News and Events

Congratulations to Andrew Kuo on his publication!


Kuo A, Hla T. Regulation of cellular and systemic sphingolipid homeostasis. Nat Rev Mol Cell Biol. 2024 Jun 18. Epub ahead of print. PMID: 38890457.



Very best wishes to Mike and Alex!


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Hla lab hosted delicious Friday Tea, May 2024


friday tea



Daniel Lin, PhD presents at the Vascular Biology Program's Work in Progress on March 27th, 2024


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Congratulations to Hla Lab members Daniel Lin, Avishek Ghosh, Andrew Kuo, Michel Levesque and Andreane Cartier on their publication!



Lin YC, Swendeman S, Moreira IS, Ghosh A, Kuo A, Rosário-Ferreira N, Guo S, Culbertson A, Levesque MV, Cartier A, Seno T, Schmaier A, Galvani S, Inoue A, Parikh SM, FitzGerald GA, Zurakowski D, Liao M, Flaumenhaft R, Gümüş ZH, Hla T. Designer high-density lipoprotein particles enhance endothelial barrier function and suppress inflammation. Sci Signal. 2024 Feb 20;17(824):eadg9256. doi: 10.1126/scisignal.adg9256. Epub 2024 Feb 20. PMID: 38377179.


Congratulations to Avishek Ghosh who received American Heart Association grant!




The Hla Lab enjoys Holiday Lunch, December 2023


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Andrew Kuo, PhD presents at the Vascular Biology Program's Work in Progress on December 13th, 2023


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Dr. Hla, Daniel Lin, PhD and Bongnam Jung, PhD present at the 2023 Vascular Biology Retreat in Cambridge, MA

      Photographs by: Kristin Johnson 



Hla lab hosting VBP Friday Tea, November 2023


hla lab tea


Congrats and best wishes to Colin!





Congratulations to Hla Lab members Colin Niaudet, Michel Levesque, Bongnam Jung and Andrew Kuo on their publications!


Niaudet C, Jung B, Kuo A, Swendeman S, Bull E, Seno T, Crocker R, Fu Z, Smith LEH, Hla T. Therapeutic activation of endothelial sphingosine-1-phosphate receptor 1 by chaperone-bound S1P suppresses proliferative retinal neovascularization. EMBO Mol Med. 2023 May 8;15(5):e16645. doi: 10.15252/emmm.202216645. Epub 2023 Mar 13. PMID: 36912000; PMCID: PMC10165359.

Levesque MV, Hla T. Signal Transduction and Gene Regulation in the Endothelium. Cold Spring Harb Perspect Med. 2023 Jan 3;13(1):a041153. doi: 10.1101/cshperspect.a041153. PMID: 35667710; PMCID: PMC9722983.


Congrats and very best wishes to Steve!

Steve, who joined the Hla lab in 2012 and had such an influence to the lab, will start his next adventure in Vertex Pharmaceuticals in Boston. We will miss you!




The Hla Lab enjoys a Holiday Lunch, December 2022


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Daniel Lin, PhD presents at the Vascular Biology Program's Work in Progress on November 9th, 2022


                         Daniel wip


Congratulations to Hla Lab members Andrew Kuo, Colin Niaudet, and Bongnam Jung on their publications!


Kuo A, Checa A, Niaudet C, Jung B, Fu Z, Wheelock CE, Singh SA, Aikawa M, Smith LE, Proia RL, Hla T. Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis. Elife. 2022 Oct 5.


Colin Niaudet, PhD presents at the Vascular Biology Program's Work in Progress on May 12th, 2021


colin wip



Congrats and best wishes to Dr. Takahiro Seno!

Takahiro, who joined the Hla lab in 2017, will start his next adventure as a faculty member at Kyoto Prefectoral University in Japan




Congratulations to Hla Lab members Andreane Cartier, Michel Levesque, Eric Engelbrecht, Colin Niaudet, Bongnam Jung, and Steve Swendeman on their publications!


Cartier A, Hla T. Sphingosine 1-phosphate: Lipid signaling in pathology and therapy. Science. 2019 Oct 18.

Cartier A, Leigh T, Liu CH, Hla T. Endothelial sphingosine 1-phosphate receptors promote vascular normalization and antitumor therapy. Proc Natl Acad Sci USA. 2020 Feb.

Yanagida K, Engelbrecht E, Niaudet C, Jung B, Gaengel K, Holton K, Swendeman S, Liu CH, Levesque MV, Kuo A, Fu Z, Smith LEH, Betsholtz C, Hla T. Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization. Dev Cell. 2020 Feb 6.

Engelbrecht E, Levesque MV, He L, Vanlandewijck M, Nitzsche A, Niazi H, Kuo A, Singh SA, Aikawa M, Holton K, Proia RL, Kono M, Pu WT, Camerer E, Betsholtz C, Hla T. Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta. Elife. 2020 Feb 24.


The Hla Lab enjoys a Holiday BBQ Lunch 





Steve Swendeman, PhD and Dr. Hla present at the 2019 Vascular Biology Retreat in Cambridge, MA

      Photographs by: Kristin Johnson          








Andreane Carter, PhD presents at Work In Progress on Novermber 6th, 2019 





The Hla Lab hosts the 2019 Fondation Leducq Retreat in Boston








The Hla Lab hosts VBP's Friday Tea!

                                          Hla lab FL



Congrats and best wishes to Dr. Sylvain Galvani!

Sylvain, the passsionate French sicentist in the Hla lab, will start his next adventure in Vertex Pharmaceuticals in Boston. We will miss you! 

                sG1   DL2


Good luck to Dr. Yuichi Inagaki!




Farewell Mario Castro! 

We bid farewell to Mario Castro, who supported the Hla Lab for 9 productive years. He is moving back to New York city to join Pfizer HQ as an executive assistant. Best of luck and bon voyage!

    Mario and Vivian at VBP 2018 retreat.


Dr. Michel Levesque presented at Work in Progress on April 10, 2019


                         (image credit to Abby Marzec, VBP)


Dr. Keisuke Yanagida spoke at the VBP Work in Progress seminar series on October 24, 2018

keisuke WIP seminar


Farewell and best wishes to Hisano and his beautiful family in Japan!

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Thank you for having us for the end of summer BBQ, Hla family!

hla and hisanosnight shenanigans
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Good luck to our SUMMER STUDENTS: Vitoria and Ebuka!

summer students


Hla Lab Spring Teas!





Drs. Andreane Cartier and Yu Hisano presented at the Work In Progress Seminar

for the Vascular Biology Program




Welcome to the lab, baby Riku!

baby riku
Congratulations, Dr. and Mrs. Hisano!

Hla Lab at the 2018 Vascular Biology Program Retreat

hla lab vbp retreat 2018


Congratulations on your grant, Cecilia!

cecilia grantDr. Cecilia Frej has received a 4-year postdoc grant from the Novo Nordisk Foundation, a Danish foundation focusing on diabetes and diabetic co-morbidities. Her grant will support Cecilia for 3 years in Dr. Hla’s lab at Boston Children’s Hospital, Boston, Massachusetts followed by one year with Dr. Craig Wheelock at the Karolinska Institute in Stockholm, Sweden.


The Hla lab bonding & enjoying an end-of-summer Japanese BBQ lunch!



Eric Engelbrecht answering questions at the poster session at the 2017 Gordon Research Conference on Angiogenesis in Salve Regina University in Newport, Rhode Island



Dr. Michel Levesque presenting his poster at the 2017 FASEB: Lysophospholipid and Related Mediators-from Bench to Clinic meeting in New Orleans, LA


We were happy to host Dr. Holger Gerhardt for a special STANDING ROOM ONLY seminar for the Vascular Biology Program on August 15, 2017!



Yuquan's farewell luncheon - Best of luck!

Yuquan Farewell


Wishing Tani well on her future endeavors!




We welcome some new faces to the Hla lab!


From Left to Right: Andrew Kuo, Yuichi Inagaki, Cecilia Frej, and Martinique Ogle


Dr. Hla was honored to give the 9th Annual Dr. Judah Folkman Lecture on May 18, 2017

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