Research Overview

The Randolph Lab studies the immunobiology of critical illness in children with a focus on life-threatening and fatal infections and acute lung injury. Our long-term goal is to identify new diagnostic tests and therapies that could restore health more rapidly and decrease morbidity and mortality. Our laboratory focuses on clinical-translational research in the areas of the immune response of pediatric patients with acute respiratory distress syndrome and/or overwhelming sepsis, and on identifying genomic pathways that influence disease susceptibility and/or severity. Dr. Randolph founded the Pediatric Acute Lung Injury and Sepsis Investigator’s Network in 2002 (https://www.palisi.org/) and was the Chair for its first 8 years. PALISI is a voluntary clinical-translational research consortium that now includes 80 pediatric intensive care units across the U.S. and Canada.

The PALISI Network has published over 175 clinical and translational studies in critically ill children, including multiple landmark randomized clinical trials published in NEJM and JAMA. In 2008, Dr. Randolph developed the Pediatric Intensive Care Influenza (PICFLU) Study Group within PALISI with a grant from the U.S. Centers for Disease Control and Prevention Public Health Genomics division to identify genes underlying influenza virus susceptibility and severity. Additional funding was received to increase enrollment during the 2009 H1N1 influenza pandemic. In 2010, National Institute of Health National Institute of Allergy and Infectious Diseases funded PICFLU to study the genetic epidemiology and immune response to life-threatening and fatal influenza infection in children and young adults. The PICFLU group has received over $13 million in total from multiple sources including from Genentech Omni Biomarkers program to evaluate lipid mediators of inflammation in influenza infected patients and from the National Institute of Child Health and Human Development to identify genes that are expressed in influenza infected children who develop multiple organ dysfunction syndrome and/or immunoparalysis. Dr. Randolph is also on the medical advisory boards for Families Fighting Flu and for the ARDS Foundation. For more information about the PICFLU network, visit our website http://picflu.org.

Research Background

Dr. Randolph graduated from Stanford Medical School and completed her pediatrics residency and critical care fellowship at the University of California, San Francisco. At UCSF she completed research fellowships at the Institute for Health Policy Studies and at the Cardiovascular Research Institute. She has a Master of Science degree in biomedical informatics from the University of Utah. She has designed and implemented clinical decision support tools for guiding care of mechanically ventilated patients and worked with trainees to use large datasets to answer important clinical questions about clinical outcomes and use of therapies in children. Dr. Randolph also performs clinical research to advance patient safety and quality in the Medical Surgical Intensive Care Unit at Boston Children’s Hospital with a focus on optimizing methods of liberating children from mechanical ventilator support and improving outcomes of children who become critically ill after stem cell transplantation.

Selected Publications

  1. Randolph AG, Wypij D, Venkataraman ST, Hanson JH, Gedeit RG, Meert K, Luckett PM, Forbes P, Lilley M, Thompson J, Cheifetz IM, Hibberd P, Wetzel R, Cox PN, Arnold JH. Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children - A randomized controlled trial. Journal of the American Medical Association 2002; 288: 2561-88.
  2. Randolph AG, Gonzales CA, Cortellini L, Yeh TS. Growth of pediatric intensive care units in the United States from 1995 to 2001. Journal of Pediatrics 2004; 144: 792-98
  3. Guidelines for the prevention of intravascular catheter-related infections - art. no. e51. Pediatrics 2002; 110: E51.
  4. Randolph AG, Lange C, Silverman EK, Lazarus R, Silverman ES, Raby B, Brown A, Ozonoff A, Richter B, Weiss ST. IL12B gene is associated with asthma. Am J Hum Genet 2004:75;709-715.

 

Education

Graduate School

Medical Informatics University of Utah
Salt Lake City UT

Graduate School

Psychology California State University
Fresno CA

Medical School

Stanford University School of Medicine
Stanford CA

Internship

Children's Hospital of Philadelphia
Philadelphia PA

Residency

University of California Medical Center
San Francisco CA

Fellowship

Pediatric Critical Care Medicine University of California at San Francisco and Children's Hospital
Oakland CA

Fellowship

Health Outcomes and Health Policy Research University of California at San Francisco
San Francisco CA

Fellowship

Cardiovascular Medicine University of California at San Francisco
San Francisco CA

Fellowship

University of Utah
Salt Lake City UT

Fellowship

University of Toronto
Toronto Ontario

Publications

  1. Assessing Clinical Improvement of Infants Hospitalized for Respiratory Syncytial Virus-Related Critical Illness. J Infect Dis. 2025 Jan 15. View Abstract
  2. Hospital-wide access to genomic data advanced pediatric rare disease research and clinical outcomes. NPJ Genom Med. 2024 Dec 02; 9(1):60. View Abstract
  3. Impact of Viral Lower Respiratory Tract Infection (LRTI) in Early Childhood (0-2 Years) on Lung Growth and Development and Lifelong Trajectories of Pulmonary Health: A National Institutes of Health (NIH) Workshop Summary. Pediatr Pulmonol. 2025 Jan; 60(1):e27357. View Abstract
  4. Consequences beyond acute SARS-CoV-2 infection in children. Sci Transl Med. 2024 Nov 13; 16(773):eado2099. View Abstract
  5. Causal inference can lead us to modifiable mechanisms and informative archetypes in sepsis. Intensive Care Med. 2024 Dec; 50(12):2031-2042. View Abstract
  6. Pre-existing Immunocompromising Conditions and Outcomes of Acute COVID-19 Patients Admitted for Pediatric Intensive Care. Clin Infect Dis. 2024 Aug 16; 79(2):395-404. View Abstract
  7. High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases. Cell. 2024 Aug 22; 187(17):4586-4604.e20. View Abstract
  8. Molecular mimicry in multisystem inflammatory syndrome in children. Nature. 2024 Aug; 632(8025):622-629. View Abstract
  9. From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU. Am J Respir Crit Care Med. 2024 07 15; 210(2):155-166. View Abstract
  10. Enhancing sepsis biomarker development: key considerations from public and private perspectives. Crit Care. 2024 07 13; 28(1):238. View Abstract
  11. Durability of Original Monovalent mRNA Vaccine Effectiveness Against COVID-19 Omicron-Associated Hospitalization in Children and Adolescents - United States, 2021-2023. MMWR Morb Mortal Wkly Rep. 2024 Apr 18; 73(15):330-338. View Abstract
  12. Adolescents and Young Adults: An Understudied, yet Likely Informative, Population in ARDS. Am J Respir Crit Care Med. 2024 04 01; 209(7):785-786. View Abstract
  13. International Consensus Criteria for Pediatric Sepsis and Septic Shock. JAMA. 2024 02 27; 331(8):665-674. View Abstract
  14. Development and Validation of the Phoenix Criteria for Pediatric Sepsis and Septic Shock. JAMA. 2024 02 27; 331(8):675-686. View Abstract
  15. The RECOVERY trial of PIMS-TS: important lessons from the pandemic. Lancet Child Adolesc Health. 2024 Mar; 8(3):176-177. View Abstract
  16. Characteristics and Clinical Outcomes of Vaccine-Eligible US Children Under-5 Years Hospitalized for Acute COVID-19 in a National Network. Pediatr Infect Dis J. 2024 Mar 01; 43(3):242-249. View Abstract
  17. Neutralization of SARS-CoV-2 Omicron BQ.1, BQ.1.1 and XBB.1 variants following SARS-CoV-2 infection or vaccination in children. Nat Commun. 2023 Dec 01; 14(1):7952. View Abstract
  18. Type I interferon signature and cycling lymphocytes in macrophage activation syndrome. J Clin Invest. 2023 11 15; 133(22). View Abstract
  19. Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C. Front Pediatr. 2023; 11:1260372. View Abstract
  20. Effectiveness of Maternal mRNA COVID-19 Vaccination During Pregnancy Against COVID-19-Associated Hospitalizations in Infants Aged <6 Months During SARS-CoV-2 Omicron Predominance - 20 States, March 9, 2022-May 31, 2023. MMWR Morb Mortal Wkly Rep. 2023 Sep 29; 72(39):1057-1064. View Abstract
  21. The Modified Clinical Progression Scale for Pediatric Patients: Evaluation as a Severity Metric and Outcome Measure in Severe Acute Viral Respiratory Illness. Pediatr Crit Care Med. 2023 Dec 01; 24(12):998-1009. View Abstract
  22. Infants Admitted to US Intensive Care Units for RSV Infection During the 2022 Seasonal Peak. JAMA Netw Open. 2023 08 01; 6(8):e2328950. View Abstract
  23. Transcriptomic profiles of multiple organ dysfunction syndrome phenotypes in pediatric critical influenza. Front Immunol. 2023; 14:1220028. View Abstract
  24. Early, Persistent Lymphopenia Is Associated With Prolonged Multiple Organ Failure and Mortality in Septic Children. Crit Care Med. 2023 12 01; 51(12):1766-1776. View Abstract
  25. Neurological and Psychological Sequelae Associated With Multisystem Inflammatory Syndrome in Children. JAMA Netw Open. 2023 07 03; 6(7):e2324369. View Abstract
  26. Immunomodulatory Therapy for MIS-C. Pediatrics. 2023 Jul 01; 152(1). View Abstract
  27. Single cell transcriptomics identifies distinct profiles in pediatric acute respiratory distress syndrome. Nat Commun. 2023 06 30; 14(1):3870. View Abstract
  28. Longitudinal Analysis of Contrasts in Gene Expression Data. Genes (Basel). 2023 05 24; 14(6). View Abstract
  29. Variation in Early Anakinra Use and Short-Term Outcomes in Multisystem Inflammatory Syndrome in Children. Arthritis Rheumatol. 2023 08; 75(8):1466-1476. View Abstract
  30. Operationalizing Appropriate Sepsis Definitions in Children Worldwide: Considerations for the Pediatric Sepsis Definition Taskforce. Pediatr Crit Care Med. 2023 06 01; 24(6):e263-e271. View Abstract
  31. Extracorporeal Membrane Oxygenation Characteristics and Outcomes in Children and Adolescents With COVID-19 or Multisystem Inflammatory Syndrome Admitted to U.S. ICUs. Pediatr Crit Care Med. 2023 05 01; 24(5):356-371. View Abstract
  32. Risk Factors for Multisystem Inflammatory Syndrome in Children: A Case-control Investigation. Pediatr Infect Dis J. 2023 06 01; 42(6):e190-e196. View Abstract
  33. Community-Onset Bacterial Coinfection in Children Critically Ill With Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Open Forum Infect Dis. 2023 Mar; 10(3):ofad122. View Abstract
  34. Clinical Course Associated with Aseptic Meningitis Induced by Intravenous Immunoglobulin for the Treatment of Multisystem Inflammatory Syndrome in Children. J Pediatr. 2023 06; 257:113372. View Abstract
  35. Factors Associated With COVID-19 Non-vaccination in Adolescents Hospitalized Without COVID-19. J Pediatric Infect Dis Soc. 2023 Feb 09; 12(1):29-35. View Abstract
  36. BNT162b2 mRNA Vaccination Against Coronavirus Disease 2019 is Associated With a Decreased Likelihood of Multisystem Inflammatory Syndrome in Children Aged 5-18 Years-United States, July 2021 - April 2022. Clin Infect Dis. 2023 02 08; 76(3):e90-e100. View Abstract
  37. Life-Threatening Complications of Influenza vs Coronavirus Disease 2019 (COVID-19) in US Children. Clin Infect Dis. 2023 02 08; 76(3):e280-e290. View Abstract
  38. Executive Summary of the Second International Guidelines for the Diagnosis and Management of Pediatric Acute Respiratory Distress Syndrome (PALICC-2). Pediatr Crit Care Med. 2023 02 01; 24(2):143-168. View Abstract
  39. Pulmonary Specific Ancillary Treatment for Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference. Pediatr Crit Care Med. 2023 02 01; 24(12 Suppl 2):S99-S111. View Abstract
  40. Genetic Predisposition to Neurological Complications in Patients with COVID-19. Biomolecules. 2023 01 09; 13(1). View Abstract
  41. ATP breakdown in plasma of children limits the antimicrobial effectiveness of their neutrophils. Purinergic Signal. 2023 12; 19(4):651-662. View Abstract
  42. Circulating Spike Protein Detected in Post-COVID-19 mRNA Vaccine Myocarditis. Circulation. 2023 03 14; 147(11):867-876. View Abstract
  43. The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2-associated multisystem inflammatory syndrome in children. J Clin Invest. 2023 01 03; 133(1). View Abstract
  44. Changes in Distribution of Severe Neurologic Involvement in US Pediatric Inpatients With COVID-19 or Multisystem Inflammatory Syndrome in Children in 2021 vs 2020. JAMA Neurol. 2023 01 01; 80(1):91-98. View Abstract
  45. Unsupervised outlier detection applied to SARS-CoV-2 nucleotide sequences can identify sequences of common variants and other variants of interest. BMC Bioinformatics. 2022 Dec 19; 23(1):547. View Abstract
  46. Computer clinical decision support that automates personalized clinical care: a challenging but needed healthcare delivery strategy. J Am Med Inform Assoc. 2022 12 13; 30(1):178-194. View Abstract
  47. NFKB2 haploinsufficiency identified via screening for IFN-a2 autoantibodies in children and adolescents hospitalized with SARS-CoV-2-related complications. J Allergy Clin Immunol. 2023 04; 151(4):926-930.e2. View Abstract
  48. DDX58 Is Associated With Susceptibility to Severe Influenza Virus Infection in Children and Adolescents. J Infect Dis. 2022 11 28; 226(11):2030-2036. View Abstract
  49. Association of Asthma With Treatments and Outcomes in Children With Critical Influenza. J Allergy Clin Immunol Pract. 2023 03; 11(3):836-843.e3. View Abstract
  50. Pediatric Acute Lung Injury and Sepsis Investigators (PALISI): Evolution of an Investigator-Initiated Research Network. Pediatr Crit Care Med. 2022 12 01; 23(12):1056-1066. View Abstract
  51. Postdischarge Glucocorticoid Use and Clinical Outcomes of Multisystem Inflammatory Syndrome in Children. JAMA Netw Open. 2022 11 01; 5(11):e2241622. View Abstract
  52. Tachyarrhythmias During Hospitalization for COVID-19 or Multisystem Inflammatory Syndrome in Children and Adolescents. J Am Heart Assoc. 2022 10 18; 11(20):e025915. View Abstract
  53. Measurement of Severe Acute Respiratory Syndrome Coronavirus 2 Antigens in Plasma of Pediatric Patients With Acute Coronavirus Disease 2019 or Multisystem Inflammatory Syndrome in Children Using an Ultrasensitive and Quantitative Immunoassay. Clin Infect Dis. 2022 10 12; 75(8):1351-1358. View Abstract
  54. Host Respiratory Transcriptome Signature Associated with Poor Outcome in Children with Influenza-Staphylococcus aureus Pneumonia. J Infect Dis. 2022 09 28; 226(7):1286-1294. View Abstract
  55. COVID-19 and children. Science. 2022 09 09; 377(6611):1144-1149. View Abstract
  56. Investigating Health Disparities Associated With Multisystem Inflammatory Syndrome in Children After SARS-CoV-2 Infection. Pediatr Infect Dis J. 2022 11 01; 41(11):891-898. View Abstract
  57. Health Impairments in Children and Adolescents After Hospitalization for Acute COVID-19 or MIS-C. Pediatrics. 2022 09 01; 150(3). View Abstract
  58. SARS-CoV-2-specific T cell responses in patients with multisystem inflammatory syndrome in children. Clin Immunol. 2022 Oct; 243:109106. View Abstract
  59. Vaccine Effectiveness Against Life-Threatening Influenza Illness in US Children. Clin Infect Dis. 2022 08 25; 75(2):230-238. View Abstract
  60. Author Correction: Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C. Nat Commun. 2022 Aug 12; 13(1):4732. View Abstract
  61. Treatment of Multisystem Inflammatory Syndrome in Children: Understanding Differences in Results of Comparative Effectiveness Studies. ACR Open Rheumatol. 2022 Sep; 4(9):804-810. View Abstract
  62. Maternal Vaccination and Risk of Hospitalization for Covid-19 among Infants. N Engl J Med. 2022 07 14; 387(2):109-119. View Abstract
  63. A Description of COVID-19-Directed Therapy in Children Admitted to US Intensive Care Units 2020. J Pediatric Infect Dis Soc. 2022 May 30; 11(5):191-198. View Abstract
  64. Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C. Nat Commun. 2022 05 27; 13(1):2979. View Abstract
  65. Notch1-CD22-Dependent Immune Dysregulation in the SARS-CoV2-Associated Multisystem Inflammatory Syndrome in Children. Res Sq. 2022 Apr 11. View Abstract
  66. BNT162b2 Protection against the Omicron Variant in Children and Adolescents. N Engl J Med. 2022 05 19; 386(20):1899-1909. View Abstract
  67. Resuscitation Fluid Composition and Acute Kidney Injury in Critical Illness. N Engl J Med. 2022 03 03; 386(9):888-889. View Abstract
  68. Candidacy for Extracorporeal Life Support in Children After Hematopoietic Cell Transplantation: A Position Paper From the Pediatric Acute Lung Injury and Sepsis Investigators Network's Hematopoietic Cell Transplant and Cancer Immunotherapy Subgroup. Pediatr Crit Care Med. 2022 03 01; 23(3):205-213. View Abstract
  69. Frequency, Characteristics and Complications of COVID-19 in Hospitalized Infants. Pediatr Infect Dis J. 2022 03 01; 41(3):e81-e86. View Abstract
  70. Effectiveness of Maternal Vaccination with mRNA COVID-19 Vaccine During Pregnancy Against COVID-19-Associated Hospitalization in Infants Aged <6 Months - 17 States, July 2021-January 2022. MMWR Morb Mortal Wkly Rep. 2022 Feb 18; 71(7):264-270. View Abstract
  71. Systemic and Lower Respiratory Tract Immunity to SARS-CoV-2 Omicron and Variants in Pediatric Severe COVID-19 and Mis-C. Vaccines (Basel). 2022 Feb 10; 10(2). View Abstract
  72. Immunology of SARS-CoV-2 infection in children. Nat Immunol. 2022 02; 23(2):177-185. View Abstract
  73. Effectiveness of BNT162b2 (Pfizer-BioNTech) mRNA Vaccination Against Multisystem Inflammatory Syndrome in Children Among Persons Aged 12-18 Years - United States, July-December 2021. MMWR Morb Mortal Wkly Rep. 2022 Jan 14; 71(2):52-58. View Abstract
  74. Effectiveness of BNT162b2 Vaccine against Critical Covid-19 in Adolescents. N Engl J Med. 2022 02 24; 386(8):713-723. View Abstract
  75. Optical genome mapping identifies rare structural variations as predisposition factors associated with severe COVID-19. iScience. 2022 Feb 18; 25(2):103760. View Abstract
  76. Severe COVID-19 and Multisystem Inflammatory Syndrome in Children in Children and Adolescents. Crit Care Clin. 2022 Jul; 38(3):571-586. View Abstract
  77. An Update on Multisystem Inflammatory Syndrome in Children Related to SARS-CoV-2. Pediatr Infect Dis J. 2022 01 01; 41(1):e6-e9. View Abstract
  78. Multisystem Inflammatory-like Syndrome in a Child Following COVID-19 mRNA Vaccination. Vaccines (Basel). 2021 Dec 30; 10(1). View Abstract
  79. Modeling the Impacts of Clinical Influenza Testing on Influenza Vaccine Effectiveness Estimates. J Infect Dis. 2021 12 15; 224(12):2035-2042. View Abstract
  80. Measurement of SARS-CoV-2 antigens in plasma of pediatric patients with acute COVID-19 or MIS-C using an ultrasensitive and quantitative immunoassay. medRxiv. 2021 Dec 09. View Abstract
  81. Surfactant protein D is a biomarker of influenza-related pediatric lung injury. Pediatr Pulmonol. 2022 02; 57(2):519-528. View Abstract
  82. Effectiveness of Pfizer-BioNTech mRNA Vaccination Against COVID-19 Hospitalization Among Persons Aged 12-18 Years - United States, June-September 2021. MMWR Morb Mortal Wkly Rep. 2021 Oct 22; 70(42):1483-1488. View Abstract
  83. Estimated Pao2: A Continuous and Noninvasive Method to Estimate Pao2 and Oxygenation Index. Crit Care Explor. 2021 Oct; 3(10):e0546. View Abstract
  84. Data-driven clustering identifies features distinguishing multisystem inflammatory syndrome from acute COVID-19 in children and adolescents. EClinicalMedicine. 2021 Oct; 40:101112. View Abstract
  85. Therapy for Multisystem Inflammatory Syndrome in Children. Reply. N Engl J Med. 2021 09 23; 385(13):e42. View Abstract
  86. Rate of thrombosis in children and adolescents hospitalized with COVID-19 or MIS-C. Blood. 2021 07 15; 138(2):190-198. View Abstract
  87. Mechanisms underlying genetic susceptibility to multisystem inflammatory syndrome in children (MIS-C). J Allergy Clin Immunol. 2021 09; 148(3):732-738.e1. View Abstract
  88. Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain. Genet Epidemiol. 2021 10; 45(7):685-693. View Abstract
  89. Multisystem Inflammatory Syndrome in Children - Initial Therapy and Outcomes. N Engl J Med. 2021 07 01; 385(1):23-34. View Abstract
  90. Enabling a learning healthcare system with automated computer protocols that produce replicable and personalized clinician actions. J Am Med Inform Assoc. 2021 06 12; 28(6):1330-1344. View Abstract
  91. Variation in Intravenous Acetaminophen Use in Pediatric Hospitals: Priorities for Standardization. Hosp Pediatr. 2021 07; 11(7):734-742. View Abstract
  92. Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2. JAMA Netw Open. 2021 06 01; 4(6):e2116420. View Abstract
  93. Incorporating Real-time Influenza Detection Into the Test-negative Design for Estimating Influenza Vaccine Effectiveness: The Real-time Test-negative Design (rtTND). Clin Infect Dis. 2021 05 04; 72(9):1669-1675. View Abstract
  94. Sepsis Subclasses: A Framework for Development and Interpretation. Crit Care Med. 2021 05 01; 49(5):748-759. View Abstract
  95. Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome. JAMA Neurol. 2021 05 01; 78(5):536-547. View Abstract
  96. Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19. JAMA. 2021 03 16; 325(11):1074-1087. View Abstract
  97. Publisher Correction: Exuberant fibroblast activity compromises lung function via ADAMTS4. Nature. 2020 Dec; 588(7836):E5. View Abstract
  98. Exuberant fibroblast activity compromises lung function via ADAMTS4. Nature. 2020 11; 587(7834):466-471. View Abstract
  99. Multisystem Inflammatory Syndrome in Children in the United States. Reply. N Engl J Med. 2020 10 29; 383(18):1794-1795. View Abstract
  100. Inclusion of Children in Clinical Trials of Treatments for Coronavirus Disease 2019 (COVID-19). JAMA Pediatr. 2020 Sep 01; 174(9):825-826. View Abstract
  101. Pediatric Cardiac Intensive Care Distribution, Service Delivery, and Staffing in the United States in 2018. Pediatr Crit Care Med. 2020 09; 21(9):797-803. View Abstract
  102. Immune dysregulation and multisystem inflammatory syndrome in children (MIS-C) in individuals with haploinsufficiency of SOCS1. J Allergy Clin Immunol. 2020 11; 146(5):1194-1200.e1. View Abstract
  103. Machine Learning Predicts Prolonged Acute Hypoxemic Respiratory Failure in Pediatric Severe Influenza. Crit Care Explor. 2020 Aug; 2(8):e0175. View Abstract
  104. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. N Engl J Med. 2020 07 23; 383(4):334-346. View Abstract
  105. Early Amplified Respiratory Bioactive Lipid Response Is Associated With Worse Outcomes in Pediatric Influenza-Related Respiratory Failure. Open Forum Infect Dis. 2020 May; 7(5):ofaa122. View Abstract
  106. RIG-I and TLR4 responses and adverse outcomes in pediatric influenza-related critical illness. J Allergy Clin Immunol. 2020 06; 145(6):1673-1680.e11. View Abstract
  107. Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. Pediatr Crit Care Med. 2020 02; 21(2):e52-e106. View Abstract
  108. Executive Summary: Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. Pediatr Crit Care Med. 2020 02; 21(2):186-195. View Abstract
  109. Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Med. 2020 02; 46(Suppl 1):10-67. View Abstract
  110. Executive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Med. 2020 02; 46(Suppl 1):1-9. View Abstract
  111. Growth and Changing Characteristics of Pediatric Intensive Care 2001-2016. Crit Care Med. 2019 08; 47(8):1135-1142. View Abstract
  112. The authors reply. Pediatr Crit Care Med. 2019 08; 20(8):795-796. View Abstract
  113. A Modular Cytokine Analysis Method Reveals Novel Associations With Clinical Phenotypes and Identifies Sets of Co-signaling Cytokines Across Influenza Natural Infection Cohorts and Healthy Controls. Front Immunol. 2019; 10:1338. View Abstract
  114. Evaluation of Mannose Binding Lectin Gene Variants in Pediatric Influenza Virus-Related Critical Illness. Front Immunol. 2019; 10:1005. View Abstract
  115. Cost Implications of Escalating Intravenous Acetaminophen Use in Children. JAMA Pediatr. 2019 05 01; 173(5):489-491. View Abstract
  116. Acute respiratory distress syndrome. Nat Rev Dis Primers. 2019 03 14; 5(1):18. View Abstract
  117. Antibiotic Prescription in Young Children With Respiratory Syncytial Virus-Associated Respiratory Failure and Associated Outcomes. Pediatr Crit Care Med. 2019 02; 20(2):101-109. View Abstract
  118. Vancomycin Monotherapy May Be Insufficient to Treat Methicillin-resistant Staphylococcus aureus Coinfection in Children With Influenza-related Critical Illness. Clin Infect Dis. 2019 01 18; 68(3):365-372. View Abstract
  119. Cytokine Profiles of Severe Influenza Virus-Related Complications in Children. Front Immunol. 2017; 8:1423. View Abstract
  120. A Biosignature Predicting Complicated Course in Children Presenting with Septic Shock. Why PERSEVERE? Am J Respir Crit Care Med. 2017 08 15; 196(4):411-413. View Abstract
  121. SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans. Nat Med. 2017 Aug; 23(8):975-983. View Abstract
  122. Simulation of a Novel Schedule for Intensivist Staffing to Improve Continuity of Patient Care and Reduce Physician Burnout. Crit Care Med. 2017 Jul; 45(7):1138-1144. View Abstract
  123. Evaluation of IFITM3 rs12252 Association With Severe Pediatric Influenza Infection. J Infect Dis. 2017 07 01; 216(1):14-21. View Abstract
  124. Why So Few Randomized Trials in Pediatric Critical Care Medicine? Ask the Trialists. Pediatr Crit Care Med. 2017 05; 18(5):486-487. View Abstract
  125. Mannose-Binding Lectin Levels in Critically Ill Children With Severe Infections. Pediatr Crit Care Med. 2017 02; 18(2):103-111. View Abstract
  126. 1444: MANNOSE-BINDING LECTIN AND PEDIATRIC SEPSIS SUSCEPTIBILITY: A SYSTEMATIC REVIEW AND META-ANALYSIS. Crit Care Med. 2016 Dec; 44(12 Suppl 1):436. View Abstract
  127. 933: ASSOCIATIONS BETWEEN PNEUMONIA AND CLINICAL OUTCOMES IN PICU PATIENTS WITH RSV BRONCHIOLITIS. Crit Care Med. 2016 Dec; 44(12 Suppl 1):309. View Abstract
  128. Enterovirus D68 Reemerges Globally as a Severe Pathogen Targeting Children. Pediatr Crit Care Med. 2016 11; 17(11):1088-1089. View Abstract
  129. Determinants of red blood cell transfusion in pediatric trauma patients admitted to the intensive care unit. Transfusion. 2017 01; 57(1):187-194. View Abstract
  130. Staphylococcus aureus a-Toxin Response Distinguishes Respiratory Virus-Methicillin-Resistant S. aureus Coinfection in Children. J Infect Dis. 2016 Dec 01; 214(11):1638-1646. View Abstract
  131. The Impact of Clinical Trials Conducted by Research Networks in Pediatric Critical Care. Pediatr Crit Care Med. 2016 09; 17(9):837-44. View Abstract
  132. High Variability in the Reported Management of Hepatic Veno-Occlusive Disease in Children after Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2016 10; 22(10):1823-1828. View Abstract
  133. The authors reply. Pediatr Crit Care Med. 2016 06; 17(6):583-4. View Abstract
  134. Incidence and risk factors for postoperative vomiting following atrial septal defect repair in children. Paediatr Anaesth. 2016 Jun; 26(6):644-8. View Abstract
  135. Optimizing Virus Identification in Critically Ill Children Suspected of Having an Acute Severe Viral Infection. Pediatr Crit Care Med. 2016 Apr; 17(4):279-86. View Abstract
  136. Pragmatic trials in critically ill children are CATCHing on. Lancet. 2016 Apr 23; 387(10029):1697-8. View Abstract
  137. Anesthesiologist- and System-Related Risk Factors for Risk-Adjusted Pediatric Anesthesia-Related Cardiac Arrest. Anesth Analg. 2016 Feb; 122(2):482-9. View Abstract
  138. Severity-of-Illness Scoring in Pediatric Critical Care: Quo Vadis? Pediatr Crit Care Med. 2016 Jan; 17(1):83-5. View Abstract
  139. Pooled Sequencing of Candidate Genes Implicates Rare Variants in the Development of Asthma Following Severe RSV Bronchiolitis in Infancy. PLoS One. 2015; 10(11):e0142649. View Abstract
  140. Critically Ill Children Have Low Vitamin D-Binding Protein, Influencing Bioavailability of Vitamin D. Ann Am Thorac Soc. 2015 Nov; 12(11):1654-61. View Abstract
  141. Therapeutic Hypothermia in Children. N Engl J Med. 2015 09 03; 373(10):979. View Abstract
  142. Pediatric Pulseless Arrest With "Nonshockable" Rhythm: Does Faster Time to Epinephrine Improve Outcome? JAMA. 2015 Aug 25; 314(8):776-7. View Abstract
  143. Recognizing and managing sepsis: what needs to be done? BMC Med. 2015 Apr 27; 13:98. View Abstract
  144. The tremendous burden of sepsis on China's youngest children. Pediatr Crit Care Med. 2014 Nov; 15(9):896-7. View Abstract
  145. Variability in IRBs regarding parental acceptance of passive consent. Pediatrics. 2014 Aug; 134(2):e496-503. View Abstract
  146. More consistent site institutional review board (IRB) input-more consistent site IRB output. Crit Care Med. 2014 May; 42(5):1292-3. View Abstract
  147. A multinational study of thromboprophylaxis practice in critically ill children. Crit Care Med. 2014 May; 42(5):1232-40. View Abstract
  148. Effectiveness of influenza vaccine against life-threatening RT-PCR-confirmed influenza illness in US children, 2010-2012. J Infect Dis. 2014 Sep 01; 210(5):674-83. View Abstract
  149. The authors reply. Pediatr Crit Care Med. 2014 Feb; 15(2):183. View Abstract
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  267. Positive predictive value of bilateral absence of somatosensory evoked potentials in severe traumatic brain injury. Pediatr Res. 1998; 43:33A. View Abstract
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