In parallel studies, we've examined the efficacy, safety, moderators and mediators of specific medications routinely used in treating pediatric pain patients and their common psychiatric comorbidities, as well as pharmacological interventions used to treat specific pain disorders in children and adolescents (e.g. pediatric migraine). The studies have been important in informing clinicians about the efficacy and safety about these commonly used pharmacological interventions and identifying gaps in research as well as potential moderators and mediators to include in our own clinical assessments and research trials.

Sample Publications: 

Locher C, Koechlin H, Zion S, Werner C, Kessler R, Kirsch I, Pine D, Kossowsky J. Efficacy and Safety of SSRIs, SNRIs, and Placebo in Common Psychiatric Disorders: A Comprehensive Meta-Analysis in Children and Adolescents. JAMA Psychiatry. 2017 Oct; 74(10):1011-1020.

Locher C*, Kossowsky J*, Koechlin H, Lam TL, Barthel J, Berde CB, Gaab J, Schwarzer G, Linde K, Meissner K. Efficacy, Safety and Acceptability of Pharmacological Treatments for Pediatric Migraine Prophylaxis: A Systematic Review and Network Meta-Analysis. JAMA Peds. 2020 Feb 10; 174(4):341-349.

* Co-First Authorship