 1-associated plexiform neurofibromas: a neurofibromatosis Clinical Trials Consortium phase II study. Neuro Oncol. 2015 Apr; 17(4):596-603. View Abstract
TMEM14C is required for erythroid mitochondrial heme metabolism. J Clin Invest. 2014 Oct; 124(10):4294-304. View Abstract
Survival analysis in patients with newly diagnosed primary glioblastoma multiforme using pre- and post-treatment peritumoral perfusion imaging parameters. J Neurooncol. 2014 Nov; 120(2):361-70. View Abstract
Surgical patterns of care in patients with invasive breast cancer treated with neoadjuvant systemic therapy and breast magnetic resonance imaging: results of a secondary analysis of TBCRC 017. Ann Surg Oncol. 2015 Jan; 22(1):75-81. View Abstract
Sirolimus for non-progressive NF1-associated plexiform neurofibromas: an NF clinical trials consortium phase II study. Pediatr Blood Cancer. 2014 Jun; 61(6):982-6. View Abstract
A phase 1 trial of oncolytic HSV-1, G207, given in combination with radiation for recurrent GBM demonstrates safety and radiographic responses. Mol Ther. 2014 May; 22(5):1048-55. View Abstract
Prognostic relevance of cytochrome C oxidase in primary glioblastoma multiforme. PLoS One. 2013; 8(4):e61035. View Abstract
Harvest for health gardening intervention feasibility study in cancer survivors. Acta Oncol. 2013 Aug; 52(6):1110-8. View Abstract
Magnetic resonance imaging as a predictor of pathologic response in patients treated with neoadjuvant systemic treatment for operable breast cancer. Translational Breast Cancer Research Consortium trial 017. Cancer. 2013 May 15; 119(10):1776-83. View Abstract
Preclinical evaluation of oncolytic d?(1)34.5 herpes simplex virus expressing interleukin-12 for therapy of breast cancer brain metastases. Int J Breast Cancer. 2012; 2012:628697. View Abstract
The effect of increasing doses of saw palmetto fruit extract on serum prostate specific antigen: analysis of the CAMUS randomized trial. J Urol. 2013 Feb; 189(2):486-92. View Abstract
Dynamin 3 and platelet size variation. Blood. 2012 Dec 06; 120(24):4666-7. View Abstract
Relationships among participant international prostate symptom score, benign prostatic hyperplasia impact index changes and global ratings of change in a trial of phytotherapy in men with lower urinary tract symptoms. J Urol. 2013 Mar; 189(3):987-92. View Abstract
A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation. Genes Dev. 2012 Jul 15; 26(14):1587-601. View Abstract
Death-defying apoptotic caspases in thrombopoiesis. Blood. 2012 May 03; 119(18):4098-9. View Abstract
Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol Cell. 2012 Feb 10; 45(3):330-43. View Abstract
Megakaryopoiesis and thrombopoiesis: an update on cytokines and lineage surface markers. Methods Mol Biol. 2012; 788:291-303. View Abstract
Effect of increasing doses of saw palmetto extract on lower urinary tract symptoms: a randomized trial. JAMA. 2011 Sep 28; 306(12):1344-51. View Abstract
Accuracy of breast magnetic resonance imaging in predicting pathologic response in patients treated with neoadjuvant chemotherapy. Clin Breast Cancer. 2011 Oct; 11(5):312-9. View Abstract
Treatment of advanced hepatocellular carcinoma with very low levels of amplitude-modulated electromagnetic fields. Br J Cancer. 2011 Aug 23; 105(5):640-8. View Abstract
Role of ZBP-89 in human globin gene regulation and erythroid differentiation. Blood. 2011 Sep 29; 118(13):3684-93. View Abstract
Gene expression analysis in radiotherapy patients and C57BL/6 mice as a measure of exposure to ionizing radiation. Radiat Res. 2011 Jul; 176(1):49-61. View Abstract
Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish transgenesis. Mol Cell Biol. 2011 Apr; 31(7):1344-56. View Abstract
A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell. 2010 Oct 15; 143(2):313-24. View Abstract
Phase II study of dose-intense chemotherapy with sequential topoisomerase-targeting regimens with irinotecan/oxaliplatin followed by etoposide/carboplatin in chemotherapy naive patients with extensive small cell lung cancer. Lung Cancer. 2011 May; 72(2):219-23. View Abstract
Rationally designed pharmacogenomic treatment using concurrent capecitabine and radiotherapy for glioblastoma; gene expression profiles associated with outcome. Clin Cancer Res. 2010 May 15; 16(10):2890-8. View Abstract
Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Mol Cell. 2009 Nov 25; 36(4):682-95. View Abstract
The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafish. Blood. 2009 Nov 19; 114(21):4654-63. View Abstract
Common features of megakaryocytes and hematopoietic stem cells: what's the connection? J Cell Biochem. 2009 Aug 01; 107(5):857-64. View Abstract
Differentiation-dependent interactions between RUNX-1 and FLI-1 during megakaryocyte development. Mol Cell Biol. 2009 Aug; 29(15):4103-15. View Abstract
Use of in vivo biotinylation to study protein-protein and protein-DNA interactions in mouse embryonic stem cells. Nat Protoc. 2009; 4(4):506-17. View Abstract
Tandem affinity purification of protein complexes in mouse embryonic stem cells using in vivo biotinylation. Curr Protoc Stem Cell Biol. 2009 Mar; Chapter 1:Unit1B.5. View Abstract
Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science. 2008 Dec 19; 322(5909):1839-42. View Abstract
Clinical efficacy and predictive molecular markers of neoadjuvant gemcitabine and pemetrexed in resectable non-small cell lung cancer. J Thorac Oncol. 2008 Oct; 3(10):1112-8. View Abstract
Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage. J Exp Med. 2008 Mar 17; 205(3):611-24. View Abstract
Identification of ZBP-89 as a novel GATA-1-associated transcription factor involved in megakaryocytic and erythroid development. Mol Cell Biol. 2008 Apr; 28(8):2675-89. View Abstract
Immune responses to guided imagery during breast cancer treatment. Biol Res Nurs. 2008 Jan; 9(3):205-14. View Abstract
Phase II trial of B7-1 (CD-86) transduced, cultured autologous tumor cell vaccine plus subcutaneous interleukin-2 for treatment of stage IV renal cell carcinoma. J Immunother. 2008 Jan; 31(1):72-80. View Abstract
Expression of TGFbeta type-II receptor in association with markers of proliferation and apoptosis in premalignant lung lesions. Cancer. 2007 Oct 01; 110(7):1527-31. View Abstract
Feasibility and efficacy of molecular analysis-directed individualized therapy in advanced non-small-cell lung cancer. J Clin Oncol. 2007 Jul 01; 25(19):2741-6. View Abstract
Friend of GATA-1-independent transcriptional repression: a novel mode of GATA-1 function. Blood. 2007 Jun 15; 109(12):5230-3. View Abstract
Loss of nuclear p21(Cip1/WAF1) during neoplastic progression to metastasis in gamma-irradiated p21 hemizygous mice. Exp Mol Pathol. 2007 Jun; 82(3):234-44. View Abstract
Improved survival in BRCA2 carriers with ovarian cancer. Fam Cancer. 2007; 6(1):113-9. View Abstract
A phase-I trial using a universal GM-CSF-producing and CD40L-expressing bystander cell line (GM.CD40L) in the formulation of autologous tumor cell-based vaccines for cancer patients with stage IV disease. Ann Surg Oncol. 2007 Feb; 14(2):869-84. View Abstract
A dosimetric analysis of unstranded seeds versus customized stranded seeds in transperineal interstitial permanent prostate seed brachytherapy. Brachytherapy. 2006 Oct-Dec; 5(4):244-50. View Abstract
Paget's disease in the era of sentinel lymph node biopsy. Am J Surg. 2006 Oct; 192(4):481-3. View Abstract
RRM1 modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small-cell lung cancer. J Clin Oncol. 2006 Oct 10; 24(29):4731-7. View Abstract
Treatment of intermediate-risk prostate cancer with brachytherapy without supplemental pelvic radiotherapy: a review of the H. Lee Moffitt Cancer Center experience. Urol Oncol. 2006 Sep-Oct; 24(5):384-90. View Abstract
Sequential oral 9-nitrocamptothecin and etoposide: a pharmacodynamic- and pharmacokinetic-based phase I trial. Mol Cancer Ther. 2006 Aug; 5(8):2130-7. View Abstract
Survival after surgical resection of isolated pulmonary metastases from malignant melanoma. Cancer Control. 2006 Jul; 13(3):218-23. View Abstract
Prospective evaluation of RRM1 as a predictor of response to gemcitabine/carboplatin (GC) in non-small cell lung cancer (NSCLC). J Clin Oncol. 2006 Jun 20; 24(18_suppl):7054. View Abstract
The benefits of a restaging PET scan after two cycles of neoadjuvant chemotherapy for resectable non-small cell lung cancer. J Clin Oncol. 2006 Jun 20; 24(18_suppl):17092. View Abstract
Fatigue is a cause of functional dependence in older cancer survivors. J Clin Oncol. 2006 Jun 20; 24(18_suppl):8538. View Abstract
beta2 Integrins are characteristically absent in acute promyelocytic leukemia and rapidly upregulated in vivo upon differentiation with all-trans retinoic acid. Leuk Res. 2007 Jan; 31(1):49-57. View Abstract
A complication-free course ensures a survival advantage in patients after regional therapy for metastatic colorectal cancer. Am Surg. 2006 Jun; 72(6):505-10. View Abstract
Survival outcomes in node-negative breast cancer patients evaluated with complete axillary node dissection versus sentinel lymph node biopsy. Ann Surg Oncol. 2006 May; 13(5):708-11. View Abstract
A global genome damage score predictive of lung cancer patients outcome. Oncogene. 2006 Jul 27; 25(32):4491-4. View Abstract
Pulmonary embolism after major abdominal surgery in gynecologic oncology. Obstet Gynecol. 2006 Mar; 107(3):666-71. View Abstract
Phase I study of the taxane BMS-188797 in combination with carboplatin administered every 3 weeks in patients with solid malignancies. Clin Cancer Res. 2006 Jan 15; 12(2):523-8. View Abstract
Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression. Clin Cancer Res. 2006 Jan 01; 12(1):20-8. View Abstract
Selective hepatic artery embolization for treatment of patients with metastatic carcinoid and pancreatic endocrine tumors. Cancer Control. 2006 Jan; 13(1):72-8. View Abstract
BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases. Cancer. 2005 Dec 15; 104(12):2807-16. View Abstract
Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancer. Clin Cancer Res. 2005 Dec 01; 11(23):8288-94. View Abstract
Burnout in clinical research coordinators in the United States. Oncol Nurs Forum. 2005 Nov 03; 32(6):1123-30. View Abstract
Phase II study of neoadjuvant chemotherapy with gemcitabine and vinorelbine in resectable non-small cell lung cancer. Chest. 2005 Nov; 128(5):3467-74. View Abstract
Treatment decision-making strategies and influences in patients with localized prostate carcinoma. Cancer. 2005 Oct 01; 104(7):1381-90. View Abstract
Prediction of radiation sensitivity using a gene expression classifier. Cancer Res. 2005 Aug 15; 65(16):7169-76. View Abstract
The efficacy and safety of pain management before and after implementation of hospital-wide pain management standards: is patient safety compromised by treatment based solely on numerical pain ratings? Anesth Analg. 2005 Aug; 101(2):474-480. View Abstract
Diagnosing pulmonary embolism: experience with spiral CT pulmonary angiography in gynecologic oncology. Gynecol Oncol. 2005 Aug; 98(2):289-93. View Abstract
A case-control study evaluating the association of purposeful physical activity, body fat distribution, and steroid hormones on premenopausal breast cancer risk. Breast J. 2005 Jul-Aug; 11(4):266-72. View Abstract
GATA transcription factors in hematologic disease. Int J Hematol. 2005 Jun; 81(5):378-84. View Abstract
Phase I/II study of atrasentan (A) in combination with carboplatin (C) and paclitaxel (P) in chemonaive patients (pts) with advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2005 Jun; 23(16_suppl):7105. View Abstract
Small tumor size and limited smoking history predicts activated EGFR-Stat3 in early stage non-small cell lung cancer. J Clin Oncol. 2005 Jun; 23(16_suppl):7075. View Abstract
Phase II study of induction chemotherapy with gemcitabine and carboplatin (IndGC) followed by paclitaxel and carboplatin with concurrent thoracic radiation (PCRT) for patients with unresectable stage III non-small-cell lung cancer (NSCLC): MCC-13240. J Clin Oncol. 2005 Jun; 23(16_suppl):7307. View Abstract
Phase II study of neoadjuvant chemotherapy with gemicitabine and pemetrexed (NeoGP) in resectable non-small-cell lung cancer (NSCLC): MCC 13726. J Clin Oncol. 2005 Jun; 23(16_suppl):7314. View Abstract
Phase II study of neoadjuvant chemotherapy with gemcitabine and vinorelbine in resectable non-small-cell lung cancer (NSCLC). J Clin Oncol. 2005 Jun; 23(16_suppl):7277. View Abstract
Influence of concomitant medications on toxicity from chemotherapy in elderly patients. Focus on cytochrome P-450 inhibition and protein binding effects. J Clin Oncol. 2005 Jun; 23(16_suppl):8025. View Abstract
Global genome damage is predictive of cancer patients' outcome. J Clin Oncol. 2005 Jun; 23(16_suppl):9542. View Abstract
The incidence of pulmonary embolism after gynecologic oncologic surgery. J Clin Oncol. 2005 Jun; 23(16_suppl):5089. View Abstract
Molecular staging for survival prediction of colorectal cancer patients. J Clin Oncol. 2005 May 20; 23(15):3526-35. View Abstract
Differences in Smad4 expression in human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck squamous cell carcinoma. Clin Cancer Res. 2005 May 01; 11(9):3191-7. View Abstract
EGR1 predicts PTEN and survival in patients with non-small-cell lung cancer. J Clin Oncol. 2005 Mar 20; 23(9):1921-6. View Abstract
ERCC1 expression is a predictor of survival in resected patients with non-small cell lung cancer. Chest. 2005 Mar; 127(3):978-83. View Abstract
Accuracy of intraoperative imprint cytology for sentinel lymph node evaluation in the treatment of breast carcinoma. Cancer. 2005 Feb 25; 105(1):13-20. View Abstract
Evaluation of new treatments in radiation oncology: are they better than standard treatments? JAMA. 2005 Feb 23; 293(8):970-8. View Abstract
Ribonucleotide reductase M1 gene promoter activity, polymorphisms, population frequencies, and clinical relevance. Lung Cancer. 2005 Feb; 47(2):183-92. View Abstract
103Pd brachytherapy versus radical prostatectomy in patients with clinically localized prostate cancer: a 12-year experience from a single group practice. Brachytherapy. 2005; 4(1):34-44. View Abstract
Coregulation of GATA factors by the Friend of GATA (FOG) family of multitype zinc finger proteins. Semin Cell Dev Biol. 2005 Feb; 16(1):117-28. View Abstract
Efficacy and cost-effectiveness of a minimal intervention to prevent smoking relapse: dismantling the effects of amount of content versus contact. J Consult Clin Psychol. 2004 Oct; 72(5):797-808. View Abstract
Improved survival in never-smokers vs current smokers with primary adenocarcinoma of the lung. Chest. 2004 Aug; 126(2):347-51. View Abstract
Validation of RRM1 and PTEN as prognostic parameters of outcome in non-small cell lung cancer. J Clin Oncol. 2004 Jul 15; 22(14_suppl):7154. View Abstract
Predictive utility of RRM1 promoter polymorphisms on outcome of patients with non-small cell lung cancer. J Clin Oncol. 2004 Jul 15; 22(14_suppl):7155. View Abstract
Lysophospholipids are potential biomarkers of ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2004 Jul; 13(7):1185-91. View Abstract
A randomized controlled trial to increase cancer screening among attendees of community health centers. Ann Fam Med. 2004 Jul-Aug; 2(4):294-300. View Abstract
RRM1 and PTEN as prognostic parameters for overall and disease-free survival in patients with non-small-cell lung cancer. J Clin Oncol. 2004 May 15; 22(10):1878-85. View Abstract
Colorectal cancer screening among a sample of community health center attendees. J Health Care Poor Underserved. 2004 May; 15(2):281-93. View Abstract
The specific role of isoflavones in reducing prostate cancer risk. Prostate. 2004 May 01; 59(2):141-7. View Abstract
A multi-institutional study of orthotopic neobladders: functional results in men and women. BJU Int. 2004 Apr; 93(6):803-6. View Abstract
Role of p53, CD44V6 and CD57 in differentiating between benign and malignant follicular neoplasms of the thyroid. In Vivo. 2004 Mar-Apr; 18(2):189-95. View Abstract
Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma. Blood. 2004 May 01; 103(9):3271-7. View Abstract
Coregulator-dependent facilitation of chromatin occupancy by GATA-1. Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4):980-5. View Abstract
Fatigue, weight gain, lethargy and amenorrhea in breast cancer patients on chemotherapy: is subclinical hypothyroidism the culprit? Breast Cancer Res Treat. 2004 Jan; 83(2):149-59. View Abstract
Osteopontin identified as colon cancer tumor progression marker. C R Biol. 2003 Oct-Nov; 326(10-11):1041-3. View Abstract
The importance of preservation of the ethical principle of equipoise in the design of clinical trials: relative impact of the methodological quality domains on the treatment effect in randomized controlled trials. Account Res. 2003 Oct-Dec; 10(4):301-15. View Abstract
The therapeutic effects of epidural intercellular adhesion molecule-1 monoclonal antibody in a rabbit model: involvement of the intercellular adhesion molecule-1 pathway in spinal cord ischemia. Anesth Analg. 2003 Sep; 97(3):857-862. View Abstract
Comparative outcomes analysis of procedures performed in physician offices and ambulatory surgery centers. Arch Surg. 2003 Sep; 138(9):991-5. View Abstract
GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/erythrocyte lineages. Immunity. 2003 Sep; 19(3):451-62. View Abstract
Gefitinib (ZD1839) in previously treated advanced non-small-cell lung cancer: experience from a single institution. Cancer Control. 2003 Sep-Oct; 10(5):388-95. View Abstract
Are older French patients as willing as older American patients to undertake chemotherapy? J Clin Oncol. 2003 Sep 01; 21(17):3214-9. View Abstract
p21Cip1 nullizygosity increases tumor metastasis in irradiated mice. Cancer Res. 2003 Jun 15; 63(12):3021-5. View Abstract
Discovery of distinct protein profiles specific for lung tumors and pre-malignant lung lesions by SELDI mass spectrometry. Lung Cancer. 2003 Jun; 40(3):267-79. View Abstract
Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res. 2003 Mar 15; 63(6):1270-9. View Abstract
Can older cancer patients tolerate chemotherapy? A prospective pilot study. Cancer. 2003 Feb 15; 97(4):1107-14. View Abstract
Loss of the cell cycle inhibitors p21(Cip1) and p27(Kip1) enhances tumorigenesis in knockout mouse models. Oncogene. 2002 Dec 05; 21(55):8486-97. View Abstract
Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. Cancer Res. 2002 Nov 15; 62(22):6659-66. View Abstract
Completion axillary lymph node dissection minimizes the likelihood of false negatives for patients with invasive breast carcinoma and cytokeratin positive only sentinel lymph nodes. Am J Surg. 2002 Oct; 184(4):302-6. View Abstract
Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection. Int J Cancer. 2002 Sep 10; 101(2):151-5. View Abstract
Indirect economic effects of long-term breast cancer survival. Cancer Pract. 2002 Sep-Oct; 10(5):248-55. View Abstract
Predictors of tolerance to chemotherapy in older cancer patients: a prospective pilot study. Eur J Cancer. 2002 Jul; 38(11):1466-73. View Abstract
GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis. Proc Natl Acad Sci U S A. 2002 Jul 09; 99(14):9237-42. View Abstract
Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J Exp Med. 2002 Jun 03; 195(11):1387-95. View Abstract
Brachytherapy versus radical prostatectomy in patients with clinically localized prostate cancer. Curr Urol Rep. 2002 Jun; 3(3):250-7. View Abstract
Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturation. Mol Cell Biol. 2002 Jun; 22(12):4268-79. View Abstract
Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene. 2002 May 13; 21(21):3368-76. View Abstract
Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo. Mol Cell Biol. 2002 May; 22(9):3121-8. View Abstract
Phase I trial of a B7-1 (CD80) gene modified autologous tumor cell vaccine in combination with systemic interleukin-2 in patients with metastatic renal cell carcinoma. J Urol. 2002 May; 167(5):1995-2000. View Abstract
Osteopontin identified as lead marker of colon cancer progression, using pooled sample expression profiling. J Natl Cancer Inst. 2002 Apr 03; 94(7):513-21. View Abstract
Fatal disseminated Candida lusitaniae infection in an infant with chronic granulomatous disease. Pediatr Infect Dis J. 2002 Mar; 21(3):262-4. View Abstract
Age and body mass index may increase the chance of failure in sentinel lymph node biopsy for women with breast cancer. Breast J. 2002 Mar-Apr; 8(2):88-91. View Abstract
The specific role of isoflavones on estrogen metabolism in premenopausal women. Cancer. 2002 Feb 15; 94(4):1166-74. View Abstract
Expression of early lung cancer detection marker: hnRNP-A2/B1 and its relation to microsatellite alteration in non-small cell lung cancer. Lung Cancer. 2001 Dec; 34(3):341-50. View Abstract
Learning curves for breast cancer sentinel lymph node mapping based on surgical volume analysis. J Am Coll Surg. 2001 Dec; 193(6):593-600. View Abstract
The relationship between age and the fatty acid composition of cerebral cortex and erythrocytes in human subjects. Brain Res Bull. 2001 Sep 15; 56(2):79-85. View Abstract
Projecting the standard error of the Kaplan-Meier estimator. Stat Med. 2001 Jul 30; 20(14):2091-7. View Abstract
Effect of fractionated regional external beam radiotherapy on peripheral blood cell count. Int J Radiat Oncol Biol Phys. 2001 Jun 01; 50(2):465-72. View Abstract
Characteristics of the sentinel lymph node in breast cancer predict further involvement of higher-echelon nodes in the axilla: a study to evaluate the need for complete axillary lymph node dissection. Arch Surg. 2001 Jun; 136(6):688-92. View Abstract
Importance of lymphatic mapping in ductal carcinoma in situ (DCIS): why map DCIS? Am Surg. 2001 Jun; 67(6):513-9; discussion 519-21. View Abstract
Sentinel lymph node micrometastasis and other histologic factors that predict outcome in patients with thicker melanomas. J Am Acad Dermatol. 2001 May; 44(5):762-6. View Abstract
Learning curves and breast cancer lymphatic mapping: institutional volume index. J Surg Res. 2001 May 01; 97(1):92-6. View Abstract
Does prosthetic covering of nitinol stents alter healing characteristics or hemodynamics? J Endovasc Ther. 2000 Dec; 7(6):469-78. View Abstract
Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model. Oncogene. 2000 Nov 09; 19(47):5338-47. View Abstract
Risk factors associated with hypothyroidism after laryngectomy. Otolaryngol Head Neck Surg. 2000 Sep; 123(3):211-7. View Abstract
The uncertainty principle and industry-sponsored research. Lancet. 2000 Aug 19; 356(9230):635-8. View Abstract
Prognostic factors in malignant gastrointestinal stromal tumors. Ann Clin Lab Sci. 2000 Jul; 30(3):239-47. View Abstract
Android obesity at diagnosis and breast carcinoma survival: Evaluation of the effects of anthropometric variables at diagnosis, including body composition and body fat distribution and weight gain during life span,and survival from breast carcinoma. Cancer. 2000 Jun 15; 88(12):2751-7. View Abstract
Do cytokeratin-positive-only sentinel lymph nodes warrant complete axillary lymph node dissection in patients with invasive breast cancer? Am Surg. 2000 Jun; 66(6):574-8. View Abstract
Evolution of techniques for ultrasound-guided palladium 103 brachytherapy in 950 patients with prostate cancer. Tech Urol. 2000 Jun; 6(2):128-34. View Abstract
Clonal variability in CD95 expression is the major determinant in Fas-medicated, but not chemotherapy-medicated apoptosis in the RPMI 8226 multiple myeloma cell line. Leukemia. 2000 May; 14(5):830-40. View Abstract
Minimally invasive treatment for localized adenocarcinoma of the prostate: review of 1048 patients treated with ultrasound-guided palladium-103 brachytherapy. J Endourol. 2000 May; 14(4):343-50. View Abstract
Differential diagnosis of endometrial hyperplasia and carcinoma by computerized image cytometry of cell proliferation, apoptosis and Bcl-2 expression. Ann Clin Lab Sci. 1999 Oct-Dec; 29(4):308-15. View Abstract
Lymphatic mapping and sentinel lymph node biopsy in patients with melanoma of the lower extremity. Plast Reconstr Surg. 1999 Sep; 104(4):964-9. View Abstract
Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene. Development. 1999 Jun; 126(12):2799-811. View Abstract
Predictability of PSA failure in prostate cancer by computerized cytometric assessment of tumoral cell proliferation. Urology. 1999 May; 53(5):931-8. View Abstract
FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped. Proc Natl Acad Sci U S A. 1999 Feb 02; 96(3):950-5. View Abstract
Surgical and endovascular intervention for infrainguinal vein graft stenosis. J Vasc Surg. 1999 Jan; 29(1):60-70; discussion 70-1. View Abstract
Ischemia detection in women: the diagnostic value of exercise QRS duration changes. J Electrocardiol. 1998 Oct; 31(4):271-7. View Abstract
Review and evaluation of MRI nonuniformity corrections for brain tumor response measurements. Med Phys. 1998 Sep; 25(9):1655-66. View Abstract
Development of a head and neck companion module for the quality of life-radiation therapy instrument (QOL-RTI) Int J Radiat Oncol Biol Phys. 1998 Sep 01; 42(2):257-61. View Abstract
CD44V6 expression in human colorectal carcinoma. Hum Pathol. 1998 Jun; 29(6):627-35. View Abstract
Efficacy of hyperthermic isolated limb perfusion for extremity-confined recurrent melanoma. Ann Surg Oncol. 1998 Jun; 5(4):376-83. View Abstract
Outpatient ultrasound-guided palladium 103 brachytherapy for localized adenocarcinoma of the prostate: a preliminary report of 434 patients. Urology. 1998 May; 51(5):796-803. View Abstract
Treatment of unresectable or metastatic pediatric soft tissue sarcomas with surgery, irradiation, and chemotherapy: a Pediatric Oncology Group study. Med Pediatr Oncol. 1998 Apr; 30(4):201-9. View Abstract
Postoperative accelerated radiotherapy in high-risk squamous cell carcinoma of the head and neck: long-term results of a prospective trial. Head Neck. 1998 Mar; 20(2):119-23. View Abstract
Ischemia detection after myocardial infarction: diagnostic value of exercise-induced QRS duration changes evaluated by a new computerized method. J Electrocardiol. 1998 Jan; 31(1):9-15. View Abstract
QRS prolongation measured by a new computerized method: a sensitive marker for detecting exercise-induced ischemia. Cardiology. 1997 Sep-Oct; 88(5):446-52. View Abstract
Randomized study of intensive MOPP-ABVD with or without low-dose total-nodal radiation therapy in the treatment of stages IIB, IIIA2, IIIB, and IV Hodgkin's disease in pediatric patients: a Pediatric Oncology Group study. J Clin Oncol. 1997 Aug; 15(8):2769-79. View Abstract
Weight gain associated with adjuvant tamoxifen therapy in stage I and II breast cancer: fact or artifact? Breast Cancer Res Treat. 1997 Jun; 44(2):135-43. View Abstract
Bilaterality and recurrence rates for lobular breast cancer: considerations for treatment. Ann Surg Oncol. 1997 Apr-May; 4(3):198-202. View Abstract
Amphotericin B colloidal dispersion vs. amphotericin B as therapy for invasive aspergillosis. Clin Infect Dis. 1997 Apr; 24(4):635-42. View Abstract
Genetic staging of unresectable or metastatic neuroblastoma in infants: a Pediatric Oncology Group study. J Natl Cancer Inst. 1997 Mar 05; 89(5):373-80. View Abstract
Spot urine osmolality, age and bladder capacity as predictors of response to desmopressin in nocturnal enuresis. Scand J Urol Nephrol Suppl. 1997; 183:41-5. View Abstract
Multiple primary melanomas: implications for screening and follow-up programs for melanoma. Ann Surg Oncol. 1997 Jan; 4(1):19-23. View Abstract
Chemotherapy for patients with recurrent or refractory neuroblastoma: a POG Phase II study. J Pediatr Hematol Oncol. 1997 Jan-Feb; 19(1):62-7. View Abstract
Lymphatic mapping and sentinel node biopsy in the patient with breast cancer. JAMA. 1996 Dec 11; 276(22):1818-22. View Abstract
Peptide amidating activity in human bronchoalveolar lavage fluid. Lung Cancer. 1996 Jun; 14(2-3):239-51. View Abstract
Modified histologic grading of neuroblastomas by replacement of mitotic rate with mitosis karyorrhexis index. A clinicopathologic study of 223 cases from the Pediatric Oncology Group. Cancer. 1996 Apr 15; 77(8):1582-8. View Abstract
Power calculation for the log rank test using historical data. Control Clin Trials. 1996 Apr; 17(2):111-6. View Abstract
Age and family relationship accentuate the risk of insulin-dependent diabetes mellitus (IDDM) in relatives of patients with IDDM. J Clin Endocrinol Metab. 1995 Dec; 80(12):3739-43. View Abstract
Tumor biology of infiltrating lobular carcinoma. Implications for management. Ann Surg. 1995 Oct; 222(4):549-59; discussion 559-61. View Abstract
Nonrhabdomyosarcomatous soft tissue sarcomas of childhood: formulation of a simplified system for grading. Mod Pathol. 1995 Sep; 8(7):705-10. View Abstract
A test of the association of a time-dependent state variable to survival. Comput Methods Programs Biomed. 1995 Feb; 46(2):101-5. View Abstract
Treatment of osteosarcoma with ifosfamide: comparison of response in pediatric patients with recurrent disease versus patients previously untreated: a Pediatric Oncology Group study. Med Pediatr Oncol. 1995 Feb; 24(2):87-92. View Abstract
Phase II investigational window using carboplatin, iproplatin, ifosfamide, and epirubicin in children with untreated disseminated neuroblastoma: a Pediatric Oncology Group study. J Clin Oncol. 1994 Aug; 12(8):1616-20. View Abstract
The role of prognostic factors in treatment selection for early-stage Hodgkin's disease. Am J Clin Oncol. 1994 Jun; 17(3):189-95. View Abstract
A modified isometric test to evaluate blood pressure control with once-daily slow-release verapamil. S Afr Med J. 1993 Nov; 83(11):840-2. View Abstract
Correlation between morphologic and other prognostic markers of neuroblastoma. A study of histologic grade, DNA index, N-myc gene copy number, and lactic dehydrogenase in patients in the Pediatric Oncology Group. Cancer. 1993 May 15; 71(10):3173-81. View Abstract
Association between high levels of expression of the TRK gene and favorable outcome in human neuroblastoma. N Engl J Med. 1993 Mar 25; 328(12):847-54. View Abstract
Cisplatin, vincristine, and fluorouracil therapy for hepatoblastoma: a Pediatric Oncology Group study. J Clin Oncol. 1993 Jan; 11(1):96-9. View Abstract
Lysosomal enzyme phosphorylation. II. Protein recognition determinants in either lobe of procathepsin D are sufficient for phosphorylation of both the amino and carboxyl lobe oligosaccharides. J Biol Chem. 1992 Nov 15; 267(32):23349-56. View Abstract
Lysosomal enzyme phosphorylation. I. Protein recognition determinants in both lobes of procathepsin D mediate its interaction with UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase. J Biol Chem. 1992 Nov 15; 267(32):23342-8. View Abstract
Phosphorylation of Asn-linked oligosaccharides located at novel sites on the lysosomal enzyme cathepsin D. J Biol Chem. 1992 Nov 15; 267(32):23357-63. View Abstract
A method for [3H]mannose labeling of Asn-linked oligosaccharides on recombinant glycoproteins synthesized in Xenopus oocytes. Anal Biochem. 1992 Sep; 205(2):220-6. View Abstract
Recommendations for modification of terminology of neuroblastic tumors and prognostic significance of Shimada classification. A clinicopathologic study of 213 cases from the Pediatric Oncology Group. Cancer. 1992 Apr 15; 69(8):2183-96. View Abstract
Age-linked prognostic categorization based on a new histologic grading system of neuroblastomas. A clinicopathologic study of 211 cases from the Pediatric Oncology Group. Cancer. 1992 Apr 15; 69(8):2197-211. View Abstract
Loss of heterozygosity for chromosomes 1 or 14 defines subsets of advanced neuroblastomas. Cancer Res. 1992 Apr 01; 52(7):1780-5. View Abstract
Gallium-67 scans as an adjunct to computed tomography scans for the assessment of a residual mediastinal mass in pediatric patients with Hodgkin's disease. A Pediatric Oncology Group study. Cancer. 1991 Dec 01; 68(11):2478-80. View Abstract
CD5+ B lymphocytes in high-risk islet cell antibody-positive and newly diagnosed IDDM subjects. Diabetes. 1991 Oct; 40(10):1314-8. View Abstract
Intensive chemotherapy and low-dose radiotherapy for the treatment of advanced-stage Hodgkin's disease in pediatric patients: a Pediatric Oncology Group study. J Clin Oncol. 1991 Sep; 9(9):1591-8. View Abstract
The prognostic significance of autologous bone marrow transplant in advanced neuroblastoma. J Clin Oncol. 1991 Jun; 9(6):1045-9. View Abstract
Comparative effectiveness of two combined modality regimens in the treatment of surgical stage III Hodgkin's disease in children. An 8-year follow-up study by the Pediatric Oncology Group. Am J Pediatr Hematol Oncol. 1991; 13(4):450-8. View Abstract
Widowhood, sexuality and aging: a life span analysis. J Sex Marital Ther. 1988; 14(1):49-62. View Abstract
Recognition site directing vitamin K-dependent gamma-carboxylation resides on the propeptide of factor IX. Cell. 1987 Jan 30; 48(2):185-91. View Abstract
The course of pregnancy in patients with artificial heart valves treated with dipyridamole. Int J Gynaecol Obstet. 1980 Sep-Oct; 18(2):128-32. View Abstract
The Coagulation and Sterilization of Culture Media. J Bacteriol. 1943 Aug; 46(2):203-4. View Abstract
A Microscopic Alkali-Solubility Test for the Identification of Gonococcus Colonies. J Bacteriol. 1942 Aug; 44(2):237-40. View Abstract