Research Fellow, Vascular Biology Program, Boston Children's Hospital
Research Fellow, Harvard Medical School
Chao completed his PhD in Genetics at Fudan University in 2022, where his research primarily focused on the mechanisms by which noncoding RNAs contribute to the development of congenital heart diseases. This work paved the way for his interest in molecular biology and gene regulation within cardiovascular development and pathologies. Building upon his expertise in genetic regulation and signaling pathways, he joined the laboratory of Dr. Timothy Hla in Jaunuary 2024. Chao is actively involved in researching the role of the S1P signaling pathway in cardiac development and aortic aging. He hopes to apply and expand his knowledge of signaling pathways, specifically in the context of development and aging, to understand potential therapeutic targeting of cardiovascular conditions.
Publication Highlights:
Li, C., Li, H., Yao, X., Liu, D., Wang, Y., Huang, X., ... & Wang, H. (2022). Master microRNA-222 regulates cardiac microRNA maturation and triggers Tetralogy of Fallot. Signal Transduction and Targeted Therapy, 7(1), 1-4.
Li, C., Ni, J., Liu, Y. X., Wang, H., Liang, Z. Q., & Wang, X. (2017). Response of MiRNA-22-3p and MiRNA-149-5p to folate deficiency and the differential regulation of MTHFR expression in normal and cancerous human hepatocytes. PloS one, 12(1), e0168049.
Zhang, H., Lu, L., Li, C., Li, H., Tian, J., & Wang, H. (2022). Downregulated nuclear lncRNA NRON inhibits SHP2/Wnt/β-catenin signaling and cardiomyocyte differentiation during the development of Tetralogy of Fallot. Genes & Diseases.