Research Overview

Our lab has three main broad areas of research: drug delivery, biomaterials, and nanomedicine, with considerable overlap between these. Some of our projects are driven by developing new technologies, others by trying to find cures for specific diseases. Pain, otitis media and other otic diseases, ophthalmic diseases, peritoneal adhesions, sepsis, and cancer are among the medical conditions that receive the most attention in our group.

 

Research Background

Dr. Daniel S. Kohane obtained his MD and a PhD in Physiology from Boston University. He subsequently completed residencies in Pediatrics (Boston Children's Hospital) and Anesthesiology (Massachusetts general Hospital), followed by a fellowship in Pediatric Critical Care (Boston Children's Hospital). He is currently a Senior Associate in Pediatric Critical Care at Boston Children's Hospital at Harvard Medical School, where he directs the Laboratory for Biomaterials and Drug Delivery.

 

Education

Graduate School

PhD, Physiology Boston University School of Medicine
1990 Boston MA

Medical School

Boston University School of Medicine
1990 Boston MA

Internship

Pediatrics Boston Children's Hospital
1991 Boston MA

Residency

Pediatrics/Anesthesia Boston Combined Residency Program (BCRP)
1995 Boston MA

Fellowship

Pediatric Critical Care Boston Children's Hospital
1997 Boston MA

Publications

  1. Sensory-selective Sciatic Nerve Block with 2',6' Pipecolylxylidine in an Ovine Model. Anesthesiology. 2026 Jun 12. View Abstract
  2. Sensory-selective Peripheral and Neuraxial Nerve Blockade with 2',6'-Pipecoloxylidide: Erratum. Anesthesiology. 2026 Jun 01; 144(6):1520. View Abstract
  3. Polymeric rapamycin nanoparticles encapsulating ponatinib cause regression of venous malformations in mice. Sci Transl Med. 2026 May 06; 18(848):eaeb7597. View Abstract
  4. Polyketal-conjugated tafluprost microparticles enable long-acting glaucoma therapy. Nat Commun. 2026 Apr 29. View Abstract
  5. Precise Spatiotemporal Control of Sensory Nerve Blockade via Light-Triggered Click-Release Uncaging of 2',6'-Pipecoloxylidide. Angew Chem Int Ed Engl. 2026 05 25; 65(22):e5262692. View Abstract
  6. Mineral-originated bioelectronics for inhibition via lithium electrochemistry. Nat Mater. 2026 Mar 27. View Abstract
  7. Besifloxacin-eluting contact lens with sustained drug delivery and enhanced bioavailability. Int J Pharm X. 2026 Jun; 11:100511. View Abstract
  8. Extended local anesthesia enabled by flavonoid permeation enhancers. Proc Natl Acad Sci U S A. 2026 Mar 10; 123(10):e2523195123. View Abstract
  9. Sex Differences in Sensory-selective Nerve Blockade Induced by 2',6'-Pipecoloxylidide. Anesthesiology. 2026 Mar 01; 144(3):728-731. View Abstract
  10. Overcoming Antimicrobial Resistance in Bacterial Keratitis With an Antibiotic-Eluting Contact Lens. Invest Ophthalmol Vis Sci. 2025 Dec 01; 66(15):38. View Abstract
  11. Treating venous malformations with nanomedicines. Nanomedicine (Lond). 2025 12; 20(23):2847-2850. View Abstract
  12. Injectable Microparticle-Nanoliposome Hydrogel for Extended Release of Small Hydrophilic Molecules. ACS Nano. 2025 Oct 21; 19(41):36342-36352. View Abstract
  13. Sensory-selective Peripheral and Neuraxial Nerve Blockade with 2',6'-Pipecoloxylidide. Anesthesiology. 2025 Nov 01; 143(5):1296-1312. View Abstract
  14. Enhanced Control of Liposomal Drug Release by Drug-Aptamer Complexes. Adv Mater. 2025 Oct; 37(40):e2503872. View Abstract
  15. Size-dependent Nanoparticle Accumulation In Venous Malformations. J Vasc Anom (Phila). 2024 Dec; 5(4):e00103. View Abstract
  16. Hybrid Nanoparticle-Hydrogel Systems for Drug Delivery Depots and Other Biomedical Applications. ACS Nano. 2024 08 27; 18(34):22780-22792. View Abstract
  17. Reciprocal Interaction with Neutrophils Facilitates Cutaneous Accumulation of Liposomes. ACS Nano. 2024 07 16; 18(28):18769-18784. View Abstract
  18. Polymeric Prodrugs using Dynamic Covalent Chemistry for Prolonged Local Anesthesia. Angew Chem Int Ed Engl. 2024 07 29; 63(31):e202406158. View Abstract
  19. Injectable hydrogel based on liposome self-assembly for controlled release of small hydrophilic molecules. Acta Biomater. 2024 07 15; 183:101-110. View Abstract
  20. Correction to "A Simple, Yet Multifunctional, Nanoformulation for Eradicating Tumors and Preventing Recurrence with Safely Low Administration Dose". Nano Lett. 2024 May 08; 24(18):5670-5671. View Abstract
  21. Miniaturized therapeutic systems for ultrasound-modulated drug delivery to the central and peripheral nervous system. Adv Drug Deliv Rev. 2024 05; 208:115275. View Abstract
  22. Corrigendum to "Selective binding of C-6OH sulfated hyaluronic acid to the angiogenic isoform of VEGF165" [Biomaterials 77(2016) 130-138]. Biomaterials. 2024 Jun; 307:122501. View Abstract
  23. A hybrid nanoparticle-protein hydrogel system for prolonged local anesthesia. Biomaterials. 2024 04; 306:122494. View Abstract
  24. Correction to "Enhanced Photothermal Effect of Plasmonic Nanoparticles Coated with Reduced Graphene Oxide". Nano Lett. 2024 Jan 31; 24(4):1464-1465. View Abstract
  25. On-Demand Opioid Effect Reversal with an Injectable Light-Triggered Polymer-Naloxone Conjugate. Nano Lett. 2023 11 22; 23(22):10545-10553. View Abstract
  26. Aromatized liposomes for sustained drug delivery. Nat Commun. 2023 10 20; 14(1):6659. View Abstract
  27. Methyl-Branched Liposomes as a Depot for Sustained Drug Delivery. Nano Lett. 2023 10 25; 23(20):9250-9256. View Abstract
  28. Ablation of Venous Malformations by Photothermal Therapy with Intravenous Gold Nanoshells. Nano Lett. 2023 08 09; 23(15):7092-7099. View Abstract
  29. Enhancement of polymer thermoresponsiveness and drug delivery across biological barriers by addition of small molecules. Heliyon. 2023 Jun; 9(6):e16923. View Abstract
  30. Squaraine Dye-Sensitized Upconversion with Enhanced Stability and Minimized Aggregation-Caused Quenching. Nano Lett. 2023 Jun 14; 23(11):5209-5216. View Abstract
  31. An aptamer-based depot system for sustained release of small molecule therapeutics. Nat Commun. 2023 04 28; 14(1):2444. View Abstract
  32. Materials for Controlled Release of Local Anesthetics. ChemMedChem. 2023 06 01; 18(11):e202300009. View Abstract
  33. Benzonatate as a local anesthetic. PLoS One. 2023; 18(4):e0284401. View Abstract
  34. Terbinafine Nanohybrid: Proposing a Hydrogel Carrying Nanoparticles for Topical Release. Pharmaceutics. 2023 Mar 04; 15(3). View Abstract
  35. Enhancement of Trans-Tympanic Drug Delivery by Pharmacological Induction of Inflammation. Mol Pharm. 2023 02 06; 20(2):1375-1381. View Abstract
  36. Topical Sustained Delivery of Miltefosine Via Drug-Eluting Contact Lenses to Treat Acanthamoeba Keratitis. Pharmaceutics. 2022 Dec 08; 14(12). View Abstract
  37. Enhancement of single upconversion nanoparticle imaging by topologically segregated core-shell structure with inward energy migration. Nat Commun. 2022 10 07; 13(1):5927. View Abstract
  38. Prolonged Retrobulbar Local Anesthesia of the Cornea Does Not Cause Keratopathy in Mice. Transl Vis Sci Technol. 2022 01 03; 11(1):33. View Abstract
  39. A novel, sensitive, and widely accessible besifloxacin quantification method by HPLC-fluorescence: Application to an ocular pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Nov 15; 1185:123010. View Abstract
  40. Modular ketal-linked prodrugs and biomaterials enabled by organocatalytic transisopropenylation of alcohols. Nat Commun. 2021 09 20; 12(1):5532. View Abstract
  41. Delivery of local anaesthetics by a self-assembled supramolecular system mimicking their interactions with a sodium channel. Nat Biomed Eng. 2021 09; 5(9):1099-1109. View Abstract
  42. Dexamethasone-Eluting Contact Lens for the Prevention of Postphotorefractive Keratectomy Scar in a New Zealand White Rabbit Model. Cornea. 2021 Sep 01; 40(9):1175-1180. View Abstract
  43. Targeting Nanoparticles to Bioengineered Human Vascular Networks. Nano Lett. 2021 08 11; 21(15):6609-6616. View Abstract
  44. Synergy in Nanomedicine: What It Is Not, and What It Might Be. Nano Lett. 2021 07 14; 21(13):5457-5460. View Abstract
  45. Permeation of polyethylene glycols across the tympanic membrane. Giant (Oxf). 2021 Jun; 6. View Abstract
  46. Enhancement of the Mechanical and Drug-Releasing Properties of Poloxamer 407 Hydrogels with Casein. Pharm Res. 2021 Mar; 38(3):515-522. View Abstract
  47. Initial Method for Characterization of Tympanic Membrane Drug Permeability in Human Temporal Bones In Situ. Front Neurol. 2021; 12:580392. View Abstract
  48. Keeping Nanomedicine on Target. Nano Lett. 2021 01 13; 21(1):3-5. View Abstract
  49. Drug Delivery across Barriers to the Middle and Inner Ear. Adv Funct Mater. 2021 Oct 26; 31(44). View Abstract
  50. Local anesthesia enhanced with increasing high-frequency ultrasound intensity. Drug Deliv Transl Res. 2020 10; 10(5):1507-1516. View Abstract
  51. Steroid-eluting contact lenses for corneal and intraocular inflammation. Acta Biomater. 2020 10 15; 116:149-161. View Abstract
  52. Dually Enzyme- and Acid-Triggered Self-Immolative Ketal Glycoside Nanoparticles for Effective Cancer Prodrug Monotherapy. Nano Lett. 2020 07 08; 20(7):5465-5472. View Abstract
  53. Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia. Nat Commun. 2020 05 08; 11(1):2323. View Abstract
  54. Functionalized Multiarmed Polycaprolactones as Biocompatible Tissue Adhesives. ACS Appl Mater Interfaces. 2020 Apr 15; 12(15):17314-17320. View Abstract
  55. Synthesis of Poly(acyclic orthoester)s: Acid-Sensitive Biomaterials for Enhancing Immune Responses of Protein Vaccine. Angew Chem Int Ed Engl. 2020 04 27; 59(18):7235-7239. View Abstract
  56. The Duration of Nerve Block from Local Anesthetic Formulations in Male and Female Rats. Pharm Res. 2019 Nov 08; 36(12):179. View Abstract
  57. Transcytosis of Nanomedicine for Tumor Penetration. Nano Lett. 2019 11 13; 19(11):8010-8020. View Abstract
  58. Prolonged Duration Topical Corneal Anesthesia With the Cationic Lidocaine Derivative QX-314. Transl Vis Sci Technol. 2019 Sep; 8(5):28. View Abstract
  59. Prolonged Duration Local Anesthesia by Combined Delivery of Capsaicin- and Tetrodotoxin-Loaded Liposomes. Anesth Analg. 2019 09; 129(3):709-717. View Abstract
  60. Nanoscale systems for local drug delivery. Nano Today. 2019 Oct; 28. View Abstract
  61. A Simple, Yet Multifunctional, Nanoformulation for Eradicating Tumors and Preventing Recurrence with Safely Low Administration Dose. Nano Lett. 2019 08 14; 19(8):5515-5523. View Abstract
  62. Topical sustained drug delivery to the retina with a drug-eluting contact lens. Biomaterials. 2019 10; 217:119285. View Abstract
  63. Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity. Nat Commun. 2019 06 12; 10(1):2566. View Abstract
  64. Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy. Proc Natl Acad Sci U S A. 2019 05 28; 116(22):10674-10680. View Abstract
  65. Quantile Regression and Its Applications: A Primer for Anesthesiologists. Anesth Analg. 2019 04; 128(4):820-830. View Abstract
  66. Prolonged Duration Local Anesthesia by Combined Delivery of Capsaicin- and Tetrodotoxin-Loaded Liposomes. Anesth Analg. 2019 Mar 11. View Abstract
  67. Transtympanic Delivery of Local Anesthetics for Pain in Acute Otitis Media. Mol Pharm. 2019 04 01; 16(4):1555-1562. View Abstract
  68. Intravenous treatment of choroidal neovascularization by photo-targeted nanoparticles. Nat Commun. 2019 02 18; 10(1):804. View Abstract
  69. Nanoscale Bupivacaine Formulations To Enhance the Duration and Safety of Intravenous Regional Anesthesia. ACS Nano. 2019 01 22; 13(1):18-25. View Abstract
  70. PLGA-encapsulation of the Pseudomonas aeruginosa PopB vaccine antigen improves Th17 responses and confers protection against experimental acute pneumonia. Vaccine. 2018 11 12; 36(46):6926-6932. View Abstract
  71. Treatment of Streptococcus pneumoniae otitis media in a chinchilla model by transtympanic delivery of antibiotics. JCI Insight. 2018 10 04; 3(19). View Abstract
  72. Externally triggered patient-controlled local anesthesia. Pain Manag. 2018 09 01; 8(5):313-315. View Abstract
  73. Long-acting liposomal corneal anesthetics. Biomaterials. 2018 10; 181:372-377. View Abstract
  74. Predicting the tissue depth for remote triggering of drug delivery systems. J Control Release. 2018 09 28; 286:55-63. View Abstract
  75. Antibody-modified conduits for highly selective cytokine elimination from blood. JCI Insight. 2018 07 12; 3(13). View Abstract
  76. Synergy between chemical permeation enhancers and drug permeation across the tympanic membrane. J Control Release. 2018 11 10; 289:94-101. View Abstract
  77. Prolonged Duration Local Anesthesia Using Liposomal Bupivacaine Combined With Liposomal Dexamethasone and Dexmedetomidine. Anesth Analg. 2018 04; 126(4):1170-1175. View Abstract
  78. BaTiO3-core Au-shell nanoparticles for photothermal therapy and bimodal imaging. Acta Biomater. 2018 05; 72:287-294. View Abstract
  79. High-frequency, low-intensity ultrasound and microbubbles enhance nerve blockade. J Control Release. 2018 04 28; 276:150-156. View Abstract
  80. Ultrasound-triggered liposomes for on-demand local anesthesia. Ther Deliv. 2018 01; 9(1):5-8. View Abstract
  81. Hollow Silica Nanoparticles Penetrate the Peripheral Nerve and Enhance the Nerve Blockade from Tetrodotoxin. Nano Lett. 2018 01 10; 18(1):32-37. View Abstract
  82. Light-Emitting Photon-Upconversion Nanoparticles in the Generation of Transdermal Reactive-Oxygen Species. ACS Appl Mater Interfaces. 2017 Dec 06; 9(48):41737-41747. View Abstract
  83. Enhanced Triggering of Local Anesthetic Particles by Photosensitization and Photothermal Effect Using a Common Wavelength. Nano Lett. 2017 11 08; 17(11):7138-7145. View Abstract
  84. Ultrasound-triggered local anaesthesia. Nat Biomed Eng. 2017; 1:644-653. View Abstract
  85. Getting Drugs Across Biological Barriers. Adv Mater. 2017 Oct; 29(37). View Abstract
  86. Tetrodotoxin, Epinephrine, and Chemical Permeation Enhancer Combinations in Peripheral Nerve Blockade. Anesth Analg. 2017 06; 124(6):1804-1812. View Abstract
  87. Combination Clearance Therapy and Barbiturate Coma for Severe Carbamazepine Overdose. Pediatrics. 2017 May; 139(5). View Abstract
  88. Strong tissue glue with tunable elasticity. Acta Biomater. 2017 04 15; 53:93-99. View Abstract
  89. Multiply repeatable and adjustable on-demand phototriggered local anesthesia. J Control Release. 2017 04 10; 251:68-74. View Abstract
  90. Ultrasensitive Phototriggered Local Anesthesia. Nano Lett. 2017 02 08; 17(2):660-665. View Abstract
  91. Drug delivery systems for prolonged duration local anesthesia. Mater Today (Kidlington). 2017 Jan-Feb; 20(1):22-31. View Abstract
  92. 1074: SEVERITY OF HEMODYNAMIC INSTABILITY AROUND HIGH-DOSE VASOACTIVE SYRINGE CHANGES IN THE PICU. Crit Care Med. 2016 Dec; 44(12 Suppl 1):344. View Abstract
  93. Incorporation of heparin-binding proteins into preformed dextran sulfate-chitosan nanoparticles. Int J Nanomedicine. 2016; 11:6149-6159. View Abstract
  94. Phototriggered Drug Delivery Using Inorganic Nanomaterials. Bioconjug Chem. 2017 01 18; 28(1):98-104. View Abstract
  95. Core-Shell Nanostars for Multimodal Therapy and Imaging. Theranostics. 2016; 6(13):2306-2313. View Abstract
  96. Treatment of otitis media by transtympanic delivery of antibiotics. Sci Transl Med. 2016 09 14; 8(356):356ra120. View Abstract
  97. Latanoprost-Eluting Contact Lenses in Glaucomatous Monkeys. Ophthalmology. 2016 10; 123(10):2085-92. View Abstract
  98. Drug delivery, biomaterials and nanomedicine: an interview with Daniel S Kohane. Future Sci OA. 2016 Sep; 2(3):FSO138. View Abstract
  99. Enhanced Precision of Nanoparticle Phototargeting in Vivo at a Safe Irradiance. Nano Lett. 2016 07 13; 16(7):4516-20. View Abstract
  100. RNA therapeutics - The potential treatment for myocardial infarction. Regen Ther. 2016 Jun; 4:83-91. View Abstract
  101. A Supramolecular Shear-Thinning Anti-Inflammatory Steroid Hydrogel. Adv Mater. 2016 Aug; 28(31):6680-6. View Abstract
  102. Extended Release of Native Drug Conjugated in Polyketal Microparticles. J Am Chem Soc. 2016 05 18; 138(19):6127-30. View Abstract
  103. Titanium Coating of the Boston Keratoprosthesis. Transl Vis Sci Technol. 2016 Apr; 5(2):17. View Abstract
  104. Self-assembled gemcitabine-gadolinium nanoparticles for magnetic resonance imaging and cancer therapy. Acta Biomater. 2016 Mar; 33:34-9. View Abstract
  105. Phototriggered Local Anesthesia. Nano Lett. 2016 Jan 13; 16(1):177-81. View Abstract
  106. Repeatable and adjustable on-demand sciatic nerve block with phototriggerable liposomes. Proc Natl Acad Sci U S A. 2015 Dec 22; 112(51):15719-24. View Abstract
  107. Selective binding of C-6 OH sulfated hyaluronic acid to the angiogenic isoform of VEGF(165). Biomaterials. 2016 Jan; 77:130-138. View Abstract
  108. New Strategies in Cancer Nanomedicine. Annu Rev Pharmacol Toxicol. 2016; 56:41-57. View Abstract
  109. Ultraviolet light-mediated drug delivery: Principles, applications, and challenges. J Control Release. 2015 Dec 10; 219:31-42. View Abstract
  110. Photoresponsive nanoparticles for drug delivery. Nano Today. 2015 Aug 01; 10(4):451-467. View Abstract
  111. Efficient Triplet-Triplet Annihilation-Based Upconversion for Nanoparticle Phototargeting. Nano Lett. 2015 Oct 14; 15(10):6332-8. View Abstract
  112. Corneal Anesthesia With Site 1 Sodium Channel Blockers and Dexmedetomidine. Invest Ophthalmol Vis Sci. 2015 Jun; 56(6):3820-6. View Abstract
  113. Nonlinear Optics: NIR-Triggered Drug Delivery by Collagen-Mediated Second Harmonic Generation (Adv. Healthcare Mater. 8/2015). Adv Healthc Mater. 2015 Jun; 4(8):1108. View Abstract
  114. NIR-triggered drug delivery by collagen-mediated second harmonic generation. Adv Healthc Mater. 2015 Jun 03; 4(8):1159-63. View Abstract
  115. Preparation and characterization of SDF-1a-chitosan-dextran sulfate nanoparticles. J Vis Exp. 2015 Jan 22; (95):52323. View Abstract
  116. Aptamer photoregulation in vivo. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17099-103. View Abstract
  117. Clinicians' perspectives on the use of drug-eluting contact lenses for the treatment of glaucoma. Ther Deliv. 2014 Oct; 5(10):1077-83. View Abstract
  118. A two-component pre-seeded dermal-epidermal scaffold. Acta Biomater. 2014 Dec; 10(12):4928-4938. View Abstract
  119. Prospects for near-infrared technology in remotely triggered drug delivery. Expert Opin Drug Deliv. 2014 Nov; 11(11):1681-5. View Abstract
  120. Photothermally targeted thermosensitive polymer-masked nanoparticles. Nano Lett. 2014 Jul 09; 14(7):3697-701. View Abstract
  121. Prevention of ventilator-induced lung edema by inhalation of nanoparticles releasing ruthenium red. Am J Respir Cell Mol Biol. 2014 Jun; 50(6):1107-17. View Abstract
  122. Interview with Daniel Kohane. Ther Deliv. 2014 Apr; 5(4):387-9. View Abstract
  123. Multivesicular liposomal bupivacaine at the sciatic nerve. Biomaterials. 2014 May; 35(15):4557-64. View Abstract
  124. Near-infrared-actuated devices for remotely controlled drug delivery. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):1349-54. View Abstract
  125. Prevention of peritoneal adhesions using polymeric rheological blends. Acta Biomater. 2014 Mar; 10(3):1187-93. View Abstract
  126. Photoswitchable nanoparticles for in vivo cancer chemotherapy. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19048-53. View Abstract
  127. Photoactive electrospun fibers for inducing cell death. Adv Healthc Mater. 2014 Apr; 3(4):494-9. View Abstract
  128. SDF-1a in glycan nanoparticles exhibits full activity and reduces pulmonary hypertension in rats. Biomacromolecules. 2013 Nov 11; 14(11):4009-20. View Abstract
  129. In vivo performance of a drug-eluting contact lens to treat glaucoma for a month. Biomaterials. 2014 Jan; 35(1):432-9. View Abstract
  130. A photo-triggered layered surface coating producing reactive oxygen species. Biomaterials. 2013 Dec; 34(38):9763-9. View Abstract
  131. Biodegradable mesostructured polymer membranes. Nano Lett. 2013 Sep 11; 13(9):4410-5. View Abstract
  132. Enhanced photothermal effect of plasmonic nanoparticles coated with reduced graphene oxide. Nano Lett. 2013 Sep 11; 13(9):4075-9. View Abstract
  133. Long-lasting antifouling coating from multi-armed polymer. Langmuir. 2013 Aug 13; 29(32):10087-94. View Abstract
  134. Topical drug formulations for prolonged corneal anesthesia. Cornea. 2013 Jul; 32(7):1040-5. View Abstract
  135. Microdevices for nanomedicine. Mol Pharm. 2013 Jun 03; 10(6):2127-44. View Abstract
  136. A Stiff Injectable Biodegradable Elastomer. Adv Funct Mater. 2013 Mar 25; 23(12):1527-1533. View Abstract
  137. Local toxicity from local anesthetic polymeric microparticles. Anesth Analg. 2013 Apr; 116(4):794-803. View Abstract
  138. Controlled-release systems in neuropathic pain. Pain Manag. 2013 Mar; 3(2):91-3. View Abstract
  139. Synthetic ligand-coated magnetic nanoparticles for microfluidic bacterial separation from blood. Nano Lett. 2014 Jan 08; 14(1):1-5. View Abstract
  140. Synthesis and proton NMR spectroscopy of intra-vesicular gamma-aminobutyric acid (GABA). Annu Int Conf IEEE Eng Med Biol Soc. 2013; 2013:1093-5. View Abstract
  141. Modular 'click-in-emulsion' bone-targeted nanogels. Adv Mater. 2013 Mar 13; 25(10):1449-54. View Abstract
  142. Benchtop fabrication of microfluidic systems based on curable polymers with improved solvent compatibility. Lab Chip. 2013 Jan 21; 13(2):252-9. View Abstract
  143. Formulations for trans-tympanic antibiotic delivery. Biomaterials. 2013 Jan; 34(4):1281-8. View Abstract
  144. Materials to clinical devices: technologies for remotely triggered drug delivery. Clin Ther. 2012 Nov; 34(11):S25-35. View Abstract
  145. Prolonged nerve blockade delays the onset of neuropathic pain. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17555-60. View Abstract
  146. Nanocomposite gold-silk nanofibers. Nano Lett. 2012 Oct 10; 12(10):5403-6. View Abstract
  147. Duration and local toxicity of sciatic nerve blockade with coinjected site 1 sodium-channel blockers and quaternary lidocaine derivatives. Reg Anesth Pain Med. 2012 Sep-Oct; 37(5):483-9. View Abstract
  148. Macroporous nanowire nanoelectronic scaffolds for synthetic tissues. Nat Mater. 2012 Nov; 11(11):986-94. View Abstract
  149. Shedding light on nanomedicine. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2012 Nov-Dec; 4(6):638-62. View Abstract
  150. The smartest materials: the future of nanoelectronics in medicine. ACS Nano. 2012 Aug 28; 6(8):6541-5. View Abstract
  151. Thermoresponsive nanogels for prolonged duration local anesthesia. Acta Biomater. 2012 Oct; 8(10):3596-605. View Abstract
  152. Electrospun drug-eluting sutures for local anesthesia. J Control Release. 2012 Aug 10; 161(3):903-9. View Abstract
  153. Delivering bioactive molecules as instructive cues to engineered tissues. Expert Opin Drug Deliv. 2012 Apr; 9(4):473-92. View Abstract
  154. Photoswitchable nanoparticles for triggered tissue penetration and drug delivery. J Am Chem Soc. 2012 May 30; 134(21):8848-55. View Abstract
  155. Novel resonating nanowire arrays function as highly sensitive biosensors. Nanomedicine (Lond). 2012 Mar; 7(3):315. View Abstract
  156. Injectable scaffolds achieve sustained siRNA release for tissue repair. Nanomedicine (Lond). 2012 Mar; 7(3):315-6. View Abstract
  157. External electric fields trigger drug release from new hydrogel formulation. Nanomedicine (Lond). 2012 Mar; 7(3):316. View Abstract
  158. Toxicogenomic analysis of a sustained release local anesthetic delivery system. Biomaterials. 2012 May; 33(13):3586-93. View Abstract
  159. An in situ cross-linking hybrid hydrogel for controlled release of proteins. Acta Biomater. 2012 May; 8(5):1703-9. View Abstract
  160. Nanogel scavengers for drugs: local anesthetic uptake by thermoresponsive nanogels. Acta Biomater. 2012 Apr; 8(4):1450-8. View Abstract
  161. Nanowired three-dimensional cardiac patches. Nat Nanotechnol. 2011 Sep 25; 6(11):720-5. View Abstract
  162. Hydroxyapatite for keratoprosthesis biointegration. Invest Ophthalmol Vis Sci. 2011 Sep 22; 52(10):7392-9. View Abstract
  163. Nanoparticles targeting the infarcted heart. Nano Lett. 2011 Oct 12; 11(10):4411-4. View Abstract
  164. Liposomes for HIV prophylaxis. Biomaterials. 2011 Nov; 32(33):8663-8. View Abstract
  165. A prototype antifungal contact lens. Invest Ophthalmol Vis Sci. 2011 Aug 09; 52(9):6286-91. View Abstract
  166. Microgels for efficient protein purification. Adv Mater. 2011 Sep 22; 23(36):H258-62. View Abstract
  167. Surface modification and drug delivery for biointegration. Ther Deliv. 2011 Jun; 2(6):737-52. View Abstract
  168. Elasticity and safety of alkoxyethyl cyanoacrylate tissue adhesives. Acta Biomater. 2011 Aug; 7(8):3150-7. View Abstract
  169. Nanotechnology for surgeons. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011 May-Jun; 3(3):223-8. View Abstract
  170. Magnetically triggered nanocomposite membranes: a versatile platform for triggered drug release. Nano Lett. 2011 Mar 09; 11(3):1395-400. View Abstract
  171. Drug delivery and translation. Drug Deliv Transl Res. 2011 Feb; 1(1):4-6. View Abstract
  172. Nanotechnological strategies for engineering complex tissues. Nat Nanotechnol. 2011 Jan; 6(1):13-22. View Abstract
  173. Remotely triggerable drug delivery systems. Adv Mater. 2010 Nov 24; 22(44):4925-43. View Abstract
  174. Combinatorial extracellular matrices for human embryonic stem cell differentiation in 3D. Biomacromolecules. 2010 Aug 09; 11(8):1909-14. View Abstract
  175. A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery. Biomaterials. 2010 Jul; 31(19):5208-17. View Abstract
  176. Prolonged sensory-selective nerve blockade. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3740-5. View Abstract
  177. Rheological blends for drug delivery. I. Characterization in vitro. J Biomed Mater Res A. 2010 Feb; 92(2):575-85. View Abstract
  178. Rheological blends for drug delivery. II. Prolongation of nerve blockade, biocompatibility, and in vitro-in vivo correlations. J Biomed Mater Res A. 2010 Feb; 92(2):586-95. View Abstract
  179. Photo-targeted nanoparticles. Nano Lett. 2010 Jan; 10(1):250-4. View Abstract
  180. Injectable in situ cross-linking hydrogels for local antifungal therapy. Biomaterials. 2010 Feb; 31(6):1444-52. View Abstract
  181. Three-dimensional conductive constructs for nerve regeneration. J Biomed Mater Res A. 2009 Nov; 91(2):519-27. View Abstract
  182. A magnetically triggered composite membrane for on-demand drug delivery. Nano Lett. 2009 Oct; 9(10):3651-7. View Abstract
  183. Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery. Small. 2009 Jul; 5(13):1575-81. View Abstract
  184. Contact lenses for drug delivery. Semin Ophthalmol. 2009 May-Jun; 24(3):156-60. View Abstract
  185. Prolonged duration local anesthesia with minimal toxicity. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7125-30. View Abstract
  186. A drug-eluting contact lens. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3346-52. View Abstract
  187. Intracellular drug delivery by poly(lactic-co-glycolic acid) nanoparticles, revisited. Mol Pharm. 2009 Jan-Feb; 6(1):190-201. View Abstract
  188. Effect of chemical permeation enhancers on nerve blockade. Mol Pharm. 2009 Jan-Feb; 6(1):265-73. View Abstract
  189. Spray-dried lipid-hyaluronan-polymethacrylate microparticles for drug delivery in the peritoneum. J Biomed Mater Res A. 2008 Dec 01; 87(3):825-31. View Abstract
  190. The biocompatibility of mesoporous silicates. Biomaterials. 2008 Oct; 29(30):4045-55. View Abstract
  191. Microparticles for inhalational delivery of antipseudomonal antibiotics. AAPS J. 2008 Jun; 10(2):254-60. View Abstract
  192. Polymeric biomaterials in tissue engineering. Pediatr Res. 2008 May; 63(5):487-91. View Abstract
  193. Local myotoxicity from sustained release of bupivacaine from microparticles. Anesthesiology. 2008 May; 108(5):921-8. View Abstract
  194. Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation. Am J Respir Crit Care Med. 2007 Dec 01; 176(11):1138-45. View Abstract
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