Research Overview

Alan Cantor's laboratory is focused on further elucidating the transcriptional mechanisms that regulate normal hematopoiesis and understanding how they are perturbed in certain inherited blood disorders and hematologic malignancies. They are also interested in understanding the mechanisms that regulate human developmental globin gene switching and applying this knowledge to the treatment of beta-hemoglobinopathies such as sickle cell anemia and beta-thalassemia. Cantor and colleagues are specifically interested in the role of GATA, FOG, RUNX and ETS family transcription factors and their association with epigenetic regulators and cell-signaling molecules. The Cantor laboratory is currently taking a number of approaches to these studies. These include: (1) proteomic techniques to isolate and characterize multiprotein complexes involving these factors; (2) chromatin immunoprecipitation coupled to high throughput DNA sequencing (ChIP-seq) to identify sites occupied by these transcription factors across the genome; (3) gene targeting in mice; (4) shRNA-mediated gene knock down in primary human CD34+-derived cells; (5) analysis of patient derived induced pluripotent (iPS) stem cells; and (6) whole exome sequencing and genetic linkage studies of families with inherited thrombocytopenia and predisposition to leukemia.

Research Background

Alan Cantor is a graduate of Washington University Medical School. He completed an internship and residency at St. Louis Children's Hospital and a postgraduate fellowship at Boston Children's Hospital and Dana-Farber Cancer Institute.

Education

Undergraduate School

Cornell University
Ithaca NY

Graduate School

PhD Washington University School of Medicine
St. Louis MO

Medical School

Washington University School of Medicine
St. Louis MO

Internship

St. Louis Children's Hospital
St. Louis MO

Residency

St. Louis Children's Hospital
St. Louis MO

Fellowship

Pediatric Hematology-Oncology Boston Children's Hospital/Dana-Farber Cancer Institute
Boston MA

Publications

  1. Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in RUNX1, GATA2, and DDX41. Blood Adv. 2023 10 24; 7(20):6092-6107. View Abstract
  2. Transient neonatal hemolytic anemia due to the novel gamma globin gene mutation HBG2:C.290T>C, p.Leu97Pro (hemoglobin Wareham). Pediatr Blood Cancer. 2023 01; 70(1):e30067. View Abstract
  3. Germline GATA1s-generating mutations predispose to leukemia with acquired trisomy 21 and Down syndrome-like phenotype. Blood. 2022 05 26; 139(21):3159-3165. View Abstract
  4. Opening the window for endothelial-to-hematopoietic transition. Genes Dev. 2021 11 01; 35(21-22):1398-1400. View Abstract
  5. The RUNX1 database (RUNX1db): establishment of an expert curated RUNX1 registry and genomics database as a public resource for familial platelet disorder with myeloid malignancy. Haematologica. 2021 11 01; 106(11):3004-3007. View Abstract
  6. B-cell acute lymphoblastic leukemia in patients with germline RUNX1 mutations. Blood Adv. 2021 08 24; 5(16):3199-3202. View Abstract
  7. Familial thrombocytopenia due to a complex structural variant resulting in a WAC-ANKRD26 fusion transcript. J Exp Med. 2021 06 07; 218(6). View Abstract
  8. Profound intravascular hemolysis due to clostridial sepsis in an infant with necrotizing enterocolitis. Blood. 2021 04 22; 137(16):2273. View Abstract
  9. Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits. Nat Genet. 2020 12; 52(12):1333-1345. View Abstract
  10. A phase II study of continuous oral mTOR inhibitor everolimus for recurrent, radiographic-progressive neurofibromatosis type 1-associated pediatric low-grade glioma: a Neurofibromatosis Clinical Trials Consortium study. Neuro Oncol. 2020 10 14; 22(10):1527-1535. View Abstract
  11. CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23626-23635. View Abstract
  12. Infantile Myelofibrosis and Myeloproliferation with CDC42 Dysfunction. J Clin Immunol. 2020 05; 40(4):554-566. View Abstract
  13. Role of RUNX Family Transcription Factors in DNA Damage Response. Mol Cells. 2020 Feb 29; 43(2):99-106. View Abstract
  14. Reproducibility of cognitive endpoints in clinical trials: lessons from neurofibromatosis type 1. Ann Clin Transl Neurol. 2019 12; 6(12):2555-2565. View Abstract
  15. Zfp281 (ZBP-99) plays a functionally redundant role with Zfp148 (ZBP-89) during erythroid development. Blood Adv. 2019 08 27; 3(16):2499-2511. View Abstract
  16. Bone Marrow Morphology Associated With Germline RUNX1 Mutations in Patients With Familial Platelet Disorder With Associated Myeloid Malignancy. Pediatr Dev Pathol. 2019 Jul-Aug; 22(4):315-328. View Abstract
  17. A home-based mentored vegetable gardening intervention demonstrates feasibility and improvements in physical activity and performance among breast cancer survivors. Cancer. 2018 08; 124(16):3427-3435. View Abstract
  18. Pilot Randomized Controlled Trial of a Home Vegetable Gardening Intervention among Older Cancer Survivors Shows Feasibility, Satisfaction, and Promise in Improving Vegetable and Fruit Consumption, Reassurance of Worth, and the Trajectory of Central Adiposity. J Acad Nutr Diet. 2018 04; 118(4):689-704. View Abstract
  19. Choosing wisely: RUNX1 alternate promoter use. Blood. 2017 07 20; 130(3):236-237. View Abstract
  20. Erythropoietin signaling regulates heme biosynthesis. Elife. 2017 05 29; 6. View Abstract
  21. Contextual factors influencing the implementation of the obstetrics hemorrhage initiative in Florida. J Perinatol. 2017 02; 37(2):150-156. View Abstract
  22. Randomized placebo-controlled study of lovastatin in children with neurofibromatosis type 1. Neurology. 2016 Dec 13; 87(24):2575-2584. View Abstract
  23. RhoH participates in a multi-protein complex with the zinc finger protein kaiso that regulates both cytoskeletal structures and chemokine-induced T cells. Small GTPases. 2018 05 04; 9(3):260-273. View Abstract
  24. Detailed methods of two home-based vegetable gardening intervention trials to improve diet, physical activity, and quality of life in two different populations of cancer survivors. Contemp Clin Trials. 2016 09; 50:201-12. View Abstract
  25. Pregnancy and Birth Outcomes among Women with Idiopathic Thrombocytopenic Purpura. J Pregnancy. 2016; 2016:8297407. View Abstract
  26. Runx1 Phosphorylation by Src Increases Trans-activation via Augmented Stability, Reduced Histone Deacetylase (HDAC) Binding, and Increased DNA Affinity, and Activated Runx1 Favors Granulopoiesis. J Biol Chem. 2016 Jan 08; 291(2):826-36. View Abstract
  27. Utility of Wood's light in margin determination of melanoma in situ after excisional biopsy. Dermatol Surg. 2015 May; 41(5):572-8. View Abstract
  28. The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. Sci Signal. 2015 Apr 14; 8(372):ra34. View Abstract
  29. Bmi1 promotes erythroid development through regulating ribosome biogenesis. Stem Cells. 2015 Mar; 33(3):925-38. View Abstract
  30. Myeloid Proliferations Associated with Down Syndrome. J Hematop. 2015 Sep; 8(3):169-176. View Abstract
  31. Tanning accelerators: prevalence, predictors of use, and adverse effects. J Am Acad Dermatol. 2015 Jan; 72(1):99-104. View Abstract
  32. Sirolimus for progressive neurofibromatosis type 1-associated plexiform neurofibromas: a neurofibromatosis Clinical Trials Consortium phase II study. Neuro Oncol. 2015 Apr; 17(4):596-603. View Abstract
  33. TMEM14C is required for erythroid mitochondrial heme metabolism. J Clin Invest. 2014 Oct; 124(10):4294-304. View Abstract
  34. Survival analysis in patients with newly diagnosed primary glioblastoma multiforme using pre- and post-treatment peritumoral perfusion imaging parameters. J Neurooncol. 2014 Nov; 120(2):361-70. View Abstract
  35. Surgical patterns of care in patients with invasive breast cancer treated with neoadjuvant systemic therapy and breast magnetic resonance imaging: results of a secondary analysis of TBCRC 017. Ann Surg Oncol. 2015 Jan; 22(1):75-81. View Abstract
  36. Sirolimus for non-progressive NF1-associated plexiform neurofibromas: an NF clinical trials consortium phase II study. Pediatr Blood Cancer. 2014 Jun; 61(6):982-6. View Abstract
  37. A phase 1 trial of oncolytic HSV-1, G207, given in combination with radiation for recurrent GBM demonstrates safety and radiographic responses. Mol Ther. 2014 May; 22(5):1048-55. View Abstract
  38. Developmental differences in IFN signaling affect GATA1s-induced megakaryocyte hyperproliferation. J Clin Invest. 2013 Jul 01. View Abstract
  39. Prognostic relevance of cytochrome C oxidase in primary glioblastoma multiforme. PLoS One. 2013; 8(4):e61035. View Abstract
  40. Harvest for health gardening intervention feasibility study in cancer survivors. Acta Oncol. 2013 Aug; 52(6):1110-8. View Abstract
  41. Magnetic resonance imaging as a predictor of pathologic response in patients treated with neoadjuvant systemic treatment for operable breast cancer. Translational Breast Cancer Research Consortium trial 017. Cancer. 2013 May 15; 119(10):1776-83. View Abstract
  42. Preclinical evaluation of oncolytic d?(1)34.5 herpes simplex virus expressing interleukin-12 for therapy of breast cancer brain metastases. Int J Breast Cancer. 2012; 2012:628697. View Abstract
  43. The effect of increasing doses of saw palmetto fruit extract on serum prostate specific antigen: analysis of the CAMUS randomized trial. J Urol. 2013 Feb; 189(2):486-92. View Abstract
  44. Dynamin 3 and platelet size variation. Blood. 2012 Dec 06; 120(24):4666-7. View Abstract
  45. Relationships among participant international prostate symptom score, benign prostatic hyperplasia impact index changes and global ratings of change in a trial of phytotherapy in men with lower urinary tract symptoms. J Urol. 2013 Mar; 189(3):987-92. View Abstract
  46. A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation. Genes Dev. 2012 Jul 15; 26(14):1587-601. View Abstract
  47. Death-defying apoptotic caspases in thrombopoiesis. Blood. 2012 May 03; 119(18):4098-9. View Abstract
  48. Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol Cell. 2012 Feb 10; 45(3):330-43. View Abstract
  49. Megakaryopoiesis and thrombopoiesis: an update on cytokines and lineage surface markers. Methods Mol Biol. 2012; 788:291-303. View Abstract
  50. Effect of increasing doses of saw palmetto extract on lower urinary tract symptoms: a randomized trial. JAMA. 2011 Sep 28; 306(12):1344-51. View Abstract
  51. Accuracy of breast magnetic resonance imaging in predicting pathologic response in patients treated with neoadjuvant chemotherapy. Clin Breast Cancer. 2011 Oct; 11(5):312-9. View Abstract
  52. Treatment of advanced hepatocellular carcinoma with very low levels of amplitude-modulated electromagnetic fields. Br J Cancer. 2011 Aug 23; 105(5):640-8. View Abstract
  53. Role of ZBP-89 in human globin gene regulation and erythroid differentiation. Blood. 2011 Sep 29; 118(13):3684-93. View Abstract
  54. Gene expression analysis in radiotherapy patients and C57BL/6 mice as a measure of exposure to ionizing radiation. Radiat Res. 2011 Jul; 176(1):49-61. View Abstract
  55. Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish transgenesis. Mol Cell Biol. 2011 Apr; 31(7):1344-56. View Abstract
  56. A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell. 2010 Oct 15; 143(2):313-24. View Abstract
  57. Phase II study of dose-intense chemotherapy with sequential topoisomerase-targeting regimens with irinotecan/oxaliplatin followed by etoposide/carboplatin in chemotherapy naive patients with extensive small cell lung cancer. Lung Cancer. 2011 May; 72(2):219-23. View Abstract
  58. TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell. 2010 Jul 09; 142(1):133-43. View Abstract
  59. Rationally designed pharmacogenomic treatment using concurrent capecitabine and radiotherapy for glioblastoma; gene expression profiles associated with outcome. Clin Cancer Res. 2010 May 15; 16(10):2890-8. View Abstract
  60. Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Mol Cell. 2009 Nov 25; 36(4):682-95. View Abstract
  61. The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafish. Blood. 2009 Nov 19; 114(21):4654-63. View Abstract
  62. Common features of megakaryocytes and hematopoietic stem cells: what's the connection? J Cell Biochem. 2009 Aug 01; 107(5):857-64. View Abstract
  63. Differentiation-dependent interactions between RUNX-1 and FLI-1 during megakaryocyte development. Mol Cell Biol. 2009 Aug; 29(15):4103-15. View Abstract
  64. Use of in vivo biotinylation to study protein-protein and protein-DNA interactions in mouse embryonic stem cells. Nat Protoc. 2009; 4(4):506-17. View Abstract
  65. Tandem affinity purification of protein complexes in mouse embryonic stem cells using in vivo biotinylation. Curr Protoc Stem Cell Biol. 2009 Mar; Chapter 1:Unit1B.5. View Abstract
  66. Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science. 2008 Dec 19; 322(5909):1839-42. View Abstract
  67. TLX1 (HOX11) immortalization of embryonic stem cell-derived and primary murine hematopoietic progenitors. Curr Protoc Stem Cell Biol. 2008 Dec; Chapter 1:Unit 1F.7. View Abstract
  68. Clinical efficacy and predictive molecular markers of neoadjuvant gemcitabine and pemetrexed in resectable non-small cell lung cancer. J Thorac Oncol. 2008 Oct; 3(10):1112-8. View Abstract
  69. Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage. J Exp Med. 2008 Mar 17; 205(3):611-24. View Abstract
  70. Identification of ZBP-89 as a novel GATA-1-associated transcription factor involved in megakaryocytic and erythroid development. Mol Cell Biol. 2008 Apr; 28(8):2675-89. View Abstract
  71. Immune responses to guided imagery during breast cancer treatment. Biol Res Nurs. 2008 Jan; 9(3):205-14. View Abstract
  72. Phase II trial of B7-1 (CD-86) transduced, cultured autologous tumor cell vaccine plus subcutaneous interleukin-2 for treatment of stage IV renal cell carcinoma. J Immunother. 2008 Jan; 31(1):72-80. View Abstract
  73. Expression of TGFbeta type-II receptor in association with markers of proliferation and apoptosis in premalignant lung lesions. Cancer. 2007 Oct 01; 110(7):1527-31. View Abstract
  74. Feasibility and efficacy of molecular analysis-directed individualized therapy in advanced non-small-cell lung cancer. J Clin Oncol. 2007 Jul 01; 25(19):2741-6. View Abstract
  75. Friend of GATA-1-independent transcriptional repression: a novel mode of GATA-1 function. Blood. 2007 Jun 15; 109(12):5230-3. View Abstract
  76. Loss of nuclear p21(Cip1/WAF1) during neoplastic progression to metastasis in gamma-irradiated p21 hemizygous mice. Exp Mol Pathol. 2007 Jun; 82(3):234-44. View Abstract
  77. Improved survival in BRCA2 carriers with ovarian cancer. Fam Cancer. 2007; 6(1):113-9. View Abstract
  78. A phase-I trial using a universal GM-CSF-producing and CD40L-expressing bystander cell line (GM.CD40L) in the formulation of autologous tumor cell-based vaccines for cancer patients with stage IV disease. Ann Surg Oncol. 2007 Feb; 14(2):869-84. View Abstract
  79. A dosimetric analysis of unstranded seeds versus customized stranded seeds in transperineal interstitial permanent prostate seed brachytherapy. Brachytherapy. 2006 Oct-Dec; 5(4):244-50. View Abstract
  80. Paget's disease in the era of sentinel lymph node biopsy. Am J Surg. 2006 Oct; 192(4):481-3. View Abstract
  81. RRM1 modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small-cell lung cancer. J Clin Oncol. 2006 Oct 10; 24(29):4731-7. View Abstract
  82. Treatment of intermediate-risk prostate cancer with brachytherapy without supplemental pelvic radiotherapy: a review of the H. Lee Moffitt Cancer Center experience. Urol Oncol. 2006 Sep-Oct; 24(5):384-90. View Abstract
  83. Sequential oral 9-nitrocamptothecin and etoposide: a pharmacodynamic- and pharmacokinetic-based phase I trial. Mol Cancer Ther. 2006 Aug; 5(8):2130-7. View Abstract
  84. Survival after surgical resection of isolated pulmonary metastases from malignant melanoma. Cancer Control. 2006 Jul; 13(3):218-23. View Abstract
  85. Prospective evaluation of RRM1 as a predictor of response to gemcitabine/carboplatin (GC) in non-small cell lung cancer (NSCLC). J Clin Oncol. 2006 Jun 20; 24(18_suppl):7054. View Abstract
  86. The benefits of a restaging PET scan after two cycles of neoadjuvant chemotherapy for resectable non-small cell lung cancer. J Clin Oncol. 2006 Jun 20; 24(18_suppl):17092. View Abstract
  87. Fatigue is a cause of functional dependence in older cancer survivors. J Clin Oncol. 2006 Jun 20; 24(18_suppl):8538. View Abstract
  88. beta2 Integrins are characteristically absent in acute promyelocytic leukemia and rapidly upregulated in vivo upon differentiation with all-trans retinoic acid. Leuk Res. 2007 Jan; 31(1):49-57. View Abstract
  89. A complication-free course ensures a survival advantage in patients after regional therapy for metastatic colorectal cancer. Am Surg. 2006 Jun; 72(6):505-10. View Abstract
  90. Survival outcomes in node-negative breast cancer patients evaluated with complete axillary node dissection versus sentinel lymph node biopsy. Ann Surg Oncol. 2006 May; 13(5):708-11. View Abstract
  91. A global genome damage score predictive of lung cancer patients outcome. Oncogene. 2006 Jul 27; 25(32):4491-4. View Abstract
  92. Pulmonary embolism after major abdominal surgery in gynecologic oncology. Obstet Gynecol. 2006 Mar; 107(3):666-71. View Abstract
  93. Phase I study of the taxane BMS-188797 in combination with carboplatin administered every 3 weeks in patients with solid malignancies. Clin Cancer Res. 2006 Jan 15; 12(2):523-8. View Abstract
  94. Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression. Clin Cancer Res. 2006 Jan 01; 12(1):20-8. View Abstract
  95. Selective hepatic artery embolization for treatment of patients with metastatic carcinoid and pancreatic endocrine tumors. Cancer Control. 2006 Jan; 13(1):72-8. View Abstract
  96. BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases. Cancer. 2005 Dec 15; 104(12):2807-16. View Abstract
  97. Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancer. Clin Cancer Res. 2005 Dec 01; 11(23):8288-94. View Abstract
  98. Burnout in clinical research coordinators in the United States. Oncol Nurs Forum. 2005 Nov 03; 32(6):1123-30. View Abstract
  99. Phase II study of neoadjuvant chemotherapy with gemcitabine and vinorelbine in resectable non-small cell lung cancer. Chest. 2005 Nov; 128(5):3467-74. View Abstract
  100. Treatment decision-making strategies and influences in patients with localized prostate carcinoma. Cancer. 2005 Oct 01; 104(7):1381-90. View Abstract
  101. Prediction of radiation sensitivity using a gene expression classifier. Cancer Res. 2005 Aug 15; 65(16):7169-76. View Abstract
  102. The efficacy and safety of pain management before and after implementation of hospital-wide pain management standards: is patient safety compromised by treatment based solely on numerical pain ratings? Anesth Analg. 2005 Aug; 101(2):474-480. View Abstract
  103. Diagnosing pulmonary embolism: experience with spiral CT pulmonary angiography in gynecologic oncology. Gynecol Oncol. 2005 Aug; 98(2):289-93. View Abstract
  104. A case-control study evaluating the association of purposeful physical activity, body fat distribution, and steroid hormones on premenopausal breast cancer risk. Breast J. 2005 Jul-Aug; 11(4):266-72. View Abstract
  105. GATA transcription factors in hematologic disease. Int J Hematol. 2005 Jun; 81(5):378-84. View Abstract
  106. Phase I/II study of atrasentan (A) in combination with carboplatin (C) and paclitaxel (P) in chemonaive patients (pts) with advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2005 Jun; 23(16_suppl):7105. View Abstract
  107. Small tumor size and limited smoking history predicts activated EGFR-Stat3 in early stage non-small cell lung cancer. J Clin Oncol. 2005 Jun; 23(16_suppl):7075. View Abstract
  108. Phase II study of induction chemotherapy with gemcitabine and carboplatin (IndGC) followed by paclitaxel and carboplatin with concurrent thoracic radiation (PCRT) for patients with unresectable stage III non-small-cell lung cancer (NSCLC): MCC-13240. J Clin Oncol. 2005 Jun; 23(16_suppl):7307. View Abstract
  109. Phase II study of neoadjuvant chemotherapy with gemicitabine and pemetrexed (NeoGP) in resectable non-small-cell lung cancer (NSCLC): MCC 13726. J Clin Oncol. 2005 Jun; 23(16_suppl):7314. View Abstract
  110. Phase II study of neoadjuvant chemotherapy with gemcitabine and vinorelbine in resectable non-small-cell lung cancer (NSCLC). J Clin Oncol. 2005 Jun; 23(16_suppl):7277. View Abstract
  111. Influence of concomitant medications on toxicity from chemotherapy in elderly patients. Focus on cytochrome P-450 inhibition and protein binding effects. J Clin Oncol. 2005 Jun; 23(16_suppl):8025. View Abstract
  112. Global genome damage is predictive of cancer patients' outcome. J Clin Oncol. 2005 Jun; 23(16_suppl):9542. View Abstract
  113. The incidence of pulmonary embolism after gynecologic oncologic surgery. J Clin Oncol. 2005 Jun; 23(16_suppl):5089. View Abstract
  114. Molecular staging for survival prediction of colorectal cancer patients. J Clin Oncol. 2005 May 20; 23(15):3526-35. View Abstract
  115. Differences in Smad4 expression in human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck squamous cell carcinoma. Clin Cancer Res. 2005 May 01; 11(9):3191-7. View Abstract
  116. EGR1 predicts PTEN and survival in patients with non-small-cell lung cancer. J Clin Oncol. 2005 Mar 20; 23(9):1921-6. View Abstract
  117. ERCC1 expression is a predictor of survival in resected patients with non-small cell lung cancer. Chest. 2005 Mar; 127(3):978-83. View Abstract
  118. Accuracy of intraoperative imprint cytology for sentinel lymph node evaluation in the treatment of breast carcinoma. Cancer. 2005 Feb 25; 105(1):13-20. View Abstract
  119. Evaluation of new treatments in radiation oncology: are they better than standard treatments? JAMA. 2005 Feb 23; 293(8):970-8. View Abstract
  120. Ribonucleotide reductase M1 gene promoter activity, polymorphisms, population frequencies, and clinical relevance. Lung Cancer. 2005 Feb; 47(2):183-92. View Abstract
  121. 103Pd brachytherapy versus radical prostatectomy in patients with clinically localized prostate cancer: a 12-year experience from a single group practice. Brachytherapy. 2005; 4(1):34-44. View Abstract
  122. Coregulation of GATA factors by the Friend of GATA (FOG) family of multitype zinc finger proteins. Semin Cell Dev Biol. 2005 Feb; 16(1):117-28. View Abstract
  123. Efficacy and cost-effectiveness of a minimal intervention to prevent smoking relapse: dismantling the effects of amount of content versus contact. J Consult Clin Psychol. 2004 Oct; 72(5):797-808. View Abstract
  124. Improved survival in never-smokers vs current smokers with primary adenocarcinoma of the lung. Chest. 2004 Aug; 126(2):347-51. View Abstract
  125. Validation of RRM1 and PTEN as prognostic parameters of outcome in non-small cell lung cancer. J Clin Oncol. 2004 Jul 15; 22(14_suppl):7154. View Abstract
  126. Predictive utility of RRM1 promoter polymorphisms on outcome of patients with non-small cell lung cancer. J Clin Oncol. 2004 Jul 15; 22(14_suppl):7155. View Abstract
  127. Lysophospholipids are potential biomarkers of ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2004 Jul; 13(7):1185-91. View Abstract
  128. A randomized controlled trial to increase cancer screening among attendees of community health centers. Ann Fam Med. 2004 Jul-Aug; 2(4):294-300. View Abstract
  129. RRM1 and PTEN as prognostic parameters for overall and disease-free survival in patients with non-small-cell lung cancer. J Clin Oncol. 2004 May 15; 22(10):1878-85. View Abstract
  130. Colorectal cancer screening among a sample of community health center attendees. J Health Care Poor Underserved. 2004 May; 15(2):281-93. View Abstract
  131. The specific role of isoflavones in reducing prostate cancer risk. Prostate. 2004 May 01; 59(2):141-7. View Abstract
  132. A multi-institutional study of orthotopic neobladders: functional results in men and women. BJU Int. 2004 Apr; 93(6):803-6. View Abstract
  133. Role of p53, CD44V6 and CD57 in differentiating between benign and malignant follicular neoplasms of the thyroid. In Vivo. 2004 Mar-Apr; 18(2):189-95. View Abstract
  134. Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma. Blood. 2004 May 01; 103(9):3271-7. View Abstract
  135. Coregulator-dependent facilitation of chromatin occupancy by GATA-1. Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4):980-5. View Abstract
  136. Fatigue, weight gain, lethargy and amenorrhea in breast cancer patients on chemotherapy: is subclinical hypothyroidism the culprit? Breast Cancer Res Treat. 2004 Jan; 83(2):149-59. View Abstract
  137. Osteopontin identified as colon cancer tumor progression marker. C R Biol. 2003 Oct-Nov; 326(10-11):1041-3. View Abstract
  138. The importance of preservation of the ethical principle of equipoise in the design of clinical trials: relative impact of the methodological quality domains on the treatment effect in randomized controlled trials. Account Res. 2003 Oct-Dec; 10(4):301-15. View Abstract
  139. The therapeutic effects of epidural intercellular adhesion molecule-1 monoclonal antibody in a rabbit model: involvement of the intercellular adhesion molecule-1 pathway in spinal cord ischemia. Anesth Analg. 2003 Sep; 97(3):857-862. View Abstract
  140. Comparative outcomes analysis of procedures performed in physician offices and ambulatory surgery centers. Arch Surg. 2003 Sep; 138(9):991-5. View Abstract
  141. GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/erythrocyte lineages. Immunity. 2003 Sep; 19(3):451-62. View Abstract
  142. Gefitinib (ZD1839) in previously treated advanced non-small-cell lung cancer: experience from a single institution. Cancer Control. 2003 Sep-Oct; 10(5):388-95. View Abstract
  143. Are older French patients as willing as older American patients to undertake chemotherapy? J Clin Oncol. 2003 Sep 01; 21(17):3214-9. View Abstract
  144. p21Cip1 nullizygosity increases tumor metastasis in irradiated mice. Cancer Res. 2003 Jun 15; 63(12):3021-5. View Abstract
  145. Discovery of distinct protein profiles specific for lung tumors and pre-malignant lung lesions by SELDI mass spectrometry. Lung Cancer. 2003 Jun; 40(3):267-79. View Abstract
  146. Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res. 2003 Mar 15; 63(6):1270-9. View Abstract
  147. Can older cancer patients tolerate chemotherapy? A prospective pilot study. Cancer. 2003 Feb 15; 97(4):1107-14. View Abstract
  148. Loss of the cell cycle inhibitors p21(Cip1) and p27(Kip1) enhances tumorigenesis in knockout mouse models. Oncogene. 2002 Dec 05; 21(55):8486-97. View Abstract
  149. Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. Cancer Res. 2002 Nov 15; 62(22):6659-66. View Abstract
  150. Completion axillary lymph node dissection minimizes the likelihood of false negatives for patients with invasive breast carcinoma and cytokeratin positive only sentinel lymph nodes. Am J Surg. 2002 Oct; 184(4):302-6. View Abstract
  151. Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection. Int J Cancer. 2002 Sep 10; 101(2):151-5. View Abstract
  152. Indirect economic effects of long-term breast cancer survival. Cancer Pract. 2002 Sep-Oct; 10(5):248-55. View Abstract
  153. Predictors of tolerance to chemotherapy in older cancer patients: a prospective pilot study. Eur J Cancer. 2002 Jul; 38(11):1466-73. View Abstract
  154. GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis. Proc Natl Acad Sci U S A. 2002 Jul 09; 99(14):9237-42. View Abstract
  155. Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J Exp Med. 2002 Jun 03; 195(11):1387-95. View Abstract
  156. Brachytherapy versus radical prostatectomy in patients with clinically localized prostate cancer. Curr Urol Rep. 2002 Jun; 3(3):250-7. View Abstract
  157. Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturation. Mol Cell Biol. 2002 Jun; 22(12):4268-79. View Abstract
  158. Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene. 2002 May 13; 21(21):3368-76. View Abstract
  159. Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo. Mol Cell Biol. 2002 May; 22(9):3121-8. View Abstract
  160. Phase I trial of a B7-1 (CD80) gene modified autologous tumor cell vaccine in combination with systemic interleukin-2 in patients with metastatic renal cell carcinoma. J Urol. 2002 May; 167(5):1995-2000. View Abstract
  161. Osteopontin identified as lead marker of colon cancer progression, using pooled sample expression profiling. J Natl Cancer Inst. 2002 Apr 03; 94(7):513-21. View Abstract
  162. Fatal disseminated Candida lusitaniae infection in an infant with chronic granulomatous disease. Pediatr Infect Dis J. 2002 Mar; 21(3):262-4. View Abstract
  163. Age and body mass index may increase the chance of failure in sentinel lymph node biopsy for women with breast cancer. Breast J. 2002 Mar-Apr; 8(2):88-91. View Abstract
  164. The specific role of isoflavones on estrogen metabolism in premenopausal women. Cancer. 2002 Feb 15; 94(4):1166-74. View Abstract
  165. Expression of early lung cancer detection marker: hnRNP-A2/B1 and its relation to microsatellite alteration in non-small cell lung cancer. Lung Cancer. 2001 Dec; 34(3):341-50. View Abstract
  166. Learning curves for breast cancer sentinel lymph node mapping based on surgical volume analysis. J Am Coll Surg. 2001 Dec; 193(6):593-600. View Abstract
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  218. Treatment of osteosarcoma with ifosfamide: comparison of response in pediatric patients with recurrent disease versus patients previously untreated: a Pediatric Oncology Group study. Med Pediatr Oncol. 1995 Feb; 24(2):87-92. View Abstract
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  230. Age-linked prognostic categorization based on a new histologic grading system of neuroblastomas. A clinicopathologic study of 211 cases from the Pediatric Oncology Group. Cancer. 1992 Apr 15; 69(8):2197-211. View Abstract
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