1. Home
  2. Publications & Patents

Publications

​​​​For the complete list of publications and citations, please see the Google Scholar page here.

 

  1. R Mout, ...U Lendahl, D Baker, SC Blacklow, GQ Daley et al., "Design of a Soluble Multivalent Notch Agonist" bioRxiv, 2024, doi: https://doi.org/10.1101/2024.08.07.607099

  2. R Mout, R Jing, L Hensch, U Lendahl, GQ Daley. "Notch Signaling in Blood Development" Manuscript in preparation, 2024

  3. B Huang, ...R Mout, ...C Bertozzi, D Baker. "Designed Endocytosis-Triggering Proteins Mediate Targeted Degradation" bioRxiv, 2023, doi: 10.1101/2023.08.19.553321

  4. R Mout*#, RC Bretherton*, J Decarreau, S Lee, N Gregorio, NI Edman, M Ahlrichs, Y Hsia, DD Sahtoe, G Ueda, A Sharma, R Schulman, CA DeForest#, D Baker#. “De novo design of modular protein hydrogels with programmable intra- and extracellular viscoelasticity” Proc. Natl. Acad. Sci. U.S.A., 2024, 121(6), e2309457121 (#co-corresponding author)

  5. M Ray, G Brancolini, DC Luther, Z Jiang, R Cao-Milán, AM Cuadros, A Burden, V Clark, S Rana, R Mout, RF Landis, S Corni, VM Rotello. “High affinity protein surface binding through co-engineering of nanoparticles and proteins” Nanoscale, 2022, 14, 2411-2418.

  6. Y Hsia*, R Mout*, ..., D Baker. “Design of multi-scale protein complexes by hierarchical building block fusion” Nat commun., 2021, 12, 2294 (*equal contribution)

  7. YW Lee*, R Mout*, ..., VM Rotello. “In Vivo Editing of Macrophages through Systemic Delivery of CRISPR‐Cas9‐Ribonucleoprotein‐Nanoparticle Nanoassemblies” Adv. Therap. 2019, 2, 1900041 (*equal contribution)

  8. M Ray, YW Lee, J Hardie, R Mout, GY Tonga, ME Farkas, VM Rotello “CRISPRed Macrophages for Cell-Based Cancer Immunotherapy” Bioconjugate Chem. 2018, 29, 445-450.

  9. R Mout, VM Rotello. “A General Method for Intracellular Protein Delivery through ‘E-tag’ Protein Engineering and Arginine Functionalized Gold Nanoparticles” Bio-protocol, 2017, 7, e2661.

  10. F Scaletti, D Luther, R Mout, M Ray, YW Lee, VM Rotello. “CRISPR/Cas9 Protein Delivery Technologies” G.I.T Laboratory Journal, 2017, 21, 22-23.

  11. R Mout, VM Rotello. “Cytosolic and Nuclear Delivery of CRISPR/Cas9-Ribonucleoprotein for Gene Editing using Arginine Functionalized Gold Nanoparticle” Bio-protocol, 2017, 7, e2586.

  12. R Mout, M Ray, T Tray, K Sasaki, GY Tonga, VM Rotello. “General Strategy for Direct Cytosolic Protein Delivery via Protein-Nanoparticle Coengineering” ACS Nano, 2017, 11, 6416-6421.

  13. NDB Le, GY Tonga, R Mout, et al., “Cancer Cell Discrimination Using Host-Guest 'Doubled' Arrays” J. Am. Chem. Soc., 2017, 139, 8008-8012.

  14. R Mout, M Ray, Y-W Lee, F Scaletti, VM Rotello. “In Vivo Delivery of CRISPR/Cas9 for Therapeutic Gene Editing: Progress and Challenges” Bioconjug. Chem., 2017, 28, 880-884.

  15. R Mout, M Ray, GY Tonga, Y.-W. Lee, T Tray, K Sasaki, VM Rotello. “Direct Cytoplasmic Delivery of CRISPR/Cas9-Ribonucleoprotein for Efficient Gene Editing” ACS Nano, 2017, 11, 2452-2458.

  16. R Mout, GY Tonga, L Wang, M Ray, T Roy, VM Rotello. “Programmed Self-Assembly of Hierarchical Nanostructures through Protein-Nanoparticle Coengineering” ACS Nano, 2017, 11, 3456-3462.

  17. K Saha, M Rahimi, M Yazdani, ST Kim, DF Moyano, S Hou, R Das, R Mout, F Rezaee, M Mahmoudi, VM Rotello. “Regulation of Macrophage Recognition Through the Interplay of Nanoparticle Surface Functionality and Protein Corona” ACS Nano, 2016, 10, 4421-4430.

  18. S Rana, SG Elci, R Mout, AK Singla, M Yazdani, M Bender, A Bajaj, K Saha, UHF Bunz, FR Jirik, VM Rotello. “Ratiometric Array of Conjugated Polymers-Fluorescent Protein Provides a Robust Mammalian Cell Sensor” J. Am. Chem. Soc., 2016, 138, 4522-4529.

  19. S Rana, ND Le*, R Mout*, K Saha, GY Tonga, RE Bain, OR Miranda, CM Rotello, VM Rotello. “A Multichannel Nanosensor for Instantaneous Readout of Cancer Drug Mechanisms” Nature Nanotechnol., 2015, 10, 65-69. (*equal contribution)

  20. GY Tonga, Y Jeong, B Duncan, T Mizuhara, R Mout, R Das, ST Kim, YC Yeh, B Yan, S Hou, VM Rotello. “Supramolecular Regulation of Bioorthogonal Catalysis in Cells using Nanoparticle-Embedded Transition Metal Catalysts” Nature Chem., 2015, 7, 597-603.

  21. S Rana, NDB Le, R Mout, B Duncan, SG Elci, K Saha, VM Rotello. “A Multichannel Biosensor for Rapid Determination of Cell Surface Glycomic Signatures” ACS Cent. Sci., 2015, 1, 191-197.

  22. CS Kim, R Mout, Y Zhao, YC Yeh, R Tang, Y Jeong, B Duncan, JA Hardy, VM Rotello. “Co-Delivery of Protein and Small Molecule Therapeutics using Nanoparticle-Stabilized Nanocapsules” Bioconjug. Chem., 2015, 26, 950-954.

  23. E Jeoung, YC Yeh, T Nelson, T Kushida, LS Wang, R Mout, X Li, K Saha, A Gupta, GY Tonga, JJ Lannutti, VM Rotello. “Fabrication of Functional Nanofibers through Post‐Nanoparticle Functionalization” Macromol. Rapid Commun., 2015, 36, 678-683.

  24. Z Ekmekci, K Saha, DF Moyano, GY Tonga, H Wang, R Mout, VM Rotello. “Probing the Protein–Nanoparticle Interface: The Role of Aromatic Substitution Pattern on Affinity” Supramol. Chem., 2015, 27, 123-126.

  25. Y Jiang, R Tang, B Duncan, Z Jiang, B Yan, R Mout, VM Rotello. “Direct Cytosolic Delivery of siRNA using Nanoparticle-Stabilized Nanocapsules” Angew. Chem. Int. Ed. Engl., 2015, 54, 506-510.

  26. X Li, YC Yeh, K Giri, R Mout, RF Landis, YS Prakash, VM Rotello. “Control of Nanoparticle Penetration into Biofilms through Surface Design” Chem. Commun., 2015, 51, 282-285.

  27. X Li, H Kong, R Mout, K Saha, DF Moyano, SM Robinson, S Rana, X Zhang, MA Riley, VM Rotello. “Rapid Identification of Bacterial Biofilms and Biofilm Wound Models using a Multichannel Nanosensor” ACS Nano, 2014, 8, 12014-12019.

  28. YC Yeh, R Tang, R Mout, Y Jeong, VM Rotello “Fabrication of Multiresponsive Bioactive Nanocapsules through Orthogonal Self-Assembly” Angew. Chem. Int. Ed. Engl., 2014, 53, 5137-5141.

  29. R Mout, GY Tonga, M Ray, DF Moyano, Y Xing, VM Rotello “Environmentally Responsive Histidine-Carboxylate Zipper Formation between Proteins and Nanoparticles” Nanoscale, 2014, 6, 8873-8877.

  30. YC Yeh, S Rana, R Mout, B Yan, FS Alfonso, VM Rotello. “Supramolecular Tailoring of Protein–Nanoparticle Interactions using Cucurbituril Mediators” Chem Commun., 2014, 50, 5565-5568.

  31. R Mout, VM Rotello. “Bio and Nano Working Together: Engineering the Protein‐Nanoparticle Interface” Isr. J. Chem., 2013, 53, 521-529.

  32. R Tang, CS Kim, DJ Solfiell, S Rana, R Mout, EM Velázquez-Delgado, A Chompoosor, Y Jeong, B Yan, ZJ Zhu, CK Kim, JA Hardy, VM Rotello. “Direct Delivery of Functional Proteins and Enzymes to the Cytosol using Nanoparticle-Stabilized Nanocapsules” ACS Nano, 2013, 7, 6667-6673.

  33. V Nandwana, R Mout, YC Yeh, S Dickert, MT Tuominen, VM Rotello. “Patterning of Protein/Quantum dot Hybrid Bionanostructures” J. Inorg. Organomet. Polym. Mater., 2013, 23, 227-232.

  34. S Rana, AK Singla, A Bajaj, SG Elci, OR Miranda, R Mout, B Yan, FR Jirik, VM Rotello. “Array-Based Sensing of Metastatic Cells and Tissues using Nanoparticle–Fluorescent Protein Conjugates” ACS Nano, 2012, 6, 8233-8240.

  35. R Mout, DF Moyano, S Rana, VM Rotello. “Surface Functionalization of Nanoparticles for Nanomedicine” Chem. Soc. Rev., 2012, 41, 2539-2544.

  36. S Rana, A Bajaj, R Mout, VM Rotello. “Monolayer Coated Gold Nanoparticles for Delivery Applications” Adv. Drug. Deliv. Rev., 2012, 64, 200-216.

  37. R Mout, Z Xu, AK Wolf, VJ Davisson, GK Jarori “Anti-Malarial Activity of Geldanamycin Derivatives in Mice Infected with Plasmodium yoelii” Malar J., 2012, 11, 54.

  38. HK Vora, FR Shaik, I Pal-Bhowmick, R Mout, GK Jarori. “Effect of Deletion of a Plant Like Pentapeptide Insert on Kinetic, Structural and Immunological Properties of Enolase from Plasmodium falciparum” Arch. Biochem. Biophys., 2009, 485, 128-138

Patents

  1. R Mout, G Daley, et al., "Methods and compositions for T-cell differentiation" Application Number: 63/413,377.
  2. R Mout, D Baker, et al., “De novo design of multi-component protein hydrogel with programmable viscoelasticity” US Patent App. 63/353,391
  3. Y Hsia, R Mout, D Baker, et al., “WORMS Scaffolds: Multi-scale protein complexes” US Patent App. 17/564,467
  4. VM Rotello, R Mout. “Nanoparticle-Protein Complex for Intracellular Protein Delivery” US application (USPTO)- US20180022831A1. Patent status: granted, 09/2020